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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHH3
Full Name:
Pleckstrin homology domain-containing family H member 3
Alias:
PKHH3; pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
Type:
Mass (Da):
85326
Number AA:
793
UniProt ID:
Q7Z736
International Prot ID:
IPI00152977
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
F
T
L
L
H
R
D
Y
G
D
G
E
L
S
G
Site 2
S30
D
Y
G
D
G
E
L
S
G
D
G
D
E
D
E
Site 3
T41
D
E
D
E
D
E
E
T
F
E
L
R
T
P
S
Site 4
T46
E
E
T
F
E
L
R
T
P
S
P
A
G
G
G
Site 5
S48
T
F
E
L
R
T
P
S
P
A
G
G
G
R
G
Site 6
T62
G
P
L
E
V
T
L
T
Q
P
V
R
S
G
P
Site 7
S67
T
L
T
Q
P
V
R
S
G
P
V
S
N
R
L
Site 8
S71
P
V
R
S
G
P
V
S
N
R
L
Q
S
W
E
Site 9
S76
P
V
S
N
R
L
Q
S
W
E
E
T
W
S
L
Site 10
T80
R
L
Q
S
W
E
E
T
W
S
L
I
P
E
K
Site 11
S82
Q
S
W
E
E
T
W
S
L
I
P
E
K
G
L
Site 12
Y103
I
V
V
K
G
W
L
Y
R
E
P
R
G
G
G
Site 13
S128
W
F
V
L
T
R
D
S
L
D
Q
F
S
S
S
Site 14
S133
R
D
S
L
D
Q
F
S
S
S
G
K
G
A
R
Site 15
S134
D
S
L
D
Q
F
S
S
S
G
K
G
A
R
R
Site 16
S135
S
L
D
Q
F
S
S
S
G
K
G
A
R
R
L
Site 17
T163
P
E
R
R
R
K
E
T
G
L
W
S
V
T
V
Site 18
S167
R
K
E
T
G
L
W
S
V
T
V
S
G
R
K
Site 19
T169
E
T
G
L
W
S
V
T
V
S
G
R
K
H
S
Site 20
S171
G
L
W
S
V
T
V
S
G
R
K
H
S
V
R
Site 21
S176
T
V
S
G
R
K
H
S
V
R
L
C
S
P
R
Site 22
S181
K
H
S
V
R
L
C
S
P
R
Q
A
E
A
E
Site 23
T206
A
S
K
A
P
L
E
T
P
T
Q
L
L
L
R
Site 24
S218
L
L
R
D
I
Q
E
S
C
G
D
P
E
A
V
Site 25
T238
R
N
P
I
L
R
H
T
S
G
A
L
Y
A
P
Site 26
Y260
V
S
A
P
G
P
G
Y
A
P
L
R
E
E
A
Site 27
S313
L
Q
L
A
K
Q
T
S
G
P
A
G
P
P
G
Site 28
T324
G
P
P
G
L
P
A
T
Q
D
P
A
A
L
R
Site 29
S367
T
E
Q
A
L
P
D
S
E
L
A
E
Y
A
R
Site 30
Y372
P
D
S
E
L
A
E
Y
A
R
F
I
R
K
A
Site 31
T407
Q
R
Q
E
L
L
C
T
V
H
C
P
G
A
G
Site 32
S442
G
R
L
G
L
A
R
S
R
N
A
F
A
L
Y
Site 33
Y449
S
R
N
A
F
A
L
Y
E
Q
R
G
A
Q
E
Site 34
S485
E
E
A
G
L
E
D
S
P
D
S
G
W
R
L
Site 35
S488
G
L
E
D
S
P
D
S
G
W
R
L
C
L
R
Site 36
S506
P
L
H
P
E
G
L
S
P
D
G
H
E
L
P
Site 37
T534
R
P
P
P
P
D
D
T
L
R
A
L
A
A
L
Site 38
S545
L
A
A
L
R
L
Q
S
L
H
R
D
F
S
P
Site 39
S551
Q
S
L
H
R
D
F
S
P
R
V
P
L
P
R
Site 40
T577
R
E
D
P
P
R
P
T
P
R
P
P
P
S
A
Site 41
S583
P
T
P
R
P
P
P
S
A
A
L
L
A
G
A
Site 42
S615
G
A
G
R
T
A
G
S
I
A
R
E
G
G
G
Site 43
S670
R
Y
D
V
L
E
L
S
T
E
P
G
R
G
A
Site 44
S691
G
L
G
A
K
A
M
S
L
S
R
P
G
E
T
Site 45
S693
G
A
K
A
M
S
L
S
R
P
G
E
T
E
P
Site 46
S703
G
E
T
E
P
I
H
S
V
S
Y
G
H
V
A
Site 47
S733
E
S
Q
L
L
L
Q
S
P
Q
V
E
E
I
M
Site 48
S751
N
A
Y
L
A
N
P
S
P
E
R
P
C
S
S
Site 49
S757
P
S
P
E
R
P
C
S
S
S
S
P
P
C
Q
Site 50
S758
S
P
E
R
P
C
S
S
S
S
P
P
C
Q
D
Site 51
S759
P
E
R
P
C
S
S
S
S
P
P
C
Q
D
L
Site 52
S760
E
R
P
C
S
S
S
S
P
P
C
Q
D
L
P
Site 53
T769
P
C
Q
D
L
P
D
T
S
P
P
S
Q
R
P
Site 54
S770
C
Q
D
L
P
D
T
S
P
P
S
Q
R
P
G
Site 55
S773
L
P
D
T
S
P
P
S
Q
R
P
G
L
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation