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Updated November 2019
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Protein Info
Short Name:
ABI3BP
Full Name:
Target of Nesh-SH3
Alias:
ABI gene family member 3-binding protein;Nesh-binding protein
Type:
Mass (Da):
118642
Number AA:
1075
UniProt ID:
Q7Z7G0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S49
H
I
N
T
T
S
D
S
I
L
L
K
F
L
R
Site 2
S58
L
L
K
F
L
R
P
S
P
N
V
K
L
E
G
Site 3
S72
G
L
L
L
G
Y
G
S
N
V
S
P
N
Q
Y
Site 4
S75
L
G
Y
G
S
N
V
S
P
N
Q
Y
F
P
L
Site 5
Y79
S
N
V
S
P
N
Q
Y
F
P
L
P
A
E
G
Site 6
T89
L
P
A
E
G
K
F
T
E
A
I
V
D
A
E
Site 7
S110
V
R
P
A
P
P
P
S
Q
K
K
S
C
S
G
Site 8
S114
P
P
P
S
Q
K
K
S
C
S
G
K
T
R
S
Site 9
S116
P
S
Q
K
K
S
C
S
G
K
T
R
S
R
K
Site 10
T119
K
K
S
C
S
G
K
T
R
S
R
K
P
L
Q
Site 11
S121
S
C
S
G
K
T
R
S
R
K
P
L
Q
L
V
Site 12
Y163
H
C
P
N
D
R
F
Y
T
I
R
Y
R
E
K
Site 13
T195
V
E
N
L
K
P
N
T
V
Y
E
F
G
V
K
Site 14
T218
S
K
I
F
N
H
K
T
V
V
G
S
K
K
V
Site 15
S231
K
V
N
G
K
I
Q
S
T
Y
D
Q
D
H
T
Site 16
Y233
N
G
K
I
Q
S
T
Y
D
Q
D
H
T
V
P
Site 17
T238
S
T
Y
D
Q
D
H
T
V
P
A
Y
V
P
R
Site 18
Y242
Q
D
H
T
V
P
A
Y
V
P
R
K
L
I
P
Site 19
S268
T
H
K
D
S
A
K
S
P
E
K
A
P
L
G
Site 20
T324
A
L
P
A
E
S
K
T
P
E
V
E
K
I
S
Site 21
T335
E
K
I
S
A
R
P
T
T
V
T
P
E
T
V
Site 22
T336
K
I
S
A
R
P
T
T
V
T
P
E
T
V
P
Site 23
T338
S
A
R
P
T
T
V
T
P
E
T
V
P
R
S
Site 24
T341
P
T
T
V
T
P
E
T
V
P
R
S
T
K
P
Site 25
S345
T
P
E
T
V
P
R
S
T
K
P
T
T
S
S
Site 26
T346
P
E
T
V
P
R
S
T
K
P
T
T
S
S
A
Site 27
T349
V
P
R
S
T
K
P
T
T
S
S
A
L
D
V
Site 28
S357
T
S
S
A
L
D
V
S
E
T
T
L
A
S
S
Site 29
T359
S
A
L
D
V
S
E
T
T
L
A
S
S
E
K
Site 30
S376
I
V
P
T
A
K
I
S
E
D
S
K
V
L
Q
Site 31
T388
V
L
Q
P
Q
T
A
T
Y
D
V
F
S
S
P
Site 32
Y389
L
Q
P
Q
T
A
T
Y
D
V
F
S
S
P
T
Site 33
S394
A
T
Y
D
V
F
S
S
P
T
T
S
D
E
P
Site 34
T397
D
V
F
S
S
P
T
T
S
D
E
P
E
I
S
Site 35
S398
V
F
S
S
P
T
T
S
D
E
P
E
I
S
D
Site 36
S404
T
S
D
E
P
E
I
S
D
S
Y
T
A
T
S
Site 37
S406
D
E
P
E
I
S
D
S
Y
T
A
T
S
D
R
Site 38
Y407
E
P
E
I
S
D
S
Y
T
A
T
S
D
R
I
Site 39
T408
P
E
I
S
D
S
Y
T
A
T
S
D
R
I
L
Site 40
T410
I
S
D
S
Y
T
A
T
S
D
R
I
L
D
S
Site 41
S411
S
D
S
Y
T
A
T
S
D
R
I
L
D
S
I
Site 42
S417
T
S
D
R
I
L
D
S
I
P
P
K
T
S
R
Site 43
T422
L
D
S
I
P
P
K
T
S
R
T
L
E
Q
P
Site 44
T425
I
P
P
K
T
S
R
T
L
E
Q
P
R
A
T
Site 45
T432
T
L
E
Q
P
R
A
T
L
A
P
S
E
T
P
Site 46
S436
P
R
A
T
L
A
P
S
E
T
P
F
V
P
Q
Site 47
T438
A
T
L
A
P
S
E
T
P
F
V
P
Q
K
L
Site 48
S450
Q
K
L
E
I
F
T
S
P
E
M
Q
P
T
T
Site 49
T456
T
S
P
E
M
Q
P
T
T
P
A
P
Q
Q
T
Site 50
T457
S
P
E
M
Q
P
T
T
P
A
P
Q
Q
T
T
Site 51
T464
T
P
A
P
Q
Q
T
T
S
I
P
S
T
P
K
Site 52
S465
P
A
P
Q
Q
T
T
S
I
P
S
T
P
K
R
Site 53
S468
Q
Q
T
T
S
I
P
S
T
P
K
R
R
P
R
Site 54
T469
Q
T
T
S
I
P
S
T
P
K
R
R
P
R
P
Site 55
T481
P
R
P
K
P
P
R
T
K
P
E
R
T
T
S
Site 56
T487
R
T
K
P
E
R
T
T
S
A
G
T
I
T
P
Site 57
S488
T
K
P
E
R
T
T
S
A
G
T
I
T
P
K
Site 58
T493
T
T
S
A
G
T
I
T
P
K
I
S
K
S
P
Site 59
S497
G
T
I
T
P
K
I
S
K
S
P
E
P
T
W
Site 60
S499
I
T
P
K
I
S
K
S
P
E
P
T
W
T
T
Site 61
T503
I
S
K
S
P
E
P
T
W
T
T
P
A
P
G
Site 62
T505
K
S
P
E
P
T
W
T
T
P
A
P
G
K
T
Site 63
T506
S
P
E
P
T
W
T
T
P
A
P
G
K
T
Q
Site 64
T512
T
T
P
A
P
G
K
T
Q
F
I
S
L
K
P
Site 65
S516
P
G
K
T
Q
F
I
S
L
K
P
K
I
P
L
Site 66
S524
L
K
P
K
I
P
L
S
P
E
V
T
H
T
K
Site 67
T528
I
P
L
S
P
E
V
T
H
T
K
P
A
P
K
Site 68
T530
L
S
P
E
V
T
H
T
K
P
A
P
K
Q
T
Site 69
T537
T
K
P
A
P
K
Q
T
P
R
A
P
P
K
P
Site 70
T546
R
A
P
P
K
P
K
T
S
P
R
P
R
I
P
Site 71
S547
A
P
P
K
P
K
T
S
P
R
P
R
I
P
Q
Site 72
T555
P
R
P
R
I
P
Q
T
Q
P
V
P
K
V
P
Site 73
T566
P
K
V
P
Q
R
V
T
A
K
P
K
T
S
P
Site 74
T571
R
V
T
A
K
P
K
T
S
P
S
P
E
V
S
Site 75
S572
V
T
A
K
P
K
T
S
P
S
P
E
V
S
Y
Site 76
S574
A
K
P
K
T
S
P
S
P
E
V
S
Y
T
T
Site 77
S578
T
S
P
S
P
E
V
S
Y
T
T
P
A
P
K
Site 78
Y579
S
P
S
P
E
V
S
Y
T
T
P
A
P
K
D
Site 79
T580
P
S
P
E
V
S
Y
T
T
P
A
P
K
D
V
Site 80
T581
S
P
E
V
S
Y
T
T
P
A
P
K
D
V
L
Site 81
Y594
V
L
L
P
H
K
P
Y
P
E
V
S
Q
S
E
Site 82
S598
H
K
P
Y
P
E
V
S
Q
S
E
P
A
P
L
Site 83
S600
P
Y
P
E
V
S
Q
S
E
P
A
P
L
E
T
Site 84
S617
I
P
F
I
P
M
I
S
P
S
P
S
Q
E
E
Site 85
S619
F
I
P
M
I
S
P
S
P
S
Q
E
E
L
Q
Site 86
S621
P
M
I
S
P
S
P
S
Q
E
E
L
Q
T
T
Site 87
T627
P
S
Q
E
E
L
Q
T
T
L
E
E
T
D
Q
Site 88
T628
S
Q
E
E
L
Q
T
T
L
E
E
T
D
Q
S
Site 89
S635
T
L
E
E
T
D
Q
S
T
Q
E
P
F
T
T
Site 90
T636
L
E
E
T
D
Q
S
T
Q
E
P
F
T
T
K
Site 91
T642
S
T
Q
E
P
F
T
T
K
I
P
R
T
T
E
Site 92
T648
T
T
K
I
P
R
T
T
E
L
A
K
T
T
Q
Site 93
T653
R
T
T
E
L
A
K
T
T
Q
A
P
H
R
F
Site 94
Y661
T
Q
A
P
H
R
F
Y
T
T
V
R
P
R
T
Site 95
T662
Q
A
P
H
R
F
Y
T
T
V
R
P
R
T
S
Site 96
T663
A
P
H
R
F
Y
T
T
V
R
P
R
T
S
D
Site 97
T668
Y
T
T
V
R
P
R
T
S
D
K
P
H
I
R
Site 98
S669
T
T
V
R
P
R
T
S
D
K
P
H
I
R
P
Site 99
S685
V
K
Q
A
P
R
P
S
G
A
D
R
N
V
S
Site 100
S692
S
G
A
D
R
N
V
S
V
D
S
T
H
P
T
Site 101
S695
D
R
N
V
S
V
D
S
T
H
P
T
K
K
P
Site 102
T696
R
N
V
S
V
D
S
T
H
P
T
K
K
P
G
Site 103
T699
S
V
D
S
T
H
P
T
K
K
P
G
T
R
R
Site 104
T704
H
P
T
K
K
P
G
T
R
R
P
P
L
P
P
Site 105
T714
P
P
L
P
P
R
P
T
H
P
R
R
K
P
L
Site 106
T727
P
L
P
P
N
N
V
T
G
K
P
G
S
A
G
Site 107
S732
N
V
T
G
K
P
G
S
A
G
I
I
S
S
G
Site 108
T743
I
S
S
G
P
I
T
T
P
P
L
R
S
T
P
Site 109
S748
I
T
T
P
P
L
R
S
T
P
R
P
T
G
T
Site 110
T749
T
T
P
P
L
R
S
T
P
R
P
T
G
T
P
Site 111
T753
L
R
S
T
P
R
P
T
G
T
P
L
E
R
I
Site 112
T755
S
T
P
R
P
T
G
T
P
L
E
R
I
E
T
Site 113
T762
T
P
L
E
R
I
E
T
D
I
K
Q
P
T
V
Site 114
T768
E
T
D
I
K
Q
P
T
V
P
A
S
G
E
E
Site 115
S772
K
Q
P
T
V
P
A
S
G
E
E
L
E
N
I
Site 116
T780
G
E
E
L
E
N
I
T
D
F
S
S
S
P
T
Site 117
S783
L
E
N
I
T
D
F
S
S
S
P
T
R
E
T
Site 118
S784
E
N
I
T
D
F
S
S
S
P
T
R
E
T
D
Site 119
S785
N
I
T
D
F
S
S
S
P
T
R
E
T
D
P
Site 120
T787
T
D
F
S
S
S
P
T
R
E
T
D
P
L
G
Site 121
T790
S
S
S
P
T
R
E
T
D
P
L
G
K
P
R
Site 122
S812
Y
I
Q
K
P
D
N
S
P
C
S
I
T
D
S
Site 123
S815
K
P
D
N
S
P
C
S
I
T
D
S
V
K
R
Site 124
S819
S
P
C
S
I
T
D
S
V
K
R
F
P
K
E
Site 125
T834
E
A
T
E
G
N
A
T
S
P
P
Q
N
P
P
Site 126
S835
A
T
E
G
N
A
T
S
P
P
Q
N
P
P
T
Site 127
T842
S
P
P
Q
N
P
P
T
N
L
T
V
V
T
V
Site 128
T845
Q
N
P
P
T
N
L
T
V
V
T
V
E
G
C
Site 129
T867
W
E
K
P
L
N
D
T
V
T
E
Y
E
V
I
Site 130
T869
K
P
L
N
D
T
V
T
E
Y
E
V
I
S
R
Site 131
Y871
L
N
D
T
V
T
E
Y
E
V
I
S
R
E
N
Site 132
S880
V
I
S
R
E
N
G
S
F
S
G
K
N
K
S
Site 133
S882
S
R
E
N
G
S
F
S
G
K
N
K
S
I
Q
Site 134
S887
S
F
S
G
K
N
K
S
I
Q
M
T
N
Q
T
Site 135
T891
K
N
K
S
I
Q
M
T
N
Q
T
F
S
T
V
Site 136
T894
S
I
Q
M
T
N
Q
T
F
S
T
V
E
N
L
Site 137
T897
M
T
N
Q
T
F
S
T
V
E
N
L
K
P
N
Site 138
T925
G
E
G
P
V
S
N
T
V
A
F
S
T
E
S
Site 139
S932
T
V
A
F
S
T
E
S
A
D
P
R
V
S
E
Site 140
S938
E
S
A
D
P
R
V
S
E
P
V
S
A
G
R
Site 141
S942
P
R
V
S
E
P
V
S
A
G
R
D
A
I
W
Site 142
T950
A
G
R
D
A
I
W
T
E
R
P
F
N
S
D
Site 143
S956
W
T
E
R
P
F
N
S
D
S
Y
S
E
C
K
Site 144
S958
E
R
P
F
N
S
D
S
Y
S
E
C
K
G
K
Site 145
Y959
R
P
F
N
S
D
S
Y
S
E
C
K
G
K
Q
Site 146
S960
P
F
N
S
D
S
Y
S
E
C
K
G
K
Q
Y
Site 147
Y967
S
E
C
K
G
K
Q
Y
V
K
R
T
W
Y
K
Site 148
Y973
Q
Y
V
K
R
T
W
Y
K
K
F
V
G
V
Q
Site 149
Y990
N
S
L
R
Y
K
I
Y
L
S
D
S
L
T
G
Site 150
S992
L
R
Y
K
I
Y
L
S
D
S
L
T
G
K
F
Site 151
S994
Y
K
I
Y
L
S
D
S
L
T
G
K
F
Y
N
Site 152
S1018
D
H
C
Q
F
V
D
S
F
L
D
G
R
T
G
Site 153
Y1039
Q
L
P
I
K
E
G
Y
F
R
A
V
R
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation