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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH3RF1
Full Name:
Putative E3 ubiquitin-protein ligase SH3RF1
Alias:
EC 6.3.2.-; POSH; Ring finger protein 142; RNF142; SH3 domain containing ring finger; SH3 domain-containing RING finger protein 1; SH3 multiple domains 2
Type:
EC 6.3.2.-; Ligase; Adaptor/scaffold
Mass (Da):
93129
Number AA:
888
UniProt ID:
Q7Z6J0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030027
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0008270
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T54
L
R
C
P
E
C
R
T
L
V
G
S
G
V
E
Site 2
S58
E
C
R
T
L
V
G
S
G
V
E
E
L
P
S
Site 3
T94
G
G
S
G
T
N
C
T
N
A
L
R
S
Q
S
Site 4
S99
N
C
T
N
A
L
R
S
Q
S
S
T
V
A
N
Site 5
S101
T
N
A
L
R
S
Q
S
S
T
V
A
N
C
S
Site 6
S102
N
A
L
R
S
Q
S
S
T
V
A
N
C
S
S
Site 7
T103
A
L
R
S
Q
S
S
T
V
A
N
C
S
S
K
Site 8
S108
S
S
T
V
A
N
C
S
S
K
D
L
Q
S
S
Site 9
S115
S
S
K
D
L
Q
S
S
Q
G
G
Q
Q
P
R
Site 10
S125
G
Q
Q
P
R
V
Q
S
W
S
P
P
V
R
G
Site 11
S127
Q
P
R
V
Q
S
W
S
P
P
V
R
G
I
P
Site 12
Y143
L
P
C
A
K
A
L
Y
N
Y
E
G
K
E
P
Site 13
Y145
C
A
K
A
L
Y
N
Y
E
G
K
E
P
G
D
Site 14
Y205
P
P
Q
C
K
A
L
Y
D
F
E
V
K
D
K
Site 15
T228
F
A
K
D
D
V
L
T
V
I
R
R
V
D
E
Site 16
S281
V
D
A
G
E
C
S
S
A
A
A
Q
S
S
T
Site 17
S287
S
S
A
A
A
Q
S
S
T
A
P
K
H
S
D
Site 18
S293
S
S
T
A
P
K
H
S
D
T
K
K
N
T
K
Site 19
S304
K
N
T
K
K
R
H
S
F
T
S
L
T
M
A
Site 20
T306
T
K
K
R
H
S
F
T
S
L
T
M
A
N
K
Site 21
S307
K
K
R
H
S
F
T
S
L
T
M
A
N
K
S
Site 22
T309
R
H
S
F
T
S
L
T
M
A
N
K
S
S
Q
Site 23
S314
S
L
T
M
A
N
K
S
S
Q
A
S
Q
N
R
Site 24
S315
L
T
M
A
N
K
S
S
Q
A
S
Q
N
R
H
Site 25
S318
A
N
K
S
S
Q
A
S
Q
N
R
H
S
M
E
Site 26
S323
Q
A
S
Q
N
R
H
S
M
E
I
S
P
P
V
Site 27
S327
N
R
H
S
M
E
I
S
P
P
V
L
I
S
S
Site 28
S335
P
P
V
L
I
S
S
S
N
P
T
A
A
A
R
Site 29
T338
L
I
S
S
S
N
P
T
A
A
A
R
I
S
E
Site 30
S355
G
L
S
C
S
A
P
S
Q
V
H
I
S
T
T
Site 31
S372
I
V
T
P
P
P
S
S
P
V
T
T
G
P
S
Site 32
T375
P
P
P
S
S
P
V
T
T
G
P
S
F
T
F
Site 33
T376
P
P
S
S
P
V
T
T
G
P
S
F
T
F
P
Site 34
S379
S
P
V
T
T
G
P
S
F
T
F
P
S
D
V
Site 35
T381
V
T
T
G
P
S
F
T
F
P
S
D
V
P
Y
Site 36
S384
G
P
S
F
T
F
P
S
D
V
P
Y
Q
A
A
Site 37
T394
P
Y
Q
A
A
L
G
T
L
N
P
P
L
P
P
Site 38
S434
G
P
R
P
M
A
G
S
T
D
Q
I
A
H
L
Site 39
T445
I
A
H
L
R
P
Q
T
R
P
S
V
Y
V
A
Site 40
S448
L
R
P
Q
T
R
P
S
V
Y
V
A
I
Y
P
Site 41
Y450
P
Q
T
R
P
S
V
Y
V
A
I
Y
P
Y
T
Site 42
Y454
P
S
V
Y
V
A
I
Y
P
Y
T
P
R
K
E
Site 43
Y456
V
Y
V
A
I
Y
P
Y
T
P
R
K
E
D
E
Site 44
T457
Y
V
A
I
Y
P
Y
T
P
R
K
E
D
E
L
Site 45
S491
K
G
T
S
M
H
T
S
K
I
G
V
F
P
G
Site 46
T509
A
P
V
T
R
A
V
T
N
A
S
Q
A
K
V
Site 47
S512
T
R
A
V
T
N
A
S
Q
A
K
V
P
M
S
Site 48
S519
S
Q
A
K
V
P
M
S
T
A
G
Q
T
S
R
Site 49
T529
G
Q
T
S
R
G
V
T
M
V
S
P
S
T
A
Site 50
S532
S
R
G
V
T
M
V
S
P
S
T
A
G
G
P
Site 51
S534
G
V
T
M
V
S
P
S
T
A
G
G
P
A
Q
Site 52
S551
Q
G
N
G
V
A
G
S
P
S
V
V
P
A
A
Site 53
S568
S
A
A
H
I
Q
T
S
P
Q
A
K
V
L
L
Site 54
T578
A
K
V
L
L
H
M
T
G
Q
M
T
V
N
Q
Site 55
T582
L
H
M
T
G
Q
M
T
V
N
Q
A
R
N
A
Site 56
T592
Q
A
R
N
A
V
R
T
V
A
A
H
N
Q
E
Site 57
T602
A
H
N
Q
E
R
P
T
A
A
V
T
P
I
Q
Site 58
T606
E
R
P
T
A
A
V
T
P
I
Q
V
Q
N
A
Site 59
S624
S
P
A
S
V
G
L
S
H
H
S
L
A
S
P
Site 60
S627
S
V
G
L
S
H
H
S
L
A
S
P
Q
P
A
Site 61
S630
L
S
H
H
S
L
A
S
P
Q
P
A
P
L
M
Site 62
T644
M
P
G
S
A
T
H
T
A
A
I
S
I
S
R
Site 63
T670
P
L
T
S
P
S
I
T
S
A
S
L
E
A
E
Site 64
S673
S
P
S
I
T
S
A
S
L
E
A
E
P
S
G
Site 65
T684
E
P
S
G
R
I
V
T
V
L
P
G
L
P
T
Site 66
T691
T
V
L
P
G
L
P
T
S
P
D
S
A
S
S
Site 67
S692
V
L
P
G
L
P
T
S
P
D
S
A
S
S
A
Site 68
S695
G
L
P
T
S
P
D
S
A
S
S
A
C
G
N
Site 69
S697
P
T
S
P
D
S
A
S
S
A
C
G
N
S
S
Site 70
S698
T
S
P
D
S
A
S
S
A
C
G
N
S
S
A
Site 71
S704
S
S
A
C
G
N
S
S
A
T
K
P
D
K
D
Site 72
T706
A
C
G
N
S
S
A
T
K
P
D
K
D
S
K
Site 73
S712
A
T
K
P
D
K
D
S
K
K
E
K
K
G
L
Site 74
S724
K
G
L
L
K
L
L
S
G
A
S
T
K
R
K
Site 75
S727
L
K
L
L
S
G
A
S
T
K
R
K
P
R
V
Site 76
T728
K
L
L
S
G
A
S
T
K
R
K
P
R
V
S
Site 77
S735
T
K
R
K
P
R
V
S
P
P
A
S
P
T
L
Site 78
S739
P
R
V
S
P
P
A
S
P
T
L
E
V
E
L
Site 79
T741
V
S
P
P
A
S
P
T
L
E
V
E
L
G
S
Site 80
S772
G
G
H
G
R
A
G
S
C
P
V
D
G
D
G
Site 81
S800
D
A
F
H
R
K
A
S
S
L
D
S
A
V
P
Site 82
S801
A
F
H
R
K
A
S
S
L
D
S
A
V
P
I
Site 83
S804
R
K
A
S
S
L
D
S
A
V
P
I
A
P
P
Site 84
S818
P
P
R
Q
A
C
S
S
L
G
P
V
L
N
E
Site 85
S826
L
G
P
V
L
N
E
S
R
P
V
V
C
E
R
Site 86
S839
E
R
H
R
V
V
V
S
Y
P
P
Q
S
E
A
Site 87
Y840
R
H
R
V
V
V
S
Y
P
P
Q
S
E
A
E
Site 88
S844
V
V
S
Y
P
P
Q
S
E
A
E
L
E
L
K
Site 89
T870
E
D
G
W
F
K
G
T
L
Q
R
N
G
K
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation