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Updated November 2019
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Protein Info
Short Name:
SLFN11
Full Name:
Schlafen family member 11
Alias:
Type:
Mass (Da):
102837
Number AA:
901
UniProt ID:
Q7Z7L1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S56
A
A
C
A
L
L
N
S
G
G
G
V
I
R
M
Site 2
S80
M
G
L
D
L
E
Q
S
L
R
E
L
I
Q
S
Site 3
S87
S
L
R
E
L
I
Q
S
S
D
L
Q
A
F
F
Site 4
Y104
K
Q
Q
G
R
C
F
Y
I
F
V
K
S
W
S
Site 5
S111
Y
I
F
V
K
S
W
S
S
G
P
F
P
E
D
Site 6
S120
G
P
F
P
E
D
R
S
V
K
P
R
L
C
S
Site 7
S127
S
V
K
P
R
L
C
S
L
S
S
S
L
Y
R
Site 8
S129
K
P
R
L
C
S
L
S
S
S
L
Y
R
R
S
Site 9
S130
P
R
L
C
S
L
S
S
S
L
Y
R
R
S
E
Site 10
S131
R
L
C
S
L
S
S
S
L
Y
R
R
S
E
T
Site 11
Y133
C
S
L
S
S
S
L
Y
R
R
S
E
T
S
V
Site 12
S136
S
S
S
L
Y
R
R
S
E
T
S
V
R
S
M
Site 13
T138
S
L
Y
R
R
S
E
T
S
V
R
S
M
D
S
Site 14
S139
L
Y
R
R
S
E
T
S
V
R
S
M
D
S
R
Site 15
S142
R
S
E
T
S
V
R
S
M
D
S
R
E
A
F
Site 16
S145
T
S
V
R
S
M
D
S
R
E
A
F
C
F
L
Site 17
T154
E
A
F
C
F
L
K
T
K
R
K
P
K
I
L
Site 18
S180
V
Y
Q
E
L
P
N
S
D
P
A
D
P
N
S
Site 19
S187
S
D
P
A
D
P
N
S
D
P
A
D
L
I
F
Site 20
Y198
D
L
I
F
Q
K
D
Y
L
E
Y
G
E
I
L
Site 21
S210
E
I
L
P
F
P
E
S
Q
L
V
E
F
K
Q
Site 22
T220
V
E
F
K
Q
F
S
T
K
H
F
Q
E
Y
V
Site 23
Y226
S
T
K
H
F
Q
E
Y
V
K
R
T
I
P
E
Site 24
Y234
V
K
R
T
I
P
E
Y
V
P
A
F
A
N
T
Site 25
S269
K
E
N
V
D
P
D
S
L
R
R
K
I
E
Q
Site 26
Y279
R
K
I
E
Q
A
I
Y
K
L
P
C
V
H
F
Site 27
T294
C
Q
P
Q
R
P
I
T
F
T
L
K
I
V
D
Site 28
Y311
K
R
G
E
L
Y
G
Y
A
C
M
I
R
V
N
Site 29
S331
V
F
S
E
A
P
N
S
W
I
V
E
D
K
Y
Site 30
Y338
S
W
I
V
E
D
K
Y
V
C
S
L
T
T
E
Site 31
S362
D
P
D
L
L
Q
L
S
E
D
F
E
C
Q
L
Site 32
S370
E
D
F
E
C
Q
L
S
L
S
S
G
P
P
L
Site 33
S372
F
E
C
Q
L
S
L
S
S
G
P
P
L
S
R
Site 34
S373
E
C
Q
L
S
L
S
S
G
P
P
L
S
R
P
Site 35
S378
L
S
S
G
P
P
L
S
R
P
V
Y
S
K
K
Site 36
Y382
P
P
L
S
R
P
V
Y
S
K
K
G
L
E
H
Site 37
S383
P
L
S
R
P
V
Y
S
K
K
G
L
E
H
K
Site 38
Y404
L
F
S
V
P
P
G
Y
L
R
Y
T
P
E
S
Site 39
Y407
V
P
P
G
Y
L
R
Y
T
P
E
S
L
W
R
Site 40
T408
P
P
G
Y
L
R
Y
T
P
E
S
L
W
R
D
Site 41
S411
Y
L
R
Y
T
P
E
S
L
W
R
D
L
I
S
Site 42
S418
S
L
W
R
D
L
I
S
E
H
R
G
L
E
E
Site 43
Y486
Q
D
A
E
G
Q
D
Y
C
T
R
T
A
F
T
Site 44
T488
A
E
G
Q
D
Y
C
T
R
T
A
F
T
L
K
Site 45
S518
R
A
K
V
L
C
L
S
P
E
S
S
A
E
A
Site 46
S531
E
A
L
E
A
A
V
S
P
M
D
Y
P
A
S
Site 47
S538
S
P
M
D
Y
P
A
S
Y
S
L
A
G
T
Q
Site 48
S540
M
D
Y
P
A
S
Y
S
L
A
G
T
Q
H
M
Site 49
Y582
N
L
L
T
A
Q
Q
Y
E
I
F
S
R
S
L
Site 50
S588
Q
Y
E
I
F
S
R
S
L
R
K
N
R
E
L
Site 51
Y629
C
E
A
H
R
I
L
Y
V
C
E
N
Q
P
L
Site 52
S641
Q
P
L
R
N
F
I
S
D
R
N
I
C
R
A
Site 53
T650
R
N
I
C
R
A
E
T
R
K
T
F
L
R
E
Site 54
T653
C
R
A
E
T
R
K
T
F
L
R
E
N
F
E
Site 55
Y681
R
T
E
D
G
D
W
Y
G
K
A
K
S
I
T
Site 56
S686
D
W
Y
G
K
A
K
S
I
T
R
R
A
K
G
Site 57
T688
Y
G
K
A
K
S
I
T
R
R
A
K
G
G
P
Site 58
S713
Q
T
S
H
L
D
C
S
G
L
P
P
L
S
D
Site 59
S719
C
S
G
L
P
P
L
S
D
Q
Y
P
R
E
E
Site 60
Y722
L
P
P
L
S
D
Q
Y
P
R
E
E
L
T
R
Site 61
Y740
N
A
D
P
I
A
K
Y
L
Q
K
E
M
Q
V
Site 62
S750
K
E
M
Q
V
I
R
S
N
P
S
F
N
I
P
Site 63
S753
Q
V
I
R
S
N
P
S
F
N
I
P
T
G
C
Site 64
S770
V
F
P
E
A
E
W
S
Q
G
V
Q
G
T
L
Site 65
T776
W
S
Q
G
V
Q
G
T
L
R
I
K
K
Y
L
Site 66
Y782
G
T
L
R
I
K
K
Y
L
T
V
E
Q
I
M
Site 67
Y804
R
R
F
F
D
R
G
Y
S
P
K
D
V
A
V
Site 68
S805
R
F
F
D
R
G
Y
S
P
K
D
V
A
V
L
Site 69
Y822
T
A
K
E
V
E
H
Y
K
Y
E
L
L
K
A
Site 70
Y824
K
E
V
E
H
Y
K
Y
E
L
L
K
A
M
R
Site 71
S839
K
K
R
V
V
Q
L
S
D
A
C
D
M
L
G
Site 72
S853
G
D
H
I
V
L
D
S
V
R
R
F
S
G
L
Site 73
S858
L
D
S
V
R
R
F
S
G
L
E
R
S
I
V
Site 74
S863
R
F
S
G
L
E
R
S
I
V
F
G
I
H
P
Site 75
T872
V
F
G
I
H
P
R
T
A
D
P
A
I
L
P
Site 76
S887
N
V
L
I
C
L
A
S
R
A
K
Q
H
L
Y
Site 77
Y894
S
R
A
K
Q
H
L
Y
I
F
P
W
G
G
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation