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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBE3B
Full Name:
Ubiquitin-protein ligase E3B
Alias:
ubiquitin protein ligase E3B
Type:
Ubiquitin conjugating system; Ligase; EC 6.3.2.-; Ubiquitin ligase
Mass (Da):
123070
Number AA:
1068
UniProt ID:
Q7Z3V4
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0016881
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
V
R
S
F
L
C
R
S
R
L
Q
R
D
I
R
Site 2
S68
F
K
A
D
D
P
E
S
T
K
R
S
A
L
C
Site 3
T69
K
A
D
D
P
E
S
T
K
R
S
A
L
C
I
Site 4
S72
D
P
E
S
T
K
R
S
A
L
C
I
F
K
I
Site 5
S102
R
F
E
K
L
C
R
S
I
L
S
S
M
D
A
Site 6
S106
L
C
R
S
I
L
S
S
M
D
A
E
N
E
P
Site 7
Y117
E
N
E
P
K
V
W
Y
V
S
L
A
C
S
K
Site 8
S119
E
P
K
V
W
Y
V
S
L
A
C
S
K
D
L
Site 9
S156
K
P
E
I
L
Q
D
S
R
L
I
T
L
Y
L
Site 10
T164
R
L
I
T
L
Y
L
T
M
L
V
T
F
T
D
Site 11
T174
V
T
F
T
D
T
S
T
W
K
I
L
R
G
K
Site 12
S184
I
L
R
G
K
G
E
S
L
R
P
A
M
N
H
Site 13
S225
A
R
P
R
P
C
L
S
K
G
T
L
T
A
A
Site 14
T276
T
V
T
P
E
R
L
T
V
L
E
S
H
D
M
Site 15
S280
E
R
L
T
V
L
E
S
H
D
M
L
R
K
F
Site 16
S303
R
C
R
D
V
C
E
S
L
E
G
C
H
T
L
Site 17
S323
L
L
H
L
G
S
L
S
P
R
V
L
E
E
E
Site 18
Y348
T
L
C
Y
C
Q
K
Y
V
S
Q
K
K
S
N
Site 19
S369
V
L
G
W
F
S
Q
S
V
D
Y
G
L
N
E
Site 20
Y372
W
F
S
Q
S
V
D
Y
G
L
N
E
S
M
H
Site 21
S409
L
S
K
K
L
L
E
S
Q
E
P
A
H
A
Q
Site 22
S419
P
A
H
A
Q
P
A
S
P
Q
N
V
L
P
V
Site 23
S428
Q
N
V
L
P
V
K
S
L
L
K
R
A
F
Q
Site 24
S437
L
K
R
A
F
Q
K
S
A
S
V
R
N
I
L
Site 25
S439
R
A
F
Q
K
S
A
S
V
R
N
I
L
R
P
Site 26
S454
V
G
G
K
R
V
D
S
A
E
V
Q
K
V
C
Site 27
T475
Q
T
S
L
T
T
L
T
Q
I
R
L
Q
I
L
Site 28
T483
Q
I
R
L
Q
I
L
T
G
L
T
Y
L
D
D
Site 29
Y487
Q
I
L
T
G
L
T
Y
L
D
D
L
L
P
K
Site 30
T519
L
E
C
L
N
N
D
T
E
E
S
K
Q
L
L
Site 31
Y549
I
L
D
D
I
E
V
Y
E
E
Q
I
S
F
K
Site 32
S554
E
V
Y
E
E
Q
I
S
F
K
L
E
E
L
V
Site 33
Y602
H
G
W
L
M
V
L
Y
E
R
D
C
R
R
R
Site 34
T611
R
D
C
R
R
R
F
T
P
E
D
H
W
L
R
Site 35
Y643
R
A
Q
L
I
L
Q
Y
I
P
H
V
I
P
H
Site 36
T673
E
K
L
G
L
V
E
T
S
S
A
S
P
H
V
Site 37
S675
L
G
L
V
E
T
S
S
A
S
P
H
V
T
H
Site 38
S677
L
V
E
T
S
S
A
S
P
H
V
T
H
I
T
Site 39
T681
S
S
A
S
P
H
V
T
H
I
T
I
R
R
S
Site 40
T684
S
P
H
V
T
H
I
T
I
R
R
S
R
M
L
Site 41
S688
T
H
I
T
I
R
R
S
R
M
L
E
D
G
Y
Site 42
Y695
S
R
M
L
E
D
G
Y
E
Q
L
R
Q
L
S
Site 43
S702
Y
E
Q
L
R
Q
L
S
Q
H
A
M
K
G
V
Site 44
T752
P
A
L
N
L
F
K
T
T
S
G
D
E
R
L
Site 45
S754
L
N
L
F
K
T
T
S
G
D
E
R
L
Y
P
Site 46
Y760
T
S
G
D
E
R
L
Y
P
S
P
T
S
Y
I
Site 47
S762
G
D
E
R
L
Y
P
S
P
T
S
Y
I
H
E
Site 48
T764
E
R
L
Y
P
S
P
T
S
Y
I
H
E
N
Y
Site 49
S765
R
L
Y
P
S
P
T
S
Y
I
H
E
N
Y
L
Site 50
Y766
L
Y
P
S
P
T
S
Y
I
H
E
N
Y
L
Q
Site 51
Y771
T
S
Y
I
H
E
N
Y
L
Q
L
F
E
F
V
Site 52
Y787
K
M
L
G
K
A
V
Y
E
G
I
V
V
D
V
Site 53
S810
Q
L
L
G
H
H
H
S
V
F
Y
S
S
V
D
Site 54
S814
H
H
H
S
V
F
Y
S
S
V
D
E
L
P
S
Site 55
S815
H
H
S
V
F
Y
S
S
V
D
E
L
P
S
L
Site 56
S821
S
S
V
D
E
L
P
S
L
D
S
E
F
Y
K
Site 57
S824
D
E
L
P
S
L
D
S
E
F
Y
K
N
L
T
Site 58
Y827
P
S
L
D
S
E
F
Y
K
N
L
T
S
I
K
Site 59
S832
E
F
Y
K
N
L
T
S
I
K
R
Y
D
G
D
Site 60
Y836
N
L
T
S
I
K
R
Y
D
G
D
I
T
D
L
Site 61
T841
K
R
Y
D
G
D
I
T
D
L
G
L
T
L
S
Site 62
S848
T
D
L
G
L
T
L
S
Y
D
E
D
V
M
G
Site 63
Y849
D
L
G
L
T
L
S
Y
D
E
D
V
M
G
Q
Site 64
T872
G
G
K
T
I
P
V
T
N
E
N
K
I
S
Y
Site 65
T890
M
A
H
F
R
M
H
T
Q
I
K
N
Q
T
A
Site 66
S916
P
E
W
I
R
M
F
S
T
P
E
L
Q
R
L
Site 67
T917
E
W
I
R
M
F
S
T
P
E
L
Q
R
L
I
Site 68
S925
P
E
L
Q
R
L
I
S
G
D
N
A
E
I
D
Site 69
T940
L
E
D
L
K
K
H
T
V
Y
Y
G
G
F
H
Site 70
Y942
D
L
K
K
H
T
V
Y
Y
G
G
F
H
G
S
Site 71
Y943
L
K
K
H
T
V
Y
Y
G
G
F
H
G
S
H
Site 72
T965
D
I
L
A
S
D
F
T
P
D
E
R
A
M
F
Site 73
S1002
S
I
R
C
V
E
V
S
D
D
Q
D
T
G
D
Site 74
T1007
E
V
S
D
D
Q
D
T
G
D
T
L
G
S
V
Site 75
T1010
D
D
Q
D
T
G
D
T
L
G
S
V
L
R
G
Site 76
T1020
S
V
L
R
G
F
F
T
I
R
K
R
E
P
G
Site 77
T1032
E
P
G
G
R
L
P
T
S
S
T
C
F
N
L
Site 78
S1033
P
G
G
R
L
P
T
S
S
T
C
F
N
L
L
Site 79
S1034
G
G
R
L
P
T
S
S
T
C
F
N
L
L
K
Site 80
Y1045
N
L
L
K
L
P
N
Y
S
K
K
S
V
L
R
Site 81
S1049
L
P
N
Y
S
K
K
S
V
L
R
E
K
L
R
Site 82
Y1057
V
L
R
E
K
L
R
Y
A
I
S
M
N
T
G
Site 83
S1060
E
K
L
R
Y
A
I
S
M
N
T
G
F
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation