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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRICKLE2
Full Name:
Prickle-like protein 2
Alias:
PRIC2; Prickle-like 2
Type:
Uncharacterized protein
Mass (Da):
95615
Number AA:
844
UniProt ID:
Q7Z3G6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0031965
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
M
P
L
E
M
E
K
T
I
S
K
L
M
F
D
Site 2
S24
M
F
D
F
Q
R
N
S
T
S
D
D
D
S
G
Site 3
T25
F
D
F
Q
R
N
S
T
S
D
D
D
S
G
C
Site 4
S26
D
F
Q
R
N
S
T
S
D
D
D
S
G
C
A
Site 5
S30
N
S
T
S
D
D
D
S
G
C
A
L
E
E
Y
Site 6
Y52
K
P
E
Q
V
H
Q
Y
Y
S
C
L
P
E
E
Site 7
Y53
P
E
Q
V
H
Q
Y
Y
S
C
L
P
E
E
K
Site 8
S54
E
Q
V
H
Q
Y
Y
S
C
L
P
E
E
K
V
Site 9
Y63
L
P
E
E
K
V
P
Y
V
N
S
P
G
E
K
Site 10
S66
E
K
V
P
Y
V
N
S
P
G
E
K
L
R
I
Site 11
Y89
P
H
D
N
E
V
R
Y
C
N
S
L
D
E
E
Site 12
S92
N
E
V
R
Y
C
N
S
L
D
E
E
E
K
R
Site 13
S106
R
E
L
K
L
F
S
S
Q
R
K
R
E
N
L
Site 14
Y234
T
V
L
G
G
Q
R
Y
I
M
K
E
G
R
P
Site 15
S307
K
Q
G
Q
I
F
C
S
R
A
C
S
A
G
E
Site 16
S311
I
F
C
S
R
A
C
S
A
G
E
D
P
N
G
Site 17
S319
A
G
E
D
P
N
G
S
D
S
S
D
S
A
F
Site 18
S321
E
D
P
N
G
S
D
S
S
D
S
A
F
Q
N
Site 19
S322
D
P
N
G
S
D
S
S
D
S
A
F
Q
N
A
Site 20
S334
Q
N
A
R
A
K
E
S
R
R
S
A
K
I
G
Site 21
S337
R
A
K
E
S
R
R
S
A
K
I
G
K
N
K
Site 22
T347
I
G
K
N
K
G
K
T
E
E
P
M
L
N
Q
Site 23
S356
E
P
M
L
N
Q
H
S
Q
L
Q
V
S
S
N
Site 24
S361
Q
H
S
Q
L
Q
V
S
S
N
R
L
S
A
D
Site 25
S362
H
S
Q
L
Q
V
S
S
N
R
L
S
A
D
V
Site 26
S366
Q
V
S
S
N
R
L
S
A
D
V
D
P
L
S
Site 27
S380
S
L
Q
M
D
M
L
S
L
S
S
Q
T
P
S
Site 28
S382
Q
M
D
M
L
S
L
S
S
Q
T
P
S
L
N
Site 29
S383
M
D
M
L
S
L
S
S
Q
T
P
S
L
N
R
Site 30
T385
M
L
S
L
S
S
Q
T
P
S
L
N
R
D
P
Site 31
S387
S
L
S
S
Q
T
P
S
L
N
R
D
P
I
W
Site 32
Y403
S
R
E
E
P
Y
H
Y
G
N
K
M
E
Q
N
Site 33
T412
N
K
M
E
Q
N
Q
T
Q
S
P
L
Q
L
L
Site 34
S414
M
E
Q
N
Q
T
Q
S
P
L
Q
L
L
S
Q
Site 35
S420
Q
S
P
L
Q
L
L
S
Q
C
N
I
R
T
S
Site 36
S427
S
Q
C
N
I
R
T
S
Y
S
P
G
G
Q
G
Site 37
Y428
Q
C
N
I
R
T
S
Y
S
P
G
G
Q
G
A
Site 38
S429
C
N
I
R
T
S
Y
S
P
G
G
Q
G
A
G
Site 39
S447
E
M
W
G
K
H
F
S
N
P
K
R
S
S
S
Site 40
S453
F
S
N
P
K
R
S
S
S
L
A
M
T
G
H
Site 41
S454
S
N
P
K
R
S
S
S
L
A
M
T
G
H
A
Site 42
S463
A
M
T
G
H
A
G
S
F
I
K
E
C
R
E
Site 43
Y472
I
K
E
C
R
E
D
Y
Y
P
G
R
L
R
S
Site 44
Y473
K
E
C
R
E
D
Y
Y
P
G
R
L
R
S
Q
Site 45
S479
Y
Y
P
G
R
L
R
S
Q
E
S
Y
S
D
M
Site 46
S482
G
R
L
R
S
Q
E
S
Y
S
D
M
S
S
Q
Site 47
Y483
R
L
R
S
Q
E
S
Y
S
D
M
S
S
Q
S
Site 48
S484
L
R
S
Q
E
S
Y
S
D
M
S
S
Q
S
F
Site 49
S487
Q
E
S
Y
S
D
M
S
S
Q
S
F
S
E
T
Site 50
S488
E
S
Y
S
D
M
S
S
Q
S
F
S
E
T
R
Site 51
S490
Y
S
D
M
S
S
Q
S
F
S
E
T
R
G
S
Site 52
S492
D
M
S
S
Q
S
F
S
E
T
R
G
S
I
Q
Site 53
T494
S
S
Q
S
F
S
E
T
R
G
S
I
Q
V
P
Site 54
S497
S
F
S
E
T
R
G
S
I
Q
V
P
K
Y
E
Site 55
Y503
G
S
I
Q
V
P
K
Y
E
E
E
E
E
E
E
Site 56
S514
E
E
E
E
G
G
L
S
T
Q
Q
C
R
T
R
Site 57
T520
L
S
T
Q
Q
C
R
T
R
H
P
I
S
S
L
Site 58
S525
C
R
T
R
H
P
I
S
S
L
K
Y
T
E
D
Site 59
S526
R
T
R
H
P
I
S
S
L
K
Y
T
E
D
M
Site 60
Y529
H
P
I
S
S
L
K
Y
T
E
D
M
T
P
T
Site 61
T530
P
I
S
S
L
K
Y
T
E
D
M
T
P
T
E
Site 62
T534
L
K
Y
T
E
D
M
T
P
T
E
Q
T
P
R
Site 63
T539
D
M
T
P
T
E
Q
T
P
R
G
S
M
E
S
Site 64
S543
T
E
Q
T
P
R
G
S
M
E
S
L
A
L
S
Site 65
S546
T
P
R
G
S
M
E
S
L
A
L
S
N
A
T
Site 66
S568
A
K
R
Q
E
H
L
S
R
F
S
M
P
D
L
Site 67
S571
Q
E
H
L
S
R
F
S
M
P
D
L
S
K
D
Site 68
S576
R
F
S
M
P
D
L
S
K
D
S
G
M
N
V
Site 69
S579
M
P
D
L
S
K
D
S
G
M
N
V
S
E
K
Site 70
S584
K
D
S
G
M
N
V
S
E
K
L
S
N
M
G
Site 71
S588
M
N
V
S
E
K
L
S
N
M
G
T
L
N
S
Site 72
T592
E
K
L
S
N
M
G
T
L
N
S
S
M
Q
F
Site 73
S595
S
N
M
G
T
L
N
S
S
M
Q
F
R
S
A
Site 74
S596
N
M
G
T
L
N
S
S
M
Q
F
R
S
A
E
Site 75
S601
N
S
S
M
Q
F
R
S
A
E
S
V
R
S
L
Site 76
S604
M
Q
F
R
S
A
E
S
V
R
S
L
L
S
A
Site 77
S607
R
S
A
E
S
V
R
S
L
L
S
A
Q
Q
Y
Site 78
S610
E
S
V
R
S
L
L
S
A
Q
Q
Y
Q
E
M
Site 79
Y614
S
L
L
S
A
Q
Q
Y
Q
E
M
E
G
N
L
Site 80
S625
E
G
N
L
H
Q
L
S
N
P
I
G
Y
R
D
Site 81
S652
F
D
G
G
M
A
G
S
K
L
P
G
Q
E
G
Site 82
S666
G
V
R
I
Q
P
M
S
E
R
T
R
R
R
A
Site 83
T669
I
Q
P
M
S
E
R
T
R
R
R
A
T
S
R
Site 84
T674
E
R
T
R
R
R
A
T
S
R
D
D
N
R
R
Site 85
S675
R
T
R
R
R
A
T
S
R
D
D
N
R
R
F
Site 86
S687
R
R
F
R
P
H
R
S
R
R
S
R
R
S
R
Site 87
S690
R
P
H
R
S
R
R
S
R
R
S
R
S
D
N
Site 88
S693
R
S
R
R
S
R
R
S
R
S
D
N
A
L
H
Site 89
S695
R
R
S
R
R
S
R
S
D
N
A
L
H
L
A
Site 90
Y723
P
L
R
A
R
E
D
Y
D
Q
F
M
R
Q
R
Site 91
S731
D
Q
F
M
R
Q
R
S
F
Q
E
S
M
G
H
Site 92
S735
R
Q
R
S
F
Q
E
S
M
G
H
G
S
R
R
Site 93
S740
Q
E
S
M
G
H
G
S
R
R
D
L
Y
G
Q
Site 94
Y745
H
G
S
R
R
D
L
Y
G
Q
C
P
R
T
V
Site 95
T751
L
Y
G
Q
C
P
R
T
V
S
D
L
A
L
Q
Site 96
S753
G
Q
C
P
R
T
V
S
D
L
A
L
Q
N
A
Site 97
S776
F
A
E
Y
D
W
C
S
T
C
S
S
S
S
E
Site 98
T777
A
E
Y
D
W
C
S
T
C
S
S
S
S
E
S
Site 99
S779
Y
D
W
C
S
T
C
S
S
S
S
E
S
D
N
Site 100
S780
D
W
C
S
T
C
S
S
S
S
E
S
D
N
E
Site 101
S781
W
C
S
T
C
S
S
S
S
E
S
D
N
E
G
Site 102
S782
C
S
T
C
S
S
S
S
E
S
D
N
E
G
Y
Site 103
S784
T
C
S
S
S
S
E
S
D
N
E
G
Y
F
L
Site 104
Y789
S
E
S
D
N
E
G
Y
F
L
G
E
P
I
P
Site 105
Y803
P
Q
P
A
R
L
R
Y
V
T
S
D
E
L
L
Site 106
T805
P
A
R
L
R
Y
V
T
S
D
E
L
L
H
K
Site 107
S806
A
R
L
R
Y
V
T
S
D
E
L
L
H
K
Y
Site 108
Y813
S
D
E
L
L
H
K
Y
S
S
Y
G
L
P
K
Site 109
S814
D
E
L
L
H
K
Y
S
S
Y
G
L
P
K
S
Site 110
S815
E
L
L
H
K
Y
S
S
Y
G
L
P
K
S
S
Site 111
Y816
L
L
H
K
Y
S
S
Y
G
L
P
K
S
S
T
Site 112
S821
S
S
Y
G
L
P
K
S
S
T
L
G
G
R
G
Site 113
S822
S
Y
G
L
P
K
S
S
T
L
G
G
R
G
Q
Site 114
T823
Y
G
L
P
K
S
S
T
L
G
G
R
G
Q
L
Site 115
S832
G
G
R
G
Q
L
H
S
R
K
R
Q
K
S
K
Site 116
S838
H
S
R
K
R
Q
K
S
K
N
C
I
I
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation