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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMED4
Full Name:
Transmembrane emp24 domain-containing protein 4
Alias:
Endoplasmic reticulum stress-response protein 25;Putative NF-kappa-B-activating protein 156
Type:
Mass (Da):
25943
Number AA:
227
UniProt ID:
Q7Z7H5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y31
A
T
G
A
Q
G
L
Y
F
H
I
G
E
T
E
Site 2
T50
I
E
E
I
P
D
E
T
M
V
I
G
N
Y
R
Site 3
S71
Q
K
E
V
F
L
P
S
T
P
G
L
G
M
H
Site 4
S91
P
D
G
K
V
V
L
S
R
Q
Y
G
S
E
G
Site 5
Y94
K
V
V
L
S
R
Q
Y
G
S
E
G
R
F
T
Site 6
S96
V
L
S
R
Q
Y
G
S
E
G
R
F
T
F
T
Site 7
T101
Y
G
S
E
G
R
F
T
F
T
S
H
T
P
G
Site 8
S104
E
G
R
F
T
F
T
S
H
T
P
G
D
H
Q
Site 9
T106
R
F
T
F
T
S
H
T
P
G
D
H
Q
I
C
Site 10
Y144
V
G
E
H
A
N
N
Y
P
E
I
A
A
K
D
Site 11
T154
I
A
A
K
D
K
L
T
E
L
Q
L
R
A
R
Site 12
Y176
Q
I
Q
K
E
Q
D
Y
Q
R
Y
R
E
E
R
Site 13
T187
R
E
E
R
F
R
L
T
S
E
S
T
N
Q
R
Site 14
S188
E
E
R
F
R
L
T
S
E
S
T
N
Q
R
V
Site 15
S190
R
F
R
L
T
S
E
S
T
N
Q
R
V
L
W
Site 16
T191
F
R
L
T
S
E
S
T
N
Q
R
V
L
W
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation