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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APTX
Full Name:
Aprataxin
Alias:
AOA; AOA1; Ataxia 1, early onset with hypoalbuminemia; AXA1; EAOH; EC 3.-.-.-; EOAHA; FHA-HIT; FLJ20157; Forkhead-associated domain histidine triad-like protein
Type:
EC 3.-.-.-; RNA binding protein; DNA repair; Phosphatase (non-protein)
Mass (Da):
40740
Number AA:
356
UniProt ID:
Q7Z2E3
International Prot ID:
IPI00180685
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005730
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0033699
GO:0003682
GO:0003684
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0006302
GO:0031647
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T50
R
G
P
E
T
K
I
T
D
K
K
C
S
R
Q
Site 2
Y69
K
A
E
C
N
K
G
Y
V
K
V
K
Q
V
G
Site 3
S84
V
N
P
T
S
I
D
S
V
V
I
G
K
D
Q
Site 4
Y110
M
V
N
E
L
Y
P
Y
I
V
E
F
E
E
E
Site 5
T125
A
K
N
P
G
L
E
T
H
R
K
R
K
R
S
Site 6
S132
T
H
R
K
R
K
R
S
G
N
S
D
S
I
E
Site 7
S135
K
R
K
R
S
G
N
S
D
S
I
E
R
D
A
Site 8
S137
K
R
S
G
N
S
D
S
I
E
R
D
A
A
Q
Site 9
S156
G
T
G
L
E
P
G
S
N
S
G
Q
C
S
V
Site 10
S158
G
L
E
P
G
S
N
S
G
Q
C
S
V
P
L
Site 11
S162
G
S
N
S
G
Q
C
S
V
P
L
K
K
G
K
Site 12
S177
D
A
P
I
K
K
E
S
L
G
H
W
S
Q
G
Site 13
S182
K
E
S
L
G
H
W
S
Q
G
L
K
I
S
M
Site 14
Y209
V
V
V
I
K
D
K
Y
P
K
A
R
Y
H
W
Site 15
Y214
D
K
Y
P
K
A
R
Y
H
W
L
V
L
P
W
Site 16
Y264
K
L
R
F
R
L
G
Y
H
A
I
P
S
M
S
Site 17
S271
Y
H
A
I
P
S
M
S
H
V
H
L
H
V
I
Site 18
S284
V
I
S
Q
D
F
D
S
P
C
L
K
N
K
K
Site 19
Y300
W
N
S
F
N
T
E
Y
F
L
E
S
Q
A
V
Site 20
T318
V
Q
E
A
G
R
V
T
V
R
D
G
M
P
E
Site 21
S342
E
C
Q
Q
L
L
P
S
I
P
Q
L
K
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation