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Updated November 2019
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Protein Info
Short Name:
GPRIN1
Full Name:
G protein-regulated inducer of neurite outgrowth 1
Alias:
G protein regulated inducer of neurite outgrowth 1; GRIN1; KIAA1893
Type:
Cell development/differentiation
Mass (Da):
102371
Number AA:
1008
UniProt ID:
Q7Z2K8
International Prot ID:
IPI00332155
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0030426
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
Q
L
L
Q
K
D
S
S
P
P
G
P
R
P
Site 2
S18
Q
L
L
Q
K
D
S
S
P
P
G
P
R
P
T
Site 3
T25
S
P
P
G
P
R
P
T
A
F
F
C
P
Q
D
Site 4
S40
G
S
L
G
A
G
S
S
A
M
R
D
Y
C
P
Site 5
Y45
G
S
S
A
M
R
D
Y
C
P
S
Q
Q
K
A
Site 6
S48
A
M
R
D
Y
C
P
S
Q
Q
K
A
S
P
A
Site 7
S53
C
P
S
Q
Q
K
A
S
P
A
P
P
R
H
T
Site 8
T60
S
P
A
P
P
R
H
T
P
D
Q
S
P
G
M
Site 9
S64
P
R
H
T
P
D
Q
S
P
G
M
E
S
R
H
Site 10
S69
D
Q
S
P
G
M
E
S
R
H
R
S
P
S
G
Site 11
S73
G
M
E
S
R
H
R
S
P
S
G
A
G
E
G
Site 12
S75
E
S
R
H
R
S
P
S
G
A
G
E
G
A
S
Site 13
S82
S
G
A
G
E
G
A
S
C
S
D
G
P
R
G
Site 14
S84
A
G
E
G
A
S
C
S
D
G
P
R
G
S
L
Site 15
S90
C
S
D
G
P
R
G
S
L
A
C
P
S
P
T
Site 16
S95
R
G
S
L
A
C
P
S
P
T
C
F
S
P
Q
Site 17
S100
C
P
S
P
T
C
F
S
P
Q
E
S
P
S
K
Site 18
S104
T
C
F
S
P
Q
E
S
P
S
K
E
T
L
E
Site 19
S106
F
S
P
Q
E
S
P
S
K
E
T
L
E
A
H
Site 20
T120
H
G
A
S
I
S
G
T
T
E
A
T
T
S
G
Site 21
S126
G
T
T
E
A
T
T
S
G
K
P
E
P
V
S
Site 22
S133
S
G
K
P
E
P
V
S
S
V
K
T
E
P
K
Site 23
S134
G
K
P
E
P
V
S
S
V
K
T
E
P
K
S
Site 24
T137
E
P
V
S
S
V
K
T
E
P
K
S
S
D
D
Site 25
S141
S
V
K
T
E
P
K
S
S
D
D
R
N
P
M
Site 26
S142
V
K
T
E
P
K
S
S
D
D
R
N
P
M
F
Site 27
S157
L
E
K
M
D
F
K
S
S
K
Q
A
D
S
T
Site 28
S158
E
K
M
D
F
K
S
S
K
Q
A
D
S
T
S
Site 29
S163
K
S
S
K
Q
A
D
S
T
S
I
G
K
E
D
Site 30
T164
S
S
K
Q
A
D
S
T
S
I
G
K
E
D
P
Site 31
S165
S
K
Q
A
D
S
T
S
I
G
K
E
D
P
G
Site 32
S173
I
G
K
E
D
P
G
S
S
R
K
A
D
P
M
Site 33
S174
G
K
E
D
P
G
S
S
R
K
A
D
P
M
F
Site 34
T205
P
G
R
M
D
P
M
T
V
R
K
E
D
L
G
Site 35
S213
V
R
K
E
D
L
G
S
L
G
K
V
D
P
L
Site 36
S222
G
K
V
D
P
L
C
S
S
K
T
Y
T
V
S
Site 37
T225
D
P
L
C
S
S
K
T
Y
T
V
S
P
R
K
Site 38
Y226
P
L
C
S
S
K
T
Y
T
V
S
P
R
K
E
Site 39
T227
L
C
S
S
K
T
Y
T
V
S
P
R
K
E
D
Site 40
S229
S
S
K
T
Y
T
V
S
P
R
K
E
D
P
G
Site 41
S237
P
R
K
E
D
P
G
S
L
R
K
V
D
P
V
Site 42
S245
L
R
K
V
D
P
V
S
S
D
K
V
D
P
V
Site 43
S246
R
K
V
D
P
V
S
S
D
K
V
D
P
V
F
Site 44
Y261
P
R
K
E
E
P
R
Y
S
G
K
E
H
P
V
Site 45
S262
R
K
E
E
P
R
Y
S
G
K
E
H
P
V
S
Site 46
S269
S
G
K
E
H
P
V
S
S
E
K
V
A
P
T
Site 47
S270
G
K
E
H
P
V
S
S
E
K
V
A
P
T
S
Site 48
S277
S
E
K
V
A
P
T
S
A
E
K
V
D
L
V
Site 49
S286
E
K
V
D
L
V
L
S
G
K
R
D
P
G
P
Site 50
S294
G
K
R
D
P
G
P
S
G
K
A
D
P
V
P
Site 51
S304
A
D
P
V
P
L
E
S
M
D
S
A
S
T
G
Site 52
S307
V
P
L
E
S
M
D
S
A
S
T
G
K
T
E
Site 53
S309
L
E
S
M
D
S
A
S
T
G
K
T
E
P
G
Site 54
T313
D
S
A
S
T
G
K
T
E
P
G
L
L
G
K
Site 55
S325
L
G
K
L
I
P
G
S
S
G
K
N
G
P
V
Site 56
S326
G
K
L
I
P
G
S
S
G
K
N
G
P
V
S
Site 57
S333
S
G
K
N
G
P
V
S
S
G
T
G
A
P
G
Site 58
S334
G
K
N
G
P
V
S
S
G
T
G
A
P
G
S
Site 59
T336
N
G
P
V
S
S
G
T
G
A
P
G
S
L
G
Site 60
S341
S
G
T
G
A
P
G
S
L
G
R
L
D
P
T
Site 61
T348
S
L
G
R
L
D
P
T
C
L
G
M
A
D
P
Site 62
T367
N
V
E
T
V
P
A
T
K
E
D
S
R
F
L
Site 63
S381
L
G
K
M
D
P
A
S
S
G
E
G
R
P
V
Site 64
S382
G
K
M
D
P
A
S
S
G
E
G
R
P
V
S
Site 65
S389
S
G
E
G
R
P
V
S
G
H
T
D
T
T
A
Site 66
T394
P
V
S
G
H
T
D
T
T
A
S
A
K
T
D
Site 67
T395
V
S
G
H
T
D
T
T
A
S
A
K
T
D
L
Site 68
S404
S
A
K
T
D
L
T
S
L
K
N
V
D
P
M
Site 69
S412
L
K
N
V
D
P
M
S
S
G
K
V
D
P
V
Site 70
S420
S
G
K
V
D
P
V
S
L
G
K
M
D
P
M
Site 71
S429
G
K
M
D
P
M
C
S
G
K
P
E
L
L
S
Site 72
S436
S
G
K
P
E
L
L
S
P
G
Q
A
E
R
V
Site 73
S444
P
G
Q
A
E
R
V
S
V
G
K
A
G
T
V
Site 74
T450
V
S
V
G
K
A
G
T
V
S
P
G
K
E
D
Site 75
S452
V
G
K
A
G
T
V
S
P
G
K
E
D
P
V
Site 76
S460
P
G
K
E
D
P
V
S
S
R
R
E
D
P
I
Site 77
S461
G
K
E
D
P
V
S
S
R
R
E
D
P
I
S
Site 78
S468
S
R
R
E
D
P
I
S
A
G
S
R
K
T
S
Site 79
S471
E
D
P
I
S
A
G
S
R
K
T
S
S
E
K
Site 80
T474
I
S
A
G
S
R
K
T
S
S
E
K
V
N
P
Site 81
S475
S
A
G
S
R
K
T
S
S
E
K
V
N
P
E
Site 82
S476
A
G
S
R
K
T
S
S
E
K
V
N
P
E
S
Site 83
S483
S
E
K
V
N
P
E
S
S
G
K
T
N
P
V
Site 84
T487
N
P
E
S
S
G
K
T
N
P
V
S
S
G
P
Site 85
S491
S
G
K
T
N
P
V
S
S
G
P
G
D
P
R
Site 86
S492
G
K
T
N
P
V
S
S
G
P
G
D
P
R
S
Site 87
S499
S
G
P
G
D
P
R
S
L
G
T
A
G
P
P
Site 88
S507
L
G
T
A
G
P
P
S
A
V
K
A
E
P
A
Site 89
T515
A
V
K
A
E
P
A
T
G
G
K
G
D
P
L
Site 90
S523
G
G
K
G
D
P
L
S
S
E
K
A
G
L
V
Site 91
S524
G
K
G
D
P
L
S
S
E
K
A
G
L
V
A
Site 92
S540
G
K
A
A
P
T
A
S
G
K
A
E
P
L
A
Site 93
S555
V
G
K
E
D
P
V
S
K
G
K
A
D
A
G
Site 94
S564
G
K
A
D
A
G
P
S
G
Q
G
D
S
V
S
Site 95
S569
G
P
S
G
Q
G
D
S
V
S
I
G
K
V
V
Site 96
S571
S
G
Q
G
D
S
V
S
I
G
K
V
V
S
T
Site 97
T582
V
V
S
T
P
G
K
T
V
P
V
P
S
G
K
Site 98
S587
G
K
T
V
P
V
P
S
G
K
V
D
P
V
S
Site 99
S594
S
G
K
V
D
P
V
S
L
G
K
A
E
A
I
Site 100
S608
I
P
E
G
K
V
G
S
L
P
L
E
K
G
S
Site 101
S615
S
L
P
L
E
K
G
S
P
V
T
T
T
K
A
Site 102
T618
L
E
K
G
S
P
V
T
T
T
K
A
D
P
R
Site 103
T619
E
K
G
S
P
V
T
T
T
K
A
D
P
R
A
Site 104
S627
T
K
A
D
P
R
A
S
G
K
A
Q
P
Q
S
Site 105
S634
S
G
K
A
Q
P
Q
S
G
G
K
A
E
T
K
Site 106
T663
A
V
C
L
K
K
E
T
P
Q
A
S
E
K
V
Site 107
S674
S
E
K
V
D
P
G
S
C
R
K
A
E
P
L
Site 108
S683
R
K
A
E
P
L
A
S
G
K
G
E
P
V
S
Site 109
S690
S
G
K
G
E
P
V
S
L
G
K
A
D
S
A
Site 110
S696
V
S
L
G
K
A
D
S
A
P
S
R
K
T
E
Site 111
T702
D
S
A
P
S
R
K
T
E
S
P
S
L
G
K
Site 112
S704
A
P
S
R
K
T
E
S
P
S
L
G
K
V
V
Site 113
S706
S
R
K
T
E
S
P
S
L
G
K
V
V
P
L
Site 114
S714
L
G
K
V
V
P
L
S
L
E
K
T
K
P
S
Site 115
T718
V
P
L
S
L
E
K
T
K
P
S
S
S
S
R
Site 116
S721
S
L
E
K
T
K
P
S
S
S
S
R
Q
L
D
Site 117
S722
L
E
K
T
K
P
S
S
S
S
R
Q
L
D
R
Site 118
S723
E
K
T
K
P
S
S
S
S
R
Q
L
D
R
K
Site 119
S734
L
D
R
K
A
L
G
S
A
R
S
P
E
G
A
Site 120
S737
K
A
L
G
S
A
R
S
P
E
G
A
R
G
S
Site 121
S744
S
P
E
G
A
R
G
S
E
G
R
V
E
P
K
Site 122
S756
E
P
K
A
E
P
V
S
S
T
E
A
S
S
L
Site 123
S757
P
K
A
E
P
V
S
S
T
E
A
S
S
L
G
Site 124
T758
K
A
E
P
V
S
S
T
E
A
S
S
L
G
Q
Site 125
S761
P
V
S
S
T
E
A
S
S
L
G
Q
K
D
L
Site 126
S762
V
S
S
T
E
A
S
S
L
G
Q
K
D
L
E
Site 127
S776
E
A
A
G
A
E
R
S
P
C
P
E
A
A
A
Site 128
T790
A
P
P
P
G
P
R
T
R
D
N
F
T
K
A
Site 129
T795
P
R
T
R
D
N
F
T
K
A
P
S
W
E
A
Site 130
S799
D
N
F
T
K
A
P
S
W
E
A
S
A
P
P
Site 131
S803
K
A
P
S
W
E
A
S
A
P
P
P
P
R
E
Site 132
T814
P
P
R
E
D
A
G
T
Q
A
G
A
Q
A
C
Site 133
S830
S
V
A
V
S
P
M
S
P
Q
D
G
A
G
G
Site 134
S838
P
Q
D
G
A
G
G
S
A
F
S
F
Q
A
A
Site 135
S850
Q
A
A
P
R
A
P
S
P
P
S
R
R
D
A
Site 136
S853
P
R
A
P
S
P
P
S
R
R
D
A
G
L
Q
Site 137
S862
R
D
A
G
L
Q
V
S
L
G
A
A
E
T
R
Site 138
T868
V
S
L
G
A
A
E
T
R
S
V
A
T
G
P
Site 139
T873
A
E
T
R
S
V
A
T
G
P
M
T
P
Q
A
Site 140
T877
S
V
A
T
G
P
M
T
P
Q
A
A
A
P
P
Site 141
S895
E
V
R
V
R
P
G
S
A
L
A
A
A
V
A
Site 142
S914
A
E
P
V
R
D
V
S
W
D
E
K
G
M
T
Site 143
Y925
K
G
M
T
W
E
V
Y
G
A
A
M
E
V
E
Site 144
S968
A
R
A
G
P
G
R
S
G
S
V
R
T
A
P
Site 145
S970
A
G
P
G
R
S
G
S
V
R
T
A
P
P
D
Site 146
T973
G
R
S
G
S
V
R
T
A
P
P
D
G
A
A
Site 147
S993
L
F
R
A
L
L
Q
S
V
R
R
P
R
C
C
Site 148
S1001
V
R
R
P
R
C
C
S
R
A
G
P
T
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation