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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRMD5
Full Name:
FERM domain-containing protein 5
Alias:
FERM domain containing 5; FERM domain-containing 5; FLJ41022; MGC14161
Type:
Mass (Da):
65065
Number AA:
570
UniProt ID:
Q7Z6J6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008092
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
L
S
R
L
M
S
G
S
S
Site 2
S7
_
M
L
S
R
L
M
S
G
S
S
R
S
L
E
Site 3
S9
L
S
R
L
M
S
G
S
S
R
S
L
E
R
E
Site 4
S10
S
R
L
M
S
G
S
S
R
S
L
E
R
E
Y
Site 5
S12
L
M
S
G
S
S
R
S
L
E
R
E
Y
S
C
Site 6
Y17
S
R
S
L
E
R
E
Y
S
C
T
V
R
L
L
Site 7
S18
R
S
L
E
R
E
Y
S
C
T
V
R
L
L
D
Site 8
T20
L
E
R
E
Y
S
C
T
V
R
L
L
D
D
S
Site 9
S27
T
V
R
L
L
D
D
S
E
Y
T
C
T
I
Q
Site 10
Y29
R
L
L
D
D
S
E
Y
T
C
T
I
Q
R
D
Site 11
T32
D
D
S
E
Y
T
C
T
I
Q
R
D
A
K
G
Site 12
Y41
Q
R
D
A
K
G
Q
Y
L
F
D
L
L
C
H
Site 13
S77
H
W
L
E
F
T
K
S
V
V
K
Q
L
R
S
Site 14
S84
S
V
V
K
Q
L
R
S
Q
P
P
F
T
M
C
Site 15
T89
L
R
S
Q
P
P
F
T
M
C
F
R
V
K
F
Site 16
Y97
M
C
F
R
V
K
F
Y
P
A
D
P
A
A
L
Site 17
Y122
L
Q
I
K
R
D
L
Y
H
G
R
L
L
C
K
Site 18
Y148
L
Q
A
E
I
G
D
Y
D
S
G
K
H
P
E
Site 19
S150
A
E
I
G
D
Y
D
S
G
K
H
P
E
G
Y
Site 20
Y157
S
G
K
H
P
E
G
Y
S
S
K
F
Q
F
F
Site 21
S159
K
H
P
E
G
Y
S
S
K
F
Q
F
F
P
K
Site 22
T181
K
I
A
E
I
H
K
T
E
L
S
G
Q
T
P
Site 23
S184
E
I
H
K
T
E
L
S
G
Q
T
P
A
T
S
Site 24
T187
K
T
E
L
S
G
Q
T
P
A
T
S
E
L
N
Site 25
S191
S
G
Q
T
P
A
T
S
E
L
N
F
L
R
K
Site 26
T201
N
F
L
R
K
A
Q
T
L
E
T
Y
G
V
D
Site 27
T204
R
K
A
Q
T
L
E
T
Y
G
V
D
P
H
P
Site 28
T255
K
L
K
F
E
G
K
T
F
Y
L
Y
V
S
Q
Site 29
Y257
K
F
E
G
K
T
F
Y
L
Y
V
S
Q
K
E
Site 30
Y259
E
G
K
T
F
Y
L
Y
V
S
Q
K
E
E
K
Site 31
S261
K
T
F
Y
L
Y
V
S
Q
K
E
E
K
K
I
Site 32
Y272
E
K
K
I
I
L
T
Y
F
A
P
T
P
E
A
Site 33
S299
A
F
Y
K
L
E
K
S
S
Q
V
R
T
V
S
Site 34
S300
F
Y
K
L
E
K
S
S
Q
V
R
T
V
S
S
Site 35
T304
E
K
S
S
Q
V
R
T
V
S
S
S
N
L
F
Site 36
S306
S
S
Q
V
R
T
V
S
S
S
N
L
F
F
K
Site 37
S308
Q
V
R
T
V
S
S
S
N
L
F
F
K
G
S
Site 38
S315
S
N
L
F
F
K
G
S
R
F
R
Y
S
G
R
Site 39
Y319
F
K
G
S
R
F
R
Y
S
G
R
V
A
K
E
Site 40
S320
K
G
S
R
F
R
Y
S
G
R
V
A
K
E
V
Site 41
S349
H
R
A
G
M
V
P
S
R
S
C
P
S
I
T
Site 42
S351
A
G
M
V
P
S
R
S
C
P
S
I
T
H
G
Site 43
S354
V
P
S
R
S
C
P
S
I
T
H
G
P
R
L
Site 44
T356
S
R
S
C
P
S
I
T
H
G
P
R
L
S
S
Site 45
S362
I
T
H
G
P
R
L
S
S
V
P
R
T
R
R
Site 46
S363
T
H
G
P
R
L
S
S
V
P
R
T
R
R
R
Site 47
T367
R
L
S
S
V
P
R
T
R
R
R
A
V
H
I
Site 48
S375
R
R
R
A
V
H
I
S
I
M
E
G
L
E
S
Site 49
S382
S
I
M
E
G
L
E
S
L
R
D
S
A
H
S
Site 50
S386
G
L
E
S
L
R
D
S
A
H
S
T
P
V
R
Site 51
S389
S
L
R
D
S
A
H
S
T
P
V
R
S
T
S
Site 52
T390
L
R
D
S
A
H
S
T
P
V
R
S
T
S
H
Site 53
T395
H
S
T
P
V
R
S
T
S
H
G
D
T
F
L
Site 54
S396
S
T
P
V
R
S
T
S
H
G
D
T
F
L
P
Site 55
T400
R
S
T
S
H
G
D
T
F
L
P
H
V
R
S
Site 56
S407
T
F
L
P
H
V
R
S
S
R
T
D
S
N
E
Site 57
S408
F
L
P
H
V
R
S
S
R
T
D
S
N
E
R
Site 58
S412
V
R
S
S
R
T
D
S
N
E
R
V
A
V
I
Site 59
S455
Q
I
N
G
A
T
C
S
I
E
E
E
K
E
S
Site 60
S462
S
I
E
E
E
K
E
S
E
A
S
T
P
T
A
Site 61
S465
E
E
K
E
S
E
A
S
T
P
T
A
T
E
V
Site 62
T466
E
K
E
S
E
A
S
T
P
T
A
T
E
V
E
Site 63
S487
R
A
L
C
Q
G
H
S
G
P
E
E
E
Q
V
Site 64
T538
F
F
R
D
I
R
Q
T
P
E
F
E
Q
F
H
Site 65
Y546
P
E
F
E
Q
F
H
Y
Q
Y
F
C
P
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation