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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKD1L3
Full Name:
Polycystic kidney disease protein 1-like 3
Alias:
PC1-like 3 protein;Polycystin-1L3
Type:
Mass (Da):
195894
Number AA:
1732
UniProt ID:
Q7Z443
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
R
T
S
I
I
L
G
S
E
L
N
S
P
A
P
Site 2
S25
I
L
G
S
E
L
N
S
P
A
P
H
G
Q
N
Site 3
Y50
S
F
E
E
A
Q
H
Y
C
H
V
Q
R
G
F
Site 4
Y73
V
Q
D
L
I
R
D
Y
L
E
E
G
K
K
W
Site 5
Y97
K
K
H
Q
D
N
K
Y
P
A
D
V
A
A
N
Site 6
S111
N
G
P
P
K
P
L
S
C
T
Y
L
S
R
N
Site 7
Y114
P
K
P
L
S
C
T
Y
L
S
R
N
F
I
R
Site 8
S123
S
R
N
F
I
R
I
S
S
K
G
D
K
C
L
Site 9
S124
R
N
F
I
R
I
S
S
K
G
D
K
C
L
L
Site 10
Y134
D
K
C
L
L
K
Y
Y
F
I
C
Q
T
G
D
Site 11
Y149
F
L
D
G
D
A
H
Y
E
R
N
G
N
N
S
Site 12
Y159
N
G
N
N
S
H
L
Y
Q
R
H
K
K
T
K
Site 13
T165
L
Y
Q
R
H
K
K
T
K
R
G
V
A
I
A
Site 14
T185
P
G
P
G
H
L
P
T
T
C
H
Y
P
L
P
Site 15
T186
G
P
G
H
L
P
T
T
C
H
Y
P
L
P
A
Site 16
Y189
H
L
P
T
T
C
H
Y
P
L
P
A
H
L
S
Site 17
T198
L
P
A
H
L
S
K
T
L
C
H
P
I
S
Q
Site 18
S219
S
I
T
S
Q
V
T
S
A
A
S
E
P
S
S
Site 19
S222
S
Q
V
T
S
A
A
S
E
P
S
S
Q
P
L
Site 20
S225
T
S
A
A
S
E
P
S
S
Q
P
L
P
V
I
Site 21
S226
S
A
A
S
E
P
S
S
Q
P
L
P
V
I
T
Site 22
S240
T
Q
L
T
M
P
V
S
V
T
H
A
G
Q
S
Site 23
S247
S
V
T
H
A
G
Q
S
L
A
E
T
T
S
S
Site 24
T251
A
G
Q
S
L
A
E
T
T
S
S
P
K
E
E
Site 25
S253
Q
S
L
A
E
T
T
S
S
P
K
E
E
G
H
Site 26
S254
S
L
A
E
T
T
S
S
P
K
E
E
G
H
P
Site 27
T263
K
E
E
G
H
P
N
T
F
T
S
Y
L
Q
V
Site 28
Y267
H
P
N
T
F
T
S
Y
L
Q
V
S
L
Q
K
Site 29
S271
F
T
S
Y
L
Q
V
S
L
Q
K
A
S
G
Q
Site 30
T314
L
Q
K
L
T
A
L
T
P
R
F
S
K
P
A
Site 31
S318
T
A
L
T
P
R
F
S
K
P
A
Q
V
N
L
Site 32
S346
I
P
F
Q
N
N
N
S
L
G
F
K
V
P
P
Site 33
S360
P
T
V
C
P
F
H
S
L
N
N
V
T
K
A
Site 34
S371
V
T
K
A
G
E
G
S
W
L
E
S
K
R
H
Site 35
S375
G
E
G
S
W
L
E
S
K
R
H
T
E
P
V
Site 36
T379
W
L
E
S
K
R
H
T
E
P
V
E
D
I
L
Site 37
S406
A
F
L
E
Q
N
Q
S
P
E
S
S
V
T
L
Site 38
S409
E
Q
N
Q
S
P
E
S
S
V
T
L
T
S
A
Site 39
S410
Q
N
Q
S
P
E
S
S
V
T
L
T
S
A
N
Site 40
T412
Q
S
P
E
S
S
V
T
L
T
S
A
N
A
T
Site 41
T419
T
L
T
S
A
N
A
T
L
L
L
S
R
Q
N
Site 42
S428
L
L
S
R
Q
N
I
S
T
L
P
L
S
S
Y
Site 43
T429
L
S
R
Q
N
I
S
T
L
P
L
S
S
Y
T
Site 44
S433
N
I
S
T
L
P
L
S
S
Y
T
L
G
H
P
Site 45
Y435
S
T
L
P
L
S
S
Y
T
L
G
H
P
A
P
Site 46
S449
P
V
R
L
G
F
P
S
A
L
A
L
K
E
L
Site 47
S517
I
M
L
W
R
N
V
S
L
E
T
H
P
T
S
Site 48
T523
V
S
L
E
T
H
P
T
S
L
N
M
S
T
H
Site 49
S524
S
L
E
T
H
P
T
S
L
N
M
S
T
H
Q
Site 50
S528
H
P
T
S
L
N
M
S
T
H
Q
L
T
I
T
Site 51
Y565
T
L
Y
L
G
F
Q
Y
Q
P
N
C
T
H
F
Site 52
Y590
V
W
Q
K
D
E
E
Y
T
W
V
L
N
P
E
Site 53
S613
Y
Y
I
T
A
V
L
S
E
R
Q
E
G
A
Q
Site 54
T622
R
Q
E
G
A
Q
Q
T
P
S
L
V
S
V
I
Site 55
T661
P
Q
S
T
I
L
R
T
Q
C
L
C
N
H
L
Site 56
Y711
L
A
S
L
L
G
F
Y
V
I
T
V
V
W
A
Site 57
T714
L
L
G
F
Y
V
I
T
V
V
W
A
R
K
K
Site 58
T751
H
Y
L
I
Q
V
Y
T
G
Y
R
R
S
A
A
Site 59
Y753
L
I
Q
V
Y
T
G
Y
R
R
S
A
A
T
T
Site 60
S756
V
Y
T
G
Y
R
R
S
A
A
T
T
A
K
V
Site 61
T759
G
Y
R
R
S
A
A
T
T
A
K
V
V
I
T
Site 62
Y768
A
K
V
V
I
T
L
Y
G
S
E
G
R
S
E
Site 63
S770
V
V
I
T
L
Y
G
S
E
G
R
S
E
P
H
Site 64
S774
L
Y
G
S
E
G
R
S
E
P
H
H
L
C
D
Site 65
T785
H
L
C
D
P
Q
K
T
V
F
E
R
G
G
L
Site 66
S808
T
S
L
G
N
L
H
S
L
R
L
W
H
D
N
Site 67
S819
W
H
D
N
S
G
V
S
P
S
W
Y
V
S
Q
Site 68
S821
D
N
S
G
V
S
P
S
W
Y
V
S
Q
V
I
Site 69
S863
D
R
V
F
I
P
V
S
K
R
E
L
F
S
F
Site 70
S869
V
S
K
R
E
L
F
S
F
R
H
L
F
S
S
Site 71
T1008
V
V
E
E
L
K
E
T
V
R
F
L
L
R
R
Site 72
T1017
R
F
L
L
R
R
N
T
Y
L
L
S
K
C
E
Site 73
Y1018
F
L
L
R
R
N
T
Y
L
L
S
K
C
E
Q
Site 74
S1021
R
R
N
T
Y
L
L
S
K
C
E
Q
P
P
W
Site 75
T1034
P
W
S
S
W
D
I
T
K
L
V
K
L
L
S
Site 76
S1045
K
L
L
S
S
L
V
S
S
H
L
E
G
Q
G
Site 77
S1085
R
V
L
Q
R
L
K
S
H
L
G
T
L
G
L
Site 78
T1089
R
L
K
S
H
L
G
T
L
G
L
T
Q
G
H
Site 79
T1093
H
L
G
T
L
G
L
T
Q
G
H
Q
S
C
D
Site 80
S1106
C
D
F
L
D
A
A
S
Q
L
Q
K
L
Q
E
Site 81
T1117
K
L
Q
E
L
L
E
T
H
I
L
P
T
E
Q
Site 82
S1127
L
P
T
E
Q
E
P
S
R
E
V
T
S
F
A
Site 83
T1131
Q
E
P
S
R
E
V
T
S
F
A
I
L
S
S
Site 84
S1132
E
P
S
R
E
V
T
S
F
A
I
L
S
S
E
Site 85
S1146
E
E
G
K
K
P
I
S
N
G
L
S
K
W
L
Site 86
S1150
K
P
I
S
N
G
L
S
K
W
L
T
S
V
C
Site 87
S1180
A
L
Y
S
L
E
L
S
K
D
Q
A
T
S
W
Site 88
T1185
E
L
S
K
D
Q
A
T
S
W
M
I
S
I
I
Site 89
S1219
F
L
Y
S
L
M
M
S
R
M
P
R
L
N
K
Site 90
S1244
A
L
L
A
K
C
S
S
S
V
P
G
S
R
D
Site 91
S1245
L
L
A
K
C
S
S
S
V
P
G
S
R
D
K
Site 92
S1249
C
S
S
S
V
P
G
S
R
D
K
N
N
P
V
Site 93
Y1257
R
D
K
N
N
P
V
Y
V
A
P
A
I
N
S
Site 94
S1264
Y
V
A
P
A
I
N
S
P
T
K
H
P
E
R
Site 95
Y1300
T
L
L
M
T
A
I
Y
S
A
K
N
S
N
R
Site 96
S1301
L
L
M
T
A
I
Y
S
A
K
N
S
N
R
F
Site 97
Y1309
A
K
N
S
N
R
F
Y
L
H
Q
A
I
W
K
Site 98
S1323
K
T
F
S
H
Q
F
S
E
I
K
L
L
Q
D
Site 99
S1342
A
N
H
I
L
L
P
S
L
Y
G
D
Y
R
G
Site 100
Y1344
H
I
L
L
P
S
L
Y
G
D
Y
R
G
K
N
Site 101
Y1347
L
P
S
L
Y
G
D
Y
R
G
K
N
A
V
L
Site 102
T1374
F
Q
I
P
R
T
K
T
Y
E
K
V
D
E
G
Site 103
Y1375
Q
I
P
R
T
K
T
Y
E
K
V
D
E
G
Q
Site 104
S1397
H
T
C
G
R
P
K
S
L
F
P
G
L
H
L
Site 105
S1408
G
L
H
L
R
R
F
S
Y
I
C
S
P
R
P
Site 106
Y1409
L
H
L
R
R
F
S
Y
I
C
S
P
R
P
M
Site 107
T1429
D
E
L
H
E
R
L
T
S
K
N
E
N
G
F
Site 108
S1430
E
L
H
E
R
L
T
S
K
N
E
N
G
F
S
Site 109
Y1438
K
N
E
N
G
F
S
Y
I
M
R
G
A
F
F
Site 110
S1452
F
T
S
L
R
L
E
S
F
T
S
L
Q
M
S
Site 111
T1454
S
L
R
L
E
S
F
T
S
L
Q
M
S
K
K
Site 112
S1455
L
R
L
E
S
F
T
S
L
Q
M
S
K
K
G
Site 113
S1459
S
F
T
S
L
Q
M
S
K
K
G
C
V
W
S
Site 114
T1497
Q
Q
K
W
R
F
F
T
G
K
R
N
I
L
D
Site 115
S1511
D
T
S
I
I
L
I
S
F
I
L
L
G
L
D
Site 116
S1521
L
L
G
L
D
M
K
S
I
S
L
H
K
K
N
Site 117
S1523
G
L
D
M
K
S
I
S
L
H
K
K
N
M
A
Site 118
S1541
D
D
Q
D
R
F
I
S
F
Y
E
A
V
K
V
Site 119
Y1543
Q
D
R
F
I
S
F
Y
E
A
V
K
V
N
S
Site 120
S1574
L
W
N
L
L
R
H
S
P
R
L
R
V
I
S
Site 121
S1581
S
P
R
L
R
V
I
S
R
T
L
S
R
A
W
Site 122
T1583
R
L
R
V
I
S
R
T
L
S
R
A
W
D
E
Site 123
S1585
R
V
I
S
R
T
L
S
R
A
W
D
E
V
V
Site 124
Y1620
F
G
C
S
I
S
D
Y
R
T
F
F
S
S
A
Site 125
S1684
A
F
G
K
E
R
K
S
L
K
K
E
A
A
L
Site 126
T1694
K
E
A
A
L
I
D
T
L
L
Q
K
L
S
N
Site 127
S1706
L
S
N
L
L
G
I
S
W
P
Q
K
T
S
S
Site 128
S1713
S
W
P
Q
K
T
S
S
E
Q
A
A
T
T
A
Site 129
T1718
T
S
S
E
Q
A
A
T
T
A
V
G
S
D
T
Site 130
T1719
S
S
E
Q
A
A
T
T
A
V
G
S
D
T
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation