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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TIPARP
Full Name:
TCDD-inducible poly [ADP-ribose] polymerase
Alias:
Poly [ADP-ribose] polymerase 7
Type:
Mass (Da):
76227
Number AA:
657
UniProt ID:
Q7Z3E1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
D
C
V
V
Q
P
P
S
P
P
D
D
F
S
C
Site 2
S24
P
S
P
P
D
D
F
S
C
Q
M
R
L
S
E
Site 3
S30
F
S
C
Q
M
R
L
S
E
K
I
T
P
L
K
Site 4
T34
M
R
L
S
E
K
I
T
P
L
K
T
C
F
K
Site 5
T38
E
K
I
T
P
L
K
T
C
F
K
K
K
D
Q
Site 6
T50
K
D
Q
K
R
L
G
T
G
T
L
R
S
L
R
Site 7
T52
Q
K
R
L
G
T
G
T
L
R
S
L
R
P
I
Site 8
S68
N
T
L
L
E
S
G
S
L
D
G
V
F
R
S
Site 9
S75
S
L
D
G
V
F
R
S
R
N
Q
S
T
D
E
Site 10
S79
V
F
R
S
R
N
Q
S
T
D
E
N
S
L
H
Site 11
T80
F
R
S
R
N
Q
S
T
D
E
N
S
L
H
E
Site 12
S84
N
Q
S
T
D
E
N
S
L
H
E
P
M
M
K
Site 13
S99
K
A
M
E
I
N
S
S
C
P
P
A
E
N
N
Site 14
S108
P
P
A
E
N
N
M
S
V
L
I
P
D
R
T
Site 15
T115
S
V
L
I
P
D
R
T
N
V
G
D
Q
I
P
Site 16
S127
Q
I
P
E
A
H
P
S
T
E
A
P
E
R
V
Site 17
T128
I
P
E
A
H
P
S
T
E
A
P
E
R
V
V
Site 18
S141
V
V
P
I
Q
D
H
S
F
P
S
E
T
L
S
Site 19
S144
I
Q
D
H
S
F
P
S
E
T
L
S
G
T
V
Site 20
T146
D
H
S
F
P
S
E
T
L
S
G
T
V
A
D
Site 21
S148
S
F
P
S
E
T
L
S
G
T
V
A
D
S
T
Site 22
T150
P
S
E
T
L
S
G
T
V
A
D
S
T
P
A
Site 23
S154
L
S
G
T
V
A
D
S
T
P
A
H
F
Q
T
Site 24
T155
S
G
T
V
A
D
S
T
P
A
H
F
Q
T
D
Site 25
S168
T
D
L
L
H
P
V
S
S
D
V
P
T
S
P
Site 26
S169
D
L
L
H
P
V
S
S
D
V
P
T
S
P
D
Site 27
T173
P
V
S
S
D
V
P
T
S
P
D
C
L
D
K
Site 28
S174
V
S
S
D
V
P
T
S
P
D
C
L
D
K
V
Site 29
Y198
E
N
S
F
T
I
Q
Y
I
L
D
T
S
D
K
Site 30
T202
T
I
Q
Y
I
L
D
T
S
D
K
L
S
T
E
Site 31
S203
I
Q
Y
I
L
D
T
S
D
K
L
S
T
E
L
Site 32
S207
L
D
T
S
D
K
L
S
T
E
L
F
Q
D
K
Site 33
S215
T
E
L
F
Q
D
K
S
E
E
A
S
L
D
L
Site 34
S219
Q
D
K
S
E
E
A
S
L
D
L
V
F
E
L
Site 35
Y232
E
L
V
N
Q
L
Q
Y
H
T
H
Q
E
N
G
Site 36
T234
V
N
Q
L
Q
Y
H
T
H
Q
E
N
G
I
E
Site 37
Y253
F
L
Q
G
T
C
I
Y
G
R
D
C
L
K
H
Site 38
Y266
K
H
H
T
V
L
P
Y
H
W
Q
I
K
R
T
Site 39
S280
T
T
T
Q
K
W
Q
S
V
F
N
D
S
Q
E
Site 40
S285
W
Q
S
V
F
N
D
S
Q
E
H
L
E
R
F
Site 41
Y293
Q
E
H
L
E
R
F
Y
C
N
P
E
N
D
R
Site 42
S332
F
D
Q
L
R
R
L
S
T
P
P
S
S
N
V
Site 43
T333
D
Q
L
R
R
L
S
T
P
P
S
S
N
V
N
Site 44
S336
R
R
L
S
T
P
P
S
S
N
V
N
S
I
Y
Site 45
S337
R
L
S
T
P
P
S
S
N
V
N
S
I
Y
H
Site 46
S341
P
P
S
S
N
V
N
S
I
Y
H
T
V
W
K
Site 47
Y343
S
S
N
V
N
S
I
Y
H
T
V
W
K
F
F
Site 48
Y360
D
H
F
G
W
R
E
Y
P
E
S
V
I
R
L
Site 49
S363
G
W
R
E
Y
P
E
S
V
I
R
L
I
E
E
Site 50
Y388
F
M
M
W
N
N
H
Y
I
L
H
N
S
F
F
Site 51
S407
K
R
R
P
L
F
R
S
C
F
I
L
L
P
Y
Site 52
T423
Q
T
L
G
G
V
P
T
Q
A
P
P
P
L
E
Site 53
S433
P
P
P
L
E
A
T
S
S
S
Q
I
I
C
P
Site 54
S434
P
P
L
E
A
T
S
S
S
Q
I
I
C
P
D
Site 55
S435
P
L
E
A
T
S
S
S
Q
I
I
C
P
D
G
Site 56
Y449
G
V
T
S
A
N
F
Y
P
E
T
W
V
Y
M
Site 57
S468
D
F
I
Q
V
P
V
S
A
E
D
K
S
Y
R
Site 58
S473
P
V
S
A
E
D
K
S
Y
R
I
I
Y
N
L
Site 59
Y474
V
S
A
E
D
K
S
Y
R
I
I
Y
N
L
F
Site 60
Y478
D
K
S
Y
R
I
I
Y
N
L
F
H
K
T
V
Site 61
T484
I
Y
N
L
F
H
K
T
V
P
E
F
K
Y
R
Site 62
Y490
K
T
V
P
E
F
K
Y
R
I
L
Q
I
L
R
Site 63
Y507
N
Q
F
L
W
E
K
Y
K
R
K
K
E
Y
M
Site 64
Y513
K
Y
K
R
K
K
E
Y
M
N
R
K
M
F
G
Site 65
S535
R
H
L
F
H
G
T
S
Q
D
V
V
D
G
I
Site 66
S563
A
T
M
F
G
Q
G
S
Y
F
A
K
K
A
S
Site 67
Y564
T
M
F
G
Q
G
S
Y
F
A
K
K
A
S
Y
Site 68
S570
S
Y
F
A
K
K
A
S
Y
S
H
N
F
S
K
Site 69
Y571
Y
F
A
K
K
A
S
Y
S
H
N
F
S
K
K
Site 70
S572
F
A
K
K
A
S
Y
S
H
N
F
S
K
K
S
Site 71
S576
A
S
Y
S
H
N
F
S
K
K
S
S
K
G
V
Site 72
S579
S
H
N
F
S
K
K
S
S
K
G
V
H
F
M
Site 73
Y596
A
K
V
L
T
G
R
Y
T
M
G
S
H
G
M
Site 74
T597
K
V
L
T
G
R
Y
T
M
G
S
H
G
M
R
Site 75
S600
T
G
R
Y
T
M
G
S
H
G
M
R
R
P
P
Site 76
S613
P
P
P
V
N
P
G
S
V
T
S
D
L
Y
D
Site 77
S616
V
N
P
G
S
V
T
S
D
L
Y
D
S
C
V
Site 78
Y619
G
S
V
T
S
D
L
Y
D
S
C
V
D
N
F
Site 79
Y641
I
F
N
D
D
Q
S
Y
P
Y
F
V
I
Q
Y
Site 80
Y643
N
D
D
Q
S
Y
P
Y
F
V
I
Q
Y
E
E
Site 81
Y648
Y
P
Y
F
V
I
Q
Y
E
E
V
S
N
T
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation