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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIWIL3
Full Name:
Piwi-like protein 3
Alias:
Type:
Mass (Da):
101089
Number AA:
882
UniProt ID:
Q7Z3Z3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
P
G
R
A
R
T
R
A
R
G
R
A
R
Site 2
S18
G
R
A
R
R
R
E
S
Y
Q
Q
E
A
P
G
Site 3
Y19
R
A
R
R
R
E
S
Y
Q
Q
E
A
P
G
G
Site 4
S32
G
G
P
R
A
P
G
S
A
T
T
Q
E
P
P
Site 5
S43
Q
E
P
P
Q
L
Q
S
T
P
R
P
L
Q
E
Site 6
T44
E
P
P
Q
L
Q
S
T
P
R
P
L
Q
E
E
Site 7
S73
G
A
G
G
G
A
Q
S
Q
G
V
K
E
P
G
Site 8
S116
D
M
K
H
V
K
D
S
K
T
G
S
E
G
T
Site 9
T118
K
H
V
K
D
S
K
T
G
S
E
G
T
V
V
Site 10
S120
V
K
D
S
K
T
G
S
E
G
T
V
V
Q
L
Site 11
T123
S
K
T
G
S
E
G
T
V
V
Q
L
L
A
N
Site 12
Y143
S
R
P
Q
W
V
A
Y
K
Y
N
V
D
Y
K
Site 13
Y145
P
Q
W
V
A
Y
K
Y
N
V
D
Y
K
P
D
Site 14
Y149
A
Y
K
Y
N
V
D
Y
K
P
D
I
E
D
G
Site 15
S180
R
H
I
F
D
G
N
S
L
L
L
S
R
P
L
Site 16
S184
D
G
N
S
L
L
L
S
R
P
L
K
E
R
R
Site 17
S196
E
R
R
V
E
W
L
S
T
T
K
D
K
N
I
Site 18
T197
R
R
V
E
W
L
S
T
T
K
D
K
N
I
V
Site 19
T207
D
K
N
I
V
K
I
T
V
E
F
S
K
E
L
Site 20
T215
V
E
F
S
K
E
L
T
P
T
S
P
D
C
L
Site 21
T217
F
S
K
E
L
T
P
T
S
P
D
C
L
R
Y
Site 22
S218
S
K
E
L
T
P
T
S
P
D
C
L
R
Y
Y
Site 23
Y224
T
S
P
D
C
L
R
Y
Y
N
I
L
F
R
R
Site 24
Y225
S
P
D
C
L
R
Y
Y
N
I
L
F
R
R
T
Site 25
T232
Y
N
I
L
F
R
R
T
F
K
L
L
D
F
E
Site 26
Y245
F
E
Q
V
G
R
N
Y
Y
T
K
K
K
A
I
Site 27
Y246
E
Q
V
G
R
N
Y
Y
T
K
K
K
A
I
Q
Site 28
Y255
K
K
K
A
I
Q
L
Y
R
H
G
T
S
L
E
Site 29
T259
I
Q
L
Y
R
H
G
T
S
L
E
I
W
L
G
Site 30
T279
L
Q
Y
E
N
S
I
T
L
C
A
D
V
S
H
Site 31
T293
H
K
L
L
R
I
E
T
A
Y
D
F
I
K
R
Site 32
Y295
L
L
R
I
E
T
A
Y
D
F
I
K
R
T
S
Site 33
S302
Y
D
F
I
K
R
T
S
A
Q
A
Q
T
G
N
Site 34
T325
L
I
G
S
I
V
L
T
K
Y
N
N
K
T
Y
Site 35
Y327
G
S
I
V
L
T
K
Y
N
N
K
T
Y
R
V
Site 36
T331
L
T
K
Y
N
N
K
T
Y
R
V
D
D
I
D
Site 37
T346
W
K
Q
N
P
E
D
T
F
N
K
S
D
G
S
Site 38
S350
P
E
D
T
F
N
K
S
D
G
S
K
I
T
Y
Site 39
Y357
S
D
G
S
K
I
T
Y
I
D
Y
Y
R
Q
Q
Site 40
Y360
S
K
I
T
Y
I
D
Y
Y
R
Q
Q
H
K
E
Site 41
Y361
K
I
T
Y
I
D
Y
Y
R
Q
Q
H
K
E
I
Site 42
S379
K
K
Q
P
L
L
V
S
Q
G
R
W
K
K
G
Site 43
Y415
T
D
E
I
C
K
D
Y
S
I
V
K
E
L
A
Site 44
S416
D
E
I
C
K
D
Y
S
I
V
K
E
L
A
K
Site 45
S428
L
A
K
H
T
R
L
S
P
R
R
R
H
H
T
Site 46
T435
S
P
R
R
R
H
H
T
L
K
E
F
I
N
T
Site 47
T442
T
L
K
E
F
I
N
T
L
Q
D
N
K
K
V
Site 48
S466
K
F
D
T
N
F
L
S
V
P
G
R
V
L
K
Site 49
S488
R
R
M
V
K
A
N
S
Q
G
D
W
S
R
E
Site 50
Y514
L
H
S
W
L
I
L
Y
S
R
S
S
H
R
E
Site 51
S515
H
S
W
L
I
L
Y
S
R
S
S
H
R
E
A
Site 52
S517
W
L
I
L
Y
S
R
S
S
H
R
E
A
M
S
Site 53
S518
L
I
L
Y
S
R
S
S
H
R
E
A
M
S
L
Site 54
S524
S
S
H
R
E
A
M
S
L
K
G
H
L
Q
S
Site 55
S554
E
V
D
G
D
A
N
S
Y
I
D
T
L
R
K
Site 56
T558
D
A
N
S
Y
I
D
T
L
R
K
Y
T
R
P
Site 57
Y562
Y
I
D
T
L
R
K
Y
T
R
P
T
L
Q
M
Site 58
T563
I
D
T
L
R
K
Y
T
R
P
T
L
Q
M
G
Site 59
T566
L
R
K
Y
T
R
P
T
L
Q
M
G
M
S
C
Site 60
Y591
P
N
D
D
K
R
R
Y
D
S
I
K
R
Y
L
Site 61
S593
D
D
K
R
R
Y
D
S
I
K
R
Y
L
C
T
Site 62
Y597
R
Y
D
S
I
K
R
Y
L
C
T
K
C
P
I
Site 63
T600
S
I
K
R
Y
L
C
T
K
C
P
I
P
S
Q
Site 64
T613
S
Q
C
V
V
K
K
T
L
E
K
V
Q
A
R
Site 65
T643
G
A
L
W
K
V
E
T
D
V
Q
R
T
M
F
Site 66
S718
N
E
S
S
M
P
H
S
V
I
V
Y
R
D
G
Site 67
Y722
M
P
H
S
V
I
V
Y
R
D
G
V
G
D
G
Site 68
S743
D
H
E
A
K
K
M
S
T
Y
L
K
T
I
S
Site 69
Y745
E
A
K
K
M
S
T
Y
L
K
T
I
S
P
N
Site 70
T748
K
M
S
T
Y
L
K
T
I
S
P
N
N
F
T
Site 71
S750
S
T
Y
L
K
T
I
S
P
N
N
F
T
L
A
Site 72
T767
V
V
K
K
R
I
N
T
R
F
F
L
K
H
G
Site 73
S775
R
F
F
L
K
H
G
S
N
F
Q
N
P
P
P
Site 74
T784
F
Q
N
P
P
P
G
T
V
I
D
V
E
L
T
Site 75
T809
S
Q
S
V
Q
D
G
T
V
T
P
T
H
Y
N
Site 76
T811
S
V
Q
D
G
T
V
T
P
T
H
Y
N
V
I
Site 77
Y819
P
T
H
Y
N
V
I
Y
D
T
I
G
L
S
P
Site 78
T821
H
Y
N
V
I
Y
D
T
I
G
L
S
P
D
T
Site 79
S825
I
Y
D
T
I
G
L
S
P
D
T
V
Q
R
L
Site 80
T828
T
I
G
L
S
P
D
T
V
Q
R
L
T
Y
C
Site 81
Y861
H
Y
A
H
K
L
A
Y
L
V
G
Q
S
I
H
Site 82
S874
I
H
Q
E
P
N
R
S
L
S
T
R
L
F
Y
Site 83
S876
Q
E
P
N
R
S
L
S
T
R
L
F
Y
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation