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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYPN
Full Name:
Myopalladin
Alias:
145 kDa sarcomeric protein; MYOP
Type:
Actin binding protein
Mass (Da):
145257
Number AA:
1320
UniProt ID:
Q86TC9
International Prot ID:
IPI00645179
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0030017
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0003779
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
Q
D
D
S
I
E
A
S
T
S
I
S
Q
L
L
Site 2
S11
D
S
I
E
A
S
T
S
I
S
Q
L
L
R
E
Site 3
S13
I
E
A
S
T
S
I
S
Q
L
L
R
E
S
Y
Site 4
S19
I
S
Q
L
L
R
E
S
Y
L
A
E
T
R
H
Site 5
Y20
S
Q
L
L
R
E
S
Y
L
A
E
T
R
H
R
Site 6
S33
H
R
G
N
N
E
R
S
R
A
E
P
S
S
N
Site 7
S38
E
R
S
R
A
E
P
S
S
N
P
C
H
F
G
Site 8
S39
R
S
R
A
E
P
S
S
N
P
C
H
F
G
S
Site 9
S46
S
N
P
C
H
F
G
S
P
S
G
A
A
E
G
Site 10
S48
P
C
H
F
G
S
P
S
G
A
A
E
G
G
G
Site 11
S64
Q
D
D
L
P
D
L
S
A
F
L
S
Q
E
E
Site 12
S68
P
D
L
S
A
F
L
S
Q
E
E
L
D
E
S
Site 13
S75
S
Q
E
E
L
D
E
S
V
N
L
A
R
L
A
Site 14
Y85
L
A
R
L
A
I
N
Y
D
P
L
E
K
A
D
Site 15
T94
P
L
E
K
A
D
E
T
Q
A
R
K
R
L
S
Site 16
S101
T
Q
A
R
K
R
L
S
P
D
Q
M
K
H
S
Site 17
S108
S
P
D
Q
M
K
H
S
P
N
L
S
F
E
P
Site 18
S124
F
C
Q
D
N
P
R
S
P
T
S
S
K
E
S
Site 19
T126
Q
D
N
P
R
S
P
T
S
S
K
E
S
P
Q
Site 20
S127
D
N
P
R
S
P
T
S
S
K
E
S
P
Q
E
Site 21
S128
N
P
R
S
P
T
S
S
K
E
S
P
Q
E
A
Site 22
S131
S
P
T
S
S
K
E
S
P
Q
E
A
K
R
P
Site 23
Y140
Q
E
A
K
R
P
Q
Y
C
S
E
T
Q
S
K
Site 24
S142
A
K
R
P
Q
Y
C
S
E
T
Q
S
K
K
V
Site 25
T144
R
P
Q
Y
C
S
E
T
Q
S
K
K
V
F
L
Site 26
S162
A
D
F
I
E
E
L
S
S
L
F
K
S
H
S
Site 27
S163
D
F
I
E
E
L
S
S
L
F
K
S
H
S
S
Site 28
S167
E
L
S
S
L
F
K
S
H
S
S
K
R
I
R
Site 29
S169
S
S
L
F
K
S
H
S
S
K
R
I
R
P
R
Site 30
S170
S
L
F
K
S
H
S
S
K
R
I
R
P
R
A
Site 31
S183
R
A
C
K
N
H
K
S
K
L
E
S
Q
N
K
Site 32
S187
N
H
K
S
K
L
E
S
Q
N
K
V
M
Q
E
Site 33
S196
N
K
V
M
Q
E
N
S
S
S
F
S
D
L
S
Site 34
S197
K
V
M
Q
E
N
S
S
S
F
S
D
L
S
E
Site 35
S198
V
M
Q
E
N
S
S
S
F
S
D
L
S
E
R
Site 36
S200
Q
E
N
S
S
S
F
S
D
L
S
E
R
R
E
Site 37
S203
S
S
S
F
S
D
L
S
E
R
R
E
R
S
S
Site 38
S209
L
S
E
R
R
E
R
S
S
V
P
I
P
I
P
Site 39
S210
S
E
R
R
E
R
S
S
V
P
I
P
I
P
A
Site 40
T219
P
I
P
I
P
A
D
T
R
D
N
E
V
N
H
Site 41
S243
R
E
A
E
Q
A
A
S
E
A
A
G
G
D
T
Site 42
T250
S
E
A
A
G
G
D
T
T
P
G
S
S
P
S
Site 43
T251
E
A
A
G
G
D
T
T
P
G
S
S
P
S
S
Site 44
S254
G
G
D
T
T
P
G
S
S
P
S
S
L
Y
Y
Site 45
S255
G
D
T
T
P
G
S
S
P
S
S
L
Y
Y
E
Site 46
S257
T
T
P
G
S
S
P
S
S
L
Y
Y
E
E
P
Site 47
S258
T
P
G
S
S
P
S
S
L
Y
Y
E
E
P
L
Site 48
Y260
G
S
S
P
S
S
L
Y
Y
E
E
P
L
G
Q
Site 49
Y261
S
S
P
S
S
L
Y
Y
E
E
P
L
G
Q
P
Site 50
T272
L
G
Q
P
P
R
F
T
Q
K
L
R
S
R
E
Site 51
S277
R
F
T
Q
K
L
R
S
R
E
V
P
E
G
T
Site 52
Y303
P
P
P
Q
V
R
W
Y
C
E
G
K
E
L
E
Site 53
S312
E
G
K
E
L
E
N
S
P
D
I
H
I
V
Q
Site 54
T336
A
E
A
F
E
E
D
T
G
R
Y
S
C
F
A
Site 55
S340
E
E
D
T
G
R
Y
S
C
F
A
S
N
I
Y
Site 56
S344
G
R
Y
S
C
F
A
S
N
I
Y
G
T
D
S
Site 57
Y347
S
C
F
A
S
N
I
Y
G
T
D
S
T
S
A
Site 58
S351
S
N
I
Y
G
T
D
S
T
S
A
E
I
Y
I
Site 59
S353
I
Y
G
T
D
S
T
S
A
E
I
Y
I
E
G
Site 60
Y357
D
S
T
S
A
E
I
Y
I
E
G
V
S
S
S
Site 61
S362
E
I
Y
I
E
G
V
S
S
S
D
S
E
G
D
Site 62
S363
I
Y
I
E
G
V
S
S
S
D
S
E
G
D
P
Site 63
S364
Y
I
E
G
V
S
S
S
D
S
E
G
D
P
N
Site 64
S366
E
G
V
S
S
S
D
S
E
G
D
P
N
K
E
Site 65
S385
I
Q
K
P
N
E
V
S
S
P
P
T
T
S
A
Site 66
S386
Q
K
P
N
E
V
S
S
P
P
T
T
S
A
V
Site 67
T389
N
E
V
S
S
P
P
T
T
S
A
V
I
P
P
Site 68
T390
E
V
S
S
P
P
T
T
S
A
V
I
P
P
A
Site 69
T412
V
A
Q
P
R
V
A
T
I
Q
Q
C
Q
S
P
Site 70
S418
A
T
I
Q
Q
C
Q
S
P
T
N
Y
L
Q
G
Site 71
T420
I
Q
Q
C
Q
S
P
T
N
Y
L
Q
G
L
D
Site 72
Y422
Q
C
Q
S
P
T
N
Y
L
Q
G
L
D
G
K
Site 73
S445
T
K
M
L
Q
N
L
S
A
S
E
G
Q
L
V
Site 74
S463
C
R
V
K
G
A
P
S
P
K
V
E
W
Y
R
Site 75
Y469
P
S
P
K
V
E
W
Y
R
E
G
T
L
I
E
Site 76
T473
V
E
W
Y
R
E
G
T
L
I
E
D
S
P
D
Site 77
S478
E
G
T
L
I
E
D
S
P
D
F
R
I
L
Q
Site 78
S490
I
L
Q
K
K
P
R
S
M
A
E
P
E
E
I
Site 79
T514
A
E
D
S
G
C
F
T
C
T
A
S
N
K
Y
Site 80
T516
D
S
G
C
F
T
C
T
A
S
N
K
Y
G
T
Site 81
Y521
T
C
T
A
S
N
K
Y
G
T
V
S
S
I
A
Site 82
T523
T
A
S
N
K
Y
G
T
V
S
S
I
A
Q
L
Site 83
S525
S
N
K
Y
G
T
V
S
S
I
A
Q
L
H
V
Site 84
S526
N
K
Y
G
T
V
S
S
I
A
Q
L
H
V
R
Site 85
S539
V
R
G
N
E
D
L
S
N
N
G
S
L
H
S
Site 86
S543
E
D
L
S
N
N
G
S
L
H
S
A
N
S
T
Site 87
S546
S
N
N
G
S
L
H
S
A
N
S
T
T
N
L
Site 88
T550
S
L
H
S
A
N
S
T
T
N
L
A
A
I
E
Site 89
S561
A
A
I
E
P
Q
P
S
P
P
H
S
E
P
P
Site 90
S565
P
Q
P
S
P
P
H
S
E
P
P
S
V
E
Q
Site 91
S569
P
P
H
S
E
P
P
S
V
E
Q
P
P
K
P
Site 92
S590
V
N
H
N
E
P
R
S
S
S
R
I
G
L
R
Site 93
S591
N
H
N
E
P
R
S
S
S
R
I
G
L
R
V
Site 94
S592
H
N
E
P
R
S
S
S
R
I
G
L
R
V
H
Site 95
S609
L
P
E
D
D
K
G
S
E
A
S
S
E
A
G
Site 96
S613
D
K
G
S
E
A
S
S
E
A
G
V
V
T
T
Site 97
T619
S
S
E
A
G
V
V
T
T
R
Q
T
R
P
D
Site 98
T623
G
V
V
T
T
R
Q
T
R
P
D
S
F
Q
E
Site 99
S627
T
R
Q
T
R
P
D
S
F
Q
E
R
F
N
G
Site 100
T637
E
R
F
N
G
Q
A
T
K
T
P
E
P
S
S
Site 101
T639
F
N
G
Q
A
T
K
T
P
E
P
S
S
P
V
Site 102
S643
A
T
K
T
P
E
P
S
S
P
V
K
E
P
P
Site 103
S644
T
K
T
P
E
P
S
S
P
V
K
E
P
P
P
Site 104
T661
A
K
P
K
L
D
S
T
Q
L
Q
Q
L
H
N
Site 105
S683
Q
L
Q
N
P
P
P
S
S
P
K
E
F
P
F
Site 106
S684
L
Q
N
P
P
P
S
S
P
K
E
F
P
F
S
Site 107
S691
S
P
K
E
F
P
F
S
M
T
V
L
N
S
N
Site 108
T693
K
E
F
P
F
S
M
T
V
L
N
S
N
A
P
Site 109
S697
F
S
M
T
V
L
N
S
N
A
P
P
A
V
T
Site 110
S707
P
P
A
V
T
T
S
S
K
Q
V
K
A
P
S
Site 111
S714
S
K
Q
V
K
A
P
S
S
Q
T
F
S
L
A
Site 112
S715
K
Q
V
K
A
P
S
S
Q
T
F
S
L
A
R
Site 113
T717
V
K
A
P
S
S
Q
T
F
S
L
A
R
P
K
Site 114
S719
A
P
S
S
Q
T
F
S
L
A
R
P
K
Y
F
Site 115
Y725
F
S
L
A
R
P
K
Y
F
F
P
S
T
N
T
Site 116
T730
P
K
Y
F
F
P
S
T
N
T
T
A
A
T
V
Site 117
T736
S
T
N
T
T
A
A
T
V
A
P
S
S
S
P
Site 118
T746
P
S
S
S
P
V
F
T
L
S
S
T
P
Q
T
Site 119
S748
S
S
P
V
F
T
L
S
S
T
P
Q
T
I
Q
Site 120
S749
S
P
V
F
T
L
S
S
T
P
Q
T
I
Q
R
Site 121
T750
P
V
F
T
L
S
S
T
P
Q
T
I
Q
R
T
Site 122
T753
T
L
S
S
T
P
Q
T
I
Q
R
T
V
S
K
Site 123
T757
T
P
Q
T
I
Q
R
T
V
S
K
E
S
L
L
Site 124
S759
Q
T
I
Q
R
T
V
S
K
E
S
L
L
V
S
Site 125
S762
Q
R
T
V
S
K
E
S
L
L
V
S
H
P
S
Site 126
S766
S
K
E
S
L
L
V
S
H
P
S
V
Q
T
K
Site 127
S769
S
L
L
V
S
H
P
S
V
Q
T
K
S
P
G
Site 128
T772
V
S
H
P
S
V
Q
T
K
S
P
G
G
L
S
Site 129
S774
H
P
S
V
Q
T
K
S
P
G
G
L
S
I
Q
Site 130
S779
T
K
S
P
G
G
L
S
I
Q
N
E
P
L
P
Site 131
T790
E
P
L
P
P
G
P
T
E
P
T
P
P
P
F
Site 132
T793
P
P
G
P
T
E
P
T
P
P
P
F
T
F
S
Site 133
T798
E
P
T
P
P
P
F
T
F
S
I
P
S
G
N
Site 134
S800
T
P
P
P
F
T
F
S
I
P
S
G
N
Q
F
Site 135
S803
P
F
T
F
S
I
P
S
G
N
Q
F
Q
P
R
Site 136
S813
Q
F
Q
P
R
C
V
S
P
I
P
V
S
P
T
Site 137
S818
C
V
S
P
I
P
V
S
P
T
S
R
I
Q
N
Site 138
S821
P
I
P
V
S
P
T
S
R
I
Q
N
P
V
A
Site 139
T843
S
L
P
A
I
P
P
T
N
A
M
G
L
P
R
Site 140
S851
N
A
M
G
L
P
R
S
A
P
S
M
P
S
Q
Site 141
S854
G
L
P
R
S
A
P
S
M
P
S
Q
G
L
A
Site 142
T865
Q
G
L
A
K
K
N
T
K
S
P
Q
P
V
N
Site 143
S867
L
A
K
K
N
T
K
S
P
Q
P
V
N
D
D
Site 144
T879
N
D
D
N
I
R
E
T
K
N
A
V
I
R
D
Site 145
T892
R
D
L
G
K
K
I
T
F
S
D
V
R
P
N
Site 146
S894
L
G
K
K
I
T
F
S
D
V
R
P
N
Q
Q
Site 147
Y903
V
R
P
N
Q
Q
E
Y
K
I
S
S
F
E
Q
Site 148
S907
Q
Q
E
Y
K
I
S
S
F
E
Q
R
L
M
N
Site 149
T923
I
E
F
R
L
E
R
T
P
V
D
E
S
D
D
Site 150
S928
E
R
T
P
V
D
E
S
D
D
E
I
Q
H
D
Site 151
T957
R
L
K
H
F
R
V
T
E
G
S
P
V
T
F
Site 152
S960
H
F
R
V
T
E
G
S
P
V
T
F
T
C
K
Site 153
Y977
G
I
P
V
P
K
V
Y
W
F
K
D
G
K
Q
Site 154
T1001
M
R
R
E
G
D
G
T
C
S
L
H
I
E
S
Site 155
S1003
R
E
G
D
G
T
C
S
L
H
I
E
S
T
T
Site 156
S1011
L
H
I
E
S
T
T
S
D
D
D
G
N
Y
T
Site 157
Y1017
T
S
D
D
D
G
N
Y
T
I
M
A
A
N
P
Site 158
S1029
A
N
P
Q
G
R
I
S
C
S
G
H
L
M
V
Site 159
S1038
S
G
H
L
M
V
Q
S
L
P
I
R
S
R
L
Site 160
S1043
V
Q
S
L
P
I
R
S
R
L
T
S
A
G
Q
Site 161
T1046
L
P
I
R
S
R
L
T
S
A
G
Q
S
H
R
Site 162
S1047
P
I
R
S
R
L
T
S
A
G
Q
S
H
R
G
Site 163
S1051
R
L
T
S
A
G
Q
S
H
R
G
R
S
R
V
Site 164
S1056
G
Q
S
H
R
G
R
S
R
V
Q
E
R
D
K
Site 165
S1097
C
R
L
D
C
K
V
S
G
L
P
P
P
E
L
Site 166
T1137
S
L
L
I
D
P
L
T
Q
R
D
A
G
T
Y
Site 167
Y1144
T
Q
R
D
A
G
T
Y
K
C
I
A
T
N
K
Site 168
T1152
K
C
I
A
T
N
K
T
G
Q
N
S
F
S
L
Site 169
S1156
T
N
K
T
G
Q
N
S
F
S
L
E
L
S
V
Site 170
S1158
K
T
G
Q
N
S
F
S
L
E
L
S
V
V
A
Site 171
T1215
D
N
E
T
I
P
C
T
R
E
R
I
S
M
H
Site 172
S1220
P
C
T
R
E
R
I
S
M
H
Q
D
T
T
G
Site 173
T1225
R
I
S
M
H
Q
D
T
T
G
Y
A
C
L
L
Site 174
S1239
L
I
Q
P
A
K
K
S
D
A
G
W
Y
T
L
Site 175
T1245
K
S
D
A
G
W
Y
T
L
S
A
K
N
E
A
Site 176
S1276
H
Q
I
P
P
P
M
S
V
R
P
S
G
S
R
Site 177
S1280
P
P
M
S
V
R
P
S
G
S
R
Y
G
S
L
Site 178
S1282
M
S
V
R
P
S
G
S
R
Y
G
S
L
T
S
Site 179
Y1284
V
R
P
S
G
S
R
Y
G
S
L
T
S
K
G
Site 180
S1286
P
S
G
S
R
Y
G
S
L
T
S
K
G
L
D
Site 181
T1288
G
S
R
Y
G
S
L
T
S
K
G
L
D
I
F
Site 182
S1296
S
K
G
L
D
I
F
S
A
F
S
S
M
E
S
Site 183
S1303
S
A
F
S
S
M
E
S
T
M
V
Y
S
C
S
Site 184
T1304
A
F
S
S
M
E
S
T
M
V
Y
S
C
S
S
Site 185
Y1307
S
M
E
S
T
M
V
Y
S
C
S
S
R
S
V
Site 186
S1310
S
T
M
V
Y
S
C
S
S
R
S
V
V
E
S
Site 187
S1311
T
M
V
Y
S
C
S
S
R
S
V
V
E
S
D
Site 188
S1313
V
Y
S
C
S
S
R
S
V
V
E
S
D
E
L
Site 189
S1317
S
S
R
S
V
V
E
S
D
E
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation