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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
endofin
Full Name:
Zinc finger FYVE domain-containing protein 16
Alias:
DKFZp686K236; Endofin; Endosome-associated FYVE-domain protein; KIAA0305; ZFY16; ZFYVE16; Zinc finger, FYVE domain containing 16
Type:
Lipid binding protein
Mass (Da):
168849
Number AA:
1539
UniProt ID:
Q7Z3T8
International Prot ID:
IPI00424460
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031901
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005545
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0016197
GO:0006622
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
Y
F
K
A
A
V
S
D
L
D
K
L
L
D
Site 2
Y28
Q
N
P
D
E
Q
D
Y
L
Q
D
V
Q
N
A
Site 3
Y36
L
Q
D
V
Q
N
A
Y
D
S
N
H
C
S
V
Site 4
S38
D
V
Q
N
A
Y
D
S
N
H
C
S
V
S
S
Site 5
S42
A
Y
D
S
N
H
C
S
V
S
S
E
L
A
S
Site 6
S44
D
S
N
H
C
S
V
S
S
E
L
A
S
S
Q
Site 7
S45
S
N
H
C
S
V
S
S
E
L
A
S
S
Q
R
Site 8
S49
S
V
S
S
E
L
A
S
S
Q
R
T
S
L
L
Site 9
S50
V
S
S
E
L
A
S
S
Q
R
T
S
L
L
P
Site 10
S54
L
A
S
S
Q
R
T
S
L
L
P
K
D
Q
E
Site 11
S65
K
D
Q
E
C
V
N
S
C
A
S
S
E
T
S
Site 12
S69
C
V
N
S
C
A
S
S
E
T
S
Y
G
T
N
Site 13
S72
S
C
A
S
S
E
T
S
Y
G
T
N
E
S
S
Site 14
Y73
C
A
S
S
E
T
S
Y
G
T
N
E
S
S
L
Site 15
T75
S
S
E
T
S
Y
G
T
N
E
S
S
L
N
E
Site 16
S79
S
Y
G
T
N
E
S
S
L
N
E
K
T
L
K
Site 17
T84
E
S
S
L
N
E
K
T
L
K
G
L
T
S
I
Site 18
T89
E
K
T
L
K
G
L
T
S
I
Q
N
E
K
N
Site 19
S90
K
T
L
K
G
L
T
S
I
Q
N
E
K
N
V
Site 20
T98
I
Q
N
E
K
N
V
T
G
L
D
L
L
S
S
Site 21
S105
T
G
L
D
L
L
S
S
V
D
G
G
T
S
D
Site 22
S111
S
S
V
D
G
G
T
S
D
E
I
Q
P
L
Y
Site 23
Y118
S
D
E
I
Q
P
L
Y
M
G
R
C
S
K
P
Site 24
T140
M
G
N
L
V
H
A
T
N
S
E
E
D
I
K
Site 25
S142
N
L
V
H
A
T
N
S
E
E
D
I
K
K
L
Site 26
S156
L
L
P
D
D
F
K
S
N
A
D
S
L
I
G
Site 27
S160
D
F
K
S
N
A
D
S
L
I
G
L
D
L
S
Site 28
S167
S
L
I
G
L
D
L
S
S
V
S
D
T
P
C
Site 29
S168
L
I
G
L
D
L
S
S
V
S
D
T
P
C
V
Site 30
S170
G
L
D
L
S
S
V
S
D
T
P
C
V
S
S
Site 31
T172
D
L
S
S
V
S
D
T
P
C
V
S
S
T
D
Site 32
S176
V
S
D
T
P
C
V
S
S
T
D
H
D
S
D
Site 33
T178
D
T
P
C
V
S
S
T
D
H
D
S
D
T
V
Site 34
S182
V
S
S
T
D
H
D
S
D
T
V
R
E
Q
Q
Site 35
T184
S
T
D
H
D
S
D
T
V
R
E
Q
Q
N
D
Site 36
S193
R
E
Q
Q
N
D
T
S
S
E
L
Q
N
R
E
Site 37
S194
E
Q
Q
N
D
T
S
S
E
L
Q
N
R
E
I
Site 38
T213
E
L
G
I
K
V
D
T
T
L
S
D
S
Y
N
Site 39
T214
L
G
I
K
V
D
T
T
L
S
D
S
Y
N
Y
Site 40
S216
I
K
V
D
T
T
L
S
D
S
Y
N
Y
S
G
Site 41
S218
V
D
T
T
L
S
D
S
Y
N
Y
S
G
T
E
Site 42
Y219
D
T
T
L
S
D
S
Y
N
Y
S
G
T
E
N
Site 43
Y221
T
L
S
D
S
Y
N
Y
S
G
T
E
N
L
K
Site 44
S222
L
S
D
S
Y
N
Y
S
G
T
E
N
L
K
D
Site 45
S245
S
I
V
D
F
N
M
S
S
A
L
T
R
Q
S
Site 46
T249
F
N
M
S
S
A
L
T
R
Q
S
S
K
M
F
Site 47
S252
S
S
A
L
T
R
Q
S
S
K
M
F
H
A
K
Site 48
S253
S
A
L
T
R
Q
S
S
K
M
F
H
A
K
D
Site 49
S266
K
D
K
L
Q
H
K
S
Q
P
C
G
L
L
K
Site 50
T299
C
L
K
E
E
G
K
T
S
A
L
T
C
S
L
Site 51
S300
L
K
E
E
G
K
T
S
A
L
T
C
S
L
P
Site 52
S317
E
D
L
C
L
N
D
S
N
S
R
D
E
N
F
Site 53
S319
L
C
L
N
D
S
N
S
R
D
E
N
F
K
L
Site 54
S330
N
F
K
L
P
D
F
S
F
Q
E
D
K
T
V
Site 55
T336
F
S
F
Q
E
D
K
T
V
I
K
Q
S
A
Q
Site 56
S341
D
K
T
V
I
K
Q
S
A
Q
E
D
S
K
S
Site 57
S346
K
Q
S
A
Q
E
D
S
K
S
L
D
L
K
D
Site 58
S348
S
A
Q
E
D
S
K
S
L
D
L
K
D
N
D
Site 59
S360
D
N
D
V
I
Q
D
S
S
S
A
L
H
V
S
Site 60
S362
D
V
I
Q
D
S
S
S
A
L
H
V
S
S
K
Site 61
S367
S
S
S
A
L
H
V
S
S
K
D
V
P
S
S
Site 62
S368
S
S
A
L
H
V
S
S
K
D
V
P
S
S
L
Site 63
S374
S
S
K
D
V
P
S
S
L
S
C
L
P
A
S
Site 64
S376
K
D
V
P
S
S
L
S
C
L
P
A
S
G
S
Site 65
S387
A
S
G
S
M
C
G
S
L
I
E
S
K
A
R
Site 66
S391
M
C
G
S
L
I
E
S
K
A
R
G
D
F
L
Site 67
S420
I
H
E
E
I
Q
N
S
V
V
L
G
G
E
P
Site 68
S446
C
K
S
I
L
L
Q
S
L
I
E
G
M
E
D
Site 69
T461
R
K
I
D
P
D
Q
T
V
I
R
A
E
S
L
Site 70
S467
Q
T
V
I
R
A
E
S
L
D
G
G
D
T
S
Site 71
T473
E
S
L
D
G
G
D
T
S
S
T
V
V
E
S
Site 72
S474
S
L
D
G
G
D
T
S
S
T
V
V
E
S
Q
Site 73
S475
L
D
G
G
D
T
S
S
T
V
V
E
S
Q
E
Site 74
T476
D
G
G
D
T
S
S
T
V
V
E
S
Q
E
G
Site 75
S480
T
S
S
T
V
V
E
S
Q
E
G
L
S
G
T
Site 76
S485
V
E
S
Q
E
G
L
S
G
T
H
V
P
E
S
Site 77
T487
S
Q
E
G
L
S
G
T
H
V
P
E
S
S
D
Site 78
S492
S
G
T
H
V
P
E
S
S
D
C
C
E
G
F
Site 79
S504
E
G
F
I
N
T
F
S
S
N
D
M
D
G
Q
Site 80
Y515
M
D
G
Q
D
L
D
Y
F
N
I
D
E
G
A
Site 81
S524
N
I
D
E
G
A
K
S
G
P
L
I
S
D
A
Site 82
Y541
D
A
F
L
T
E
Q
Y
L
Q
T
T
N
I
K
Site 83
S549
L
Q
T
T
N
I
K
S
F
E
E
N
V
N
D
Site 84
Y578
D
G
N
I
N
N
I
Y
F
N
A
E
A
G
A
Site 85
S610
N
T
I
E
N
G
L
S
L
G
E
K
S
T
I
Site 86
S615
G
L
S
L
G
E
K
S
T
I
P
V
Q
Q
G
Site 87
T616
L
S
L
G
E
K
S
T
I
P
V
Q
Q
G
L
Site 88
S626
V
Q
Q
G
L
P
T
S
K
S
E
I
T
N
Q
Site 89
S628
Q
G
L
P
T
S
K
S
E
I
T
N
Q
L
S
Site 90
S635
S
E
I
T
N
Q
L
S
V
S
D
I
N
S
Q
Site 91
S637
I
T
N
Q
L
S
V
S
D
I
N
S
Q
S
V
Site 92
S641
L
S
V
S
D
I
N
S
Q
S
V
G
G
A
R
Site 93
S643
V
S
D
I
N
S
Q
S
V
G
G
A
R
P
K
Site 94
S654
A
R
P
K
Q
L
F
S
L
P
S
R
T
R
S
Site 95
S657
K
Q
L
F
S
L
P
S
R
T
R
S
S
K
D
Site 96
S661
S
L
P
S
R
T
R
S
S
K
D
L
N
K
P
Site 97
S662
L
P
S
R
T
R
S
S
K
D
L
N
K
P
D
Site 98
T673
N
K
P
D
V
P
D
T
I
E
S
E
P
S
T
Site 99
S679
D
T
I
E
S
E
P
S
T
A
D
T
V
V
P
Site 100
T680
T
I
E
S
E
P
S
T
A
D
T
V
V
P
I
Site 101
S700
S
T
A
D
P
Q
V
S
F
N
S
N
Y
I
D
Site 102
Y705
Q
V
S
F
N
S
N
Y
I
D
I
E
S
N
S
Site 103
S710
S
N
Y
I
D
I
E
S
N
S
E
G
G
S
S
Site 104
S712
Y
I
D
I
E
S
N
S
E
G
G
S
S
F
V
Site 105
S716
E
S
N
S
E
G
G
S
S
F
V
T
A
N
E
Site 106
S717
S
N
S
E
G
G
S
S
F
V
T
A
N
E
D
Site 107
T720
E
G
G
S
S
F
V
T
A
N
E
D
S
V
P
Site 108
S725
F
V
T
A
N
E
D
S
V
P
E
N
T
C
K
Site 109
Y789
N
R
K
C
K
L
Q
Y
L
E
K
E
A
R
V
Site 110
S815
Q
A
F
E
R
M
M
S
P
T
G
S
N
L
K
Site 111
T817
F
E
R
M
M
S
P
T
G
S
N
L
K
S
N
Site 112
S819
R
M
M
S
P
T
G
S
N
L
K
S
N
H
S
Site 113
S823
P
T
G
S
N
L
K
S
N
H
S
D
E
C
T
Site 114
S826
S
N
L
K
S
N
H
S
D
E
C
T
T
V
Q
Site 115
T830
S
N
H
S
D
E
C
T
T
V
Q
P
P
Q
E
Site 116
T831
N
H
S
D
E
C
T
T
V
Q
P
P
Q
E
N
Site 117
S841
P
P
Q
E
N
Q
T
S
S
I
P
S
P
A
T
Site 118
S842
P
Q
E
N
Q
T
S
S
I
P
S
P
A
T
L
Site 119
S845
N
Q
T
S
S
I
P
S
P
A
T
L
P
V
S
Site 120
S864
P
G
V
E
G
L
C
S
K
E
Q
K
R
V
W
Site 121
T885
P
N
G
E
V
A
D
T
T
K
L
S
S
G
S
Site 122
T886
N
G
E
V
A
D
T
T
K
L
S
S
G
S
K
Site 123
S889
V
A
D
T
T
K
L
S
S
G
S
K
R
C
S
Site 124
S890
A
D
T
T
K
L
S
S
G
S
K
R
C
S
E
Site 125
S892
T
T
K
L
S
S
G
S
K
R
C
S
E
D
F
Site 126
S896
S
S
G
S
K
R
C
S
E
D
F
S
P
L
S
Site 127
S900
K
R
C
S
E
D
F
S
P
L
S
P
D
V
P
Site 128
S903
S
E
D
F
S
P
L
S
P
D
V
P
M
T
V
Site 129
T909
L
S
P
D
V
P
M
T
V
N
T
V
D
H
S
Site 130
T912
D
V
P
M
T
V
N
T
V
D
H
S
H
S
T
Site 131
T920
V
D
H
S
H
S
T
T
V
E
K
P
N
N
E
Site 132
T928
V
E
K
P
N
N
E
T
G
D
I
T
R
N
E
Site 133
T932
N
N
E
T
G
D
I
T
R
N
E
I
I
Q
S
Site 134
S939
T
R
N
E
I
I
Q
S
P
I
S
Q
V
P
S
Site 135
S942
E
I
I
Q
S
P
I
S
Q
V
P
S
V
E
K
Site 136
S946
S
P
I
S
Q
V
P
S
V
E
K
L
S
M
N
Site 137
S951
V
P
S
V
E
K
L
S
M
N
T
G
N
E
G
Site 138
T961
T
G
N
E
G
L
P
T
S
G
S
F
T
L
D
Site 139
S962
G
N
E
G
L
P
T
S
G
S
F
T
L
D
D
Site 140
S964
E
G
L
P
T
S
G
S
F
T
L
D
D
D
V
Site 141
T975
D
D
D
V
F
A
E
T
E
E
P
S
S
P
T
Site 142
S980
A
E
T
E
E
P
S
S
P
T
G
V
L
V
N
Site 143
S994
N
S
N
L
P
I
A
S
I
S
D
Y
R
L
L
Site 144
S1034
V
A
S
G
E
K
G
S
V
P
V
V
E
E
H
Site 145
S1043
P
V
V
E
E
H
P
S
H
E
Q
I
I
L
L
Site 146
Y1076
V
N
V
K
F
I
F
Y
S
S
D
K
Y
W
Y
Site 147
Y1081
I
F
Y
S
S
D
K
Y
W
Y
F
S
T
N
G
Site 148
Y1083
Y
S
S
D
K
Y
W
Y
F
S
T
N
G
L
H
Site 149
T1109
L
C
L
P
N
E
D
T
I
P
K
D
I
F
R
Site 150
T1120
D
I
F
R
L
F
I
T
I
Y
K
D
A
L
K
Site 151
T1138
I
E
N
L
D
N
I
T
F
T
E
S
F
L
S
Site 152
T1140
N
L
D
N
I
T
F
T
E
S
F
L
S
S
K
Site 153
S1142
D
N
I
T
F
T
E
S
F
L
S
S
K
D
H
Site 154
S1145
T
F
T
E
S
F
L
S
S
K
D
H
G
G
F
Site 155
S1146
F
T
E
S
F
L
S
S
K
D
H
G
G
F
L
Site 156
S1166
F
Q
K
L
D
D
L
S
L
P
S
N
P
F
L
Site 157
Y1201
M
L
R
L
G
A
E
Y
K
A
Y
P
A
P
L
Site 158
Y1204
L
G
A
E
Y
K
A
Y
P
A
P
L
T
S
I
Site 159
T1209
K
A
Y
P
A
P
L
T
S
I
R
G
R
K
P
Site 160
S1210
A
Y
P
A
P
L
T
S
I
R
G
R
K
P
L
Site 161
Y1235
L
L
V
D
L
R
N
Y
Q
Y
T
L
H
N
I
Site 162
Y1237
V
D
L
R
N
Y
Q
Y
T
L
H
N
I
D
Q
Site 163
Y1263
I
K
I
P
R
K
K
Y
S
D
V
M
K
V
L
Site 164
S1279
S
S
N
E
H
V
I
S
I
G
A
S
F
S
T
Site 165
Y1301
C
I
Q
N
D
G
I
Y
E
T
Q
A
N
S
A
Site 166
T1303
Q
N
D
G
I
Y
E
T
Q
A
N
S
A
T
G
Site 167
S1331
N
G
A
L
K
T
S
S
G
F
L
A
K
S
S
Site 168
S1337
S
S
G
F
L
A
K
S
S
I
V
E
D
G
L
Site 169
S1399
K
G
N
K
G
V
I
S
S
V
D
G
I
S
L
Site 170
S1405
I
S
S
V
D
G
I
S
L
Q
G
F
P
S
E
Site 171
S1411
I
S
L
Q
G
F
P
S
E
K
I
K
L
E
A
Site 172
Y1434
V
K
C
T
E
V
F
Y
F
L
K
D
Q
D
L
Site 173
S1442
F
L
K
D
Q
D
L
S
I
L
S
T
S
Y
Q
Site 174
S1445
D
Q
D
L
S
I
L
S
T
S
Y
Q
F
A
K
Site 175
T1446
Q
D
L
S
I
L
S
T
S
Y
Q
F
A
K
E
Site 176
S1471
P
H
L
K
T
L
K
S
N
G
M
N
K
I
G
Site 177
S1482
N
K
I
G
L
R
V
S
I
D
T
D
M
V
E
Site 178
Y1503
G
Q
L
L
P
Q
H
Y
L
N
D
L
D
S
A
Site 179
S1520
P
V
I
H
G
G
T
S
N
S
S
L
P
L
E
Site 180
S1522
I
H
G
G
T
S
N
S
S
L
P
L
E
I
E
Site 181
S1523
H
G
G
T
S
N
S
S
L
P
L
E
I
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation