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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLN
Full Name:
DNA polymerase nu
Alias:
Type:
Mass (Da):
100307
Number AA:
900
UniProt ID:
Q7Z5Q5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
S
V
A
Q
K
I
M
S
A
M
H
S
G
D
L
Site 2
S30
K
I
M
S
A
M
H
S
G
D
L
V
D
S
K
Site 3
S36
H
S
G
D
L
V
D
S
K
T
W
G
K
S
T
Site 4
T38
G
D
L
V
D
S
K
T
W
G
K
S
T
E
T
Site 5
S42
D
S
K
T
W
G
K
S
T
E
T
M
E
V
I
Site 6
S52
T
M
E
V
I
N
K
S
S
V
K
Y
S
V
Q
Site 7
Y56
I
N
K
S
S
V
K
Y
S
V
Q
L
E
D
R
Site 8
S57
N
K
S
S
V
K
Y
S
V
Q
L
E
D
R
K
Site 9
T65
V
Q
L
E
D
R
K
T
Q
S
P
E
K
K
D
Site 10
S67
L
E
D
R
K
T
Q
S
P
E
K
K
D
L
K
Site 11
S75
P
E
K
K
D
L
K
S
L
R
S
Q
T
S
R
Site 12
S78
K
D
L
K
S
L
R
S
Q
T
S
R
G
S
A
Site 13
T80
L
K
S
L
R
S
Q
T
S
R
G
S
A
K
L
Site 14
S81
K
S
L
R
S
Q
T
S
R
G
S
A
K
L
S
Site 15
S84
R
S
Q
T
S
R
G
S
A
K
L
S
P
Q
S
Site 16
S88
S
R
G
S
A
K
L
S
P
Q
S
F
S
V
R
Site 17
S91
S
A
K
L
S
P
Q
S
F
S
V
R
L
T
D
Site 18
S93
K
L
S
P
Q
S
F
S
V
R
L
T
D
Q
L
Site 19
T97
Q
S
F
S
V
R
L
T
D
Q
L
S
A
D
Q
Site 20
S101
V
R
L
T
D
Q
L
S
A
D
Q
K
Q
K
S
Site 21
S108
S
A
D
Q
K
Q
K
S
I
S
S
L
T
L
S
Site 22
S110
D
Q
K
Q
K
S
I
S
S
L
T
L
S
S
C
Site 23
S111
Q
K
Q
K
S
I
S
S
L
T
L
S
S
C
L
Site 24
Y122
S
S
C
L
I
P
Q
Y
N
Q
E
A
S
V
L
Site 25
Y161
L
K
R
K
H
I
T
Y
N
N
L
S
E
K
T
Site 26
S169
N
N
L
S
E
K
T
S
K
Q
M
A
L
E
E
Site 27
T178
Q
M
A
L
E
E
D
T
D
D
A
E
G
Y
L
Site 28
Y184
D
T
D
D
A
E
G
Y
L
N
S
G
N
S
G
Site 29
S190
G
Y
L
N
S
G
N
S
G
A
L
K
K
H
F
Site 30
T239
T
Q
L
G
A
D
Q
T
P
V
S
S
V
R
G
Site 31
Y282
V
S
D
D
P
C
I
Y
I
Q
I
E
H
S
A
Site 32
S359
A
A
W
L
I
D
P
S
D
A
T
P
S
F
E
Site 33
T362
L
I
D
P
S
D
A
T
P
S
F
E
D
L
V
Site 34
S364
D
P
S
D
A
T
P
S
F
E
D
L
V
E
K
Site 35
Y372
F
E
D
L
V
E
K
Y
C
E
K
S
I
T
V
Site 36
S376
V
E
K
Y
C
E
K
S
I
T
V
K
V
N
S
Site 37
T378
K
Y
C
E
K
S
I
T
V
K
V
N
S
T
Y
Site 38
S383
S
I
T
V
K
V
N
S
T
Y
G
N
S
S
R
Site 39
T384
I
T
V
K
V
N
S
T
Y
G
N
S
S
R
N
Site 40
Y385
T
V
K
V
N
S
T
Y
G
N
S
S
R
N
I
Site 41
S388
V
N
S
T
Y
G
N
S
S
R
N
I
V
N
Q
Site 42
T403
N
V
R
E
N
L
K
T
L
Y
R
L
T
M
D
Site 43
Y418
L
C
S
K
L
K
D
Y
G
L
W
Q
L
F
R
Site 44
T453
N
K
E
E
M
E
K
T
S
A
L
L
G
A
R
Site 45
S480
G
E
R
F
L
I
T
S
N
N
Q
L
R
E
I
Site 46
S498
K
L
K
L
H
L
L
S
Q
R
N
S
L
P
R
Site 47
S502
H
L
L
S
Q
R
N
S
L
P
R
T
G
L
Q
Site 48
T506
Q
R
N
S
L
P
R
T
G
L
Q
K
Y
P
S
Site 49
Y511
P
R
T
G
L
Q
K
Y
P
S
T
S
E
A
V
Site 50
S513
T
G
L
Q
K
Y
P
S
T
S
E
A
V
L
N
Site 51
S515
L
Q
K
Y
P
S
T
S
E
A
V
L
N
A
L
Site 52
S543
R
Q
V
H
K
I
K
S
T
F
V
D
G
L
L
Site 53
S557
L
A
C
M
K
K
G
S
I
S
S
T
W
N
Q
Site 54
T561
K
K
G
S
I
S
S
T
W
N
Q
T
G
T
V
Site 55
T567
S
T
W
N
Q
T
G
T
V
T
G
R
L
S
A
Site 56
T569
W
N
Q
T
G
T
V
T
G
R
L
S
A
K
H
Site 57
S573
G
T
V
T
G
R
L
S
A
K
H
P
N
I
Q
Site 58
T591
K
H
P
I
Q
I
T
T
P
K
N
F
K
G
K
Site 59
T604
G
K
E
D
K
I
L
T
I
S
P
R
A
M
F
Site 60
S613
S
P
R
A
M
F
V
S
S
K
G
H
T
F
L
Site 61
T633
Q
I
E
L
R
I
L
T
H
L
S
G
D
P
E
Site 62
S648
L
L
K
L
F
Q
E
S
E
R
D
D
V
F
S
Site 63
S655
S
E
R
D
D
V
F
S
T
L
T
S
Q
W
K
Site 64
T656
E
R
D
D
V
F
S
T
L
T
S
Q
W
K
D
Site 65
S659
D
V
F
S
T
L
T
S
Q
W
K
D
V
P
V
Site 66
T677
T
H
A
D
R
E
Q
T
K
K
V
V
Y
A
V
Site 67
S710
E
A
A
Q
F
L
E
S
F
L
Q
K
Y
K
K
Site 68
Y715
L
E
S
F
L
Q
K
Y
K
K
I
K
D
F
A
Site 69
S771
V
N
F
V
V
Q
G
S
A
A
D
L
C
K
L
Site 70
S827
L
V
R
R
T
M
E
S
L
E
Q
V
Q
A
L
Site 71
S847
V
P
L
K
V
S
L
S
A
G
R
S
W
G
H
Site 72
T871
P
P
P
G
P
C
R
T
E
S
P
S
N
S
L
Site 73
S873
P
G
P
C
R
T
E
S
P
S
N
S
L
A
A
Site 74
S875
P
C
R
T
E
S
P
S
N
S
L
A
A
P
G
Site 75
S877
R
T
E
S
P
S
N
S
L
A
A
P
G
S
P
Site 76
S883
N
S
L
A
A
P
G
S
P
A
S
T
Q
P
P
Site 77
S886
A
A
P
G
S
P
A
S
T
Q
P
P
P
L
H
Site 78
T887
A
P
G
S
P
A
S
T
Q
P
P
P
L
H
F
Site 79
S895
Q
P
P
P
L
H
F
S
P
S
F
C
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation