PhosphoNET

           
Protein Info 
   
Short Name:  SH2D6
Full Name:  SH2 domain-containing protein 6
Alias: 
Type: 
Mass (Da):  19279
Number AA:  175
UniProt ID:  Q7Z4S9
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S13YPPPPQLSPRSHLCP
Site 2S16PPQLSPRSHLCPPPP
Site 3T26CPPPPHPTPPQLNNL
Site 4S42LLEGRKSSLPSVAPT
Site 5S45GRKSSLPSVAPTGSA
Site 6S51PSVAPTGSASAAEDS
Site 7S58SASAAEDSDLLTQPW
Site 8T62AEDSDLLTQPWYSGN
Site 9Y66DLLTQPWYSGNCDRY
Site 10Y73YSGNCDRYAVESALL
Site 11S77CDRYAVESALLHLQK
Site 12Y88HLQKDGAYTVRPSSG
Site 13T89LQKDGAYTVRPSSGP
Site 14S93GAYTVRPSSGPHGSQ
Site 15S94AYTVRPSSGPHGSQP
Site 16S99PSSGPHGSQPFTLAV
Site 17Y126RLDGGRHYALGREGR
Site 18S140RNREELFSSVAAMVQ
Site 19S141NREELFSSVAAMVQH
Site 20S161LPLVDRHSGSRELTC
Site 21T167HSGSRELTCLLFPTK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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