KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TRPM1
Full Name:
Transient receptor potential cation channel subfamily M member 1
Alias:
LTRPC1; melastatin 1; MLSN1; transient receptor potential cation channel, subfamily M, member 1
Type:
Channel, calcium
Mass (Da):
182178
Number AA:
1603
UniProt ID:
Q7Z4N2
International Prot ID:
IPI00385124
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005262
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
Q
H
I
P
P
L
P
S
A
T
P
S
K
N
E
Site 2
T24
I
P
P
L
P
S
A
T
P
S
K
N
E
E
E
Site 3
S26
P
L
P
S
A
T
P
S
K
N
E
E
E
S
K
Site 4
S43
E
T
Q
P
E
K
W
S
V
A
K
H
T
Q
S
Site 5
S50
S
V
A
K
H
T
Q
S
Y
P
T
D
S
Y
G
Site 6
Y51
V
A
K
H
T
Q
S
Y
P
T
D
S
Y
G
V
Site 7
S55
T
Q
S
Y
P
T
D
S
Y
G
V
L
E
F
Q
Site 8
Y56
Q
S
Y
P
T
D
S
Y
G
V
L
E
F
Q
G
Site 9
Y72
G
Y
S
N
K
A
M
Y
I
R
V
S
Y
D
T
Site 10
S76
K
A
M
Y
I
R
V
S
Y
D
T
K
P
D
S
Site 11
Y77
A
M
Y
I
R
V
S
Y
D
T
K
P
D
S
L
Site 12
T79
Y
I
R
V
S
Y
D
T
K
P
D
S
L
L
H
Site 13
S83
S
Y
D
T
K
P
D
S
L
L
H
L
M
V
K
Site 14
S156
G
D
A
L
K
D
H
S
S
K
S
R
G
R
V
Site 15
S157
D
A
L
K
D
H
S
S
K
S
R
G
R
V
C
Site 16
S159
L
K
D
H
S
S
K
S
R
G
R
V
C
A
I
Site 17
Y189
G
K
D
V
T
R
V
Y
Q
T
M
S
N
P
L
Site 18
S193
T
R
V
Y
Q
T
M
S
N
P
L
S
K
L
S
Site 19
S197
Q
T
M
S
N
P
L
S
K
L
S
V
L
N
N
Site 20
S200
S
N
P
L
S
K
L
S
V
L
N
N
S
H
T
Site 21
T207
S
V
L
N
N
S
H
T
H
F
I
L
A
D
N
Site 22
Y220
D
N
G
T
L
G
K
Y
G
A
E
V
K
L
R
Site 23
S235
R
L
L
E
K
H
I
S
L
Q
K
I
N
T
R
Site 24
S286
C
D
G
S
G
R
A
S
D
I
L
S
F
A
H
Site 25
S290
G
R
A
S
D
I
L
S
F
A
H
K
Y
C
E
Site 26
S305
E
G
G
I
I
N
E
S
L
R
E
Q
L
L
V
Site 27
T317
L
L
V
T
I
Q
K
T
F
N
Y
N
K
A
Q
Site 28
Y320
T
I
Q
K
T
F
N
Y
N
K
A
Q
S
H
Q
Site 29
T343
M
K
K
K
E
L
V
T
V
F
R
M
G
S
E
Site 30
S349
V
T
V
F
R
M
G
S
E
G
Q
Q
D
I
E
Site 31
S376
V
S
A
P
D
Q
L
S
L
A
L
A
W
N
R
Site 32
S403
P
H
W
P
P
L
G
S
L
A
P
P
T
D
S
Site 33
T408
L
G
S
L
A
P
P
T
D
S
K
A
T
E
K
Site 34
S410
S
L
A
P
P
T
D
S
K
A
T
E
K
E
K
Site 35
T423
E
K
K
P
P
M
A
T
T
K
G
G
R
G
K
Site 36
T424
K
K
P
P
M
A
T
T
K
G
G
R
G
K
G
Site 37
Y500
I
P
R
L
E
E
L
Y
N
T
R
L
G
P
P
Site 38
T502
R
L
E
E
L
Y
N
T
R
L
G
P
P
N
T
Site 39
T509
T
R
L
G
P
P
N
T
L
H
L
L
V
R
D
Site 40
S520
L
V
R
D
V
K
K
S
N
L
P
P
D
Y
H
Site 41
Y526
K
S
N
L
P
P
D
Y
H
I
S
L
I
D
I
Site 42
Y545
E
Y
L
M
G
G
A
Y
R
C
N
Y
T
R
K
Site 43
Y549
G
G
A
Y
R
C
N
Y
T
R
K
N
F
R
T
Site 44
T556
Y
T
R
K
N
F
R
T
L
Y
N
N
L
F
G
Site 45
Y558
R
K
N
F
R
T
L
Y
N
N
L
F
G
P
K
Site 46
S659
M
A
H
E
S
S
E
S
D
L
V
D
D
I
S
Site 47
S666
S
D
L
V
D
D
I
S
Q
D
L
D
N
N
S
Site 48
S673
S
Q
D
L
D
N
N
S
K
D
F
G
Q
L
A
Site 49
Y688
L
E
L
L
D
Q
S
Y
K
H
D
E
Q
I
A
Site 50
S709
E
L
K
N
W
S
N
S
T
C
L
K
L
A
V
Site 51
T727
H
R
D
F
I
A
H
T
C
S
Q
M
L
L
T
Site 52
Y769
L
F
L
E
F
R
T
Y
D
D
F
S
Y
Q
T
Site 53
S773
F
R
T
Y
D
D
F
S
Y
Q
T
S
K
E
N
Site 54
Y774
R
T
Y
D
D
F
S
Y
Q
T
S
K
E
N
E
Site 55
S777
D
D
F
S
Y
Q
T
S
K
E
N
E
D
G
K
Site 56
T791
K
E
K
E
E
E
N
T
D
A
N
A
D
A
G
Site 57
S813
N
E
H
K
K
Q
R
S
I
P
I
G
T
K
I
Site 58
T818
Q
R
S
I
P
I
G
T
K
I
C
E
F
Y
N
Site 59
S882
K
I
R
E
I
L
M
S
E
P
G
K
L
S
Q
Site 60
S888
M
S
E
P
G
K
L
S
Q
K
I
K
V
W
L
Site 61
Y923
L
R
L
Q
N
Q
P
Y
M
G
Y
G
R
V
I
Site 62
Y926
Q
N
Q
P
Y
M
G
Y
G
R
V
I
Y
C
V
Site 63
S995
L
H
P
E
E
K
P
S
W
K
L
A
R
N
I
Site 64
Y1022
F
A
D
Q
I
D
L
Y
A
M
E
I
N
P
P
Site 65
Y1035
P
P
C
G
E
N
L
Y
D
E
E
G
K
R
L
Site 66
Y1095
Q
V
W
K
F
Q
R
Y
Q
L
I
M
T
F
H
Site 67
T1100
Q
R
Y
Q
L
I
M
T
F
H
D
R
P
V
L
Site 68
S1148
R
G
L
K
L
F
L
S
D
E
E
L
K
R
L
Site 69
S1176
E
K
E
D
E
Q
Q
S
S
S
D
E
R
I
R
Site 70
S1177
K
E
D
E
Q
Q
S
S
S
D
E
R
I
R
V
Site 71
S1178
E
D
E
Q
Q
S
S
S
D
E
R
I
R
V
T
Site 72
T1185
S
D
E
R
I
R
V
T
S
E
R
V
E
N
M
Site 73
S1186
D
E
R
I
R
V
T
S
E
R
V
E
N
M
S
Site 74
S1193
S
E
R
V
E
N
M
S
M
R
L
E
E
I
N
Site 75
T1204
E
E
I
N
E
R
E
T
F
M
K
T
S
L
Q
Site 76
S1240
N
L
A
G
I
D
R
S
D
L
I
Q
A
R
S
Site 77
S1247
S
D
L
I
Q
A
R
S
R
A
S
S
E
C
E
Site 78
S1250
I
Q
A
R
S
R
A
S
S
E
C
E
A
T
Y
Site 79
S1251
Q
A
R
S
R
A
S
S
E
C
E
A
T
Y
L
Site 80
T1256
A
S
S
E
C
E
A
T
Y
L
L
R
Q
S
S
Site 81
Y1257
S
S
E
C
E
A
T
Y
L
L
R
Q
S
S
I
Site 82
S1262
A
T
Y
L
L
R
Q
S
S
I
N
S
A
D
G
Site 83
S1263
T
Y
L
L
R
Q
S
S
I
N
S
A
D
G
Y
Site 84
S1266
L
R
Q
S
S
I
N
S
A
D
G
Y
S
L
Y
Site 85
Y1270
S
I
N
S
A
D
G
Y
S
L
Y
R
Y
H
F
Site 86
Y1273
S
A
D
G
Y
S
L
Y
R
Y
H
F
N
G
E
Site 87
Y1275
D
G
Y
S
L
Y
R
Y
H
F
N
G
E
E
L
Site 88
T1287
E
E
L
L
F
E
D
T
S
L
S
T
S
P
G
Site 89
S1288
E
L
L
F
E
D
T
S
L
S
T
S
P
G
T
Site 90
S1290
L
F
E
D
T
S
L
S
T
S
P
G
T
G
V
Site 91
S1292
E
D
T
S
L
S
T
S
P
G
T
G
V
R
K
Site 92
T1295
S
L
S
T
S
P
G
T
G
V
R
K
K
T
C
Site 93
T1301
G
T
G
V
R
K
K
T
C
S
F
R
I
K
E
Site 94
S1303
G
V
R
K
K
T
C
S
F
R
I
K
E
E
K
Site 95
T1314
K
E
E
K
D
V
K
T
H
L
V
P
E
C
Q
Site 96
S1327
C
Q
N
S
L
H
L
S
L
G
T
S
T
S
A
Site 97
S1331
L
H
L
S
L
G
T
S
T
S
A
T
P
D
G
Site 98
S1333
L
S
L
G
T
S
T
S
A
T
P
D
G
S
H
Site 99
T1335
L
G
T
S
T
S
A
T
P
D
G
S
H
L
A
Site 100
S1361
L
G
P
D
I
G
I
S
K
E
D
D
E
R
Q
Site 101
T1369
K
E
D
D
E
R
Q
T
D
S
K
K
E
E
T
Site 102
S1371
D
D
E
R
Q
T
D
S
K
K
E
E
T
I
S
Site 103
T1376
T
D
S
K
K
E
E
T
I
S
P
S
L
N
K
Site 104
S1378
S
K
K
E
E
T
I
S
P
S
L
N
K
T
D
Site 105
S1380
K
E
E
T
I
S
P
S
L
N
K
T
D
V
I
Site 106
T1384
I
S
P
S
L
N
K
T
D
V
I
H
G
Q
D
Site 107
S1393
V
I
H
G
Q
D
K
S
D
V
Q
N
T
Q
L
Site 108
T1401
D
V
Q
N
T
Q
L
T
V
E
T
T
N
I
E
Site 109
S1412
T
N
I
E
G
T
I
S
Y
P
L
E
E
T
K
Site 110
Y1413
N
I
E
G
T
I
S
Y
P
L
E
E
T
K
I
Site 111
T1421
P
L
E
E
T
K
I
T
R
Y
F
P
D
E
T
Site 112
Y1423
E
E
T
K
I
T
R
Y
F
P
D
E
T
I
N
Site 113
T1434
E
T
I
N
A
C
K
T
M
K
S
R
S
F
V
Site 114
S1437
N
A
C
K
T
M
K
S
R
S
F
V
Y
S
R
Site 115
S1439
C
K
T
M
K
S
R
S
F
V
Y
S
R
G
R
Site 116
S1443
K
S
R
S
F
V
Y
S
R
G
R
K
L
V
G
Site 117
Y1458
G
V
N
Q
D
V
E
Y
S
S
I
T
D
Q
Q
Site 118
S1480
Q
V
Q
K
I
T
R
S
H
S
T
D
I
P
Y
Site 119
S1482
Q
K
I
T
R
S
H
S
T
D
I
P
Y
I
V
Site 120
S1522
I
P
R
I
P
R
L
S
L
T
I
T
D
R
N
Site 121
T1524
R
I
P
R
L
S
L
T
I
T
D
R
N
G
M
Site 122
T1526
P
R
L
S
L
T
I
T
D
R
N
G
M
E
N
Site 123
S1536
N
G
M
E
N
L
L
S
V
K
P
D
Q
T
L
Site 124
T1542
L
S
V
K
P
D
Q
T
L
G
F
P
S
L
R
Site 125
S1547
D
Q
T
L
G
F
P
S
L
R
S
K
S
L
H
Site 126
S1550
L
G
F
P
S
L
R
S
K
S
L
H
G
H
P
Site 127
S1552
F
P
S
L
R
S
K
S
L
H
G
H
P
R
N
Site 128
S1562
G
H
P
R
N
V
K
S
I
Q
G
K
L
D
R
Site 129
S1570
I
Q
G
K
L
D
R
S
G
H
A
S
S
V
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation