KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SHF
Full Name:
SH2 domain-containing adapter protein F
Alias:
Srcy 2 domain containing F
Type:
Unknown function
Mass (Da):
53297
Number AA:
480
UniProt ID:
Q7M4L6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
S
D
A
H
H
A
L
T
I
T
L
S
E
R
L
Site 2
S36
N
F
T
R
R
K
I
S
S
D
P
P
P
Y
N
Site 3
S37
F
T
R
R
K
I
S
S
D
P
P
P
Y
N
F
Site 4
Y42
I
S
S
D
P
P
P
Y
N
F
L
E
A
R
E
Site 5
S67
Q
E
G
G
P
V
R
S
A
P
C
R
T
G
T
Site 6
T74
S
A
P
C
R
T
G
T
L
E
G
S
R
Q
G
Site 7
S78
R
T
G
T
L
E
G
S
R
Q
G
S
P
G
H
Site 8
S82
L
E
G
S
R
Q
G
S
P
G
H
K
K
R
A
Site 9
S90
P
G
H
K
K
R
A
S
P
K
G
S
L
S
S
Site 10
S94
K
R
A
S
P
K
G
S
L
S
S
A
Q
P
H
Site 11
S96
A
S
P
K
G
S
L
S
S
A
Q
P
H
S
W
Site 12
S97
S
P
K
G
S
L
S
S
A
Q
P
H
S
W
M
Site 13
S102
L
S
S
A
Q
P
H
S
W
M
L
T
P
S
P
Site 14
T106
Q
P
H
S
W
M
L
T
P
S
P
L
N
S
H
Site 15
S108
H
S
W
M
L
T
P
S
P
L
N
S
H
C
A
Site 16
S112
L
T
P
S
P
L
N
S
H
C
A
H
R
E
P
Site 17
S121
C
A
H
R
E
P
I
S
S
S
P
Q
P
V
A
Site 18
S122
A
H
R
E
P
I
S
S
S
P
Q
P
V
A
N
Site 19
S123
H
R
E
P
I
S
S
S
P
Q
P
V
A
N
G
Site 20
S137
G
P
K
Q
K
K
K
S
N
W
R
S
T
T
R
Site 21
S141
K
K
K
S
N
W
R
S
T
T
R
L
R
I
I
Site 22
T142
K
K
S
N
W
R
S
T
T
R
L
R
I
I
R
Site 23
T143
K
S
N
W
R
S
T
T
R
L
R
I
I
R
L
Site 24
Y165
P
L
A
I
L
E
D
Y
A
D
P
F
D
V
Q
Site 25
S178
V
Q
E
T
G
E
G
S
A
G
A
S
G
A
P
Site 26
S182
G
E
G
S
A
G
A
S
G
A
P
E
K
V
P
Site 27
Y194
K
V
P
E
N
D
G
Y
M
E
P
Y
E
A
Q
Site 28
Y198
N
D
G
Y
M
E
P
Y
E
A
Q
K
M
M
A
Site 29
S210
M
M
A
E
I
R
G
S
K
E
T
A
T
Q
P
Site 30
T215
R
G
S
K
E
T
A
T
Q
P
L
P
L
Y
D
Site 31
Y221
A
T
Q
P
L
P
L
Y
D
T
P
Y
E
P
E
Site 32
T223
Q
P
L
P
L
Y
D
T
P
Y
E
P
E
E
D
Site 33
Y225
L
P
L
Y
D
T
P
Y
E
P
E
E
D
G
A
Site 34
T233
E
P
E
E
D
G
A
T
P
E
G
E
G
A
P
Site 35
S245
G
A
P
W
P
R
E
S
R
L
P
E
D
D
E
Site 36
Y258
D
E
R
P
P
E
E
Y
D
Q
P
W
E
W
K
Site 37
S270
E
W
K
K
E
R
I
S
K
A
F
A
V
D
I
Site 38
S294
P
P
V
G
Q
L
D
S
S
P
S
L
P
D
G
Site 39
S295
P
V
G
Q
L
D
S
S
P
S
L
P
D
G
D
Site 40
S297
G
Q
L
D
S
S
P
S
L
P
D
G
D
R
D
Site 41
S306
P
D
G
D
R
D
I
S
G
P
A
S
P
L
P
Site 42
S310
R
D
I
S
G
P
A
S
P
L
P
E
P
S
L
Site 43
S316
A
S
P
L
P
E
P
S
L
E
D
S
S
A
Q
Site 44
S320
P
E
P
S
L
E
D
S
S
A
Q
F
E
G
P
Site 45
S321
E
P
S
L
E
D
S
S
A
Q
F
E
G
P
E
Site 46
S330
Q
F
E
G
P
E
K
S
C
L
S
P
G
R
E
Site 47
S333
G
P
E
K
S
C
L
S
P
G
R
E
E
K
G
Site 48
S347
G
R
L
P
P
R
L
S
A
G
N
P
K
S
A
Site 49
S353
L
S
A
G
N
P
K
S
A
K
P
L
S
M
E
Site 50
S358
P
K
S
A
K
P
L
S
M
E
P
S
S
P
L
Site 51
S362
K
P
L
S
M
E
P
S
S
P
L
G
E
W
T
Site 52
S363
P
L
S
M
E
P
S
S
P
L
G
E
W
T
D
Site 53
T369
S
S
P
L
G
E
W
T
D
P
A
L
P
L
E
Site 54
S401
L
R
L
C
K
E
A
S
Y
L
V
R
N
S
E
Site 55
Y402
R
L
C
K
E
A
S
Y
L
V
R
N
S
E
T
Site 56
S407
A
S
Y
L
V
R
N
S
E
T
S
K
N
D
F
Site 57
S410
L
V
R
N
S
E
T
S
K
N
D
F
S
L
S
Site 58
S415
E
T
S
K
N
D
F
S
L
S
L
K
S
S
Q
Site 59
S417
S
K
N
D
F
S
L
S
L
K
S
S
Q
G
F
Site 60
S420
D
F
S
L
S
L
K
S
S
Q
G
F
M
H
M
Site 61
S421
F
S
L
S
L
K
S
S
Q
G
F
M
H
M
K
Site 62
Y437
S
R
T
K
N
N
K
Y
V
L
G
Q
N
S
P
Site 63
S443
K
Y
V
L
G
Q
N
S
P
P
F
S
S
V
P
Site 64
S447
G
Q
N
S
P
P
F
S
S
V
P
E
I
V
H
Site 65
S448
Q
N
S
P
P
F
S
S
V
P
E
I
V
H
H
Site 66
Y456
V
P
E
I
V
H
H
Y
A
S
R
K
L
P
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation