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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MIER3
Full Name:
Mesoderm induction early response protein 3
Alias:
DKFZp781G1119; DKFZp781I1119
Type:
Uncharacterized
Mass (Da):
61838
Number AA:
554
UniProt ID:
Q7Z3K6
International Prot ID:
IPI00465053
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
E
A
S
F
G
S
S
S
P
V
Site 2
S9
A
E
A
S
F
G
S
S
S
P
V
G
S
L
S
Site 3
S10
E
A
S
F
G
S
S
S
P
V
G
S
L
S
S
Site 4
S14
G
S
S
S
P
V
G
S
L
S
S
E
D
H
D
Site 5
S16
S
S
P
V
G
S
L
S
S
E
D
H
D
F
D
Site 6
S17
S
P
V
G
S
L
S
S
E
D
H
D
F
D
P
Site 7
T25
E
D
H
D
F
D
P
T
A
E
M
L
V
H
D
Site 8
Y33
A
E
M
L
V
H
D
Y
D
D
E
R
T
L
E
Site 9
T38
H
D
Y
D
D
E
R
T
L
E
E
E
E
M
M
Site 10
S52
M
D
E
G
K
N
F
S
S
E
I
E
D
L
E
Site 11
S53
D
E
G
K
N
F
S
S
E
I
E
D
L
E
K
Site 12
T63
E
D
L
E
K
E
G
T
M
P
L
E
D
L
L
Site 13
S85
T
I
P
A
V
A
N
S
S
A
N
S
S
P
S
Site 14
S86
I
P
A
V
A
N
S
S
A
N
S
S
P
S
E
Site 15
S89
V
A
N
S
S
A
N
S
S
P
S
E
L
A
D
Site 16
S90
A
N
S
S
A
N
S
S
P
S
E
L
A
D
E
Site 17
T102
A
D
E
L
P
D
M
T
L
D
K
E
E
I
A
Site 18
S114
E
I
A
K
D
L
L
S
G
D
D
E
E
T
Q
Site 19
T120
L
S
G
D
D
E
E
T
Q
S
S
A
D
D
L
Site 20
S122
G
D
D
E
E
T
Q
S
S
A
D
D
L
T
P
Site 21
S123
D
D
E
E
T
Q
S
S
A
D
D
L
T
P
S
Site 22
T128
Q
S
S
A
D
D
L
T
P
S
V
T
S
H
E
Site 23
S130
S
A
D
D
L
T
P
S
V
T
S
H
E
T
S
Site 24
S133
D
L
T
P
S
V
T
S
H
E
T
S
D
F
F
Site 25
S137
S
V
T
S
H
E
T
S
D
F
F
P
R
P
L
Site 26
S146
F
F
P
R
P
L
R
S
N
T
A
C
D
G
D
Site 27
T148
P
R
P
L
R
S
N
T
A
C
D
G
D
K
E
Site 28
S156
A
C
D
G
D
K
E
S
E
V
E
D
V
E
T
Site 29
T163
S
E
V
E
D
V
E
T
D
S
G
N
S
P
E
Site 30
S165
V
E
D
V
E
T
D
S
G
N
S
P
E
D
L
Site 31
S168
V
E
T
D
S
G
N
S
P
E
D
L
R
K
E
Site 32
Y189
Y
Q
A
E
I
P
P
Y
L
G
E
Y
D
G
N
Site 33
Y221
L
E
S
K
V
K
E
Y
L
V
E
T
S
L
R
Site 34
S226
K
E
Y
L
V
E
T
S
L
R
T
G
S
E
K
Site 35
S231
E
T
S
L
R
T
G
S
E
K
I
M
D
R
I
Site 36
S239
E
K
I
M
D
R
I
S
A
G
T
H
T
R
D
Site 37
T242
M
D
R
I
S
A
G
T
H
T
R
D
N
E
Q
Site 38
Y252
R
D
N
E
Q
A
L
Y
E
L
L
K
C
N
H
Site 39
Y268
I
K
E
A
I
E
R
Y
C
C
N
G
K
A
S
Site 40
T313
K
N
K
V
R
T
R
T
V
A
E
C
V
A
F
Site 41
Y322
A
E
C
V
A
F
Y
Y
M
W
K
K
S
E
R
Site 42
Y332
K
K
S
E
R
Y
D
Y
F
A
Q
Q
T
R
F
Site 43
Y353
H
H
P
G
V
T
D
Y
M
D
R
L
V
D
E
Site 44
T361
M
D
R
L
V
D
E
T
E
A
L
G
G
T
V
Site 45
S375
V
N
A
S
A
L
T
S
N
R
P
E
P
I
P
Site 46
S391
Q
Q
L
N
I
L
N
S
F
T
A
S
D
L
T
Site 47
S419
D
V
N
C
L
D
D
S
F
P
P
L
G
N
T
Site 48
T426
S
F
P
P
L
G
N
T
P
R
G
Q
V
N
H
Site 49
T443
V
V
T
E
E
L
L
T
L
P
S
N
G
E
S
Site 50
S446
E
E
L
L
T
L
P
S
N
G
E
S
D
C
F
Site 51
S450
T
L
P
S
N
G
E
S
D
C
F
N
L
F
E
Site 52
Y461
N
L
F
E
T
G
F
Y
H
S
E
L
N
P
M
Site 53
S475
M
N
M
C
S
E
E
S
E
R
P
A
K
R
L
Site 54
S497
E
S
F
M
N
E
V
S
V
N
N
L
G
V
D
Site 55
S526
V
S
V
A
D
F
G
S
L
S
A
N
E
T
N
Site 56
S528
V
A
D
F
G
S
L
S
A
N
E
T
N
G
F
Site 57
T532
G
S
L
S
A
N
E
T
N
G
F
I
S
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation