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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRT28
Full Name:
Keratin, type I cytoskeletal 28
Alias:
Cytokeratin-28; K1C28; Keratin 25D; Keratin 28; KRT25D; Type I inner root sheath specific keratin 25 irs4
Type:
Cytoskeletal, Intermediate filament protein
Mass (Da):
50595
Number AA:
464
UniProt ID:
Q7Z3Y7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
S
R
H
V
C
L
R
S
G
A
G
S
V
R
P
Site 2
S20
C
L
R
S
G
A
G
S
V
R
P
L
N
G
G
Site 3
S39
G
S
S
A
C
G
G
S
V
A
G
S
E
F
S
Site 4
S83
G
S
E
G
G
L
L
S
G
N
E
K
V
T
M
Site 5
S99
N
L
N
D
R
L
A
S
Y
L
D
N
V
R
A
Site 6
Y100
L
N
D
R
L
A
S
Y
L
D
N
V
R
A
L
Site 7
Y122
E
R
K
I
K
G
W
Y
E
K
Y
G
P
G
S
Site 8
Y125
I
K
G
W
Y
E
K
Y
G
P
G
S
C
R
G
Site 9
S129
Y
E
K
Y
G
P
G
S
C
R
G
L
D
H
D
Site 10
Y137
C
R
G
L
D
H
D
Y
S
R
Y
H
L
T
I
Site 11
S138
R
G
L
D
H
D
Y
S
R
Y
H
L
T
I
E
Site 12
T143
D
Y
S
R
Y
H
L
T
I
E
D
L
K
N
K
Site 13
S154
L
K
N
K
I
I
S
S
T
T
T
N
A
N
V
Site 14
Y179
A
D
D
F
R
L
K
Y
E
N
E
L
T
L
H
Site 15
T184
L
K
Y
E
N
E
L
T
L
H
Q
N
V
E
A
Site 16
T204
R
R
V
L
D
E
L
T
L
C
R
T
D
Q
E
Site 17
Y214
R
T
D
Q
E
L
Q
Y
E
S
L
S
E
E
M
Site 18
S216
D
Q
E
L
Q
Y
E
S
L
S
E
E
M
T
Y
Site 19
S218
E
L
Q
Y
E
S
L
S
E
E
M
T
Y
L
K
Site 20
T222
E
S
L
S
E
E
M
T
Y
L
K
K
N
H
E
Site 21
Y223
S
L
S
E
E
M
T
Y
L
K
K
N
H
E
E
Site 22
Y266
L
N
N
M
R
A
E
Y
E
A
L
A
E
Q
N
Site 23
S285
E
A
W
F
N
E
K
S
A
S
L
Q
Q
Q
I
Site 24
S287
W
F
N
E
K
S
A
S
L
Q
Q
Q
I
S
H
Site 25
S293
A
S
L
Q
Q
Q
I
S
H
D
S
G
A
A
T
Site 26
S296
Q
Q
Q
I
S
H
D
S
G
A
A
T
F
A
R
Site 27
T300
S
H
D
S
G
A
A
T
F
A
R
S
Q
L
T
Site 28
S304
G
A
A
T
F
A
R
S
Q
L
T
E
M
R
R
Site 29
T312
Q
L
T
E
M
R
R
T
L
Q
T
L
E
I
Q
Site 30
T315
E
M
R
R
T
L
Q
T
L
E
I
Q
L
Q
S
Site 31
S322
T
L
E
I
Q
L
Q
S
L
M
A
T
K
H
S
Site 32
T326
Q
L
Q
S
L
M
A
T
K
H
S
L
E
C
S
Site 33
S329
S
L
M
A
T
K
H
S
L
E
C
S
L
T
E
Site 34
S333
T
K
H
S
L
E
C
S
L
T
E
T
E
S
N
Site 35
T335
H
S
L
E
C
S
L
T
E
T
E
S
N
Y
C
Site 36
T337
L
E
C
S
L
T
E
T
E
S
N
Y
C
T
Q
Site 37
S339
C
S
L
T
E
T
E
S
N
Y
C
T
Q
L
A
Site 38
T343
E
T
E
S
N
Y
C
T
Q
L
A
Q
I
Q
A
Site 39
T366
L
H
Q
V
R
T
E
T
E
G
Q
K
L
E
Y
Site 40
Y390
L
E
K
E
I
E
T
Y
C
R
L
I
D
G
D
Site 41
S400
L
I
D
G
D
G
N
S
C
S
K
S
K
G
F
Site 42
S402
D
G
D
G
N
S
C
S
K
S
K
G
F
G
S
Site 43
S404
D
G
N
S
C
S
K
S
K
G
F
G
S
G
S
Site 44
S409
S
K
S
K
G
F
G
S
G
S
P
G
N
S
S
Site 45
S411
S
K
G
F
G
S
G
S
P
G
N
S
S
K
D
Site 46
S415
G
S
G
S
P
G
N
S
S
K
D
L
S
K
T
Site 47
S416
S
G
S
P
G
N
S
S
K
D
L
S
K
T
T
Site 48
S420
G
N
S
S
K
D
L
S
K
T
T
L
V
K
T
Site 49
T422
S
S
K
D
L
S
K
T
T
L
V
K
T
V
V
Site 50
T427
S
K
T
T
L
V
K
T
V
V
E
E
L
D
Q
Site 51
S440
D
Q
R
G
K
V
L
S
S
R
I
H
S
I
E
Site 52
S441
Q
R
G
K
V
L
S
S
R
I
H
S
I
E
E
Site 53
S445
V
L
S
S
R
I
H
S
I
E
E
K
T
S
K
Site 54
T458
S
K
M
T
N
G
K
T
E
Q
R
V
P
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation