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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HS2ST1
Full Name:
Heparan sulfate 2-O-sulfotransferase 1
Alias:
2OST; 2-O-sulfotransferase; EC 2.8.2.-; HS2ST
Type:
Enzyme - Sulfotransferase. Sulfotransferase 3 family.
Mass (Da):
41881
Number AA:
356
UniProt ID:
Q7LGA3
International Prot ID:
Isoform1 - IPI00549891
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0016740
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
Q
K
L
E
E
S
R
S
K
L
E
R
A
I
A
Site 2
T58
R
E
I
E
Q
R
H
T
M
D
G
P
R
Q
D
Site 3
T67
D
G
P
R
Q
D
A
T
L
D
E
E
E
D
M
Site 4
Y78
E
E
D
M
V
I
I
Y
N
R
V
P
K
T
A
Site 5
T84
I
Y
N
R
V
P
K
T
A
S
T
S
F
T
N
Site 6
S88
V
P
K
T
A
S
T
S
F
T
N
I
A
Y
D
Site 7
T90
K
T
A
S
T
S
F
T
N
I
A
Y
D
L
C
Site 8
Y102
D
L
C
A
K
N
K
Y
H
V
L
H
I
N
T
Site 9
S117
T
K
N
N
P
V
M
S
L
Q
D
Q
V
R
F
Site 10
Y139
K
E
M
K
P
G
F
Y
H
G
H
V
S
Y
L
Site 11
Y159
G
V
K
K
K
P
I
Y
I
N
V
I
R
D
P
Site 12
S172
D
P
I
E
R
L
V
S
Y
Y
Y
F
L
R
F
Site 13
Y174
I
E
R
L
V
S
Y
Y
Y
F
L
R
F
G
D
Site 14
Y175
E
R
L
V
S
Y
Y
Y
F
L
R
F
G
D
D
Site 15
Y183
F
L
R
F
G
D
D
Y
R
P
G
L
R
R
R
Site 16
T197
R
K
Q
G
D
K
K
T
F
D
E
C
V
A
E
Site 17
Y242
W
A
M
D
Q
A
K
Y
N
L
I
N
E
Y
F
Site 18
T276
P
R
F
F
R
G
A
T
E
L
Y
R
T
G
K
Site 19
Y279
F
R
G
A
T
E
L
Y
R
T
G
K
K
S
H
Site 20
T281
G
A
T
E
L
Y
R
T
G
K
K
S
H
L
R
Site 21
S285
L
Y
R
T
G
K
K
S
H
L
R
K
T
T
E
Site 22
T290
K
K
S
H
L
R
K
T
T
E
K
K
L
P
T
Site 23
T291
K
S
H
L
R
K
T
T
E
K
K
L
P
T
K
Site 24
Y317
W
K
M
E
N
E
F
Y
E
F
A
L
E
Q
F
Site 25
Y340
R
E
K
D
G
D
L
Y
I
L
A
Q
N
F
F
Site 26
Y348
I
L
A
Q
N
F
F
Y
E
K
I
Y
P
K
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation