KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KRT74
Full Name:
Keratin, type II cytoskeletal 74
Alias:
Cytokeratin-74; K2c74; K6irs4; Keratin 6 irs4; Keratin 74; Keratin-5c; Keratin-74; Krt5c; Krt6irs4; Krt74; Type ii inner root sheath-specific keratin-k6irs4; Type ii keratin-37
Type:
Keratin filament protein
Mass (Da):
57865
Number AA:
529
UniProt ID:
Q7RTS7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0045095
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
R
Q
L
N
I
K
S
S
G
D
K
G
N
F
Site 2
S10
R
Q
L
N
I
K
S
S
G
D
K
G
N
F
S
Site 3
S17
S
G
D
K
G
N
F
S
V
H
S
A
V
V
P
Site 4
S49
G
A
G
F
G
S
R
S
L
Y
S
L
G
G
N
Site 5
Y51
G
F
G
S
R
S
L
Y
S
L
G
G
N
R
R
Site 6
S52
F
G
S
R
S
L
Y
S
L
G
G
N
R
R
I
Site 7
S60
L
G
G
N
R
R
I
S
F
N
V
A
G
G
G
Site 8
Y73
G
G
V
R
A
G
G
Y
G
F
R
P
G
S
G
Site 9
S79
G
Y
G
F
R
P
G
S
G
Y
G
G
G
R
A
Site 10
Y81
G
F
R
P
G
S
G
Y
G
G
G
R
A
S
G
Site 11
S87
G
Y
G
G
G
R
A
S
G
F
A
G
S
M
F
Site 12
S153
V
L
N
D
K
F
A
S
F
I
D
K
V
R
F
Site 13
S196
P
I
L
E
G
Y
I
S
N
L
R
K
Q
L
E
Site 14
T204
N
L
R
K
Q
L
E
T
L
S
G
D
R
V
R
Site 15
S206
R
K
Q
L
E
T
L
S
G
D
R
V
R
L
D
Site 16
S214
G
D
R
V
R
L
D
S
E
L
R
S
M
R
D
Site 17
S218
R
L
D
S
E
L
R
S
M
R
D
L
V
E
D
Site 18
Y226
M
R
D
L
V
E
D
Y
K
K
R
Y
E
V
E
Site 19
T238
E
V
E
I
N
R
R
T
T
A
E
N
E
F
V
Site 20
T239
V
E
I
N
R
R
T
T
A
E
N
E
F
V
V
Site 21
Y255
K
K
D
A
D
A
A
Y
A
V
K
V
E
L
Q
Site 22
S267
E
L
Q
A
K
V
D
S
L
D
K
E
I
K
F
Site 23
S298
S
E
T
S
V
I
L
S
M
D
N
N
R
D
L
Site 24
S309
N
R
D
L
D
L
D
S
I
I
A
E
V
R
M
Site 25
Y318
I
A
E
V
R
M
H
Y
E
E
I
A
L
K
S
Site 26
Y333
K
A
E
A
E
A
L
Y
Q
T
K
I
Q
E
L
Site 27
T335
E
A
E
A
L
Y
Q
T
K
I
Q
E
L
Q
L
Site 28
S356
D
D
L
K
H
T
R
S
E
M
V
E
L
N
R
Site 29
S381
N
V
K
K
Q
R
A
S
L
E
T
A
I
A
D
Site 30
Y425
L
A
R
M
L
R
E
Y
Q
E
L
M
S
L
K
Site 31
S430
R
E
Y
Q
E
L
M
S
L
K
L
A
L
D
M
Site 32
Y442
L
D
M
E
I
A
T
Y
R
K
L
L
E
G
E
Site 33
S454
E
G
E
E
C
R
M
S
G
E
N
P
S
S
V
Site 34
S459
R
M
S
G
E
N
P
S
S
V
S
I
S
V
I
Site 35
S462
G
E
N
P
S
S
V
S
I
S
V
I
S
S
S
Site 36
S464
N
P
S
S
V
S
I
S
V
I
S
S
S
S
Y
Site 37
S467
S
V
S
I
S
V
I
S
S
S
S
Y
S
Y
H
Site 38
S468
V
S
I
S
V
I
S
S
S
S
Y
S
Y
H
H
Site 39
S469
S
I
S
V
I
S
S
S
S
Y
S
Y
H
H
P
Site 40
S470
I
S
V
I
S
S
S
S
Y
S
Y
H
H
P
S
Site 41
Y471
S
V
I
S
S
S
S
Y
S
Y
H
H
P
S
S
Site 42
S472
V
I
S
S
S
S
Y
S
Y
H
H
P
S
S
A
Site 43
Y473
I
S
S
S
S
Y
S
Y
H
H
P
S
S
A
G
Site 44
S477
S
Y
S
Y
H
H
P
S
S
A
G
V
D
L
G
Site 45
S478
Y
S
Y
H
H
P
S
S
A
G
V
D
L
G
A
Site 46
S492
A
S
A
V
A
G
S
S
G
S
T
Q
S
G
Q
Site 47
T495
V
A
G
S
S
G
S
T
Q
S
G
Q
T
K
T
Site 48
T513
R
G
G
D
L
K
D
T
Q
G
K
S
T
P
A
Site 49
S517
L
K
D
T
Q
G
K
S
T
P
A
S
I
P
A
Site 50
T518
K
D
T
Q
G
K
S
T
P
A
S
I
P
A
R
Site 51
S521
Q
G
K
S
T
P
A
S
I
P
A
R
K
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation