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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WAPL
Full Name:
Wings apart-like protein homolog
Alias:
FOE; Friend of EBNA2; HWAPL; KIAA0261; Mammalian homolog of wings apart-like protein; Mammalian homologue of wings apart-like protein; Wings apart-like
Type:
DNA binding protein
Mass (Da):
132946
Number AA:
1190
UniProt ID:
Q7Z5K2
International Prot ID:
IPI00375330
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
T
S
R
F
G
K
T
Y
S
R
K
G
G
N
Site 2
Y9
T
S
R
F
G
K
T
Y
S
R
K
G
G
N
G
Site 3
S10
S
R
F
G
K
T
Y
S
R
K
G
G
N
G
S
Site 4
S17
S
R
K
G
G
N
G
S
S
K
F
D
E
V
F
Site 5
S18
R
K
G
G
N
G
S
S
K
F
D
E
V
F
S
Site 6
S25
S
K
F
D
E
V
F
S
N
K
R
T
T
L
S
Site 7
T29
E
V
F
S
N
K
R
T
T
L
S
T
K
W
G
Site 8
T30
V
F
S
N
K
R
T
T
L
S
T
K
W
G
E
Site 9
T33
N
K
R
T
T
L
S
T
K
W
G
E
T
T
F
Site 10
T39
S
T
K
W
G
E
T
T
F
M
A
K
L
G
Q
Site 11
T69
P
K
V
E
E
E
S
T
G
D
P
F
G
F
D
Site 12
S77
G
D
P
F
G
F
D
S
D
D
E
S
L
P
V
Site 13
S81
G
F
D
S
D
D
E
S
L
P
V
S
S
K
N
Site 14
S85
D
D
E
S
L
P
V
S
S
K
N
L
A
Q
V
Site 15
S96
L
A
Q
V
K
C
S
S
Y
S
E
S
S
E
A
Site 16
Y97
A
Q
V
K
C
S
S
Y
S
E
S
S
E
A
A
Site 17
S98
Q
V
K
C
S
S
Y
S
E
S
S
E
A
A
Q
Site 18
S100
K
C
S
S
Y
S
E
S
S
E
A
A
Q
L
E
Site 19
S111
A
Q
L
E
E
V
T
S
V
L
E
A
N
S
K
Site 20
T139
K
C
F
P
L
E
D
T
L
L
G
K
E
K
S
Site 21
S146
T
L
L
G
K
E
K
S
T
N
R
I
V
E
D
Site 22
T147
L
L
G
K
E
K
S
T
N
R
I
V
E
D
D
Site 23
S156
R
I
V
E
D
D
A
S
I
S
S
C
N
K
L
Site 24
S158
V
E
D
D
A
S
I
S
S
C
N
K
L
I
T
Site 25
S159
E
D
D
A
S
I
S
S
C
N
K
L
I
T
S
Site 26
S190
I
H
K
N
A
D
D
S
T
K
K
P
N
A
E
Site 27
T191
H
K
N
A
D
D
S
T
K
K
P
N
A
E
T
Site 28
T207
V
A
S
E
I
K
E
T
N
D
T
W
N
S
Q
Site 29
T210
E
I
K
E
T
N
D
T
W
N
S
Q
F
G
K
Site 30
S213
E
T
N
D
T
W
N
S
Q
F
G
K
R
P
E
Site 31
S221
Q
F
G
K
R
P
E
S
P
S
E
I
S
P
I
Site 32
S223
G
K
R
P
E
S
P
S
E
I
S
P
I
K
G
Site 33
S226
P
E
S
P
S
E
I
S
P
I
K
G
S
V
R
Site 34
S231
E
I
S
P
I
K
G
S
V
R
T
G
L
F
E
Site 35
S248
N
D
F
E
D
I
R
S
E
D
C
I
L
S
L
Site 36
S254
R
S
E
D
C
I
L
S
L
D
S
D
P
L
L
Site 37
S257
D
C
I
L
S
L
D
S
D
P
L
L
E
M
K
Site 38
S286
I
E
E
D
I
V
Q
S
V
L
R
P
T
N
C
Site 39
T291
V
Q
S
V
L
R
P
T
N
C
R
T
Y
C
R
Site 40
Y296
R
P
T
N
C
R
T
Y
C
R
A
N
K
T
K
Site 41
T302
T
Y
C
R
A
N
K
T
K
S
S
Q
G
A
S
Site 42
S304
C
R
A
N
K
T
K
S
S
Q
G
A
S
N
F
Site 43
S305
R
A
N
K
T
K
S
S
Q
G
A
S
N
F
D
Site 44
S309
T
K
S
S
Q
G
A
S
N
F
D
K
L
M
D
Site 45
S319
D
K
L
M
D
G
T
S
Q
A
L
A
K
A
N
Site 46
S327
Q
A
L
A
K
A
N
S
E
S
S
K
D
G
L
Site 47
S343
Q
A
K
K
G
G
V
S
C
G
T
S
F
R
G
Site 48
T346
K
G
G
V
S
C
G
T
S
F
R
G
T
V
G
Site 49
S347
G
G
V
S
C
G
T
S
F
R
G
T
V
G
R
Site 50
T351
C
G
T
S
F
R
G
T
V
G
R
T
R
D
Y
Site 51
Y358
T
V
G
R
T
R
D
Y
T
V
L
H
P
S
C
Site 52
T359
V
G
R
T
R
D
Y
T
V
L
H
P
S
C
L
Site 53
T376
C
N
V
T
I
Q
D
T
M
E
R
S
M
D
E
Site 54
S380
I
Q
D
T
M
E
R
S
M
D
E
F
T
A
S
Site 55
S387
S
M
D
E
F
T
A
S
T
P
A
D
L
G
E
Site 56
T388
M
D
E
F
T
A
S
T
P
A
D
L
G
E
A
Site 57
T409
A
D
I
A
T
S
K
T
T
T
R
F
R
P
S
Site 58
T411
I
A
T
S
K
T
T
T
R
F
R
P
S
N
T
Site 59
S416
T
T
T
R
F
R
P
S
N
T
K
S
K
K
D
Site 60
S420
F
R
P
S
N
T
K
S
K
K
D
V
K
L
E
Site 61
T436
F
G
F
E
D
H
E
T
G
G
D
E
G
G
S
Site 62
S443
T
G
G
D
E
G
G
S
G
S
S
N
Y
K
I
Site 63
S445
G
D
E
G
G
S
G
S
S
N
Y
K
I
K
Y
Site 64
Y448
G
G
S
G
S
S
N
Y
K
I
K
Y
F
G
F
Site 65
Y452
S
S
N
Y
K
I
K
Y
F
G
F
D
D
L
S
Site 66
S459
Y
F
G
F
D
D
L
S
E
S
E
D
D
E
D
Site 67
S461
G
F
D
D
L
S
E
S
E
D
D
E
D
D
D
Site 68
T475
D
C
Q
V
E
R
K
T
S
K
K
R
T
K
T
Site 69
S476
C
Q
V
E
R
K
T
S
K
K
R
T
K
T
A
Site 70
T480
R
K
T
S
K
K
R
T
K
T
A
P
S
P
S
Site 71
T482
T
S
K
K
R
T
K
T
A
P
S
P
S
L
Q
Site 72
S485
K
R
T
K
T
A
P
S
P
S
L
Q
P
P
P
Site 73
S487
T
K
T
A
P
S
P
S
L
Q
P
P
P
E
S
Site 74
S494
S
L
Q
P
P
P
E
S
N
D
N
S
Q
D
S
Site 75
S498
P
P
E
S
N
D
N
S
Q
D
S
Q
S
G
T
Site 76
S501
S
N
D
N
S
Q
D
S
Q
S
G
T
N
N
A
Site 77
S503
D
N
S
Q
D
S
Q
S
G
T
N
N
A
E
N
Site 78
T505
S
Q
D
S
Q
S
G
T
N
N
A
E
N
L
D
Site 79
T514
N
A
E
N
L
D
F
T
E
D
L
P
G
V
P
Site 80
S523
D
L
P
G
V
P
E
S
V
K
K
P
I
N
K
Site 81
S535
I
N
K
Q
G
D
K
S
K
E
N
T
R
K
I
Site 82
T539
G
D
K
S
K
E
N
T
R
K
I
F
S
G
P
Site 83
S544
E
N
T
R
K
I
F
S
G
P
K
R
S
P
T
Site 84
S549
I
F
S
G
P
K
R
S
P
T
K
A
V
Y
N
Site 85
T551
S
G
P
K
R
S
P
T
K
A
V
Y
N
A
R
Site 86
Y555
R
S
P
T
K
A
V
Y
N
A
R
H
W
N
H
Site 87
S565
R
H
W
N
H
P
D
S
E
E
L
P
G
P
P
Site 88
S578
P
P
V
V
K
P
Q
S
V
T
V
R
L
S
S
Site 89
T580
V
V
K
P
Q
S
V
T
V
R
L
S
S
K
E
Site 90
S584
Q
S
V
T
V
R
L
S
S
K
E
P
N
Q
K
Site 91
S585
S
V
T
V
R
L
S
S
K
E
P
N
Q
K
D
Site 92
S603
F
K
A
P
A
P
P
S
K
V
I
K
T
V
T
Site 93
T608
P
P
S
K
V
I
K
T
V
T
I
P
T
Q
P
Site 94
T610
S
K
V
I
K
T
V
T
I
P
T
Q
P
Y
Q
Site 95
Y633
R
R
E
D
K
E
L
Y
T
V
V
Q
H
V
K
Site 96
T634
R
E
D
K
E
L
Y
T
V
V
Q
H
V
K
H
Site 97
Y660
E
F
T
D
D
I
E
Y
L
L
S
G
L
K
S
Site 98
S663
D
D
I
E
Y
L
L
S
G
L
K
S
T
Q
P
Site 99
S667
Y
L
L
S
G
L
K
S
T
Q
P
L
N
T
R
Site 100
T673
K
S
T
Q
P
L
N
T
R
C
L
S
V
I
S
Site 101
S710
V
F
K
T
L
D
D
S
Q
H
H
Q
N
L
S
Site 102
S717
S
Q
H
H
Q
N
L
S
L
C
T
A
A
L
M
Site 103
S755
L
E
L
E
Q
D
A
S
S
A
K
L
L
N
E
Site 104
T778
K
I
R
R
L
C
E
T
V
H
N
K
H
L
D
Site 105
T791
L
D
L
E
N
I
T
T
G
H
L
A
M
E
T
Site 106
S804
E
T
L
L
S
L
T
S
K
R
A
G
D
W
F
Site 107
S836
K
E
C
V
D
H
L
S
R
D
E
D
E
E
K
Site 108
S860
R
C
L
R
V
L
E
S
V
T
V
H
N
P
E
Site 109
Y871
H
N
P
E
N
Q
S
Y
L
I
A
Y
K
D
S
Site 110
S883
K
D
S
Q
L
I
V
S
S
A
K
A
L
Q
H
Site 111
Y898
C
E
E
L
I
Q
Q
Y
N
R
A
E
D
S
I
Site 112
S904
Q
Y
N
R
A
E
D
S
I
C
L
A
D
S
K
Site 113
S910
D
S
I
C
L
A
D
S
K
P
L
P
H
Q
N
Site 114
T941
I
G
V
L
L
N
L
T
N
D
N
E
W
G
S
Site 115
Y971
C
V
L
Q
V
P
K
Y
L
P
Q
E
Q
R
F
Site 116
Y994
L
L
I
N
L
V
E
Y
S
A
R
N
R
H
C
Site 117
T1007
H
C
L
V
N
M
E
T
S
C
S
F
D
S
S
Site 118
S1010
V
N
M
E
T
S
C
S
F
D
S
S
I
C
S
Site 119
S1013
E
T
S
C
S
F
D
S
S
I
C
S
G
E
G
Site 120
S1014
T
S
C
S
F
D
S
S
I
C
S
G
E
G
D
Site 121
S1017
S
F
D
S
S
I
C
S
G
E
G
D
D
S
L
Site 122
S1023
C
S
G
E
G
D
D
S
L
R
I
G
G
Q
V
Site 123
S1052
R
A
A
Q
L
A
E
S
K
T
D
E
L
I
K
Site 124
T1063
E
L
I
K
D
A
P
T
T
Q
H
D
K
S
G
Site 125
T1064
L
I
K
D
A
P
T
T
Q
H
D
K
S
G
E
Site 126
S1069
P
T
T
Q
H
D
K
S
G
E
W
Q
E
T
S
Site 127
T1075
K
S
G
E
W
Q
E
T
S
G
E
I
Q
W
V
Site 128
S1076
S
G
E
W
Q
E
T
S
G
E
I
Q
W
V
S
Site 129
S1083
S
G
E
I
Q
W
V
S
T
E
K
T
D
G
T
Site 130
T1087
Q
W
V
S
T
E
K
T
D
G
T
E
E
K
H
Site 131
T1090
S
T
E
K
T
D
G
T
E
E
K
H
K
K
E
Site 132
T1142
E
S
P
I
N
V
T
T
V
R
E
Y
L
P
E
Site 133
Y1146
N
V
T
T
V
R
E
Y
L
P
E
G
D
F
S
Site 134
S1153
Y
L
P
E
G
D
F
S
I
M
T
E
M
L
K
Site 135
S1179
V
G
T
T
G
Q
K
S
I
S
R
V
I
E
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation