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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYH14
Full Name:
Myosin-14
Alias:
DFNA4; FLJ13881; KIAA2034; MHC16; MYH17; Myosin heavy chain 14; Myosin heavy chain, nonmuscle IIc; Myosin heavy chain, non-muscle IIc; Myosin, heavy chain 14, non-muscle; NHMCII; NMHC II-C; Non-muscle myosin heavy chain IIc
Type:
Motor protein
Mass (Da):
228002
Number AA:
1995
UniProt ID:
Q7Z406
International Prot ID:
IPI00029818
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0008360
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
A
A
Q
P
F
L
F
T
P
R
G
P
S
A
G
Site 2
S35
L
F
T
P
R
G
P
S
A
G
G
G
P
G
S
Site 3
S42
S
A
G
G
G
P
G
S
G
T
S
P
Q
V
E
Site 4
T44
G
G
G
P
G
S
G
T
S
P
Q
V
E
W
T
Site 5
S45
G
G
P
G
S
G
T
S
P
Q
V
E
W
T
A
Site 6
T51
T
S
P
Q
V
E
W
T
A
R
R
L
V
W
V
Site 7
S60
R
R
L
V
W
V
P
S
E
L
H
G
F
E
A
Site 8
S85
A
E
V
E
L
A
E
S
G
R
R
L
R
L
P
Site 9
Y129
L
H
N
L
R
E
R
Y
Y
S
G
L
I
Y
T
Site 10
Y130
H
N
L
R
E
R
Y
Y
S
G
L
I
Y
T
Y
Site 11
S131
N
L
R
E
R
Y
Y
S
G
L
I
Y
T
Y
S
Site 12
Y137
Y
S
G
L
I
Y
T
Y
S
G
L
F
C
V
V
Site 13
Y154
P
Y
K
Q
L
P
I
Y
T
E
A
I
V
E
M
Site 14
Y162
T
E
A
I
V
E
M
Y
R
G
K
K
R
H
E
Site 15
Y175
H
E
V
P
P
H
V
Y
A
V
T
E
G
A
Y
Site 16
S193
L
Q
D
R
E
D
Q
S
I
L
C
T
G
E
S
Site 17
T197
E
D
Q
S
I
L
C
T
G
E
S
G
A
G
K
Site 18
S200
S
I
L
C
T
G
E
S
G
A
G
K
T
E
N
Site 19
T205
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Site 20
T208
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
Site 21
Y214
N
T
K
K
V
I
Q
Y
L
A
H
V
A
S
S
Site 22
S220
Q
Y
L
A
H
V
A
S
S
P
K
G
R
K
E
Site 23
S221
Y
L
A
H
V
A
S
S
P
K
G
R
K
E
P
Site 24
T253
E
A
F
G
N
A
K
T
V
K
N
D
N
S
S
Site 25
S259
K
T
V
K
N
D
N
S
S
R
F
G
K
F
I
Site 26
S260
T
V
K
N
D
N
S
S
R
F
G
K
F
I
R
Site 27
Y284
V
G
A
N
I
E
T
Y
L
L
E
K
S
R
A
Site 28
S289
E
T
Y
L
L
E
K
S
R
A
I
R
Q
A
K
Site 29
S325
D
L
L
L
E
P
C
S
H
Y
R
F
L
T
N
Site 30
T331
C
S
H
Y
R
F
L
T
N
G
P
S
S
S
P
Site 31
S335
R
F
L
T
N
G
P
S
S
S
P
G
Q
E
R
Site 32
S336
F
L
T
N
G
P
S
S
S
P
G
Q
E
R
E
Site 33
S337
L
T
N
G
P
S
S
S
P
G
Q
E
R
E
L
Site 34
T386
A
L
K
R
E
R
N
T
D
Q
A
T
M
P
D
Site 35
S412
G
L
G
V
T
D
F
S
R
A
L
L
T
P
R
Site 36
T417
D
F
S
R
A
L
L
T
P
R
I
K
V
G
R
Site 37
Y426
R
I
K
V
G
R
D
Y
V
Q
K
A
Q
T
K
Site 38
Y448
E
A
L
A
K
A
T
Y
E
R
L
F
R
W
L
Site 39
S466
L
N
R
A
L
D
R
S
P
R
Q
G
A
S
F
Site 40
S472
R
S
P
R
Q
G
A
S
F
L
G
I
L
D
I
Site 41
T498
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
L
Site 42
Y518
F
V
L
E
Q
E
E
Y
Q
R
E
G
I
P
W
Site 43
T526
Q
R
E
G
I
P
W
T
F
L
D
F
G
L
D
Site 44
S567
F
P
K
A
T
D
K
S
F
V
E
K
V
A
Q
Site 45
S595
L
R
D
Q
A
D
F
S
V
L
H
Y
A
G
K
Site 46
Y599
A
D
F
S
V
L
H
Y
A
G
K
V
D
Y
K
Site 47
Y605
H
Y
A
G
K
V
D
Y
K
A
N
E
W
L
M
Site 48
T630
A
A
L
L
H
Q
S
T
D
R
L
T
A
E
I
Site 49
T634
H
Q
S
T
D
R
L
T
A
E
I
W
K
D
V
Site 50
S652
V
G
L
E
Q
V
S
S
L
G
D
G
P
P
G
Site 51
T669
P
R
R
G
M
F
R
T
V
G
Q
L
Y
K
E
Site 52
Y674
F
R
T
V
G
Q
L
Y
K
E
S
L
S
R
L
Site 53
S677
V
G
Q
L
Y
K
E
S
L
S
R
L
M
A
T
Site 54
S679
Q
L
Y
K
E
S
L
S
R
L
M
A
T
L
S
Site 55
T684
S
L
S
R
L
M
A
T
L
S
N
T
N
P
S
Site 56
S686
S
R
L
M
A
T
L
S
N
T
N
P
S
F
V
Site 57
Y745
F
Q
E
F
R
Q
R
Y
E
I
L
T
P
N
A
Site 58
T749
R
Q
R
Y
E
I
L
T
P
N
A
I
P
K
G
Site 59
Y778
L
E
L
D
P
N
L
Y
R
V
G
Q
S
K
I
Site 60
T804
E
E
R
D
L
K
V
T
D
I
I
V
S
F
Q
Site 61
Y817
F
Q
A
A
A
R
G
Y
L
A
R
R
A
F
Q
Site 62
S831
Q
K
R
Q
Q
Q
Q
S
A
L
R
V
M
Q
R
Site 63
Y843
M
Q
R
N
C
A
A
Y
L
K
L
R
H
W
Q
Site 64
S888
V
Q
E
L
Q
Q
Q
S
A
R
E
V
G
E
L
Site 65
T926
L
C
A
E
A
E
E
T
R
G
R
L
A
A
R
Site 66
S955
V
G
E
E
E
E
C
S
R
Q
M
Q
T
E
K
Site 67
T993
L
Q
L
E
K
V
T
T
E
A
K
M
K
K
F
Site 68
S1012
L
L
L
E
D
Q
N
S
K
L
S
K
S
G
S
Site 69
S1015
E
D
Q
N
S
K
L
S
K
S
G
S
C
W
K
Site 70
S1017
Q
N
S
K
L
S
K
S
G
S
C
W
K
I
V
Site 71
S1019
S
K
L
S
K
S
G
S
C
W
K
I
V
W
P
Site 72
S1039
Q
L
R
R
R
R
R
S
R
A
S
I
S
Y
G
Site 73
S1042
R
R
R
R
S
R
A
S
I
S
Y
G
S
N
M
Site 74
S1044
R
R
S
R
A
S
I
S
Y
G
S
N
M
R
P
Site 75
Y1045
R
S
R
A
S
I
S
Y
G
S
N
M
R
P
Q
Site 76
S1047
R
A
S
I
S
Y
G
S
N
M
R
P
Q
S
Q
Site 77
S1053
G
S
N
M
R
P
Q
S
Q
T
W
R
D
R
L
Site 78
T1055
N
M
R
P
Q
S
Q
T
W
R
D
R
L
R
K
Site 79
S1081
K
R
R
L
D
G
E
S
S
E
L
Q
E
Q
M
Site 80
S1082
R
R
L
D
G
E
S
S
E
L
Q
E
Q
M
V
Site 81
S1129
A
R
A
Q
L
L
K
S
L
R
E
A
Q
A
A
Site 82
S1146
E
A
Q
E
D
L
E
S
E
R
V
A
R
T
K
Site 83
T1175
L
R
G
E
L
E
D
T
L
D
S
T
N
A
Q
Site 84
S1178
E
L
E
D
T
L
D
S
T
N
A
Q
Q
E
L
Site 85
T1179
L
E
D
T
L
D
S
T
N
A
Q
Q
E
L
R
Site 86
S1187
N
A
Q
Q
E
L
R
S
K
R
E
Q
E
V
T
Site 87
T1194
S
K
R
E
Q
E
V
T
E
L
K
K
T
L
E
Site 88
T1199
E
V
T
E
L
K
K
T
L
E
E
E
T
R
I
Site 89
T1204
K
K
T
L
E
E
E
T
R
I
H
E
A
A
V
Site 90
S1258
S
E
L
R
A
E
L
S
S
L
Q
T
A
R
Q
Site 91
S1259
E
L
R
A
E
L
S
S
L
Q
T
A
R
Q
E
Site 92
T1262
A
E
L
S
S
L
Q
T
A
R
Q
E
G
E
Q
Site 93
S1318
G
A
L
N
E
A
E
S
K
T
I
R
L
S
K
Site 94
T1320
L
N
E
A
E
S
K
T
I
R
L
S
K
E
L
Site 95
S1324
E
S
K
T
I
R
L
S
K
E
L
S
S
T
E
Site 96
S1328
I
R
L
S
K
E
L
S
S
T
E
A
Q
L
H
Site 97
S1329
R
L
S
K
E
L
S
S
T
E
A
Q
L
H
D
Site 98
T1330
L
S
K
E
L
S
S
T
E
A
Q
L
H
D
A
Site 99
S1391
Q
T
A
Q
A
Q
L
S
E
W
R
R
R
Q
E
Site 100
T1429
T
Q
R
L
A
E
K
T
E
T
V
D
R
L
E
Site 101
T1431
R
L
A
E
K
T
E
T
V
D
R
L
E
R
G
Site 102
T1450
Q
Q
E
L
D
D
A
T
M
D
L
E
Q
Q
R
Site 103
T1462
Q
Q
R
Q
L
V
S
T
L
E
K
K
Q
R
K
Site 104
S1504
E
R
E
A
R
A
L
S
L
T
R
A
L
E
E
Site 105
T1506
E
A
R
A
L
S
L
T
R
A
L
E
E
E
Q
Site 106
S1535
A
E
L
E
A
L
L
S
S
K
D
D
V
G
K
Site 107
S1543
S
K
D
D
V
G
K
S
V
H
E
L
E
R
A
Site 108
T1573
T
E
L
E
D
E
L
T
A
A
E
D
A
K
L
Site 109
T1585
A
K
L
R
L
E
V
T
V
Q
A
L
K
T
Q
Site 110
T1591
V
T
V
Q
A
L
K
T
Q
H
E
R
D
L
Q
Site 111
T1630
D
E
E
R
K
Q
R
T
L
A
V
A
A
R
K
Site 112
T1681
L
W
R
E
V
E
E
T
R
T
S
R
E
E
I
Site 113
T1683
R
E
V
E
E
T
R
T
S
R
E
E
I
F
S
Site 114
S1684
E
V
E
E
T
R
T
S
R
E
E
I
F
S
Q
Site 115
S1690
T
S
R
E
E
I
F
S
Q
N
R
E
S
E
K
Site 116
S1695
I
F
S
Q
N
R
E
S
E
K
R
L
K
G
L
Site 117
S1716
L
Q
E
E
L
A
A
S
D
R
A
R
R
Q
A
Site 118
S1740
E
V
A
N
G
N
L
S
K
A
A
I
L
E
E
Site 119
S1767
E
E
L
E
E
E
Q
S
N
S
E
L
L
N
D
Site 120
S1769
L
E
E
E
Q
S
N
S
E
L
L
N
D
R
Y
Site 121
Y1776
S
E
L
L
N
D
R
Y
R
K
L
L
L
Q
V
Site 122
S1791
E
S
L
T
T
E
L
S
A
E
R
S
F
S
A
Site 123
S1795
T
E
L
S
A
E
R
S
F
S
A
K
A
E
S
Site 124
S1797
L
S
A
E
R
S
F
S
A
K
A
E
S
G
R
Site 125
S1802
S
F
S
A
K
A
E
S
G
R
Q
Q
L
E
R
Site 126
S1857
E
T
R
E
R
I
L
S
G
K
L
V
R
R
A
Site 127
S1911
E
E
A
E
E
E
A
S
R
A
Q
A
G
R
R
Site 128
T1928
Q
R
E
L
E
D
V
T
E
S
A
E
S
M
N
Site 129
S1933
D
V
T
E
S
A
E
S
M
N
R
E
V
T
T
Site 130
T1939
E
S
M
N
R
E
V
T
T
L
R
N
R
L
R
Site 131
T1940
S
M
N
R
E
V
T
T
L
R
N
R
L
R
R
Site 132
T1951
R
L
R
R
G
P
L
T
F
T
T
R
T
V
R
Site 133
T1953
R
R
G
P
L
T
F
T
T
R
T
V
R
Q
V
Site 134
T1956
P
L
T
F
T
T
R
T
V
R
Q
V
F
R
L
Site 135
S1969
R
L
E
E
G
V
A
S
D
E
E
A
E
E
A
Site 136
S1980
A
E
E
A
Q
P
G
S
G
P
S
P
E
P
E
Site 137
S1983
A
Q
P
G
S
G
P
S
P
E
P
E
G
S
P
Site 138
S1989
P
S
P
E
P
E
G
S
P
P
A
H
P
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation