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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DKFZP434B0335
Full Name:
Tectonin beta-propeller repeat-containing protein 1
Alias:
FLJ23419; FLJ90593; KIAA1358; Tectonin beta-propeller repeat containing 1
Type:
Mass (Da):
129696
Number AA:
1165
UniProt ID:
Q7Z6L1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
D
L
F
G
R
V
Y
T
L
S
T
A
G
Q
Y
Site 2
Y72
I
R
R
R
E
E
A
Y
E
N
Q
R
W
N
P
Site 3
S96
L
S
D
R
W
G
W
S
D
V
S
G
L
Q
H
Site 4
S99
R
W
G
W
S
D
V
S
G
L
Q
H
R
P
L
Site 5
S113
L
D
R
V
A
L
P
S
P
H
W
E
W
E
S
Site 6
Y140
T
E
K
G
G
W
T
Y
A
I
D
F
P
A
T
Site 7
Y166
R
R
R
K
W
I
R
Y
R
R
Y
K
S
R
D
Site 8
Y169
K
W
I
R
Y
R
R
Y
K
S
R
D
I
W
A
Site 9
S195
P
D
P
F
N
D
L
S
V
G
G
W
E
I
T
Site 10
T202
S
V
G
G
W
E
I
T
E
E
P
V
G
R
L
Site 11
S215
R
L
S
V
W
A
V
S
L
Q
G
K
V
W
Y
Site 12
Y222
S
L
Q
G
K
V
W
Y
R
E
D
V
S
H
S
Site 13
S227
V
W
Y
R
E
D
V
S
H
S
N
P
E
G
S
Site 14
S229
Y
R
E
D
V
S
H
S
N
P
E
G
S
S
W
Site 15
S234
S
H
S
N
P
E
G
S
S
W
S
L
L
D
T
Site 16
S237
N
P
E
G
S
S
W
S
L
L
D
T
P
G
E
Site 17
S274
V
R
E
G
I
N
R
S
N
P
K
G
S
S
W
Site 18
S280
R
S
N
P
K
G
S
S
W
S
I
V
E
P
P
Site 19
S282
N
P
K
G
S
S
W
S
I
V
E
P
P
G
S
Site 20
S289
S
I
V
E
P
P
G
S
E
N
G
V
M
H
I
Site 21
S301
M
H
I
S
V
G
V
S
V
V
W
A
V
T
K
Site 22
Y357
G
C
E
D
R
A
V
Y
F
R
Q
G
V
T
P
Site 23
T363
V
Y
F
R
Q
G
V
T
P
S
E
L
S
G
K
Site 24
S384
A
A
R
E
C
D
R
S
H
S
G
S
S
S
S
Site 25
S386
R
E
C
D
R
S
H
S
G
S
S
S
S
L
L
Site 26
S388
C
D
R
S
H
S
G
S
S
S
S
L
L
S
A
Site 27
S389
D
R
S
H
S
G
S
S
S
S
L
L
S
A
G
Site 28
S390
R
S
H
S
G
S
S
S
S
L
L
S
A
G
C
Site 29
S391
S
H
S
G
S
S
S
S
L
L
S
A
G
C
F
Site 30
S394
G
S
S
S
S
L
L
S
A
G
C
F
F
G
D
Site 31
S406
F
G
D
E
V
R
G
S
G
E
S
A
P
S
D
Site 32
S409
E
V
R
G
S
G
E
S
A
P
S
D
T
D
A
Site 33
S412
G
S
G
E
S
A
P
S
D
T
D
A
S
S
E
Site 34
T414
G
E
S
A
P
S
D
T
D
A
S
S
E
V
E
Site 35
S417
A
P
S
D
T
D
A
S
S
E
V
E
R
P
G
Site 36
S418
P
S
D
T
D
A
S
S
E
V
E
R
P
G
P
Site 37
S437
P
A
E
P
L
D
D
S
K
N
A
T
G
N
S
Site 38
T441
L
D
D
S
K
N
A
T
G
N
S
A
S
G
L
Site 39
S444
S
K
N
A
T
G
N
S
A
S
G
L
G
A
G
Site 40
S446
N
A
T
G
N
S
A
S
G
L
G
A
G
R
T
Site 41
T453
S
G
L
G
A
G
R
T
A
E
D
T
V
E
D
Site 42
T457
A
G
R
T
A
E
D
T
V
E
D
A
C
P
A
Site 43
T474
S
R
E
A
R
P
N
T
H
P
G
P
A
P
T
Site 44
T481
T
H
P
G
P
A
P
T
P
A
E
L
P
W
T
Site 45
T488
T
P
A
E
L
P
W
T
N
I
D
L
K
E
A
Site 46
S502
A
K
K
V
P
S
H
S
A
A
G
F
P
E
T
Site 47
T509
S
A
A
G
F
P
E
T
T
S
L
S
S
L
G
Site 48
T587
K
Q
I
F
Q
Q
L
T
E
R
T
K
R
E
L
Site 49
Y600
E
L
E
N
F
R
H
Y
E
Q
A
V
E
Q
S
Site 50
S645
G
H
D
G
V
R
D
S
I
L
F
I
Y
Y
V
Site 51
Y650
R
D
S
I
L
F
I
Y
Y
V
V
H
E
E
K
Site 52
Y651
D
S
I
L
F
I
Y
Y
V
V
H
E
E
K
K
Site 53
Y659
V
V
H
E
E
K
K
Y
I
H
I
F
L
N
E
Site 54
S680
V
L
N
E
T
K
H
S
F
A
L
Y
T
P
E
Site 55
Y684
T
K
H
S
F
A
L
Y
T
P
E
R
T
R
Q
Site 56
T685
K
H
S
F
A
L
Y
T
P
E
R
T
R
Q
R
Site 57
T701
P
V
R
L
A
A
A
T
E
Q
D
M
N
D
W
Site 58
S719
L
S
L
S
C
C
E
S
R
K
V
Q
G
R
P
Site 59
S727
R
K
V
Q
G
R
P
S
P
Q
A
I
W
S
I
Site 60
S743
C
K
G
D
I
F
V
S
E
P
S
P
D
L
E
Site 61
S746
D
I
F
V
S
E
P
S
P
D
L
E
A
H
E
Site 62
Y793
Y
D
H
T
A
W
V
Y
T
G
G
Y
G
G
G
Site 63
S808
C
F
Q
G
L
A
S
S
T
S
N
I
Y
T
Q
Site 64
S810
Q
G
L
A
S
S
T
S
N
I
Y
T
Q
S
D
Site 65
T814
S
S
T
S
N
I
Y
T
Q
S
D
V
K
C
V
Site 66
T833
N
Q
R
W
N
P
V
T
G
Y
T
S
R
G
L
Site 67
Y835
R
W
N
P
V
T
G
Y
T
S
R
G
L
P
T
Site 68
T836
W
N
P
V
T
G
Y
T
S
R
G
L
P
T
D
Site 69
T842
Y
T
S
R
G
L
P
T
D
R
Y
M
W
S
D
Site 70
Y845
R
G
L
P
T
D
R
Y
M
W
S
D
A
S
G
Site 71
S848
P
T
D
R
Y
M
W
S
D
A
S
G
L
Q
E
Site 72
T861
Q
E
C
T
K
A
G
T
K
P
P
S
L
Q
W
Site 73
S865
K
A
G
T
K
P
P
S
L
Q
W
A
W
V
S
Site 74
S879
S
D
W
F
V
D
F
S
V
P
G
G
T
D
Q
Site 75
Y891
T
D
Q
E
G
W
Q
Y
A
S
D
F
P
A
S
Site 76
S898
Y
A
S
D
F
P
A
S
Y
H
G
S
K
T
M
Site 77
Y899
A
S
D
F
P
A
S
Y
H
G
S
K
T
M
K
Site 78
S902
F
P
A
S
Y
H
G
S
K
T
M
K
D
F
V
Site 79
T904
A
S
Y
H
G
S
K
T
M
K
D
F
V
R
R
Site 80
S938
P
I
A
L
R
D
V
S
I
I
P
E
S
P
G
Site 81
S943
D
V
S
I
I
P
E
S
P
G
A
E
G
S
G
Site 82
S949
E
S
P
G
A
E
G
S
G
H
S
I
A
L
W
Site 83
S978
S
E
L
N
P
A
G
S
S
W
L
H
V
G
T
Site 84
T985
S
S
W
L
H
V
G
T
D
Q
P
F
A
S
I
Site 85
S1008
W
A
V
A
R
D
G
S
A
F
Y
R
G
S
V
Site 86
S1014
G
S
A
F
Y
R
G
S
V
Y
P
S
Q
P
A
Site 87
Y1016
A
F
Y
R
G
S
V
Y
P
S
Q
P
A
G
D
Site 88
S1018
Y
R
G
S
V
Y
P
S
Q
P
A
G
D
C
W
Site 89
Y1026
Q
P
A
G
D
C
W
Y
H
I
P
S
P
P
R
Site 90
S1030
D
C
W
Y
H
I
P
S
P
P
R
Q
R
L
K
Site 91
S1040
R
Q
R
L
K
Q
V
S
A
G
Q
T
S
V
Y
Site 92
Y1047
S
A
G
Q
T
S
V
Y
A
L
D
E
N
G
N
Site 93
T1062
L
W
Y
R
Q
G
I
T
P
S
Y
P
Q
G
S
Site 94
S1064
Y
R
Q
G
I
T
P
S
Y
P
Q
G
S
S
W
Site 95
Y1065
R
Q
G
I
T
P
S
Y
P
Q
G
S
S
W
E
Site 96
S1070
P
S
Y
P
Q
G
S
S
W
E
H
V
S
N
N
Site 97
S1082
S
N
N
V
C
R
V
S
V
G
P
L
D
Q
V
Site 98
S1099
I
A
N
K
V
Q
G
S
H
S
L
S
R
G
T
Site 99
S1101
N
K
V
Q
G
S
H
S
L
S
R
G
T
V
C
Site 100
S1103
V
Q
G
S
H
S
L
S
R
G
T
V
C
H
R
Site 101
T1106
S
H
S
L
S
R
G
T
V
C
H
R
T
G
V
Site 102
Y1125
P
K
G
H
G
W
D
Y
G
I
G
G
G
W
D
Site 103
S1135
G
G
G
W
D
H
I
S
V
R
A
N
A
T
R
Site 104
T1141
I
S
V
R
A
N
A
T
R
A
P
R
S
S
S
Site 105
S1146
N
A
T
R
A
P
R
S
S
S
Q
E
Q
E
P
Site 106
S1147
A
T
R
A
P
R
S
S
S
Q
E
Q
E
P
S
Site 107
S1148
T
R
A
P
R
S
S
S
Q
E
Q
E
P
S
A
Site 108
S1154
S
S
Q
E
Q
E
P
S
A
P
P
E
A
H
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation