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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
P4HA3
Full Name:
Prolyl 4-hydroxylase subunit alpha-3
Alias:
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3
Type:
Mass (Da):
61126
Number AA:
544
UniProt ID:
Q7Z4N8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
R
A
A
A
R
G
D
T
F
S
A
L
T
S
V
Site 2
S32
A
A
R
G
D
T
F
S
A
L
T
S
V
A
R
Site 3
Y54
L
L
G
L
L
R
R
Y
L
R
G
E
E
A
R
Site 4
T66
E
A
R
L
R
D
L
T
R
F
Y
D
K
V
L
Site 5
Y69
L
R
D
L
T
R
F
Y
D
K
V
L
S
L
H
Site 6
S74
R
F
Y
D
K
V
L
S
L
H
E
D
S
T
T
Site 7
S79
V
L
S
L
H
E
D
S
T
T
P
V
A
N
P
Site 8
T80
L
S
L
H
E
D
S
T
T
P
V
A
N
P
L
Site 9
T81
S
L
H
E
D
S
T
T
P
V
A
N
P
L
L
Site 10
S98
T
L
I
K
R
L
Q
S
D
W
R
N
V
V
H
Site 11
S106
D
W
R
N
V
V
H
S
L
E
A
S
E
N
I
Site 12
S110
V
V
H
S
L
E
A
S
E
N
I
R
A
L
K
Site 13
Y120
I
R
A
L
K
D
G
Y
E
K
V
E
Q
D
L
Site 14
Y147
L
M
R
L
Q
D
V
Y
M
L
N
V
K
G
L
Site 15
Y171
G
S
A
I
T
D
L
Y
S
P
K
R
L
F
S
Site 16
S172
S
A
I
T
D
L
Y
S
P
K
R
L
F
S
L
Site 17
S178
Y
S
P
K
R
L
F
S
L
T
G
D
D
C
F
Site 18
T180
P
K
R
L
F
S
L
T
G
D
D
C
F
Q
V
Site 19
Y198
A
Y
D
M
G
D
Y
Y
H
A
I
P
W
L
E
Site 20
S209
P
W
L
E
E
A
V
S
L
F
R
G
S
Y
G
Site 21
S214
A
V
S
L
F
R
G
S
Y
G
E
W
K
T
E
Site 22
Y215
V
S
L
F
R
G
S
Y
G
E
W
K
T
E
D
Site 23
T220
G
S
Y
G
E
W
K
T
E
D
E
A
S
L
E
Site 24
S225
W
K
T
E
D
E
A
S
L
E
D
A
L
D
H
Site 25
Y256
L
S
R
E
F
L
L
Y
S
P
D
N
K
R
M
Site 26
S257
S
R
E
F
L
L
Y
S
P
D
N
K
R
M
A
Site 27
Y270
M
A
R
N
V
L
K
Y
E
R
L
L
A
E
S
Site 28
S277
Y
E
R
L
L
A
E
S
P
N
H
V
V
A
E
Site 29
T300
P
H
L
Q
T
R
D
T
Y
E
G
L
C
Q
T
Site 30
Y301
H
L
Q
T
R
D
T
Y
E
G
L
C
Q
T
L
Site 31
T307
T
Y
E
G
L
C
Q
T
L
G
S
Q
P
T
L
Site 32
T313
Q
T
L
G
S
Q
P
T
L
Y
Q
I
P
S
L
Site 33
S319
P
T
L
Y
Q
I
P
S
L
Y
C
S
Y
E
T
Site 34
Y321
L
Y
Q
I
P
S
L
Y
C
S
Y
E
T
N
S
Site 35
S323
Q
I
P
S
L
Y
C
S
Y
E
T
N
S
N
A
Site 36
Y324
I
P
S
L
Y
C
S
Y
E
T
N
S
N
A
Y
Site 37
Y351
L
E
P
Y
I
A
L
Y
H
D
F
V
S
D
S
Site 38
S356
A
L
Y
H
D
F
V
S
D
S
E
A
Q
K
I
Site 39
S358
Y
H
D
F
V
S
D
S
E
A
Q
K
I
R
E
Site 40
S374
A
E
P
W
L
Q
R
S
V
V
A
S
G
E
K
Site 41
S378
L
Q
R
S
V
V
A
S
G
E
K
Q
L
Q
V
Site 42
S390
L
Q
V
E
Y
R
I
S
K
S
A
W
L
K
D
Site 43
S392
V
E
Y
R
I
S
K
S
A
W
L
K
D
T
V
Site 44
T398
K
S
A
W
L
K
D
T
V
D
P
K
L
V
T
Site 45
T414
N
H
R
I
A
A
L
T
G
L
D
V
R
P
P
Site 46
Y425
V
R
P
P
Y
A
E
Y
L
Q
V
V
N
Y
G
Site 47
Y431
E
Y
L
Q
V
V
N
Y
G
I
G
G
H
Y
E
Site 48
Y437
N
Y
G
I
G
G
H
Y
E
P
H
F
D
H
A
Site 49
T445
E
P
H
F
D
H
A
T
S
P
S
S
P
L
Y
Site 50
S446
P
H
F
D
H
A
T
S
P
S
S
P
L
Y
R
Site 51
S449
D
H
A
T
S
P
S
S
P
L
Y
R
M
K
S
Site 52
Y452
T
S
P
S
S
P
L
Y
R
M
K
S
G
N
R
Site 53
S456
S
P
L
Y
R
M
K
S
G
N
R
V
A
T
F
Site 54
T462
K
S
G
N
R
V
A
T
F
M
I
Y
L
S
S
Site 55
S506
H
R
S
G
E
G
D
S
D
T
L
H
A
G
C
Site 56
T508
S
G
E
G
D
S
D
T
L
H
A
G
C
P
V
Site 57
S539
Q
E
F
R
R
P
C
S
S
S
P
E
D
_
_
Site 58
S540
E
F
R
R
P
C
S
S
S
P
E
D
_
_
_
Site 59
S541
F
R
R
P
C
S
S
S
P
E
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation