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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIWIL4
Full Name:
Piwi-like protein 4
Alias:
HILI2; HIWI2; PIWI; Piwi-like 2; Piwi-like 4; PIWL4
Type:
Uncharacterized protein
Mass (Da):
96589
Number AA:
852
UniProt ID:
Q7Z3Z4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043186
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0034584
PhosphoSite+
KinaseNET
Biological Process:
GO:0043046
GO:0030154
GO:0031047
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
K
A
R
G
I
A
R
S
P
S
A
T
E
V
G
Site 2
S17
R
G
I
A
R
S
P
S
A
T
E
V
G
R
I
Site 3
T19
I
A
R
S
P
S
A
T
E
V
G
R
I
Q
A
Site 4
S27
E
V
G
R
I
Q
A
S
P
L
P
R
S
V
D
Site 5
S32
Q
A
S
P
L
P
R
S
V
D
L
S
N
N
E
Site 6
S36
L
P
R
S
V
D
L
S
N
N
E
A
S
S
S
Site 7
S41
D
L
S
N
N
E
A
S
S
S
N
G
F
L
G
Site 8
S42
L
S
N
N
E
A
S
S
S
N
G
F
L
G
T
Site 9
S43
S
N
N
E
A
S
S
S
N
G
F
L
G
T
S
Site 10
T49
S
S
N
G
F
L
G
T
S
R
I
S
T
N
D
Site 11
S50
S
N
G
F
L
G
T
S
R
I
S
T
N
D
K
Site 12
S53
F
L
G
T
S
R
I
S
T
N
D
K
Y
G
I
Site 13
T54
L
G
T
S
R
I
S
T
N
D
K
Y
G
I
S
Site 14
Y58
R
I
S
T
N
D
K
Y
G
I
S
S
G
D
A
Site 15
S61
T
N
D
K
Y
G
I
S
S
G
D
A
G
S
T
Site 16
S62
N
D
K
Y
G
I
S
S
G
D
A
G
S
T
F
Site 17
S67
I
S
S
G
D
A
G
S
T
F
M
E
R
G
V
Site 18
T68
S
S
G
D
A
G
S
T
F
M
E
R
G
V
K
Site 19
S84
K
Q
D
F
M
D
L
S
I
C
T
R
E
K
L
Site 20
Y145
R
L
R
I
A
L
L
Y
S
H
S
E
L
S
N
Site 21
S146
L
R
I
A
L
L
Y
S
H
S
E
L
S
N
K
Site 22
S148
I
A
L
L
Y
S
H
S
E
L
S
N
K
A
K
Site 23
T173
Q
K
L
E
E
K
V
T
E
L
S
S
E
T
Q
Site 24
T184
S
E
T
Q
R
G
E
T
I
K
M
T
I
T
L
Site 25
T190
E
T
I
K
M
T
I
T
L
K
R
E
L
P
S
Site 26
S197
T
L
K
R
E
L
P
S
S
S
P
V
C
I
Q
Site 27
S198
L
K
R
E
L
P
S
S
S
P
V
C
I
Q
V
Site 28
S199
K
R
E
L
P
S
S
S
P
V
C
I
Q
V
F
Site 29
S218
R
K
I
L
K
K
L
S
M
Y
Q
I
G
R
N
Site 30
Y220
I
L
K
K
L
S
M
Y
Q
I
G
R
N
F
Y
Site 31
Y227
Y
Q
I
G
R
N
F
Y
N
P
S
E
P
M
E
Site 32
S230
G
R
N
F
Y
N
P
S
E
P
M
E
I
P
Q
Site 33
Y252
G
F
A
I
S
V
S
Y
F
E
R
K
L
L
F
Site 34
S260
F
E
R
K
L
L
F
S
A
D
V
S
Y
K
V
Site 35
Y265
L
F
S
A
D
V
S
Y
K
V
L
R
N
E
T
Site 36
Y306
G
L
I
V
L
T
R
Y
N
N
R
T
Y
S
I
Site 37
T310
L
T
R
Y
N
N
R
T
Y
S
I
D
D
I
D
Site 38
Y311
T
R
Y
N
N
R
T
Y
S
I
D
D
I
D
W
Site 39
T323
I
D
W
S
V
K
P
T
H
T
F
Q
K
R
D
Site 40
T325
W
S
V
K
P
T
H
T
F
Q
K
R
D
G
T
Site 41
T332
T
F
Q
K
R
D
G
T
E
I
T
Y
V
D
Y
Site 42
Y336
R
D
G
T
E
I
T
Y
V
D
Y
Y
K
Q
Q
Site 43
Y339
T
E
I
T
Y
V
D
Y
Y
K
Q
Q
Y
D
I
Site 44
Y340
E
I
T
Y
V
D
Y
Y
K
Q
Q
Y
D
I
T
Site 45
T347
Y
K
Q
Q
Y
D
I
T
V
S
D
L
N
Q
P
Site 46
S349
Q
Q
Y
D
I
T
V
S
D
L
N
Q
P
M
L
Site 47
S368
K
K
K
R
N
D
N
S
E
A
Q
L
A
H
L
Site 48
T390
T
G
L
T
D
Q
A
T
S
D
F
Q
L
M
K
Site 49
S406
V
A
E
K
T
R
L
S
P
S
G
R
Q
Q
R
Site 50
S408
E
K
T
R
L
S
P
S
G
R
Q
Q
R
L
A
Site 51
T425
V
D
N
I
Q
R
N
T
N
A
R
F
E
L
E
Site 52
T433
N
A
R
F
E
L
E
T
W
G
L
H
F
G
S
Site 53
S440
T
W
G
L
H
F
G
S
Q
I
S
L
T
G
R
Site 54
T445
F
G
S
Q
I
S
L
T
G
R
I
V
P
S
E
Site 55
S451
L
T
G
R
I
V
P
S
E
K
I
L
M
Q
D
Site 56
S470
P
V
S
A
A
D
W
S
K
D
I
R
T
C
K
Site 57
Y497
L
C
S
D
R
T
E
Y
V
A
E
S
F
L
N
Site 58
S501
R
T
E
Y
V
A
E
S
F
L
N
C
L
R
R
Site 59
Y519
S
M
G
F
N
V
D
Y
P
K
I
I
K
V
Q
Site 60
T557
I
L
P
S
N
Q
K
T
Y
Y
D
S
I
K
K
Site 61
Y559
P
S
N
Q
K
T
Y
Y
D
S
I
K
K
Y
L
Site 62
S561
N
Q
K
T
Y
Y
D
S
I
K
K
Y
L
S
S
Site 63
Y565
Y
Y
D
S
I
K
K
Y
L
S
S
D
C
P
V
Site 64
S567
D
S
I
K
K
Y
L
S
S
D
C
P
V
P
S
Site 65
S568
S
I
K
K
Y
L
S
S
D
C
P
V
P
S
Q
Site 66
S574
S
S
D
C
P
V
P
S
Q
C
V
L
A
R
T
Site 67
Y678
T
G
A
L
N
K
W
Y
K
Y
N
H
D
L
P
Site 68
Y680
A
L
N
K
W
Y
K
Y
N
H
D
L
P
A
R
Site 69
T702
V
G
D
G
Q
L
K
T
L
I
E
Y
E
V
P
Site 70
S713
Y
E
V
P
Q
L
L
S
S
V
A
E
S
S
S
Site 71
S714
E
V
P
Q
L
L
S
S
V
A
E
S
S
S
N
Site 72
S718
L
L
S
S
V
A
E
S
S
S
N
T
S
S
R
Site 73
S719
L
S
S
V
A
E
S
S
S
N
T
S
S
R
L
Site 74
S720
S
S
V
A
E
S
S
S
N
T
S
S
R
L
S
Site 75
T722
V
A
E
S
S
S
N
T
S
S
R
L
S
V
I
Site 76
S723
A
E
S
S
S
N
T
S
S
R
L
S
V
I
V
Site 77
S724
E
S
S
S
N
T
S
S
R
L
S
V
I
V
V
Site 78
S727
S
N
T
S
S
R
L
S
V
I
V
V
R
K
K
Site 79
T746
F
F
T
E
M
N
R
T
V
Q
N
P
P
L
G
Site 80
T754
V
Q
N
P
P
L
G
T
V
V
D
S
E
A
T
Site 81
S758
P
L
G
T
V
V
D
S
E
A
T
R
N
E
W
Site 82
Y766
E
A
T
R
N
E
W
Y
D
F
Y
L
I
S
Q
Site 83
Y769
R
N
E
W
Y
D
F
Y
L
I
S
Q
V
A
C
Site 84
T779
S
Q
V
A
C
R
G
T
V
S
P
T
Y
Y
N
Site 85
Y784
R
G
T
V
S
P
T
Y
Y
N
V
I
Y
D
D
Site 86
Y785
G
T
V
S
P
T
Y
Y
N
V
I
Y
D
D
N
Site 87
Y789
P
T
Y
Y
N
V
I
Y
D
D
N
G
L
K
P
Site 88
S842
Q
S
I
H
K
E
P
S
L
E
L
A
N
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation