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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DAAM2
Full Name:
Disheveled-associated activator of morphogenesis 2
Alias:
Dishevelled associated activator of morphogenesis 2; KIAA0381
Type:
Mass (Da):
123499
Number AA:
1068
UniProt ID:
Q86T65
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0017048
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
P
R
K
R
S
H
H
G
L
G
F
L
Site 2
S40
L
Q
F
M
E
F
S
S
P
I
P
N
A
E
E
Site 3
T62
L
V
D
E
L
D
L
T
D
K
N
R
E
A
M
Site 4
Y81
P
E
K
K
W
Q
I
Y
C
S
K
K
K
E
Q
Site 5
Y101
L
A
T
S
W
P
D
Y
Y
I
D
R
I
N
S
Site 6
Y102
A
T
S
W
P
D
Y
Y
I
D
R
I
N
S
M
Site 7
T135
Q
V
V
E
D
L
K
T
A
L
R
T
Q
P
M
Site 8
T146
T
Q
P
M
R
F
V
T
R
F
I
E
L
E
G
Site 9
T168
L
R
S
M
D
H
A
T
C
E
S
R
I
H
T
Site 10
S188
I
K
A
L
M
N
N
S
Q
G
R
A
H
V
L
Site 11
T203
A
Q
P
E
A
I
S
T
I
A
Q
S
L
R
T
Site 12
S207
A
I
S
T
I
A
Q
S
L
R
T
E
N
S
K
Site 13
S213
Q
S
L
R
T
E
N
S
K
T
K
V
A
V
L
Site 14
T215
L
R
T
E
N
S
K
T
K
V
A
V
L
E
I
Site 15
Y246
A
M
L
H
Y
Q
V
Y
A
A
E
R
T
R
F
Site 16
T255
A
E
R
T
R
F
Q
T
L
L
N
E
L
D
R
Site 17
S263
L
L
N
E
L
D
R
S
L
G
R
Y
R
D
E
Site 18
Y267
L
D
R
S
L
G
R
Y
R
D
E
V
N
L
K
Site 19
T275
R
D
E
V
N
L
K
T
A
I
M
S
F
I
N
Site 20
T353
F
D
M
V
H
I
D
T
K
S
A
S
Q
M
F
Site 21
S355
M
V
H
I
D
T
K
S
A
S
Q
M
F
E
L
Site 22
S357
H
I
D
T
K
S
A
S
Q
M
F
E
L
I
H
Site 23
Y369
L
I
H
K
K
L
K
Y
T
E
A
Y
P
C
L
Site 24
Y394
P
Y
K
R
N
G
G
Y
F
Q
Q
W
Q
L
L
Site 25
T473
E
R
E
C
E
T
K
T
L
E
K
E
E
M
M
Site 26
T482
E
K
E
E
M
M
R
T
L
N
K
M
K
D
K
Site 27
S494
K
D
K
L
A
R
E
S
Q
E
L
R
Q
A
R
Site 28
S515
V
A
Q
L
S
E
L
S
T
G
P
V
S
S
P
Site 29
T516
A
Q
L
S
E
L
S
T
G
P
V
S
S
P
P
Site 30
S520
E
L
S
T
G
P
V
S
S
P
P
P
P
G
G
Site 31
S521
L
S
T
G
P
V
S
S
P
P
P
P
G
G
P
Site 32
T530
P
P
P
G
G
P
L
T
L
S
S
S
M
T
T
Site 33
S532
P
G
G
P
L
T
L
S
S
S
M
T
T
N
D
Site 34
S534
G
P
L
T
L
S
S
S
M
T
T
N
D
L
P
Site 35
T536
L
T
L
S
S
S
M
T
T
N
D
L
P
P
P
Site 36
T537
T
L
S
S
S
M
T
T
N
D
L
P
P
P
P
Site 37
T567
L
P
P
G
G
P
P
T
P
P
G
A
P
P
C
Site 38
Y586
L
P
L
P
Q
D
P
Y
P
S
S
D
V
P
L
Site 39
S589
P
Q
D
P
Y
P
S
S
D
V
P
L
R
K
K
Site 40
S602
K
K
R
V
P
Q
P
S
H
P
L
K
S
F
N
Site 41
S607
Q
P
S
H
P
L
K
S
F
N
W
V
K
L
N
Site 42
T621
N
E
E
R
V
P
G
T
V
W
N
E
I
D
D
Site 43
Y647
F
E
K
M
F
S
A
Y
Q
R
H
Q
K
E
L
Site 44
S656
R
H
Q
K
E
L
G
S
T
E
D
I
Y
L
A
Site 45
T657
H
Q
K
E
L
G
S
T
E
D
I
Y
L
A
S
Site 46
Y661
L
G
S
T
E
D
I
Y
L
A
S
R
K
V
K
Site 47
S671
S
R
K
V
K
E
L
S
V
I
D
G
R
R
A
Site 48
S686
Q
N
C
I
I
L
L
S
K
L
K
L
S
N
E
Site 49
S691
L
L
S
K
L
K
L
S
N
E
E
I
R
Q
A
Site 50
S724
L
K
F
I
P
E
K
S
D
I
D
L
L
E
E
Site 51
Y747
A
R
A
D
R
F
L
Y
E
M
S
R
I
D
H
Site 52
Y755
E
M
S
R
I
D
H
Y
Q
Q
R
L
Q
A
L
Site 53
S792
A
S
R
E
L
V
R
S
K
R
L
R
Q
M
L
Site 54
Y818
K
G
Q
R
G
G
A
Y
G
F
R
V
A
S
L
Site 55
T831
S
L
N
K
I
A
D
T
K
S
S
I
D
R
N
Site 56
S833
N
K
I
A
D
T
K
S
S
I
D
R
N
I
S
Site 57
Y844
R
N
I
S
L
L
H
Y
L
I
M
I
L
E
K
Site 58
Y897
A
V
E
V
E
L
E
Y
Q
R
R
Q
V
R
E
Site 59
S906
R
R
Q
V
R
E
P
S
D
K
F
V
P
V
M
Site 60
S923
F
I
T
V
S
S
F
S
F
S
E
L
E
D
Q
Site 61
S925
T
V
S
S
F
S
F
S
E
L
E
D
Q
L
N
Site 62
S1016
K
V
L
A
A
G
S
S
L
E
E
G
G
E
F
Site 63
S1028
G
E
F
D
D
L
V
S
A
L
R
S
G
E
V
Site 64
S1032
D
L
V
S
A
L
R
S
G
E
V
F
D
K
D
Site 65
S1046
D
L
C
K
L
K
R
S
R
K
R
S
G
S
Q
Site 66
S1050
L
K
R
S
R
K
R
S
G
S
Q
A
L
E
V
Site 67
S1052
R
S
R
K
R
S
G
S
Q
A
L
E
V
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation