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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMC3
Full Name:
Transmembrane channel-like protein 3
Alias:
Type:
Mass (Da):
125868
Number AA:
1102
UniProt ID:
Q7Z5M5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
K
T
S
K
A
S
Q
R
Y
R
G
I
R
Site 2
S18
R
G
I
R
R
N
A
S
Q
C
Y
L
Y
Q
E
Site 3
Y21
R
R
N
A
S
Q
C
Y
L
Y
Q
E
S
L
L
Site 4
Y23
N
A
S
Q
C
Y
L
Y
Q
E
S
L
L
L
N
Site 5
S26
Q
C
Y
L
Y
Q
E
S
L
L
L
N
L
D
D
Site 6
S34
L
L
L
N
L
D
D
S
F
S
A
D
E
T
G
Site 7
S36
L
N
L
D
D
S
F
S
A
D
E
T
G
D
S
Site 8
T40
D
S
F
S
A
D
E
T
G
D
S
N
D
P
E
Site 9
S43
S
A
D
E
T
G
D
S
N
D
P
E
Q
I
F
Site 10
T69
N
I
R
C
R
P
W
T
M
G
Q
K
L
R
A
Site 11
T92
L
K
F
E
G
R
L
T
R
T
R
G
Y
Q
A
Site 12
Y97
R
L
T
R
T
R
G
Y
Q
A
A
G
A
E
L
Site 13
S131
M
R
I
K
K
I
E
S
H
F
G
S
G
V
A
Site 14
S175
I
A
G
Q
P
F
G
S
T
A
R
K
T
I
P
Site 15
T176
A
G
Q
P
F
G
S
T
A
R
K
T
I
P
K
Site 16
T180
F
G
S
T
A
R
K
T
I
P
K
E
Q
V
S
Site 17
T194
S
S
A
Q
D
L
D
T
V
W
S
L
G
G
Y
Site 18
S197
Q
D
L
D
T
V
W
S
L
G
G
Y
L
Q
Y
Site 19
Y209
L
Q
Y
S
V
L
F
Y
G
Y
Y
G
R
E
R
Site 20
Y212
S
V
L
F
Y
G
Y
Y
G
R
E
R
K
I
G
Site 21
Y223
R
K
I
G
R
A
G
Y
R
L
P
L
A
Y
F
Site 22
S252
L
K
R
M
A
K
N
S
R
T
S
L
A
S
A
Site 23
T254
R
M
A
K
N
S
R
T
S
L
A
S
A
S
N
Site 24
S255
M
A
K
N
S
R
T
S
L
A
S
A
S
N
E
Site 25
S258
N
S
R
T
S
L
A
S
A
S
N
E
N
Y
T
Site 26
S260
R
T
S
L
A
S
A
S
N
E
N
Y
T
F
C
Site 27
Y264
A
S
A
S
N
E
N
Y
T
F
C
W
R
V
F
Site 28
S286
G
N
P
E
A
A
E
S
K
T
A
A
I
V
N
Site 29
S308
E
E
Q
E
K
K
K
S
K
N
L
A
V
T
I
Site 30
S343
I
Y
F
V
V
D
R
S
Q
K
L
E
Q
S
K
Site 31
S349
R
S
Q
K
L
E
Q
S
K
K
E
L
T
L
W
Site 32
T354
E
Q
S
K
K
E
L
T
L
W
E
K
N
E
V
Site 33
T389
L
E
M
Y
H
P
R
T
T
L
R
F
Q
L
A
Site 34
T390
E
M
Y
H
P
R
T
T
L
R
F
Q
L
A
R
Site 35
S421
L
D
K
V
N
S
M
S
I
E
E
M
A
T
K
Site 36
T439
S
H
W
I
D
S
T
T
F
F
A
T
R
T
A
Site 37
S453
A
P
E
E
E
K
W
S
T
S
R
P
G
M
G
Site 38
T454
P
E
E
E
K
W
S
T
S
R
P
G
M
G
L
Site 39
S455
E
E
E
K
W
S
T
S
R
P
G
M
G
L
R
Site 40
T466
M
G
L
R
R
N
N
T
W
A
L
E
E
T
S
Site 41
Y477
E
E
T
S
I
S
A
Y
T
M
P
L
I
K
A
Site 42
S493
K
T
S
L
H
T
Q
S
P
Q
D
Q
C
W
E
Site 43
Y502
Q
D
Q
C
W
E
T
Y
V
G
Q
E
M
L
K
Site 44
Y539
F
V
R
Y
L
S
D
Y
W
C
W
D
L
E
S
Site 45
Y551
L
E
S
K
F
P
E
Y
G
E
F
K
I
A
E
Site 46
S613
H
Q
Q
V
F
R
A
S
R
S
N
N
F
Y
L
Site 47
S644
A
I
V
R
Y
K
P
S
L
N
C
G
P
F
S
Site 48
S651
S
L
N
C
G
P
F
S
G
Q
E
K
I
Y
D
Site 49
Y657
F
S
G
Q
E
K
I
Y
D
I
V
S
E
T
I
Site 50
S661
E
K
I
Y
D
I
V
S
E
T
I
E
K
D
F
Site 51
S705
Y
L
Q
S
I
A
R
S
L
K
L
S
N
H
Q
Site 52
S709
I
A
R
S
L
K
L
S
N
H
Q
L
K
M
Q
Site 53
T741
G
K
A
A
R
I
Q
T
Q
E
E
S
T
K
K
Site 54
S745
R
I
Q
T
Q
E
E
S
T
K
K
L
P
N
D
Site 55
S753
T
K
K
L
P
N
D
S
D
L
T
S
Q
L
S
Site 56
T756
L
P
N
D
S
D
L
T
S
Q
L
S
S
A
H
Site 57
S757
P
N
D
S
D
L
T
S
Q
L
S
S
A
H
S
Site 58
S760
S
D
L
T
S
Q
L
S
S
A
H
S
G
T
P
Site 59
S761
D
L
T
S
Q
L
S
S
A
H
S
G
T
P
Q
Site 60
S764
S
Q
L
S
S
A
H
S
G
T
P
Q
N
N
G
Site 61
T766
L
S
S
A
H
S
G
T
P
Q
N
N
G
N
V
Site 62
S778
G
N
V
A
H
F
D
S
G
S
S
K
S
G
R
Site 63
S780
V
A
H
F
D
S
G
S
S
K
S
G
R
I
E
Site 64
S783
F
D
S
G
S
S
K
S
G
R
I
E
T
V
A
Site 65
T788
S
K
S
G
R
I
E
T
V
A
Q
S
M
P
Q
Site 66
S792
R
I
E
T
V
A
Q
S
M
P
Q
S
P
R
P
Site 67
S796
V
A
Q
S
M
P
Q
S
P
R
P
G
D
R
A
Site 68
S805
R
P
G
D
R
A
P
S
S
P
L
P
G
V
P
Site 69
S806
P
G
D
R
A
P
S
S
P
L
P
G
V
P
K
Site 70
S814
P
L
P
G
V
P
K
S
R
L
E
H
E
T
N
Site 71
T820
K
S
R
L
E
H
E
T
N
R
Y
L
H
G
L
Site 72
Y823
L
E
H
E
T
N
R
Y
L
H
G
L
C
A
S
Site 73
S830
Y
L
H
G
L
C
A
S
T
S
D
L
H
R
N
Site 74
S832
H
G
L
C
A
S
T
S
D
L
H
R
N
R
S
Site 75
S839
S
D
L
H
R
N
R
S
R
T
P
M
T
F
T
Site 76
T841
L
H
R
N
R
S
R
T
P
M
T
F
T
T
H
Site 77
T844
N
R
S
R
T
P
M
T
F
T
T
H
I
E
D
Site 78
S854
T
H
I
E
D
V
H
S
E
P
L
F
R
K
D
Site 79
S875
P
H
R
G
P
Q
A
S
T
L
L
A
Q
G
P
Site 80
Y889
P
R
P
H
A
P
R
Y
Y
V
I
N
E
C
D
Site 81
Y890
R
P
H
A
P
R
Y
Y
V
I
N
E
C
D
S
Site 82
Y898
V
I
N
E
C
D
S
Y
K
K
K
H
L
N
V
Site 83
S916
R
H
F
K
I
D
A
S
G
D
I
V
E
L
Y
Site 84
Y923
S
G
D
I
V
E
L
Y
P
R
N
V
R
Q
Y
Site 85
Y930
Y
P
R
N
V
R
Q
Y
A
S
R
V
P
R
Q
Site 86
S940
R
V
P
R
Q
P
P
S
P
Q
L
S
E
E
E
Site 87
S944
Q
P
P
S
P
Q
L
S
E
E
E
E
E
T
P
Site 88
T950
L
S
E
E
E
E
E
T
P
S
R
D
W
I
K
Site 89
S952
E
E
E
E
E
T
P
S
R
D
W
I
K
R
S
Site 90
S959
S
R
D
W
I
K
R
S
L
P
P
R
S
L
I
Site 91
S964
K
R
S
L
P
P
R
S
L
I
D
L
R
R
A
Site 92
Y975
L
R
R
A
P
H
F
Y
I
G
E
R
S
E
S
Site 93
S980
H
F
Y
I
G
E
R
S
E
S
Q
T
R
D
P
Site 94
S982
Y
I
G
E
R
S
E
S
Q
T
R
D
P
E
H
Site 95
T984
G
E
R
S
E
S
Q
T
R
D
P
E
H
Q
G
Site 96
Y995
E
H
Q
G
R
V
H
Y
K
S
W
N
E
D
F
Site 97
Y1011
G
H
L
E
R
P
A
Y
V
P
R
K
P
R
S
Site 98
S1018
Y
V
P
R
K
P
R
S
R
N
F
Q
Y
P
Q
Site 99
Y1023
P
R
S
R
N
F
Q
Y
P
Q
P
P
L
K
P
Site 100
S1039
G
K
P
R
F
E
P
S
L
T
E
S
D
S
V
Site 101
T1041
P
R
F
E
P
S
L
T
E
S
D
S
V
S
A
Site 102
S1043
F
E
P
S
L
T
E
S
D
S
V
S
A
A
S
Site 103
S1045
P
S
L
T
E
S
D
S
V
S
A
A
S
S
S
Site 104
S1047
L
T
E
S
D
S
V
S
A
A
S
S
S
D
Q
Site 105
S1050
S
D
S
V
S
A
A
S
S
S
D
Q
Q
N
S
Site 106
S1051
D
S
V
S
A
A
S
S
S
D
Q
Q
N
S
S
Site 107
S1052
S
V
S
A
A
S
S
S
D
Q
Q
N
S
S
A
Site 108
S1058
S
S
D
Q
Q
N
S
S
A
D
Q
Y
L
Q
V
Site 109
Y1062
Q
N
S
S
A
D
Q
Y
L
Q
V
T
H
S
Q
Site 110
S1068
Q
Y
L
Q
V
T
H
S
Q
G
R
F
P
R
S
Site 111
S1075
S
Q
G
R
F
P
R
S
V
G
Q
P
S
R
R
Site 112
S1080
P
R
S
V
G
Q
P
S
R
R
K
A
K
S
G
Site 113
S1086
P
S
R
R
K
A
K
S
G
Q
E
L
T
V
D
Site 114
T1091
A
K
S
G
Q
E
L
T
V
D
L
D
D
L
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation