KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TMC6
Full Name:
Transmembrane channel-like protein 6
Alias:
epidermodysplasia verruciformis 1; EV1; EVER1; EVIN1; LAK-4; LAK-4P; transmembrane channel-like 6
Type:
Membrane protein, integral
Mass (Da):
90045
Number AA:
805
UniProt ID:
Q7Z403
International Prot ID:
IPI00179046
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
F
I
L
D
V
P
E
T
P
G
D
Q
G
Q
G
Site 2
S23
G
D
Q
G
Q
G
P
S
P
Y
D
E
S
E
V
Site 3
Y25
Q
G
Q
G
P
S
P
Y
D
E
S
E
V
H
D
Site 4
S28
G
P
S
P
Y
D
E
S
E
V
H
D
S
F
Q
Site 5
S33
D
E
S
E
V
H
D
S
F
Q
Q
L
I
Q
E
Site 6
S42
Q
Q
L
I
Q
E
Q
S
Q
C
T
A
Q
E
G
Site 7
T60
Q
Q
R
E
R
E
V
T
G
S
S
Q
Q
T
L
Site 8
S62
R
E
R
E
V
T
G
S
S
Q
Q
T
L
W
R
Site 9
S63
E
R
E
V
T
G
S
S
Q
Q
T
L
W
R
P
Site 10
T66
V
T
G
S
S
Q
Q
T
L
W
R
P
E
G
T
Site 11
S75
W
R
P
E
G
T
Q
S
T
A
T
L
R
I
L
Site 12
T78
E
G
T
Q
S
T
A
T
L
R
I
L
A
S
M
Site 13
S87
R
I
L
A
S
M
P
S
R
T
I
G
R
S
R
Site 14
T89
L
A
S
M
P
S
R
T
I
G
R
S
R
G
A
Site 15
S93
P
S
R
T
I
G
R
S
R
G
A
I
I
S
Q
Site 16
S99
R
S
R
G
A
I
I
S
Q
Y
Y
N
R
T
V
Site 17
Y101
R
G
A
I
I
S
Q
Y
Y
N
R
T
V
Q
L
Site 18
Y102
G
A
I
I
S
Q
Y
Y
N
R
T
V
Q
L
R
Site 19
S112
T
V
Q
L
R
C
R
S
S
R
P
L
L
G
N
Site 20
S113
V
Q
L
R
C
R
S
S
R
P
L
L
G
N
F
Site 21
S127
F
V
R
S
A
W
P
S
L
R
L
Y
D
L
E
Site 22
Y131
A
W
P
S
L
R
L
Y
D
L
E
L
D
P
T
Site 23
T138
Y
D
L
E
L
D
P
T
A
L
E
E
E
E
K
Site 24
S147
L
E
E
E
E
K
Q
S
L
L
V
K
E
L
Q
Site 25
S171
M
L
R
G
M
P
L
S
L
A
E
K
R
S
L
Site 26
S177
L
S
L
A
E
K
R
S
L
R
E
K
S
R
T
Site 27
S182
K
R
S
L
R
E
K
S
R
T
P
R
G
K
W
Site 28
T184
S
L
R
E
K
S
R
T
P
R
G
K
W
R
G
Site 29
S200
P
G
S
G
G
V
C
S
C
C
G
R
L
R
Y
Site 30
Y232
Q
A
L
M
P
W
R
Y
A
L
K
R
I
G
G
Site 31
S321
T
L
N
Q
P
C
G
S
P
L
D
G
S
Q
C
Site 32
S326
C
G
S
P
L
D
G
S
Q
C
T
P
R
V
G
Site 33
T329
P
L
D
G
S
Q
C
T
P
R
V
G
G
L
P
Site 34
S365
L
V
Y
S
M
A
H
S
F
G
E
S
Y
R
V
Site 35
S369
M
A
H
S
F
G
E
S
Y
R
V
G
S
T
S
Site 36
Y370
A
H
S
F
G
E
S
Y
R
V
G
S
T
S
G
Site 37
S374
G
E
S
Y
R
V
G
S
T
S
G
I
H
A
I
Site 38
Y389
T
V
F
C
S
W
D
Y
K
V
T
Q
K
R
A
Site 39
S397
K
V
T
Q
K
R
A
S
R
L
Q
Q
D
N
I
Site 40
S420
A
E
W
Q
L
R
H
S
P
R
S
V
C
G
R
Site 41
S423
Q
L
R
H
S
P
R
S
V
C
G
R
L
R
Q
Site 42
S462
F
S
E
F
M
I
Q
S
P
E
A
A
G
Q
E
Site 43
S575
E
L
V
W
R
I
I
S
E
K
K
L
K
R
R
Site 44
S646
P
R
R
P
W
L
A
S
H
M
S
T
V
F
L
Site 45
S679
V
W
Q
V
K
P
S
S
T
C
G
P
F
R
T
Site 46
T689
G
P
F
R
T
L
D
T
M
Y
E
A
G
R
V
Site 47
Y691
F
R
T
L
D
T
M
Y
E
A
G
R
V
W
V
Site 48
S709
E
A
A
G
P
R
V
S
W
L
P
W
V
H
R
Site 49
S758
C
L
L
K
E
Q
I
S
N
E
G
E
D
K
I
Site 50
Y775
I
N
K
L
H
S
I
Y
E
R
K
E
R
E
E
Site 51
T788
E
E
R
S
R
V
G
T
T
E
E
A
A
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation