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Updated November 2019
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Protein Info
Short Name:
VPS13B
Full Name:
Vacuolar protein sorting-associated protein 13B
Alias:
CHS1; COH1; Cohen syndrome 1; vacuolar protein sorting 13 B; vacuolar protein sorting 13B; VP13B
Type:
Membrane protein, integral; Vesicle protein
Mass (Da):
448734
Number AA:
4022
UniProt ID:
Q7Z7G8
International Prot ID:
IPI00376439
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
K
P
S
D
L
Q
L
S
L
W
G
G
D
V
V
Site 2
T56
Q
E
L
K
L
P
F
T
F
L
S
G
H
I
H
Site 3
S59
K
L
P
F
T
F
L
S
G
H
I
H
E
L
R
Site 4
T72
L
R
I
H
V
P
W
T
K
L
G
S
E
P
V
Site 5
S76
V
P
W
T
K
L
G
S
E
P
V
V
I
T
I
Site 6
S102
G
I
Q
D
D
H
E
S
C
G
S
N
S
T
N
Site 7
S105
D
D
H
E
S
C
G
S
N
S
T
N
R
S
T
Site 8
S107
H
E
S
C
G
S
N
S
T
N
R
S
T
A
E
Site 9
T108
E
S
C
G
S
N
S
T
N
R
S
T
A
E
S
Site 10
S111
G
S
N
S
T
N
R
S
T
A
E
S
T
K
S
Site 11
T112
S
N
S
T
N
R
S
T
A
E
S
T
K
S
S
Site 12
S115
T
N
R
S
T
A
E
S
T
K
S
S
I
K
P
Site 13
S118
S
T
A
E
S
T
K
S
S
I
K
P
R
R
M
Site 14
S119
T
A
E
S
T
K
S
S
I
K
P
R
R
M
Q
Site 15
T131
R
M
Q
Q
A
A
P
T
D
P
D
L
P
P
G
Site 16
Y139
D
P
D
L
P
P
G
Y
V
Q
S
L
I
R
R
Site 17
Y179
N
I
T
S
A
E
C
Y
T
V
G
E
L
W
D
Site 18
S218
C
L
D
K
R
N
A
S
G
K
I
E
F
Y
Q
Site 19
Y224
A
S
G
K
I
E
F
Y
Q
D
P
L
L
Y
K
Site 20
Y230
F
Y
Q
D
P
L
L
Y
K
C
S
F
R
T
R
Site 21
S233
D
P
L
L
Y
K
C
S
F
R
T
R
L
H
F
Site 22
Y242
R
T
R
L
H
F
T
Y
E
N
L
N
S
K
M
Site 23
S247
F
T
Y
E
N
L
N
S
K
M
P
S
V
I
K
Site 24
S251
N
L
N
S
K
M
P
S
V
I
K
I
H
T
L
Site 25
S265
L
V
E
S
L
K
L
S
I
T
D
Q
Q
L
P
Site 26
T267
E
S
L
K
L
S
I
T
D
Q
Q
L
P
M
F
Site 27
S314
M
L
G
N
I
T
G
S
E
D
E
T
R
I
D
Site 28
T318
I
T
G
S
E
D
E
T
R
I
D
M
Q
Y
P
Site 29
Y324
E
T
R
I
D
M
Q
Y
P
A
Q
H
K
G
Q
Site 30
S335
H
K
G
Q
E
L
Y
S
Q
Q
D
E
E
Q
P
Site 31
S358
S
F
V
P
A
I
V
S
Y
D
D
G
E
E
D
Site 32
S373
F
V
G
N
D
P
A
S
T
M
H
Q
Q
K
A
Site 33
T400
Y
C
T
K
A
T
V
T
F
K
L
T
E
M
Q
Site 34
S410
L
T
E
M
Q
V
E
S
S
Y
Y
S
P
Q
K
Site 35
Y412
E
M
Q
V
E
S
S
Y
Y
S
P
Q
K
V
K
Site 36
Y413
M
Q
V
E
S
S
Y
Y
S
P
Q
K
V
K
S
Site 37
S414
Q
V
E
S
S
Y
Y
S
P
Q
K
V
K
S
K
Site 38
T475
E
N
M
N
R
S
E
T
E
A
C
F
F
I
C
Site 39
Y493
L
S
T
K
G
F
T
Y
L
T
N
S
L
F
D
Site 40
T495
T
K
G
F
T
Y
L
T
N
S
L
F
D
Y
R
Site 41
S497
G
F
T
Y
L
T
N
S
L
F
D
Y
R
S
P
Site 42
Y501
L
T
N
S
L
F
D
Y
R
S
P
E
N
N
G
Site 43
S503
N
S
L
F
D
Y
R
S
P
E
N
N
G
T
R
Site 44
T509
R
S
P
E
N
N
G
T
R
A
E
F
I
L
D
Site 45
S517
R
A
E
F
I
L
D
S
T
H
H
K
E
T
Y
Site 46
T518
A
E
F
I
L
D
S
T
H
H
K
E
T
Y
T
Site 47
Y524
S
T
H
H
K
E
T
Y
T
E
I
A
G
M
Q
Site 48
Y542
A
F
Y
M
D
Y
L
Y
T
V
E
N
T
S
G
Site 49
T543
F
Y
M
D
Y
L
Y
T
V
E
N
T
S
G
K
Site 50
S552
E
N
T
S
G
K
G
S
T
N
Q
Q
D
F
S
Site 51
S559
S
T
N
Q
Q
D
F
S
S
G
K
S
E
D
L
Site 52
S560
T
N
Q
Q
D
F
S
S
G
K
S
E
D
L
G
Site 53
S563
Q
D
F
S
S
G
K
S
E
D
L
G
T
V
Q
Site 54
T568
G
K
S
E
D
L
G
T
V
Q
E
K
S
T
K
Site 55
S573
L
G
T
V
Q
E
K
S
T
K
S
L
V
I
G
Site 56
S576
V
Q
E
K
S
T
K
S
L
V
I
G
P
L
D
Site 57
Y606
V
C
A
L
E
H
E
Y
E
P
Y
S
R
L
K
Site 58
Y609
L
E
H
E
Y
E
P
Y
S
R
L
K
S
D
I
Site 59
S610
E
H
E
Y
E
P
Y
S
R
L
K
S
D
I
K
Site 60
S614
E
P
Y
S
R
L
K
S
D
I
K
N
E
N
E
Site 61
T638
L
L
E
E
Y
I
P
T
R
H
T
S
V
T
L
Site 62
T641
E
Y
I
P
T
R
H
T
S
V
T
L
L
K
C
Site 63
S642
Y
I
P
T
R
H
T
S
V
T
L
L
K
C
T
Site 64
T644
P
T
R
H
T
S
V
T
L
L
K
C
T
C
T
Site 65
T680
S
S
N
F
M
N
T
T
N
F
Q
S
L
R
P
Site 66
S684
M
N
T
T
N
F
Q
S
L
R
P
L
P
S
I
Site 67
S690
Q
S
L
R
P
L
P
S
I
R
I
L
V
D
K
Site 68
S703
D
K
I
N
L
E
H
S
V
P
M
Y
A
E
Q
Site 69
S716
E
Q
L
V
H
V
V
S
S
L
T
Q
P
S
D
Site 70
S717
Q
L
V
H
V
V
S
S
L
T
Q
P
S
D
N
Site 71
S722
V
S
S
L
T
Q
P
S
D
N
L
L
H
Y
C
Site 72
Y728
P
S
D
N
L
L
H
Y
C
Y
V
H
C
Y
L
Site 73
S746
G
F
Q
A
G
L
T
S
L
D
C
S
G
S
Y
Site 74
T776
G
K
L
L
K
L
P
T
C
W
T
K
R
S
Q
Site 75
T779
L
K
L
P
T
C
W
T
K
R
S
Q
I
A
I
Site 76
S782
P
T
C
W
T
K
R
S
Q
I
A
I
T
E
G
Site 77
T848
K
S
K
N
P
L
P
T
L
E
G
S
I
Q
N
Site 78
Y860
I
Q
N
V
E
L
K
Y
C
S
T
S
L
V
K
Site 79
S864
E
L
K
Y
C
S
T
S
L
V
K
C
A
S
G
Site 80
S899
I
P
L
L
Q
G
P
S
D
T
K
D
L
H
S
Site 81
S906
S
D
T
K
D
L
H
S
T
K
W
L
N
E
S
Site 82
S913
S
T
K
W
L
N
E
S
R
K
P
E
S
L
L
Site 83
S918
N
E
S
R
K
P
E
S
L
L
A
P
D
L
M
Site 84
Y934
F
T
I
Q
V
P
Q
Y
I
D
Y
C
H
N
S
Site 85
Y937
Q
V
P
Q
Y
I
D
Y
C
H
N
S
G
A
V
Site 86
S973
Y
Q
P
Q
K
R
T
S
R
H
M
Q
Q
Q
P
Site 87
S999
R
R
K
E
D
E
V
S
I
G
S
A
P
L
A
Site 88
S1002
E
D
E
V
S
I
G
S
A
P
L
A
K
Q
Q
Site 89
S1010
A
P
L
A
K
Q
Q
S
Y
Q
A
S
E
Y
A
Site 90
S1014
K
Q
Q
S
Y
Q
A
S
E
Y
A
S
S
P
V
Site 91
Y1016
Q
S
Y
Q
A
S
E
Y
A
S
S
P
V
K
T
Site 92
S1018
Y
Q
A
S
E
Y
A
S
S
P
V
K
T
K
T
Site 93
S1019
Q
A
S
E
Y
A
S
S
P
V
K
T
K
T
V
Site 94
T1023
Y
A
S
S
P
V
K
T
K
T
V
T
E
S
R
Site 95
T1025
S
S
P
V
K
T
K
T
V
T
E
S
R
P
L
Site 96
T1027
P
V
K
T
K
T
V
T
E
S
R
P
L
S
V
Site 97
S1029
K
T
K
T
V
T
E
S
R
P
L
S
V
P
V
Site 98
S1043
V
K
A
M
L
N
I
S
E
S
C
R
S
P
E
Site 99
S1045
A
M
L
N
I
S
E
S
C
R
S
P
E
E
R
Site 100
S1048
N
I
S
E
S
C
R
S
P
E
E
R
M
K
E
Site 101
S1087
I
P
N
D
S
L
P
S
P
S
T
I
V
S
G
Site 102
S1089
N
D
S
L
P
S
P
S
T
I
V
S
G
D
I
Site 103
T1090
D
S
L
P
S
P
S
T
I
V
S
G
D
I
P
Site 104
T1099
V
S
G
D
I
P
G
T
V
R
S
W
Y
H
G
Site 105
S1102
D
I
P
G
T
V
R
S
W
Y
H
G
Q
T
S
Site 106
Y1104
P
G
T
V
R
S
W
Y
H
G
Q
T
S
M
P
Site 107
T1108
R
S
W
Y
H
G
Q
T
S
M
P
G
T
L
V
Site 108
S1109
S
W
Y
H
G
Q
T
S
M
P
G
T
L
V
L
Site 109
Y1130
I
I
S
A
G
H
K
Y
M
E
P
L
Q
E
I
Site 110
T1155
E
G
D
A
F
P
W
T
I
S
L
H
N
F
S
Site 111
T1184
E
P
M
G
C
T
S
T
L
A
V
T
S
Q
K
Site 112
S1219
E
S
L
E
I
K
C
S
N
P
Q
V
Q
L
F
Site 113
S1249
K
R
G
N
L
N
L
S
P
T
S
P
E
T
M
Site 114
T1251
G
N
L
N
L
S
P
T
S
P
E
T
M
A
G
Site 115
S1252
N
L
N
L
S
P
T
S
P
E
T
M
A
G
P
Site 116
S1263
M
A
G
P
V
P
T
S
P
V
R
S
S
I
G
Site 117
S1267
V
P
T
S
P
V
R
S
S
I
G
T
A
P
P
Site 118
S1268
P
T
S
P
V
R
S
S
I
G
T
A
P
P
D
Site 119
T1271
P
V
R
S
S
I
G
T
A
P
P
D
T
S
T
Site 120
T1276
I
G
T
A
P
P
D
T
S
T
C
S
P
S
A
Site 121
S1277
G
T
A
P
P
D
T
S
T
C
S
P
S
A
D
Site 122
T1278
T
A
P
P
D
T
S
T
C
S
P
S
A
D
I
Site 123
S1280
P
P
D
T
S
T
C
S
P
S
A
D
I
G
T
Site 124
S1282
D
T
S
T
C
S
P
S
A
D
I
G
T
T
T
Site 125
T1287
S
P
S
A
D
I
G
T
T
T
E
G
D
S
I
Site 126
T1289
S
A
D
I
G
T
T
T
E
G
D
S
I
Q
A
Site 127
S1300
S
I
Q
A
G
E
E
S
P
F
S
D
S
V
T
Site 128
S1303
A
G
E
E
S
P
F
S
D
S
V
T
L
E
Q
Site 129
S1305
E
E
S
P
F
S
D
S
V
T
L
E
Q
T
T
Site 130
T1307
S
P
F
S
D
S
V
T
L
E
Q
T
T
S
N
Site 131
S1313
V
T
L
E
Q
T
T
S
N
I
G
G
T
S
G
Site 132
S1319
T
S
N
I
G
G
T
S
G
R
V
S
L
W
M
Site 133
T1347
P
D
P
E
N
K
G
T
E
V
C
M
V
S
E
Site 134
S1359
V
S
E
L
E
D
L
S
A
S
I
D
V
Q
D
Site 135
Y1368
S
I
D
V
Q
D
V
Y
T
K
V
K
C
K
I
Site 136
Y1383
E
S
F
N
I
D
H
Y
R
S
S
H
G
E
E
Site 137
S1403
Q
C
G
G
V
I
L
S
C
T
D
K
L
N
R
Site 138
T1412
T
D
K
L
N
R
R
T
L
L
V
R
P
I
S
Site 139
S1419
T
L
L
V
R
P
I
S
K
Q
D
P
F
R
N
Site 140
S1428
Q
D
P
F
R
N
C
S
G
F
F
P
S
T
T
Site 141
S1433
N
C
S
G
F
F
P
S
T
T
T
K
L
L
D
Site 142
T1442
T
T
K
L
L
D
G
T
H
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E
P
I
Q
C
S
K
M
Q
S
L
L
I
Site 295
S3486
I
Q
C
S
K
M
Q
S
L
L
I
S
N
K
E
Site 296
S3490
K
M
Q
S
L
L
I
S
N
K
E
L
E
E
Y
Site 297
Y3497
S
N
K
E
L
E
E
Y
K
E
K
C
F
I
K
Site 298
S3514
I
T
L
N
E
G
K
S
I
L
C
D
I
N
E
Site 299
S3523
L
C
D
I
N
E
F
S
F
E
L
K
P
A
R
Site 300
Y3532
E
L
K
P
A
R
L
Y
V
E
D
T
F
V
Y
Site 301
T3547
Y
I
K
T
L
F
D
T
Y
L
P
N
S
R
L
Site 302
Y3548
I
K
T
L
F
D
T
Y
L
P
N
S
R
L
A
Site 303
S3552
F
D
T
Y
L
P
N
S
R
L
A
G
H
S
T
Site 304
S3558
N
S
R
L
A
G
H
S
T
H
L
S
G
G
K
Site 305
T3559
S
R
L
A
G
H
S
T
H
L
S
G
G
K
Q
Site 306
S3562
A
G
H
S
T
H
L
S
G
G
K
Q
V
L
P
Site 307
T3573
Q
V
L
P
M
Q
V
T
Q
H
A
R
A
L
V
Site 308
Y3606
I
H
A
S
L
K
L
Y
I
A
S
D
H
T
P
Site 309
S3615
A
S
D
H
T
P
L
S
F
S
V
F
E
R
G
Site 310
S3617
D
H
T
P
L
S
F
S
V
F
E
R
G
P
I
Site 311
T3626
F
E
R
G
P
I
F
T
T
A
R
Q
L
V
H
Site 312
T3627
E
R
G
P
I
F
T
T
A
R
Q
L
V
H
A
Site 313
Y3679
A
D
F
F
R
L
P
Y
E
G
L
T
R
G
P
Site 314
T3683
R
L
P
Y
E
G
L
T
R
G
P
G
A
F
V
Site 315
S3691
R
G
P
G
A
F
V
S
G
V
S
R
G
T
T
Site 316
T3698
S
G
V
S
R
G
T
T
S
F
V
K
H
I
S
Site 317
S3699
G
V
S
R
G
T
T
S
F
V
K
H
I
S
K
Site 318
T3708
V
K
H
I
S
K
G
T
L
T
S
I
T
N
L
Site 319
T3710
H
I
S
K
G
T
L
T
S
I
T
N
L
A
T
Site 320
S3718
S
I
T
N
L
A
T
S
L
A
R
N
M
D
R
Site 321
S3727
A
R
N
M
D
R
L
S
L
D
E
E
H
Y
N
Site 322
Y3733
L
S
L
D
E
E
H
Y
N
R
Q
E
E
W
R
Site 323
S3746
W
R
R
Q
L
P
E
S
L
G
E
G
L
R
Q
Site 324
S3831
I
L
H
G
A
G
L
S
Q
L
P
K
Q
R
H
Site 325
Y3855
A
P
N
S
H
V
K
Y
V
W
K
M
L
Q
S
Site 326
S3880
D
V
V
L
V
R
G
S
G
Q
E
H
E
G
C
Site 327
S3899
S
E
V
L
F
V
V
S
V
S
E
D
T
Q
Q
Site 328
S3920
E
I
D
C
A
Q
D
S
K
Q
N
N
L
L
T
Site 329
T3927
S
K
Q
N
N
L
L
T
V
Q
L
K
Q
P
R
Site 330
S3949
D
G
V
R
E
R
L
S
E
Q
Q
Y
N
R
L
Site 331
Y3953
E
R
L
S
E
Q
Q
Y
N
R
L
V
D
Y
I
Site 332
Y3959
Q
Y
N
R
L
V
D
Y
I
T
K
T
S
C
H
Site 333
T3961
N
R
L
V
D
Y
I
T
K
T
S
C
H
L
A
Site 334
S3970
T
S
C
H
L
A
P
S
C
S
S
M
Q
I
P
Site 335
S3988
V
A
A
E
P
P
P
S
T
V
K
T
Y
H
Y
Site 336
T3989
A
A
E
P
P
P
S
T
V
K
T
Y
H
Y
L
Site 337
T3992
P
P
P
S
T
V
K
T
Y
H
Y
L
V
D
P
Site 338
Y3995
S
T
V
K
T
Y
H
Y
L
V
D
P
H
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation