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Updated November 2019
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Protein Info
Short Name:
senataxin
Full Name:
Probable helicase senataxin
Alias:
ALS4; Amyotrophic lateral sclerosis 4; Amyotrophic lateral sclerosis 4 protein; AOA2; Helicase senataxin; KIAA0625; SCAR1; SEN1; SEN1 homolog; Senataxin; SETX
Type:
Helicase; EC 3.6.1.-
Mass (Da):
302979
Number AA:
2677
UniProt ID:
Q7Z333
International Prot ID:
IPI00142538
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003678
PhosphoSite+
KinaseNET
Biological Process:
GO:0006396
GO:0008219
GO:0006302
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
T
I
D
F
L
K
R
Y
A
S
N
T
P
S
G
Site 2
S23
D
F
L
K
R
Y
A
S
N
T
P
S
G
E
F
Site 3
T25
L
K
R
Y
A
S
N
T
P
S
G
E
F
Q
T
Site 4
S27
R
Y
A
S
N
T
P
S
G
E
F
Q
T
A
D
Site 5
Y88
I
G
D
D
D
E
L
Y
I
V
D
N
N
G
E
Site 6
T102
E
M
P
L
F
D
I
T
G
Q
D
F
E
N
K
Site 7
Y186
G
K
V
D
R
D
D
Y
Y
D
L
Q
E
V
L
Site 8
Y187
K
V
D
R
D
D
Y
Y
D
L
Q
E
V
L
L
Site 9
Y211
L
L
E
S
P
D
I
Y
T
S
S
V
L
E
K
Site 10
T212
L
E
S
P
D
I
Y
T
S
S
V
L
E
K
G
Site 11
S214
S
P
D
I
Y
T
S
S
V
L
E
K
G
K
L
Site 12
S226
G
K
L
I
L
L
P
S
H
M
Y
D
T
T
N
Site 13
S255
L
E
E
Q
A
M
D
S
L
L
L
G
S
D
K
Site 14
T273
F
M
Q
S
I
L
H
T
M
E
R
E
A
D
D
Site 15
S282
E
R
E
A
D
D
D
S
V
D
P
F
W
P
A
Site 16
Y324
T
I
I
N
N
A
S
Y
N
R
E
I
R
H
I
Site 17
S334
E
I
R
H
I
R
N
S
S
V
R
T
K
L
E
Site 18
S335
I
R
H
I
R
N
S
S
V
R
T
K
L
E
P
Site 19
Y345
T
K
L
E
P
E
S
Y
L
D
D
M
V
T
C
Site 20
Y357
V
T
C
S
Q
I
V
Y
N
Y
N
P
E
K
T
Site 21
S368
P
E
K
T
K
K
D
S
G
W
R
T
A
I
C
Site 22
T372
K
K
D
S
G
W
R
T
A
I
C
P
D
Y
C
Site 23
Y378
R
T
A
I
C
P
D
Y
C
P
N
M
Y
E
E
Site 24
Y383
P
D
Y
C
P
N
M
Y
E
E
M
E
T
L
A
Site 25
T388
N
M
Y
E
E
M
E
T
L
A
S
V
L
Q
S
Site 26
S391
E
E
M
E
T
L
A
S
V
L
Q
S
D
I
G
Site 27
S395
T
L
A
S
V
L
Q
S
D
I
G
Q
D
M
R
Site 28
T498
K
C
A
K
L
P
T
T
A
F
T
R
S
S
E
Site 29
S503
P
T
T
A
F
T
R
S
S
E
K
S
S
G
N
Site 30
S504
T
T
A
F
T
R
S
S
E
K
S
S
G
N
C
Site 31
S507
F
T
R
S
S
E
K
S
S
G
N
C
S
K
G
Site 32
S508
T
R
S
S
E
K
S
S
G
N
C
S
K
G
T
Site 33
S512
E
K
S
S
G
N
C
S
K
G
T
A
M
I
S
Site 34
T515
S
G
N
C
S
K
G
T
A
M
I
S
S
L
S
Site 35
S525
I
S
S
L
S
L
H
S
M
P
S
N
S
V
Q
Site 36
S528
L
S
L
H
S
M
P
S
N
S
V
Q
L
A
Y
Site 37
S541
A
Y
V
Q
L
I
R
S
L
L
K
E
G
Y
Q
Site 38
Y547
R
S
L
L
K
E
G
Y
Q
L
G
Q
Q
S
L
Site 39
T577
L
S
L
G
W
Q
L
T
S
Q
E
T
H
E
L
Site 40
S578
S
L
G
W
Q
L
T
S
Q
E
T
H
E
L
Q
Site 41
S615
L
T
S
A
C
K
I
S
P
A
S
Y
N
K
E
Site 42
S618
A
C
K
I
S
P
A
S
Y
N
K
E
E
S
E
Site 43
Y619
C
K
I
S
P
A
S
Y
N
K
E
E
S
E
Q
Site 44
S624
A
S
Y
N
K
E
E
S
E
Q
M
G
K
T
S
Site 45
T630
E
S
E
Q
M
G
K
T
S
R
K
D
M
H
C
Site 46
S641
D
M
H
C
L
E
A
S
S
P
T
F
S
K
E
Site 47
S642
M
H
C
L
E
A
S
S
P
T
F
S
K
E
P
Site 48
T644
C
L
E
A
S
S
P
T
F
S
K
E
P
M
K
Site 49
S646
E
A
S
S
P
T
F
S
K
E
P
M
K
V
Q
Site 50
S655
E
P
M
K
V
Q
D
S
V
L
I
K
A
D
N
Site 51
T663
V
L
I
K
A
D
N
T
I
E
G
D
N
N
E
Site 52
S687
E
D
H
L
L
A
G
S
C
L
K
Q
S
S
K
Site 53
S693
G
S
C
L
K
Q
S
S
K
N
I
F
T
E
R
Site 54
S708
A
E
D
Q
I
K
I
S
T
R
K
Q
K
S
V
Site 55
S714
I
S
T
R
K
Q
K
S
V
K
E
I
S
S
Y
Site 56
S719
Q
K
S
V
K
E
I
S
S
Y
T
P
K
D
C
Site 57
S720
K
S
V
K
E
I
S
S
Y
T
P
K
D
C
T
Site 58
Y721
S
V
K
E
I
S
S
Y
T
P
K
D
C
T
S
Site 59
T722
V
K
E
I
S
S
Y
T
P
K
D
C
T
S
R
Site 60
T727
S
Y
T
P
K
D
C
T
S
R
N
G
P
E
R
Site 61
S750
S
T
R
L
L
T
D
S
S
T
D
A
L
E
K
Site 62
S751
T
R
L
L
T
D
S
S
T
D
A
L
E
K
V
Site 63
T752
R
L
L
T
D
S
S
T
D
A
L
E
K
V
S
Site 64
T760
D
A
L
E
K
V
S
T
S
N
E
D
F
S
L
Site 65
S761
A
L
E
K
V
S
T
S
N
E
D
F
S
L
K
Site 66
S766
S
T
S
N
E
D
F
S
L
K
D
D
A
L
A
Site 67
T775
K
D
D
A
L
A
K
T
S
K
R
K
T
K
V
Site 68
S776
D
D
A
L
A
K
T
S
K
R
K
T
K
V
Q
Site 69
T780
A
K
T
S
K
R
K
T
K
V
Q
K
D
E
I
Site 70
S802
I
K
K
Q
H
R
K
S
T
L
V
D
N
T
I
Site 71
T803
K
K
Q
H
R
K
S
T
L
V
D
N
T
I
N
Site 72
T816
I
N
L
D
E
N
L
T
V
S
N
I
E
S
F
Site 73
S818
L
D
E
N
L
T
V
S
N
I
E
S
F
Y
S
Site 74
S822
L
T
V
S
N
I
E
S
F
Y
S
R
K
D
T
Site 75
Y824
V
S
N
I
E
S
F
Y
S
R
K
D
T
G
V
Site 76
S825
S
N
I
E
S
F
Y
S
R
K
D
T
G
V
Q
Site 77
T829
S
F
Y
S
R
K
D
T
G
V
Q
K
G
D
G
Site 78
S846
H
N
L
S
L
D
P
S
G
V
L
D
D
K
N
Site 79
S858
D
K
N
G
E
Q
K
S
Q
N
N
V
L
P
K
Site 80
T900
G
K
E
L
I
P
F
T
E
M
T
N
A
S
E
Site 81
S906
F
T
E
M
T
N
A
S
E
K
K
S
S
P
F
Site 82
S910
T
N
A
S
E
K
K
S
S
P
F
K
D
L
M
Site 83
S911
N
A
S
E
K
K
S
S
P
F
K
D
L
M
T
Site 84
T918
S
P
F
K
D
L
M
T
V
P
E
S
R
D
E
Site 85
S922
D
L
M
T
V
P
E
S
R
D
E
E
M
S
N
Site 86
S928
E
S
R
D
E
E
M
S
N
S
T
S
V
I
Y
Site 87
S930
R
D
E
E
M
S
N
S
T
S
V
I
Y
S
N
Site 88
S932
E
E
M
S
N
S
T
S
V
I
Y
S
N
L
T
Site 89
S936
N
S
T
S
V
I
Y
S
N
L
T
R
E
Q
A
Site 90
S947
R
E
Q
A
P
D
I
S
P
K
S
D
T
L
T
Site 91
S950
A
P
D
I
S
P
K
S
D
T
L
T
D
S
Q
Site 92
T952
D
I
S
P
K
S
D
T
L
T
D
S
Q
I
D
Site 93
T954
S
P
K
S
D
T
L
T
D
S
Q
I
D
R
D
Site 94
S956
K
S
D
T
L
T
D
S
Q
I
D
R
D
L
H
Site 95
S966
D
R
D
L
H
K
L
S
L
L
A
Q
A
S
V
Site 96
T975
L
A
Q
A
S
V
I
T
F
P
S
D
S
P
Q
Site 97
S978
A
S
V
I
T
F
P
S
D
S
P
Q
N
S
S
Site 98
S980
V
I
T
F
P
S
D
S
P
Q
N
S
S
Q
L
Site 99
S984
P
S
D
S
P
Q
N
S
S
Q
L
Q
R
K
V
Site 100
S985
S
D
S
P
Q
N
S
S
Q
L
Q
R
K
V
K
Site 101
T999
K
E
D
K
R
C
F
T
A
N
Q
N
N
V
G
Site 102
T1008
N
Q
N
N
V
G
D
T
S
R
G
Q
V
I
I
Site 103
S1017
R
G
Q
V
I
I
I
S
D
S
D
D
D
D
D
Site 104
S1019
Q
V
I
I
I
S
D
S
D
D
D
D
D
E
R
Site 105
S1029
D
D
D
E
R
I
L
S
L
E
K
L
T
K
Q
Site 106
S1051
E
H
P
E
Q
H
V
S
T
V
N
S
K
E
E
Site 107
T1052
H
P
E
Q
H
V
S
T
V
N
S
K
E
E
K
Site 108
S1055
Q
H
V
S
T
V
N
S
K
E
E
K
N
P
V
Site 109
T1069
V
K
E
E
K
T
E
T
L
F
Q
F
E
E
S
Site 110
S1076
T
L
F
Q
F
E
E
S
D
S
Q
C
F
E
F
Site 111
S1078
F
Q
F
E
E
S
D
S
Q
C
F
E
F
E
S
Site 112
S1085
S
Q
C
F
E
F
E
S
S
S
E
V
F
S
V
Site 113
S1086
Q
C
F
E
F
E
S
S
S
E
V
F
S
V
W
Site 114
S1087
C
F
E
F
E
S
S
S
E
V
F
S
V
W
Q
Site 115
S1091
E
S
S
S
E
V
F
S
V
W
Q
D
H
P
D
Site 116
S1102
D
H
P
D
D
N
N
S
V
Q
D
G
E
K
K
Site 117
Y1126
N
G
Q
G
C
T
D
Y
V
S
E
V
V
K
K
Site 118
S1128
Q
G
C
T
D
Y
V
S
E
V
V
K
K
G
A
Site 119
T1142
A
E
G
I
E
E
H
T
R
P
R
S
I
S
V
Site 120
S1146
E
E
H
T
R
P
R
S
I
S
V
E
E
F
C
Site 121
S1148
H
T
R
P
R
S
I
S
V
E
E
F
C
E
I
Site 122
S1165
K
K
P
K
R
K
R
S
E
K
P
M
A
E
D
Site 123
S1177
A
E
D
P
V
R
P
S
S
S
V
R
N
E
G
Site 124
S1178
E
D
P
V
R
P
S
S
S
V
R
N
E
G
Q
Site 125
S1179
D
P
V
R
P
S
S
S
V
R
N
E
G
Q
S
Site 126
S1186
S
V
R
N
E
G
Q
S
D
T
N
K
R
E
L
Site 127
T1188
R
N
E
G
Q
S
D
T
N
K
R
E
L
V
G
Site 128
S1200
L
V
G
N
D
F
K
S
I
D
R
R
T
S
T
Site 129
T1205
F
K
S
I
D
R
R
T
S
T
P
N
S
R
I
Site 130
S1206
K
S
I
D
R
R
T
S
T
P
N
S
R
I
Q
Site 131
T1207
S
I
D
R
R
T
S
T
P
N
S
R
I
Q
R
Site 132
S1210
R
R
T
S
T
P
N
S
R
I
Q
R
A
T
T
Site 133
T1216
N
S
R
I
Q
R
A
T
T
V
S
Q
K
K
S
Site 134
T1217
S
R
I
Q
R
A
T
T
V
S
Q
K
K
S
S
Site 135
S1219
I
Q
R
A
T
T
V
S
Q
K
K
S
S
K
L
Site 136
S1223
T
T
V
S
Q
K
K
S
S
K
L
C
T
C
T
Site 137
T1228
K
K
S
S
K
L
C
T
C
T
E
P
I
R
K
Site 138
S1239
P
I
R
K
V
P
V
S
K
T
P
K
K
T
H
Site 139
T1241
R
K
V
P
V
S
K
T
P
K
K
T
H
S
D
Site 140
S1247
K
T
P
K
K
T
H
S
D
A
K
K
R
Q
N
Site 141
S1256
A
K
K
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S
Site 293
S2669
R
T
L
E
Q
E
D
S
S
S
K
K
R
K
L
Site 294
S2671
L
E
Q
E
D
S
S
S
K
K
R
K
L
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation