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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPRED1
Full Name:
Sprouty-related, EVH1 domain-containing protein 1
Alias:
EVH1/sprouty domain containing protein; FLJ33903; SPRE1; spred-1; sprouty-related protein 1 with EVH-1 domain; sprouty-related, EVH1 domain containing 1; sprouty-related, EVH1 domain containing protein 1; suppressor of Ras/MAPK activation
Type:
Inhibitor protein
Mass (Da):
50477
Number AA:
444
UniProt ID:
Q7Z699
International Prot ID:
IPI00166291
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005173
PhosphoSite+
KinaseNET
Biological Process:
GO:0000188
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
S
E
E
T
A
T
S
D
N
D
N
S
Y
Site 2
S8
M
S
E
E
T
A
T
S
D
N
D
N
S
Y
A
Site 3
Y14
T
S
D
N
D
N
S
Y
A
R
V
R
A
V
V
Site 4
T23
R
V
R
A
V
V
M
T
R
D
D
S
S
G
G
Site 5
S27
V
V
M
T
R
D
D
S
S
G
G
W
L
P
L
Site 6
S28
V
M
T
R
D
D
S
S
G
G
W
L
P
L
G
Site 7
Y82
M
L
K
K
D
L
I
Y
N
K
V
T
P
T
F
Site 8
T102
D
D
K
K
F
G
L
T
F
Q
S
P
A
D
A
Site 9
S105
K
F
G
L
T
F
Q
S
P
A
D
A
R
A
F
Site 10
S124
R
R
A
I
E
D
I
S
Q
G
C
P
E
S
K
Site 11
S130
I
S
Q
G
C
P
E
S
K
N
E
A
E
G
A
Site 12
S147
L
Q
A
N
E
E
D
S
S
S
S
L
V
K
D
Site 13
S148
Q
A
N
E
E
D
S
S
S
S
L
V
K
D
H
Site 14
S149
A
N
E
E
D
S
S
S
S
L
V
K
D
H
L
Site 15
S150
N
E
E
D
S
S
S
S
L
V
K
D
H
L
F
Site 16
T161
D
H
L
F
Q
Q
E
T
V
V
T
S
E
P
Y
Site 17
T164
F
Q
Q
E
T
V
V
T
S
E
P
Y
R
S
S
Site 18
Y168
T
V
V
T
S
E
P
Y
R
S
S
N
I
R
P
Site 19
S170
V
T
S
E
P
Y
R
S
S
N
I
R
P
S
P
Site 20
S171
T
S
E
P
Y
R
S
S
N
I
R
P
S
P
F
Site 21
S176
R
S
S
N
I
R
P
S
P
F
E
D
L
N
A
Site 22
Y187
D
L
N
A
R
R
V
Y
M
Q
S
Q
A
N
Q
Site 23
T196
Q
S
Q
A
N
Q
I
T
F
G
Q
P
G
L
D
Site 24
S208
G
L
D
I
Q
S
R
S
M
E
Y
V
Q
R
Q
Site 25
Y211
I
Q
S
R
S
M
E
Y
V
Q
R
Q
I
S
K
Site 26
S217
E
Y
V
Q
R
Q
I
S
K
E
C
G
S
L
K
Site 27
S222
Q
I
S
K
E
C
G
S
L
K
S
Q
N
R
V
Site 28
S225
K
E
C
G
S
L
K
S
Q
N
R
V
P
L
K
Site 29
S233
Q
N
R
V
P
L
K
S
I
R
H
V
S
F
Q
Site 30
S238
L
K
S
I
R
H
V
S
F
Q
D
E
D
E
I
Site 31
Y258
R
D
I
L
I
R
R
Y
A
D
Y
R
H
P
D
Site 32
Y261
L
I
R
R
Y
A
D
Y
R
H
P
D
M
W
K
Site 33
S278
L
E
R
D
D
A
D
S
S
I
Q
F
S
K
P
Site 34
S279
E
R
D
D
A
D
S
S
I
Q
F
S
K
P
D
Site 35
S283
A
D
S
S
I
Q
F
S
K
P
D
S
K
K
S
Site 36
S287
I
Q
F
S
K
P
D
S
K
K
S
D
Y
L
Y
Site 37
S290
S
K
P
D
S
K
K
S
D
Y
L
Y
S
C
G
Site 38
Y292
P
D
S
K
K
S
D
Y
L
Y
S
C
G
D
E
Site 39
Y294
S
K
K
S
D
Y
L
Y
S
C
G
D
E
T
K
Site 40
S295
K
K
S
D
Y
L
Y
S
C
G
D
E
T
K
L
Site 41
T300
L
Y
S
C
G
D
E
T
K
L
S
S
P
K
D
Site 42
S303
C
G
D
E
T
K
L
S
S
P
K
D
S
V
V
Site 43
S304
G
D
E
T
K
L
S
S
P
K
D
S
V
V
F
Site 44
S308
K
L
S
S
P
K
D
S
V
V
F
K
T
Q
P
Site 45
T313
K
D
S
V
V
F
K
T
Q
P
S
S
L
K
I
Site 46
S317
V
F
K
T
Q
P
S
S
L
K
I
K
K
S
K
Site 47
S323
S
S
L
K
I
K
K
S
K
R
R
K
E
D
G
Site 48
S333
R
K
E
D
G
E
R
S
R
C
V
Y
C
Q
E
Site 49
Y337
G
E
R
S
R
C
V
Y
C
Q
E
R
F
N
H
Site 50
Y364
D
P
I
K
R
C
I
Y
Q
V
S
C
M
L
C
Site 51
Y377
L
C
A
E
S
M
L
Y
H
C
M
S
D
S
E
Site 52
S381
S
M
L
Y
H
C
M
S
D
S
E
G
D
F
S
Site 53
S383
L
Y
H
C
M
S
D
S
E
G
D
F
S
D
P
Site 54
S388
S
D
S
E
G
D
F
S
D
P
C
S
C
D
T
Site 55
S392
G
D
F
S
D
P
C
S
C
D
T
S
D
D
K
Site 56
T395
S
D
P
C
S
C
D
T
S
D
D
K
F
C
L
Site 57
S396
D
P
C
S
C
D
T
S
D
D
K
F
C
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation