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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPR123
Full Name:
Probable G-protein coupled receptor 123
Alias:
KIAA1828
Type:
Mass (Da):
137203
Number AA:
1279
UniProt ID:
Q86SQ6
International Prot ID:
IPI00255554
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004930
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
R
G
H
G
N
H
S
R
L
K
S
R
C
A
Site 2
S12
G
N
H
S
R
L
K
S
R
C
A
S
L
G
N
Site 3
S16
R
L
K
S
R
C
A
S
L
G
N
V
H
H
H
Site 4
T38
A
H
C
R
G
G
R
T
P
Q
S
P
D
S
R
Site 5
S41
R
G
G
R
T
P
Q
S
P
D
S
R
G
P
T
Site 6
S44
R
T
P
Q
S
P
D
S
R
G
P
T
A
G
G
Site 7
T48
S
P
D
S
R
G
P
T
A
G
G
H
T
R
G
Site 8
T58
G
H
T
R
G
R
W
T
Y
R
P
I
E
A
L
Site 9
Y59
H
T
R
G
R
W
T
Y
R
P
I
E
A
L
I
Site 10
T78
P
G
A
K
G
G
R
T
A
E
G
E
P
S
W
Site 11
S84
R
T
A
E
G
E
P
S
W
A
W
V
F
R
S
Site 12
Y93
A
W
V
F
R
S
G
Y
L
Q
R
Q
A
L
P
Site 13
S121
Q
H
H
P
G
R
D
S
G
F
L
G
P
G
F
Site 14
S137
D
L
L
R
E
E
P
S
G
R
A
D
G
K
A
Site 15
T149
G
K
A
A
A
Q
K
T
G
R
L
Y
L
F
P
Site 16
S169
K
L
P
E
A
A
D
S
F
G
E
I
A
S
G
Site 17
T182
S
G
N
S
V
I
F
T
S
V
L
Q
S
S
H
Site 18
S183
G
N
S
V
I
F
T
S
V
L
Q
S
S
H
P
Site 19
S187
I
F
T
S
V
L
Q
S
S
H
P
P
G
T
P
Site 20
S188
F
T
S
V
L
Q
S
S
H
P
P
G
T
P
P
Site 21
T193
Q
S
S
H
P
P
G
T
P
P
P
S
A
R
K
Site 22
S197
P
P
G
T
P
P
P
S
A
R
K
P
S
P
G
Site 23
S202
P
P
S
A
R
K
P
S
P
G
A
A
M
L
V
Site 24
S224
G
A
Q
G
C
W
G
S
T
S
P
R
G
Q
A
Site 25
S226
Q
G
C
W
G
S
T
S
P
R
G
Q
A
V
S
Site 26
S233
S
P
R
G
Q
A
V
S
L
V
G
G
P
T
A
Site 27
S243
G
G
P
T
A
G
G
S
R
L
G
G
A
G
C
Site 28
T267
A
R
R
P
R
D
G
T
W
A
D
P
R
R
C
Site 29
S275
W
A
D
P
R
R
C
S
R
A
V
E
G
S
G
Site 30
S294
A
L
V
S
P
G
P
S
G
V
E
E
D
T
R
Site 31
T300
P
S
G
V
E
E
D
T
R
R
E
G
C
V
L
Site 32
S310
E
G
C
V
L
V
G
S
W
R
S
S
T
H
R
Site 33
S314
L
V
G
S
W
R
S
S
T
H
R
S
R
V
L
Site 34
T315
V
G
S
W
R
S
S
T
H
R
S
R
V
L
I
Site 35
S318
W
R
S
S
T
H
R
S
R
V
L
I
I
N
T
Site 36
T325
S
R
V
L
I
I
N
T
P
S
G
R
T
P
W
Site 37
S327
V
L
I
I
N
T
P
S
G
R
T
P
W
S
Q
Site 38
T330
I
N
T
P
S
G
R
T
P
W
S
Q
G
S
L
Site 39
S333
P
S
G
R
T
P
W
S
Q
G
S
L
G
S
T
Site 40
S336
R
T
P
W
S
Q
G
S
L
G
S
T
G
R
Y
Site 41
T340
S
Q
G
S
L
G
S
T
G
R
Y
N
Q
T
R
Site 42
Y343
S
L
G
S
T
G
R
Y
N
Q
T
R
A
P
G
Site 43
T346
S
T
G
R
Y
N
Q
T
R
A
P
G
S
Q
Q
Site 44
S351
N
Q
T
R
A
P
G
S
Q
Q
Q
G
L
C
S
Site 45
S358
S
Q
Q
Q
G
L
C
S
D
A
A
L
H
E
D
Site 46
T371
E
D
F
V
P
E
P
T
P
A
F
F
Q
Y
P
Site 47
Y377
P
T
P
A
F
F
Q
Y
P
P
Q
A
F
S
K
Site 48
T385
P
P
Q
A
F
S
K
T
K
V
R
D
L
G
R
Site 49
Y396
D
L
G
R
G
G
L
Y
A
F
S
K
E
E
K
Site 50
S399
R
G
G
L
Y
A
F
S
K
E
E
K
V
S
E
Site 51
Y413
E
A
Q
R
V
E
A
Y
E
T
H
G
L
G
L
Site 52
T415
Q
R
V
E
A
Y
E
T
H
G
L
G
L
S
T
Site 53
S421
E
T
H
G
L
G
L
S
T
G
R
Q
N
P
V
Site 54
T422
T
H
G
L
G
L
S
T
G
R
Q
N
P
V
P
Site 55
S430
G
R
Q
N
P
V
P
S
P
C
K
P
G
C
V
Site 56
S470
C
L
G
P
P
G
C
S
G
E
L
S
L
P
E
Site 57
S474
P
G
C
S
G
E
L
S
L
P
E
E
E
G
I
Site 58
Y513
L
F
T
Y
V
T
M
Y
Q
C
K
Q
E
R
I
Site 59
S529
R
L
C
I
S
G
E
S
G
R
Y
V
R
R
S
Site 60
Y532
I
S
G
E
S
G
R
Y
V
R
R
S
R
F
R
Site 61
S536
S
G
R
Y
V
R
R
S
R
F
R
N
F
A
A
Site 62
Y568
L
R
G
G
G
H
P
Y
G
D
S
Q
A
G
K
Site 63
S571
G
G
H
P
Y
G
D
S
Q
A
G
K
V
V
E
Site 64
S586
W
R
A
G
D
R
A
S
G
L
S
A
G
E
R
Site 65
S589
G
D
R
A
S
G
L
S
A
G
E
R
R
F
L
Site 66
S597
A
G
E
R
R
F
L
S
Q
S
E
L
Q
T
W
Site 67
S599
E
R
R
F
L
S
Q
S
E
L
Q
T
W
P
R
Site 68
T603
L
S
Q
S
E
L
Q
T
W
P
R
T
P
H
C
Site 69
T607
E
L
Q
T
W
P
R
T
P
H
C
V
G
K
K
Site 70
T628
A
A
D
L
A
P
D
T
S
L
C
R
K
E
G
Site 71
S629
A
D
L
A
P
D
T
S
L
C
R
K
E
G
S
Site 72
S636
S
L
C
R
K
E
G
S
S
A
S
R
S
C
R
Site 73
S637
L
C
R
K
E
G
S
S
A
S
R
S
C
R
P
Site 74
S639
R
K
E
G
S
S
A
S
R
S
C
R
P
G
P
Site 75
S641
E
G
S
S
A
S
R
S
C
R
P
G
P
G
H
Site 76
T650
R
P
G
P
G
H
L
T
R
R
E
E
D
S
F
Site 77
S656
L
T
R
R
E
E
D
S
F
R
Q
L
A
F
P
Site 78
T674
E
V
T
F
P
P
L
T
A
A
E
R
A
P
S
Site 79
S681
T
A
A
E
R
A
P
S
V
H
G
G
H
S
L
Site 80
S687
P
S
V
H
G
G
H
S
L
A
S
Q
G
L
V
Site 81
S701
V
L
A
G
R
T
R
S
V
A
S
G
G
K
Q
Site 82
T725
I
P
T
Q
D
L
K
T
V
L
S
L
P
R
Y
Site 83
S728
Q
D
L
K
T
V
L
S
L
P
R
Y
P
G
E
Site 84
Y732
T
V
L
S
L
P
R
Y
P
G
E
F
L
H
P
Site 85
S764
V
T
Y
I
V
H
Q
S
A
I
R
I
S
R
K
Site 86
S769
H
Q
S
A
I
R
I
S
R
K
G
R
H
T
L
Site 87
T775
I
S
R
K
G
R
H
T
L
L
N
F
C
F
H
Site 88
Y829
G
V
T
A
R
N
I
Y
K
Q
V
T
K
K
A
Site 89
T842
K
A
P
L
C
L
D
T
D
Q
P
P
Y
P
R
Site 90
Y847
L
D
T
D
Q
P
P
Y
P
R
Q
P
L
L
R
Site 91
Y878
A
A
T
N
I
R
N
Y
G
T
E
D
E
D
T
Site 92
Y917
C
V
Y
F
L
G
T
Y
V
Q
L
R
R
H
P
Site 93
Y928
R
R
H
P
G
R
R
Y
E
L
R
T
Q
P
E
Site 94
T932
G
R
R
Y
E
L
R
T
Q
P
E
E
Q
R
R
Site 95
T942
E
E
Q
R
R
L
A
T
P
E
G
G
R
G
I
Site 96
T953
G
R
G
I
R
P
G
T
P
P
A
H
D
A
P
Site 97
S970
S
V
L
Q
N
E
H
S
F
Q
A
Q
L
R
A
Site 98
S1065
G
R
A
A
C
L
H
S
P
G
L
G
Q
P
R
Site 99
T1112
K
M
H
C
E
P
L
T
A
D
E
A
H
V
H
Site 100
T1140
H
G
C
L
Q
G
R
T
K
P
P
Y
F
S
R
Site 101
Y1144
Q
G
R
T
K
P
P
Y
F
S
R
H
P
A
E
Site 102
S1146
R
T
K
P
P
Y
F
S
R
H
P
A
E
E
P
Site 103
Y1155
H
P
A
E
E
P
E
Y
A
Y
H
I
P
S
S
Site 104
Y1157
A
E
E
P
E
Y
A
Y
H
I
P
S
S
L
D
Site 105
S1161
E
Y
A
Y
H
I
P
S
S
L
D
G
S
P
R
Site 106
S1162
Y
A
Y
H
I
P
S
S
L
D
G
S
P
R
S
Site 107
S1166
I
P
S
S
L
D
G
S
P
R
S
S
R
T
D
Site 108
S1169
S
L
D
G
S
P
R
S
S
R
T
D
S
P
P
Site 109
S1170
L
D
G
S
P
R
S
S
R
T
D
S
P
P
S
Site 110
T1172
G
S
P
R
S
S
R
T
D
S
P
P
S
S
L
Site 111
S1174
P
R
S
S
R
T
D
S
P
P
S
S
L
D
G
Site 112
S1177
S
R
T
D
S
P
P
S
S
L
D
G
P
A
G
Site 113
S1178
R
T
D
S
P
P
S
S
L
D
G
P
A
G
T
Site 114
T1187
D
G
P
A
G
T
H
T
L
A
C
C
T
Q
G
Site 115
T1201
G
D
P
F
P
M
V
T
Q
P
E
G
S
D
G
Site 116
S1209
Q
P
E
G
S
D
G
S
P
A
L
Y
S
C
P
Site 117
Y1213
S
D
G
S
P
A
L
Y
S
C
P
T
Q
P
G
Site 118
S1214
D
G
S
P
A
L
Y
S
C
P
T
Q
P
G
R
Site 119
T1236
H
L
E
M
L
R
R
T
Q
S
L
P
F
G
G
Site 120
S1238
E
M
L
R
R
T
Q
S
L
P
F
G
G
P
S
Site 121
S1245
S
L
P
F
G
G
P
S
Q
N
G
L
P
K
G
Site 122
T1265
L
P
F
G
T
D
G
T
G
N
I
R
T
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation