KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
RNF180
Full Name:
E3 ubiquitin-protein ligase RNF180
Alias:
RING finger protein 180
Type:
Mass (Da):
68254
Number AA:
592
UniProt ID:
Q86T96
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
E
L
I
T
K
N
H
S
Q
E
E
T
S
I
L
Site 2
T17
K
N
H
S
Q
E
E
T
S
I
L
R
C
W
K
Site 3
Y38
S
S
G
C
F
M
E
Y
L
E
N
Q
V
I
K
Site 4
S50
V
I
K
D
K
D
D
S
V
D
A
Q
N
I
C
Site 5
T81
L
I
Q
K
A
Q
W
T
V
G
K
L
N
C
P
Site 6
T102
G
G
F
N
F
V
S
T
P
K
C
S
C
G
Q
Site 7
S116
Q
L
A
A
V
H
L
S
K
S
R
T
D
Y
Q
Site 8
S118
A
A
V
H
L
S
K
S
R
T
D
Y
Q
P
T
Site 9
T120
V
H
L
S
K
S
R
T
D
Y
Q
P
T
Q
A
Site 10
Y122
L
S
K
S
R
T
D
Y
Q
P
T
Q
A
G
R
Site 11
T125
S
R
T
D
Y
Q
P
T
Q
A
G
R
L
M
R
Site 12
S134
A
G
R
L
M
R
P
S
V
K
Y
L
S
H
P
Site 13
Y137
L
M
R
P
S
V
K
Y
L
S
H
P
R
V
Q
Site 14
S139
R
P
S
V
K
Y
L
S
H
P
R
V
Q
S
G
Site 15
S145
L
S
H
P
R
V
Q
S
G
C
D
K
E
A
L
Site 16
T154
C
D
K
E
A
L
L
T
G
G
G
S
E
N
R
Site 17
S158
A
L
L
T
G
G
G
S
E
N
R
N
H
R
L
Site 18
T179
N
N
D
P
G
R
L
T
E
A
L
C
L
E
V
Site 19
T189
L
C
L
E
V
R
P
T
Y
F
E
M
K
N
E
Site 20
Y190
C
L
E
V
R
P
T
Y
F
E
M
K
N
E
K
Site 21
S200
M
K
N
E
K
L
L
S
K
A
S
E
P
K
Y
Site 22
S203
E
K
L
L
S
K
A
S
E
P
K
Y
Q
L
F
Site 23
Y207
S
K
A
S
E
P
K
Y
Q
L
F
V
P
Q
L
Site 24
T221
L
V
T
G
R
C
A
T
R
A
F
H
R
K
S
Site 25
S228
T
R
A
F
H
R
K
S
H
S
L
D
L
N
I
Site 26
S230
A
F
H
R
K
S
H
S
L
D
L
N
I
S
E
Site 27
S236
H
S
L
D
L
N
I
S
E
K
L
T
L
L
P
Site 28
T244
E
K
L
T
L
L
P
T
L
Y
E
I
H
S
K
Site 29
S250
P
T
L
Y
E
I
H
S
K
T
T
A
Y
S
R
Site 30
T252
L
Y
E
I
H
S
K
T
T
A
Y
S
R
L
N
Site 31
S267
E
T
Q
P
I
D
L
S
G
L
P
L
Q
S
S
Site 32
S273
L
S
G
L
P
L
Q
S
S
K
N
S
Y
S
F
Site 33
S274
S
G
L
P
L
Q
S
S
K
N
S
Y
S
F
Q
Site 34
S277
P
L
Q
S
S
K
N
S
Y
S
F
Q
N
P
S
Site 35
Y278
L
Q
S
S
K
N
S
Y
S
F
Q
N
P
S
S
Site 36
S279
Q
S
S
K
N
S
Y
S
F
Q
N
P
S
S
F
Site 37
S284
S
Y
S
F
Q
N
P
S
S
F
D
P
S
M
L
Site 38
S285
Y
S
F
Q
N
P
S
S
F
D
P
S
M
L
L
Site 39
S289
N
P
S
S
F
D
P
S
M
L
L
Q
R
F
S
Site 40
S296
S
M
L
L
Q
R
F
S
V
A
P
H
E
T
Q
Site 41
T304
V
A
P
H
E
T
Q
T
Q
R
G
G
E
F
Q
Site 42
T324
A
S
V
Y
S
D
H
T
N
T
N
N
L
T
F
Site 43
T330
H
T
N
T
N
N
L
T
F
L
M
D
L
P
S
Site 44
S337
T
F
L
M
D
L
P
S
A
G
R
S
M
P
E
Site 45
S341
D
L
P
S
A
G
R
S
M
P
E
A
S
D
Q
Site 46
S346
G
R
S
M
P
E
A
S
D
Q
E
E
H
L
S
Site 47
S353
S
D
Q
E
E
H
L
S
P
L
D
F
L
H
S
Site 48
S360
S
P
L
D
F
L
H
S
A
N
F
S
L
G
S
Site 49
S364
F
L
H
S
A
N
F
S
L
G
S
I
N
Q
R
Site 50
S378
R
L
N
K
R
E
R
S
K
L
K
N
L
R
R
Site 51
Y400
W
L
Q
K
Q
G
K
Y
S
G
V
G
L
L
D
Site 52
T410
V
G
L
L
D
H
M
T
L
N
N
E
M
S
T
Site 53
S416
M
T
L
N
N
E
M
S
T
D
E
D
N
E
Y
Site 54
Y423
S
T
D
E
D
N
E
Y
A
E
E
K
D
S
Y
Site 55
Y430
Y
A
E
E
K
D
S
Y
I
C
A
V
C
L
D
Site 56
S466
T
L
A
K
D
N
P
S
S
T
P
C
P
L
C
Site 57
S467
L
A
K
D
N
P
S
S
T
P
C
P
L
C
R
Site 58
T468
A
K
D
N
P
S
S
T
P
C
P
L
C
R
T
Site 59
T484
I
S
R
V
F
F
Q
T
E
L
N
N
A
T
K
Site 60
T492
E
L
N
N
A
T
K
T
F
F
T
K
E
Y
L
Site 61
Y498
K
T
F
F
T
K
E
Y
L
K
I
K
Q
S
F
Site 62
S504
E
Y
L
K
I
K
Q
S
F
Q
K
S
N
S
A
Site 63
S508
I
K
Q
S
F
Q
K
S
N
S
A
K
W
P
L
Site 64
S510
Q
S
F
Q
K
S
N
S
A
K
W
P
L
P
S
Site 65
S517
S
A
K
W
P
L
P
S
C
R
K
A
F
H
L
Site 66
T536
R
R
H
A
A
P
V
T
R
R
Q
F
P
H
G
Site 67
Y549
H
G
A
H
R
M
D
Y
L
H
F
E
D
D
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation