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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZC3HAV1
Full Name:
Zinc finger CCCH-type antiviral protein 1
Alias:
CCCH-type zinc finger antiviral protein; FLB6421; FLJ13288; MGC48898; PRO1677; ZAP; ZC3H2; ZC3HDC2; ZCC2; Zinc finger antiviral protein; Zinc finger CCCH type antiviral protein 1; Zinc finger CCCH type domain containing protein 2; Zinc finger CCCH-type, antiviral 1
Type:
DNA binding protein
Mass (Da):
101431
Number AA:
902
UniProt ID:
Q7Z2W4
International Prot ID:
IPI00410067
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003950
GO:0003723
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0009615
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T61
T
G
G
E
A
G
I
T
R
S
V
V
A
T
T
Site 2
Y77
A
R
V
C
R
R
K
Y
C
Q
R
P
C
D
N
Site 3
Y98
N
L
L
G
R
C
N
Y
S
Q
S
E
R
N
L
Site 4
S99
L
L
G
R
C
N
Y
S
Q
S
E
R
N
L
C
Site 5
Y108
S
E
R
N
L
C
K
Y
S
H
E
V
L
S
E
Site 6
S109
E
R
N
L
C
K
Y
S
H
E
V
L
S
E
E
Site 7
S235
P
P
G
P
R
A
P
S
S
H
R
R
N
M
A
Site 8
S236
P
G
P
R
A
P
S
S
H
R
R
N
M
A
Y
Site 9
Y243
S
H
R
R
N
M
A
Y
R
A
R
S
K
S
R
Site 10
S247
N
M
A
Y
R
A
R
S
K
S
R
D
R
F
F
Site 11
S249
A
Y
R
A
R
S
K
S
R
D
R
F
F
Q
G
Site 12
S257
R
D
R
F
F
Q
G
S
Q
E
F
L
A
S
A
Site 13
S263
G
S
Q
E
F
L
A
S
A
S
A
S
A
E
R
Site 14
S265
Q
E
F
L
A
S
A
S
A
S
A
E
R
S
C
Site 15
S267
F
L
A
S
A
S
A
S
A
E
R
S
C
T
P
Site 16
S271
A
S
A
S
A
E
R
S
C
T
P
S
P
D
Q
Site 17
T273
A
S
A
E
R
S
C
T
P
S
P
D
Q
I
S
Site 18
S275
A
E
R
S
C
T
P
S
P
D
Q
I
S
H
R
Site 19
S280
T
P
S
P
D
Q
I
S
H
R
A
S
L
E
D
Site 20
S284
D
Q
I
S
H
R
A
S
L
E
D
A
P
V
D
Site 21
T294
D
A
P
V
D
D
L
T
R
K
F
T
Y
L
G
Site 22
T298
D
D
L
T
R
K
F
T
Y
L
G
S
Q
D
R
Site 23
Y299
D
L
T
R
K
F
T
Y
L
G
S
Q
D
R
A
Site 24
S302
R
K
F
T
Y
L
G
S
Q
D
R
A
R
P
P
Site 25
S310
Q
D
R
A
R
P
P
S
G
S
S
K
A
T
D
Site 26
S312
R
A
R
P
P
S
G
S
S
K
A
T
D
L
G
Site 27
T316
P
S
G
S
S
K
A
T
D
L
G
G
T
S
Q
Site 28
S322
A
T
D
L
G
G
T
S
Q
A
G
T
S
Q
R
Site 29
T326
G
G
T
S
Q
A
G
T
S
Q
R
F
L
E
N
Site 30
S327
G
T
S
Q
A
G
T
S
Q
R
F
L
E
N
G
Site 31
S335
Q
R
F
L
E
N
G
S
Q
E
D
L
L
H
G
Site 32
S346
L
L
H
G
N
P
G
S
T
Y
L
A
S
N
S
Site 33
T347
L
H
G
N
P
G
S
T
Y
L
A
S
N
S
T
Site 34
Y348
H
G
N
P
G
S
T
Y
L
A
S
N
S
T
S
Site 35
S351
P
G
S
T
Y
L
A
S
N
S
T
S
A
P
N
Site 36
S353
S
T
Y
L
A
S
N
S
T
S
A
P
N
W
K
Site 37
T354
T
Y
L
A
S
N
S
T
S
A
P
N
W
K
S
Site 38
S355
Y
L
A
S
N
S
T
S
A
P
N
W
K
S
L
Site 39
S361
T
S
A
P
N
W
K
S
L
T
S
W
T
N
D
Site 40
T363
A
P
N
W
K
S
L
T
S
W
T
N
D
Q
G
Site 41
S364
P
N
W
K
S
L
T
S
W
T
N
D
Q
G
A
Site 42
T366
W
K
S
L
T
S
W
T
N
D
Q
G
A
R
R
Site 43
T375
D
Q
G
A
R
R
K
T
V
F
S
P
T
L
P
Site 44
S378
A
R
R
K
T
V
F
S
P
T
L
P
A
A
R
Site 45
T380
R
K
T
V
F
S
P
T
L
P
A
A
R
S
S
Site 46
S386
P
T
L
P
A
A
R
S
S
L
G
S
L
Q
T
Site 47
S387
T
L
P
A
A
R
S
S
L
G
S
L
Q
T
P
Site 48
S390
A
A
R
S
S
L
G
S
L
Q
T
P
E
A
V
Site 49
T393
S
S
L
G
S
L
Q
T
P
E
A
V
T
T
R
Site 50
T399
Q
T
P
E
A
V
T
T
R
K
G
T
G
L
L
Site 51
T403
A
V
T
T
R
K
G
T
G
L
L
S
S
D
Y
Site 52
S407
R
K
G
T
G
L
L
S
S
D
Y
R
I
I
N
Site 53
S408
K
G
T
G
L
L
S
S
D
Y
R
I
I
N
G
Site 54
Y410
T
G
L
L
S
S
D
Y
R
I
I
N
G
K
S
Site 55
T440
D
G
V
A
T
D
I
T
S
T
R
S
L
N
Y
Site 56
S441
G
V
A
T
D
I
T
S
T
R
S
L
N
Y
K
Site 57
S444
T
D
I
T
S
T
R
S
L
N
Y
K
S
T
S
Site 58
Y447
T
S
T
R
S
L
N
Y
K
S
T
S
S
G
H
Site 59
S449
T
R
S
L
N
Y
K
S
T
S
S
G
H
R
E
Site 60
T450
R
S
L
N
Y
K
S
T
S
S
G
H
R
E
I
Site 61
S451
S
L
N
Y
K
S
T
S
S
G
H
R
E
I
S
Site 62
S452
L
N
Y
K
S
T
S
S
G
H
R
E
I
S
S
Site 63
S458
S
S
G
H
R
E
I
S
S
P
R
I
Q
D
A
Site 64
S459
S
G
H
R
E
I
S
S
P
R
I
Q
D
A
G
Site 65
S469
I
Q
D
A
G
P
A
S
R
D
V
Q
A
T
G
Site 66
T475
A
S
R
D
V
Q
A
T
G
R
I
A
D
D
A
Site 67
S492
R
V
A
L
V
N
D
S
L
S
D
V
T
S
T
Site 68
S494
A
L
V
N
D
S
L
S
D
V
T
S
T
T
S
Site 69
T497
N
D
S
L
S
D
V
T
S
T
T
S
S
R
V
Site 70
S498
D
S
L
S
D
V
T
S
T
T
S
S
R
V
D
Site 71
S501
S
D
V
T
S
T
T
S
S
R
V
D
D
H
D
Site 72
S502
D
V
T
S
T
T
S
S
R
V
D
D
H
D
S
Site 73
S509
S
R
V
D
D
H
D
S
E
E
I
C
L
D
H
Site 74
T554
T
D
F
E
H
M
E
T
I
E
K
G
Y
C
N
Site 75
Y559
M
E
T
I
E
K
G
Y
C
N
P
G
I
H
L
Site 76
S583
F
R
V
M
S
C
D
S
F
P
I
R
R
L
S
Site 77
S590
S
F
P
I
R
R
L
S
T
P
S
S
V
T
K
Site 78
T591
F
P
I
R
R
L
S
T
P
S
S
V
T
K
P
Site 79
S593
I
R
R
L
S
T
P
S
S
V
T
K
P
A
N
Site 80
S594
R
R
L
S
T
P
S
S
V
T
K
P
A
N
S
Site 81
S631
E
K
D
K
R
K
N
S
N
V
D
S
S
Y
L
Site 82
S635
R
K
N
S
N
V
D
S
S
Y
L
E
S
L
Y
Site 83
S636
K
N
S
N
V
D
S
S
Y
L
E
S
L
Y
Q
Site 84
Y637
N
S
N
V
D
S
S
Y
L
E
S
L
Y
Q
S
Site 85
S640
V
D
S
S
Y
L
E
S
L
Y
Q
S
C
P
R
Site 86
Y642
S
S
Y
L
E
S
L
Y
Q
S
C
P
R
G
V
Site 87
S644
Y
L
E
S
L
Y
Q
S
C
P
R
G
V
V
P
Site 88
S656
V
V
P
F
Q
A
G
S
R
N
Y
E
L
S
F
Site 89
Y659
F
Q
A
G
S
R
N
Y
E
L
S
F
Q
G
M
Site 90
S662
G
S
R
N
Y
E
L
S
F
Q
G
M
I
Q
T
Site 91
T669
S
F
Q
G
M
I
Q
T
N
I
A
S
K
T
Q
Site 92
S673
M
I
Q
T
N
I
A
S
K
T
Q
K
D
V
I
Site 93
T684
K
D
V
I
R
R
P
T
F
V
P
Q
W
Y
V
Site 94
Y690
P
T
F
V
P
Q
W
Y
V
Q
Q
M
K
R
G
Site 95
T705
P
D
H
Q
P
A
K
T
S
S
V
S
L
T
A
Site 96
S707
H
Q
P
A
K
T
S
S
V
S
L
T
A
T
F
Site 97
S709
P
A
K
T
S
S
V
S
L
T
A
T
F
R
P
Site 98
T711
K
T
S
S
V
S
L
T
A
T
F
R
P
Q
E
Site 99
T713
S
S
V
S
L
T
A
T
F
R
P
Q
E
D
F
Site 100
S724
Q
E
D
F
C
F
L
S
S
K
K
Y
K
L
S
Site 101
S725
E
D
F
C
F
L
S
S
K
K
Y
K
L
S
E
Site 102
Y728
C
F
L
S
S
K
K
Y
K
L
S
E
I
H
H
Site 103
S731
S
S
K
K
Y
K
L
S
E
I
H
H
L
H
P
Site 104
Y740
I
H
H
L
H
P
E
Y
V
R
V
S
E
H
F
Site 105
S744
H
P
E
Y
V
R
V
S
E
H
F
K
A
S
M
Site 106
S765
K
I
K
K
I
E
N
S
E
L
L
D
K
F
T
Site 107
T772
S
E
L
L
D
K
F
T
W
K
K
S
Q
M
K
Site 108
S776
D
K
F
T
W
K
K
S
Q
M
K
E
E
G
K
Site 109
Y787
E
E
G
K
L
L
F
Y
A
T
S
R
A
Y
V
Site 110
T789
G
K
L
L
F
Y
A
T
S
R
A
Y
V
E
S
Site 111
Y793
F
Y
A
T
S
R
A
Y
V
E
S
I
C
S
N
Site 112
S796
T
S
R
A
Y
V
E
S
I
C
S
N
N
F
D
Site 113
Y819
N
K
Y
G
K
G
I
Y
F
A
K
D
A
I
Y
Site 114
Y826
Y
F
A
K
D
A
I
Y
S
H
K
N
C
P
Y
Site 115
T856
K
F
T
E
G
N
I
T
Y
T
S
P
P
P
Q
Site 116
Y857
F
T
E
G
N
I
T
Y
T
S
P
P
P
Q
F
Site 117
T858
T
E
G
N
I
T
Y
T
S
P
P
P
Q
F
D
Site 118
S859
E
G
N
I
T
Y
T
S
P
P
P
Q
F
D
S
Site 119
S866
S
P
P
P
Q
F
D
S
C
V
D
T
R
S
N
Site 120
T870
Q
F
D
S
C
V
D
T
R
S
N
P
S
V
F
Site 121
S872
D
S
C
V
D
T
R
S
N
P
S
V
F
V
I
Site 122
Y886
I
F
Q
K
D
Q
V
Y
P
Q
Y
V
I
E
Y
Site 123
Y889
K
D
Q
V
Y
P
Q
Y
V
I
E
Y
T
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation