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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDGFRP2
Full Name:
Hepatoma-derived growth factor-related protein 2
Alias:
HDGR2; Hepatoma-derived growth factor-related protein 2: Hepatoma-derived growth factor-related protein 2: Hepatoma-derived growth factor-related protein 2 isoform 1 variant; HGDF-related pro 2; UNQ785
Type:
Secreted protein, growth factor
Mass (Da):
74317
Number AA:
671
UniProt ID:
Q7Z4V5
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
V
K
P
P
P
N
K
Y
P
I
F
F
F
G
T
Site 2
Y61
G
P
K
D
L
F
P
Y
D
K
C
K
D
K
Y
Site 3
Y68
Y
D
K
C
K
D
K
Y
G
K
P
N
K
R
K
Site 4
S91
I
Q
N
N
P
H
A
S
Y
S
A
P
P
P
V
Site 5
Y92
Q
N
N
P
H
A
S
Y
S
A
P
P
P
V
S
Site 6
S93
N
N
P
H
A
S
Y
S
A
P
P
P
V
S
S
Site 7
S99
Y
S
A
P
P
P
V
S
S
S
D
S
E
A
P
Site 8
S100
S
A
P
P
P
V
S
S
S
D
S
E
A
P
E
Site 9
S101
A
P
P
P
V
S
S
S
D
S
E
A
P
E
A
Site 10
S103
P
P
V
S
S
S
D
S
E
A
P
E
A
N
P
Site 11
S114
E
A
N
P
A
D
G
S
D
A
D
E
D
D
E
Site 12
T134
A
V
T
A
V
T
A
T
A
A
S
D
R
M
E
Site 13
S137
A
V
T
A
T
A
A
S
D
R
M
E
S
D
S
Site 14
S142
A
A
S
D
R
M
E
S
D
S
D
S
D
K
S
Site 15
S144
S
D
R
M
E
S
D
S
D
S
D
K
S
S
D
Site 16
S146
R
M
E
S
D
S
D
S
D
K
S
S
D
N
S
Site 17
S149
S
D
S
D
S
D
K
S
S
D
N
S
G
L
K
Site 18
S150
D
S
D
S
D
K
S
S
D
N
S
G
L
K
R
Site 19
S153
S
D
K
S
S
D
N
S
G
L
K
R
K
T
P
Site 20
T159
N
S
G
L
K
R
K
T
P
A
L
K
M
S
V
Site 21
S165
K
T
P
A
L
K
M
S
V
S
K
R
A
R
K
Site 22
S167
P
A
L
K
M
S
V
S
K
R
A
R
K
A
S
Site 23
S174
S
K
R
A
R
K
A
S
S
D
L
D
Q
A
S
Site 24
S175
K
R
A
R
K
A
S
S
D
L
D
Q
A
S
V
Site 25
S181
S
S
D
L
D
Q
A
S
V
S
P
S
E
E
E
Site 26
S183
D
L
D
Q
A
S
V
S
P
S
E
E
E
N
S
Site 27
S185
D
Q
A
S
V
S
P
S
E
E
E
N
S
E
S
Site 28
S190
S
P
S
E
E
E
N
S
E
S
S
S
E
S
E
Site 29
S192
S
E
E
E
N
S
E
S
S
S
E
S
E
K
T
Site 30
S194
E
E
N
S
E
S
S
S
E
S
E
K
T
S
D
Site 31
S196
N
S
E
S
S
S
E
S
E
K
T
S
D
Q
D
Site 32
T199
S
S
S
E
S
E
K
T
S
D
Q
D
F
T
P
Site 33
S200
S
S
E
S
E
K
T
S
D
Q
D
F
T
P
E
Site 34
T205
K
T
S
D
Q
D
F
T
P
E
K
K
A
A
V
Site 35
S230
R
K
K
K
K
A
P
S
A
S
D
S
D
S
K
Site 36
S232
K
K
K
A
P
S
A
S
D
S
D
S
K
A
D
Site 37
S234
K
A
P
S
A
S
D
S
D
S
K
A
D
S
D
Site 38
S236
P
S
A
S
D
S
D
S
K
A
D
S
D
G
A
Site 39
S240
D
S
D
S
K
A
D
S
D
G
A
K
P
E
P
Site 40
S253
E
P
V
A
M
A
R
S
A
S
S
S
S
S
S
Site 41
S255
V
A
M
A
R
S
A
S
S
S
S
S
S
S
S
Site 42
S256
A
M
A
R
S
A
S
S
S
S
S
S
S
S
S
Site 43
S257
M
A
R
S
A
S
S
S
S
S
S
S
S
S
S
Site 44
S258
A
R
S
A
S
S
S
S
S
S
S
S
S
S
D
Site 45
S259
R
S
A
S
S
S
S
S
S
S
S
S
S
D
S
Site 46
S260
S
A
S
S
S
S
S
S
S
S
S
S
D
S
D
Site 47
S261
A
S
S
S
S
S
S
S
S
S
S
D
S
D
V
Site 48
S262
S
S
S
S
S
S
S
S
S
S
D
S
D
V
S
Site 49
S263
S
S
S
S
S
S
S
S
S
D
S
D
V
S
V
Site 50
S264
S
S
S
S
S
S
S
S
D
S
D
V
S
V
K
Site 51
S266
S
S
S
S
S
S
D
S
D
V
S
V
K
K
P
Site 52
S269
S
S
S
D
S
D
V
S
V
K
K
P
P
R
G
Site 53
S299
P
K
P
E
R
P
P
S
S
S
S
S
D
S
D
Site 54
S300
K
P
E
R
P
P
S
S
S
S
S
D
S
D
S
Site 55
S301
P
E
R
P
P
S
S
S
S
S
D
S
D
S
D
Site 56
S302
E
R
P
P
S
S
S
S
S
D
S
D
S
D
E
Site 57
S303
R
P
P
S
S
S
S
S
D
S
D
S
D
E
V
Site 58
S305
P
S
S
S
S
S
D
S
D
S
D
E
V
D
R
Site 59
S307
S
S
S
S
D
S
D
S
D
E
V
D
R
I
S
Site 60
S314
S
D
E
V
D
R
I
S
E
W
K
R
R
D
E
Site 61
S366
R
G
E
A
E
R
G
S
G
G
S
S
G
D
E
Site 62
S369
A
E
R
G
S
G
G
S
S
G
D
E
L
R
E
Site 63
S370
E
R
G
S
G
G
S
S
G
D
E
L
R
E
D
Site 64
S395
G
R
G
R
G
P
P
S
S
S
D
S
E
P
E
Site 65
S396
R
G
R
G
P
P
S
S
S
D
S
E
P
E
A
Site 66
S397
G
R
G
P
P
S
S
S
D
S
E
P
E
A
E
Site 67
S399
G
P
P
S
S
S
D
S
E
P
E
A
E
L
E
Site 68
S412
L
E
R
E
A
K
K
S
A
K
K
P
Q
S
S
Site 69
S418
K
S
A
K
K
P
Q
S
S
S
T
E
P
A
R
Site 70
S420
A
K
K
P
Q
S
S
S
T
E
P
A
R
K
P
Site 71
T450
K
P
V
K
V
E
R
T
R
K
R
S
E
G
F
Site 72
S454
V
E
R
T
R
K
R
S
E
G
F
S
M
D
R
Site 73
S458
R
K
R
S
E
G
F
S
M
D
R
K
V
E
K
Site 74
S470
V
E
K
K
K
E
P
S
V
E
E
K
L
Q
K
Site 75
S480
E
K
L
Q
K
L
H
S
E
I
K
F
A
L
K
Site 76
S490
K
F
A
L
K
V
D
S
P
D
V
K
R
C
L
Site 77
S510
L
G
T
L
Q
V
T
S
Q
I
L
Q
K
N
T
Site 78
Y529
T
L
K
K
I
R
R
Y
K
A
N
K
D
V
M
Site 79
Y543
M
E
K
A
A
E
V
Y
T
R
L
K
S
R
V
Site 80
S548
E
V
Y
T
R
L
K
S
R
V
L
G
P
K
I
Site 81
S595
E
K
A
E
D
K
P
S
T
D
L
S
A
P
V
Site 82
T596
K
A
E
D
K
P
S
T
D
L
S
A
P
V
N
Site 83
S599
D
K
P
S
T
D
L
S
A
P
V
N
G
E
A
Site 84
S608
P
V
N
G
E
A
T
S
Q
K
G
E
S
A
E
Site 85
S613
A
T
S
Q
K
G
E
S
A
E
D
K
E
H
E
Site 86
S625
E
H
E
E
G
R
D
S
E
E
G
P
R
C
G
Site 87
S633
E
E
G
P
R
C
G
S
S
E
D
L
H
D
S
Site 88
S634
E
G
P
R
C
G
S
S
E
D
L
H
D
S
V
Site 89
S640
S
S
E
D
L
H
D
S
V
R
E
G
P
D
L
Site 90
S652
P
D
L
D
R
P
G
S
D
R
Q
E
R
E
R
Site 91
S664
R
E
R
A
R
G
D
S
E
A
L
D
E
E
S
Site 92
S671
S
E
A
L
D
E
E
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation