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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP22
Full Name:
Rho GTPase-activating protein 22
Alias:
RHG22; Rho GTPase activating 2; Rho GTPase activating 22; Rho GTPase activating protein 22; RHOGAP2
Type:
Mass (Da):
76780
Number AA:
UniProt ID:
Q7Z5H3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0030154
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
Q
A
R
R
A
R
S
K
S
L
V
M
G
E
Site 2
S16
A
R
R
A
R
S
K
S
L
V
M
G
E
Q
S
Site 3
S23
S
L
V
M
G
E
Q
S
R
S
P
G
R
M
P
Site 4
S25
V
M
G
E
Q
S
R
S
P
G
R
M
P
C
P
Site 5
Y69
R
G
D
Q
L
F
Y
Y
K
D
K
D
E
I
K
Site 6
S82
I
K
P
Q
G
F
I
S
L
Q
G
T
Q
V
T
Site 7
T89
S
L
Q
G
T
Q
V
T
E
L
P
P
G
P
E
Site 8
S106
G
K
H
L
F
E
I
S
P
G
G
A
G
E
R
Site 9
S128
E
A
L
L
L
M
A
S
S
Q
R
D
M
E
D
Site 10
S129
A
L
L
L
M
A
S
S
Q
R
D
M
E
D
W
Site 11
T160
F
G
Q
R
L
E
E
T
V
H
H
E
R
K
Y
Site 12
Y167
T
V
H
H
E
R
K
Y
G
P
R
L
A
P
L
Site 13
T189
F
I
R
E
R
G
L
T
E
E
G
L
F
R
M
Site 14
S209
L
V
R
D
L
Q
D
S
F
D
C
G
E
K
P
Site 15
S220
G
E
K
P
L
F
D
S
T
T
D
V
H
T
V
Site 16
T221
E
K
P
L
F
D
S
T
T
D
V
H
T
V
A
Site 17
T222
K
P
L
F
D
S
T
T
D
V
H
T
V
A
S
Site 18
S253
A
R
Y
E
D
F
L
S
C
A
Q
L
L
T
K
Site 19
T266
T
K
D
E
G
E
G
T
L
E
L
A
K
Q
V
Site 20
S274
L
E
L
A
K
Q
V
S
N
L
P
Q
A
N
Y
Site 21
Y281
S
N
L
P
Q
A
N
Y
N
L
L
R
Y
I
C
Site 22
Y286
A
N
Y
N
L
L
R
Y
I
C
K
F
L
D
E
Site 23
Y297
F
L
D
E
V
Q
A
Y
S
N
V
N
K
M
S
Site 24
T326
P
Q
V
E
D
P
V
T
I
M
E
G
T
S
L
Site 25
T350
R
K
H
S
Q
L
F
T
A
P
V
P
E
G
P
Site 26
S359
P
V
P
E
G
P
T
S
P
R
G
G
L
Q
C
Site 27
T376
G
W
G
S
E
E
V
T
R
D
S
Q
G
E
P
Site 28
S379
S
E
E
V
T
R
D
S
Q
G
E
P
G
G
P
Site 29
T393
P
G
L
P
A
H
R
T
S
S
L
D
G
A
A
Site 30
S394
G
L
P
A
H
R
T
S
S
L
D
G
A
A
V
Site 31
S395
L
P
A
H
R
T
S
S
L
D
G
A
A
V
A
Site 32
S414
T
A
P
T
G
P
G
S
R
C
S
P
G
K
K
Site 33
S417
T
G
P
G
S
R
C
S
P
G
K
K
V
Q
T
Site 34
T424
S
P
G
K
K
V
Q
T
L
P
S
W
K
S
S
Site 35
S427
K
K
V
Q
T
L
P
S
W
K
S
S
F
R
Q
Site 36
S430
Q
T
L
P
S
W
K
S
S
F
R
Q
P
R
S
Site 37
S431
T
L
P
S
W
K
S
S
F
R
Q
P
R
S
L
Site 38
S437
S
S
F
R
Q
P
R
S
L
S
G
S
P
K
G
Site 39
S439
F
R
Q
P
R
S
L
S
G
S
P
K
G
G
G
Site 40
S441
Q
P
R
S
L
S
G
S
P
K
G
G
G
S
S
Site 41
S447
G
S
P
K
G
G
G
S
S
L
E
V
P
I
I
Site 42
S448
S
P
K
G
G
G
S
S
L
E
V
P
I
I
S
Site 43
S466
N
W
L
M
N
G
L
S
S
L
R
G
H
R
R
Site 44
S467
W
L
M
N
G
L
S
S
L
R
G
H
R
R
A
Site 45
S475
L
R
G
H
R
R
A
S
S
G
D
R
L
K
D
Site 46
S476
R
G
H
R
R
A
S
S
G
D
R
L
K
D
S
Site 47
S483
S
G
D
R
L
K
D
S
G
S
V
Q
R
L
S
Site 48
S485
D
R
L
K
D
S
G
S
V
Q
R
L
S
T
Y
Site 49
S490
S
G
S
V
Q
R
L
S
T
Y
D
N
V
P
A
Site 50
T491
G
S
V
Q
R
L
S
T
Y
D
N
V
P
A
P
Site 51
Y492
S
V
Q
R
L
S
T
Y
D
N
V
P
A
P
G
Site 52
S513
S
V
A
S
M
A
W
S
G
A
S
S
S
E
S
Site 53
S516
S
M
A
W
S
G
A
S
S
S
E
S
S
V
G
Site 54
S517
M
A
W
S
G
A
S
S
S
E
S
S
V
G
G
Site 55
S518
A
W
S
G
A
S
S
S
E
S
S
V
G
G
S
Site 56
S520
S
G
A
S
S
S
E
S
S
V
G
G
S
L
S
Site 57
S521
G
A
S
S
S
E
S
S
V
G
G
S
L
S
S
Site 58
S525
S
E
S
S
V
G
G
S
L
S
S
C
T
A
C
Site 59
T530
G
G
S
L
S
S
C
T
A
C
R
A
S
D
S
Site 60
S535
S
C
T
A
C
R
A
S
D
S
S
A
R
S
S
Site 61
S537
T
A
C
R
A
S
D
S
S
A
R
S
S
L
H
Site 62
S538
A
C
R
A
S
D
S
S
A
R
S
S
L
H
T
Site 63
S541
A
S
D
S
S
A
R
S
S
L
H
T
D
W
A
Site 64
S542
S
D
S
S
A
R
S
S
L
H
T
D
W
A
L
Site 65
T545
S
A
R
S
S
L
H
T
D
W
A
L
E
P
S
Site 66
S552
T
D
W
A
L
E
P
S
P
L
P
S
S
S
E
Site 67
S556
L
E
P
S
P
L
P
S
S
S
E
D
P
K
S
Site 68
S557
E
P
S
P
L
P
S
S
S
E
D
P
K
S
L
Site 69
S558
P
S
P
L
P
S
S
S
E
D
P
K
S
L
D
Site 70
S563
S
S
S
E
D
P
K
S
L
D
L
D
H
S
M
Site 71
S569
K
S
L
D
L
D
H
S
M
D
E
A
G
A
G
Site 72
S580
A
G
A
G
A
S
N
S
E
P
S
E
P
D
S
Site 73
S583
G
A
S
N
S
E
P
S
E
P
D
S
P
T
R
Site 74
S587
S
E
P
S
E
P
D
S
P
T
R
E
H
A
R
Site 75
T589
P
S
E
P
D
S
P
T
R
E
H
A
R
R
S
Site 76
S596
T
R
E
H
A
R
R
S
E
A
L
Q
G
L
V
Site 77
T615
A
E
L
C
R
Q
R
T
E
Y
E
R
S
V
K
Site 78
Y617
L
C
R
Q
R
T
E
Y
E
R
S
V
K
R
I
Site 79
S620
Q
R
T
E
Y
E
R
S
V
K
R
I
E
E
G
Site 80
S628
V
K
R
I
E
E
G
S
A
D
L
R
K
R
M
Site 81
S636
A
D
L
R
K
R
M
S
R
L
E
E
E
L
D
Site 82
Y649
L
D
Q
E
K
K
K
Y
I
M
L
E
I
K
L
Site 83
S659
L
E
I
K
L
R
N
S
E
R
A
R
E
D
A
Site 84
S682
R
E
M
E
E
F
F
S
T
L
G
S
L
T
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation