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Updated November 2019
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Protein Info
Short Name:
PKD1L2
Full Name:
Polycystic kidney disease protein 1-like 2
Alias:
PC1-like 2 protein;Polycystin-1L2
Type:
Mass (Da):
272545
Number AA:
2459
UniProt ID:
Q7Z442
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
A
V
G
L
V
L
L
Site 2
T18
L
A
L
R
L
R
A
T
T
V
K
P
E
E
G
Site 3
T19
A
L
R
L
R
A
T
T
V
K
P
E
E
G
S
Site 4
S26
T
V
K
P
E
E
G
S
F
C
S
N
S
Q
V
Site 5
S29
P
E
E
G
S
F
C
S
N
S
Q
V
A
F
R
Site 6
S31
E
G
S
F
C
S
N
S
Q
V
A
F
R
D
A
Site 7
T48
E
F
V
P
L
G
R
T
F
R
D
A
Q
S
W
Site 8
S54
R
T
F
R
D
A
Q
S
W
C
E
G
Q
G
G
Site 9
T98
W
N
L
A
R
N
G
T
T
E
G
P
G
T
W
Site 10
T104
G
T
T
E
G
P
G
T
W
L
D
T
S
N
V
Site 11
T108
G
P
G
T
W
L
D
T
S
N
V
T
Y
S
N
Site 12
Y113
L
D
T
S
N
V
T
Y
S
N
W
H
G
G
Q
Site 13
T127
Q
A
A
A
A
P
D
T
C
G
H
I
G
R
G
Site 14
S136
G
H
I
G
R
G
P
S
S
E
W
V
T
S
D
Site 15
S137
H
I
G
R
G
P
S
S
E
W
V
T
S
D
C
Site 16
T141
G
P
S
S
E
W
V
T
S
D
C
A
Q
T
F
Site 17
S142
P
S
S
E
W
V
T
S
D
C
A
Q
T
F
A
Site 18
Y184
I
Q
V
Q
D
A
V
Y
G
R
Q
N
P
H
F
Site 19
S200
T
Q
D
A
G
R
P
S
D
L
E
Q
G
C
S
Site 20
S207
S
D
L
E
Q
G
C
S
W
A
N
V
K
E
E
Site 21
Y233
Q
V
A
A
D
E
T
Y
F
G
N
L
C
P
T
Site 22
Y249
G
S
Y
L
W
V
Q
Y
Q
C
R
E
A
L
Q
Site 23
T295
I
S
T
G
D
S
H
T
F
D
P
Y
N
P
P
Site 24
Y299
D
S
H
T
F
D
P
Y
N
P
P
S
V
S
S
Site 25
S303
F
D
P
Y
N
P
P
S
V
S
S
N
V
T
H
Site 26
S305
P
Y
N
P
P
S
V
S
S
N
V
T
H
Q
F
Site 27
T309
P
S
V
S
S
N
V
T
H
Q
F
T
S
P
G
Site 28
S314
N
V
T
H
Q
F
T
S
P
G
E
F
T
V
F
Site 29
T332
T
T
S
E
W
H
V
T
A
Q
R
Q
V
T
V
Site 30
T338
V
T
A
Q
R
Q
V
T
V
R
D
K
M
E
T
Site 31
T345
T
V
R
D
K
M
E
T
L
S
V
T
A
C
S
Site 32
S347
R
D
K
M
E
T
L
S
V
T
A
C
S
G
L
Site 33
T349
K
M
E
T
L
S
V
T
A
C
S
G
L
S
Q
Site 34
T399
I
T
L
A
E
S
T
T
Q
K
G
S
L
P
Y
Site 35
S403
E
S
T
T
Q
K
G
S
L
P
Y
N
L
I
L
Site 36
T414
N
L
I
L
D
R
E
T
Q
K
L
M
G
P
G
Site 37
T430
H
R
L
E
I
Q
A
T
G
N
T
T
T
S
T
Site 38
T437
T
G
N
T
T
T
S
T
I
S
R
N
I
T
V
Site 39
S459
G
L
Q
A
S
W
A
S
D
H
L
E
L
G
Q
Site 40
T478
T
I
S
L
A
Q
G
T
P
E
E
L
T
F
E
Site 41
T483
Q
G
T
P
E
E
L
T
F
E
V
A
G
L
N
Site 42
T492
E
V
A
G
L
N
A
T
F
S
H
E
Q
V
S
Site 43
S494
A
G
L
N
A
T
F
S
H
E
Q
V
S
F
G
Site 44
S499
T
F
S
H
E
Q
V
S
F
G
E
P
F
G
I
Site 45
T540
E
I
G
N
I
T
I
T
A
P
S
G
L
Q
E
Site 46
S557
G
M
N
A
E
G
K
S
K
D
K
G
D
M
E
Site 47
Y566
D
K
G
D
M
E
V
Y
I
Q
P
G
P
Y
V
Site 48
T578
P
Y
V
D
P
F
T
T
V
T
L
G
W
P
D
Site 49
T614
V
E
R
Q
L
L
R
T
D
Q
R
E
L
V
V
Site 50
S624
R
E
L
V
V
P
A
S
C
L
P
P
P
D
S
Site 51
Y654
N
R
A
E
Q
C
L
Y
V
S
A
P
W
E
L
Site 52
S666
W
E
L
R
P
R
V
S
C
E
R
N
C
R
P
Site 53
S677
N
C
R
P
V
N
A
S
K
D
I
L
L
R
V
Site 54
T685
K
D
I
L
L
R
V
T
M
G
E
D
S
P
V
Site 55
S690
R
V
T
M
G
E
D
S
P
V
A
M
F
S
W
Site 56
Y698
P
V
A
M
F
S
W
Y
L
D
N
T
P
T
E
Site 57
T702
F
S
W
Y
L
D
N
T
P
T
E
Q
A
E
P
Site 58
S723
L
R
G
F
W
P
R
S
L
T
L
L
Q
S
N
Site 59
T725
G
F
W
P
R
S
L
T
L
L
Q
S
N
T
S
Site 60
S739
S
T
L
L
L
N
S
S
F
L
Q
S
R
G
E
Site 61
S743
L
N
S
S
F
L
Q
S
R
G
E
V
I
R
I
Site 62
T753
E
V
I
R
I
R
A
T
A
L
T
R
H
A
Y
Site 63
T756
R
I
R
A
T
A
L
T
R
H
A
Y
G
E
D
Site 64
Y760
T
A
L
T
R
H
A
Y
G
E
D
T
Y
V
I
Site 65
T764
R
H
A
Y
G
E
D
T
Y
V
I
S
T
V
P
Site 66
Y765
H
A
Y
G
E
D
T
Y
V
I
S
T
V
P
P
Site 67
T769
E
D
T
Y
V
I
S
T
V
P
P
R
E
V
P
Site 68
T779
P
R
E
V
P
A
C
T
I
A
P
E
E
G
T
Site 69
S826
G
P
E
P
A
L
P
S
V
Y
L
P
L
G
E
Site 70
Y828
E
P
A
L
P
S
V
Y
L
P
L
G
E
E
N
Site 71
T884
A
V
S
E
K
I
P
T
A
L
Q
G
E
G
G
Site 72
S912
M
L
N
Q
E
H
E
S
Q
G
S
G
Q
S
L
Site 73
S915
Q
E
H
E
S
Q
G
S
G
Q
S
L
S
I
D
Site 74
S918
E
S
Q
G
S
G
Q
S
L
S
I
D
V
R
Q
Site 75
S920
Q
G
S
G
Q
S
L
S
I
D
V
R
Q
K
V
Site 76
T940
G
S
L
S
A
V
T
T
G
L
E
D
V
Q
R
Site 77
T959
A
E
V
L
R
E
V
T
C
R
S
K
E
L
T
Site 78
S962
L
R
E
V
T
C
R
S
K
E
L
T
P
S
A
Site 79
T966
T
C
R
S
K
E
L
T
P
S
A
Q
W
E
A
Site 80
S968
R
S
K
E
L
T
P
S
A
Q
W
E
A
S
L
Site 81
S974
P
S
A
Q
W
E
A
S
L
A
L
Q
H
A
S
Site 82
T986
H
A
S
E
A
L
L
T
V
S
A
K
A
R
P
Site 83
S988
S
E
A
L
L
T
V
S
A
K
A
R
P
E
D
Site 84
T1002
D
Q
R
R
Q
A
A
T
R
D
L
F
Q
A
V
Site 85
S1016
V
G
S
V
L
E
A
S
L
S
N
R
P
E
E
Site 86
S1018
S
V
L
E
A
S
L
S
N
R
P
E
E
P
A
Site 87
S1030
E
P
A
E
A
S
S
S
Q
I
A
T
V
L
R
Site 88
Y1070
A
T
P
S
I
S
V
Y
T
N
R
I
Q
P
W
Site 89
T1071
T
P
S
I
S
V
Y
T
N
R
I
Q
P
W
S
Site 90
S1078
T
N
R
I
Q
P
W
S
W
Q
G
S
S
L
R
Site 91
S1082
Q
P
W
S
W
Q
G
S
S
L
R
P
D
A
A
Site 92
S1083
P
W
S
W
Q
G
S
S
L
R
P
D
A
A
D
Site 93
S1104
P
A
A
S
S
L
S
S
L
E
G
G
Q
E
P
Site 94
S1118
P
V
D
I
K
I
M
S
F
P
K
S
P
F
P
Site 95
S1122
K
I
M
S
F
P
K
S
P
F
P
A
R
S
H
Site 96
S1128
K
S
P
F
P
A
R
S
H
F
D
V
S
G
T
Site 97
S1133
A
R
S
H
F
D
V
S
G
T
V
G
G
L
R
Site 98
S1166
E
I
L
L
P
R
H
S
Q
R
H
S
Q
P
T
Site 99
S1170
P
R
H
S
Q
R
H
S
Q
P
T
V
L
N
L
Site 100
T1173
S
Q
R
H
S
Q
P
T
V
L
N
L
T
S
P
Site 101
T1193
N
V
T
S
G
E
A
T
L
G
I
Q
L
H
W
Site 102
Y1214
T
L
S
L
G
Y
G
Y
H
P
N
K
S
S
Y
Site 103
T1238
V
A
P
D
E
L
P
T
W
I
L
S
P
Q
D
Site 104
S1242
E
L
P
T
W
I
L
S
P
Q
D
L
R
F
G
Site 105
Y1254
R
F
G
E
G
V
Y
Y
L
T
V
V
P
E
S
Site 106
T1303
G
C
Q
V
G
P
R
T
S
P
Y
Q
T
H
C
Site 107
S1304
C
Q
V
G
P
R
T
S
P
Y
Q
T
H
C
L
Site 108
Y1306
V
G
P
R
T
S
P
Y
Q
T
H
C
L
C
N
Site 109
Y1390
D
N
D
P
F
A
Q
Y
H
Y
L
V
T
V
Y
Site 110
Y1392
D
P
F
A
Q
Y
H
Y
L
V
T
V
Y
T
G
Site 111
T1398
H
Y
L
V
T
V
Y
T
G
H
R
R
G
A
A
Site 112
T1406
G
H
R
R
G
A
A
T
S
S
K
V
T
V
T
Site 113
S1407
H
R
R
G
A
A
T
S
S
K
V
T
V
T
L
Site 114
S1408
R
R
G
A
A
T
S
S
K
V
T
V
T
L
Y
Site 115
Y1415
S
K
V
T
V
T
L
Y
G
L
D
G
E
R
E
Site 116
T1431
H
H
L
A
D
P
D
T
P
V
F
E
R
G
A
Site 117
S1455
F
P
L
G
E
L
R
S
L
R
L
W
H
D
N
Site 118
S1468
D
N
S
G
D
R
P
S
W
Y
V
S
R
V
L
Site 119
Y1470
S
G
D
R
P
S
W
Y
V
S
R
V
L
V
Y
Site 120
S1472
D
R
P
S
W
Y
V
S
R
V
L
V
Y
D
L
Site 121
T1525
S
H
L
F
F
M
K
T
S
A
G
F
Q
D
G
Site 122
S1546
F
S
R
C
A
R
S
S
F
T
R
V
Q
R
V
Site 123
S1635
T
G
K
W
D
R
G
S
P
N
L
T
P
S
P
Site 124
T1639
D
R
G
S
P
N
L
T
P
S
P
Q
P
M
E
Site 125
S1641
G
S
P
N
L
T
P
S
P
Q
P
M
E
D
G
Site 126
T1651
P
M
E
D
G
L
L
T
P
E
A
V
T
K
D
Site 127
T1656
L
L
T
P
E
A
V
T
K
D
V
S
R
I
V
Site 128
S1674
F
K
A
L
K
V
P
S
P
A
L
G
W
D
S
Site 129
S1681
S
P
A
L
G
W
D
S
V
N
L
M
D
I
N
Site 130
Y1699
A
L
V
E
D
V
I
Y
P
Q
N
T
S
G
Q
Site 131
T1720
K
K
R
E
D
P
V
T
L
T
L
G
S
S
E
Site 132
T1722
R
E
D
P
V
T
L
T
L
G
S
S
E
M
K
Site 133
S1732
S
S
E
M
K
E
K
S
Q
C
P
K
P
K
A
Site 134
S1742
P
K
P
K
A
A
R
S
G
P
W
K
D
S
A
Site 135
Y1750
G
P
W
K
D
S
A
Y
R
Q
C
L
Y
L
Q
Site 136
Y1755
S
A
Y
R
Q
C
L
Y
L
Q
L
E
H
V
E
Site 137
S1774
L
V
G
P
R
G
F
S
Q
P
H
S
H
A
Q
Site 138
S1778
R
G
F
S
Q
P
H
S
H
A
Q
A
L
R
Q
Site 139
T1788
Q
A
L
R
Q
L
Q
T
L
K
G
G
L
G
V
Site 140
T1799
G
L
G
V
Q
P
G
T
W
A
P
A
H
A
S
Site 141
Y1847
T
M
L
Y
G
L
H
Y
G
R
A
S
S
L
R
Site 142
S1851
G
L
H
Y
G
R
A
S
S
L
R
W
L
I
S
Site 143
S1852
L
H
Y
G
R
A
S
S
L
R
W
L
I
S
M
Site 144
T1895
R
V
D
D
E
E
D
T
V
A
P
L
P
G
H
Site 145
Y1909
H
L
L
G
P
D
P
Y
A
L
F
R
A
R
R
Site 146
S1918
L
F
R
A
R
R
N
S
S
R
D
V
Y
Q
P
Site 147
S1919
F
R
A
R
R
N
S
S
R
D
V
Y
Q
P
P
Site 148
Y1923
R
N
S
S
R
D
V
Y
Q
P
P
L
T
A
A
Site 149
T1928
D
V
Y
Q
P
P
L
T
A
A
I
E
K
M
K
Site 150
T1936
A
A
I
E
K
M
K
T
T
H
L
K
E
Q
K
Site 151
Y1966
W
M
L
L
L
V
A
Y
G
Q
R
D
P
S
A
Site 152
S1972
A
Y
G
Q
R
D
P
S
A
Y
H
L
N
R
H
Site 153
Y1974
G
Q
R
D
P
S
A
Y
H
L
N
R
H
L
Q
Site 154
S1983
L
N
R
H
L
Q
H
S
F
T
R
G
F
S
G
Site 155
T1985
R
H
L
Q
H
S
F
T
R
G
F
S
G
V
L
Site 156
S1989
H
S
F
T
R
G
F
S
G
V
L
G
F
R
E
Site 157
T2018
G
H
P
P
G
F
I
T
D
G
N
S
K
L
V
Site 158
S2022
G
F
I
T
D
G
N
S
K
L
V
G
S
A
Q
Site 159
S2038
R
Q
V
R
V
Q
E
S
S
C
P
L
A
Q
Q
Site 160
S2039
Q
V
R
V
Q
E
S
S
C
P
L
A
Q
Q
P
Site 161
Y2057
L
N
G
C
R
A
P
Y
S
L
D
A
E
D
M
Site 162
S2058
N
G
C
R
A
P
Y
S
L
D
A
E
D
M
A
Site 163
Y2067
D
A
E
D
M
A
D
Y
G
E
G
W
N
A
T
Site 164
Y2081
T
T
L
S
E
W
Q
Y
Q
S
Q
D
Q
R
Q
Site 165
Y2090
S
Q
D
Q
R
Q
G
Y
P
I
W
G
K
L
T
Site 166
Y2121
K
H
V
K
I
L
R
Y
L
F
D
N
T
W
L
Site 167
T2126
L
R
Y
L
F
D
N
T
W
L
D
A
L
T
R
Site 168
Y2176
A
L
Q
S
L
R
L
Y
P
F
T
D
G
W
H
Site 169
S2261
N
H
R
E
E
G
I
S
F
S
E
T
A
A
A
Site 170
Y2340
F
G
W
K
L
R
S
Y
K
T
L
F
D
A
A
Site 171
T2342
W
K
L
R
S
Y
K
T
L
F
D
A
A
E
T
Site 172
Y2366
N
Y
E
E
V
L
D
Y
S
P
V
L
G
S
F
Site 173
Y2404
A
F
S
E
E
Q
K
Y
Y
Q
L
S
E
E
G
Site 174
Y2405
F
S
E
E
Q
K
Y
Y
Q
L
S
E
E
G
E
Site 175
S2429
L
S
F
L
G
I
K
S
K
R
E
E
P
G
S
Site 176
S2436
S
K
R
E
E
P
G
S
S
R
E
Q
P
G
S
Site 177
S2437
K
R
E
E
P
G
S
S
R
E
Q
P
G
S
L
Site 178
S2443
S
S
R
E
Q
P
G
S
L
S
Q
T
R
H
S
Site 179
S2445
R
E
Q
P
G
S
L
S
Q
T
R
H
S
R
P
Site 180
T2447
Q
P
G
S
L
S
Q
T
R
H
S
R
P
A
Q
Site 181
S2450
S
L
S
Q
T
R
H
S
R
P
A
Q
A
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation