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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTSL2
Full Name:
ADAMTS-like protein 2
Alias:
Type:
Mass (Da):
104621
Number AA:
951
UniProt ID:
Q86TH1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
V
V
A
G
D
T
V
S
T
G
S
T
D
N
S
Site 2
S29
G
D
T
V
S
T
G
S
T
D
N
S
P
T
S
Site 3
T30
D
T
V
S
T
G
S
T
D
N
S
P
T
S
N
Site 4
S33
S
T
G
S
T
D
N
S
P
T
S
N
S
L
E
Site 5
S36
S
T
D
N
S
P
T
S
N
S
L
E
G
G
T
Site 6
S38
D
N
S
P
T
S
N
S
L
E
G
G
T
D
A
Site 7
S62
K
W
T
A
C
S
R
S
C
G
G
G
V
T
S
Site 8
S69
S
C
G
G
G
V
T
S
Q
E
R
H
C
L
Q
Site 9
S81
C
L
Q
Q
R
R
K
S
V
P
G
P
G
N
R
Site 10
T89
V
P
G
P
G
N
R
T
C
T
G
T
S
K
R
Site 11
T91
G
P
G
N
R
T
C
T
G
T
S
K
R
Y
Q
Site 12
T93
G
N
R
T
C
T
G
T
S
K
R
Y
Q
L
C
Site 13
S111
E
C
P
P
D
G
R
S
F
R
E
E
Q
C
V
Site 14
Y140
K
P
L
Y
P
D
D
Y
V
H
I
S
S
K
P
Site 15
T169
M
V
P
A
R
D
G
T
S
C
K
L
T
D
L
Site 16
S211
G
I
C
Q
G
D
G
S
S
C
T
H
V
T
G
Site 17
T214
Q
G
D
G
S
S
C
T
H
V
T
G
N
Y
R
Site 18
Y229
K
G
N
A
H
L
G
Y
S
L
V
T
H
I
P
Site 19
Y262
A
L
A
D
E
A
G
Y
Y
F
F
N
G
N
Y
Site 20
Y263
L
A
D
E
A
G
Y
Y
F
F
N
G
N
Y
K
Site 21
Y269
Y
Y
F
F
N
G
N
Y
K
V
D
S
P
K
N
Site 22
S273
N
G
N
Y
K
V
D
S
P
K
N
F
N
I
A
Site 23
Y286
I
A
G
T
V
V
K
Y
R
R
P
M
D
V
Y
Site 24
Y293
Y
R
R
P
M
D
V
Y
E
T
G
I
E
Y
I
Site 25
S321
V
W
N
Q
N
G
K
S
P
S
I
T
F
E
Y
Site 26
S323
N
Q
N
G
K
S
P
S
I
T
F
E
Y
T
L
Site 27
T325
N
G
K
S
P
S
I
T
F
E
Y
T
L
L
Q
Site 28
Y328
S
P
S
I
T
F
E
Y
T
L
L
Q
P
P
H
Site 29
T329
P
S
I
T
F
E
Y
T
L
L
Q
P
P
H
E
Site 30
S337
L
L
Q
P
P
H
E
S
R
P
Q
P
I
Y
Y
Site 31
Y343
E
S
R
P
Q
P
I
Y
Y
G
F
S
E
S
A
Site 32
Y344
S
R
P
Q
P
I
Y
Y
G
F
S
E
S
A
E
Site 33
S347
Q
P
I
Y
Y
G
F
S
E
S
A
E
S
Q
G
Site 34
S349
I
Y
Y
G
F
S
E
S
A
E
S
Q
G
L
D
Site 35
S352
G
F
S
E
S
A
E
S
Q
G
L
D
G
A
G
Site 36
S369
G
F
V
P
H
N
G
S
L
Y
G
Q
A
S
S
Site 37
Y371
V
P
H
N
G
S
L
Y
G
Q
A
S
S
E
R
Site 38
S375
G
S
L
Y
G
Q
A
S
S
E
R
L
G
L
D
Site 39
S376
S
L
Y
G
Q
A
S
S
E
R
L
G
L
D
N
Site 40
S398
L
D
M
E
L
G
P
S
Q
G
Q
E
T
N
E
Site 41
T430
G
F
R
D
R
N
V
T
G
T
P
L
T
G
D
Site 42
T432
R
D
R
N
V
T
G
T
P
L
T
G
D
K
D
Site 43
T445
K
D
D
E
E
V
D
T
H
F
A
S
Q
E
F
Site 44
S449
E
V
D
T
H
F
A
S
Q
E
F
F
S
A
N
Site 45
T473
G
S
D
L
K
D
F
T
L
N
E
T
V
N
S
Site 46
T477
K
D
F
T
L
N
E
T
V
N
S
I
F
A
Q
Site 47
S480
T
L
N
E
T
V
N
S
I
F
A
Q
G
A
P
Site 48
S489
F
A
Q
G
A
P
R
S
S
L
A
E
S
F
F
Site 49
S494
P
R
S
S
L
A
E
S
F
F
V
D
Y
E
E
Site 50
Y499
A
E
S
F
F
V
D
Y
E
E
N
E
G
A
G
Site 51
Y508
E
N
E
G
A
G
P
Y
L
L
N
G
S
Y
L
Site 52
S513
G
P
Y
L
L
N
G
S
Y
L
E
L
S
S
D
Site 53
Y514
P
Y
L
L
N
G
S
Y
L
E
L
S
S
D
R
Site 54
S518
N
G
S
Y
L
E
L
S
S
D
R
V
A
N
S
Site 55
S519
G
S
Y
L
E
L
S
S
D
R
V
A
N
S
S
Site 56
S525
S
S
D
R
V
A
N
S
S
S
E
A
P
F
P
Site 57
S526
S
D
R
V
A
N
S
S
S
E
A
P
F
P
N
Site 58
S527
D
R
V
A
N
S
S
S
E
A
P
F
P
N
V
Site 59
S537
P
F
P
N
V
S
T
S
L
L
T
S
A
G
N
Site 60
S541
V
S
T
S
L
L
T
S
A
G
N
R
T
H
K
Site 61
S561
K
A
R
K
Q
G
V
S
P
A
D
M
Y
R
W
Site 62
Y566
G
V
S
P
A
D
M
Y
R
W
K
L
S
S
H
Site 63
S572
M
Y
R
W
K
L
S
S
H
E
P
C
S
A
T
Site 64
S577
L
S
S
H
E
P
C
S
A
T
C
T
T
G
V
Site 65
Y594
A
Y
A
M
C
V
R
Y
D
G
V
E
V
D
D
Site 66
S602
D
G
V
E
V
D
D
S
Y
C
D
A
L
T
R
Site 67
Y603
G
V
E
V
D
D
S
Y
C
D
A
L
T
R
P
Site 68
T608
D
S
Y
C
D
A
L
T
R
P
E
P
V
H
E
Site 69
S630
Q
P
R
W
E
T
S
S
W
S
E
C
S
R
T
Site 70
T637
S
W
S
E
C
S
R
T
C
G
E
G
Y
Q
F
Site 71
Y642
S
R
T
C
G
E
G
Y
Q
F
R
V
V
R
C
Site 72
S654
V
R
C
W
K
M
L
S
P
G
F
D
S
S
V
Site 73
S660
L
S
P
G
F
D
S
S
V
Y
S
D
L
C
E
Site 74
Y662
P
G
F
D
S
S
V
Y
S
D
L
C
E
A
A
Site 75
S663
G
F
D
S
S
V
Y
S
D
L
C
E
A
A
E
Site 76
T679
V
R
P
E
E
R
K
T
C
R
N
P
A
C
G
Site 77
S705
T
A
K
C
G
E
R
S
V
V
T
R
D
I
R
Site 78
S714
V
T
R
D
I
R
C
S
E
D
E
K
L
C
D
Site 79
T724
E
K
L
C
D
P
N
T
R
P
V
G
E
K
N
Site 80
T733
P
V
G
E
K
N
C
T
G
P
P
C
D
R
Q
Site 81
S750
V
S
D
W
G
P
C
S
G
S
C
G
Q
G
R
Site 82
T758
G
S
C
G
Q
G
R
T
I
R
H
V
Y
C
K
Site 83
Y763
G
R
T
I
R
H
V
Y
C
K
T
S
D
G
R
Site 84
S775
D
G
R
V
V
P
E
S
Q
C
Q
M
E
T
K
Site 85
S833
N
G
K
P
Q
T
R
S
G
P
E
C
G
L
A
Site 86
S847
A
K
K
P
P
E
E
S
T
C
F
E
R
P
C
Site 87
T848
K
K
P
P
E
E
S
T
C
F
E
R
P
C
F
Site 88
Y881
R
M
R
D
V
K
C
Y
Q
G
T
D
I
V
R
Site 89
T909
C
D
L
Q
P
C
P
T
E
P
P
D
D
S
C
Site 90
S915
P
T
E
P
P
D
D
S
C
Q
D
Q
P
G
T
Site 91
T922
S
C
Q
D
Q
P
G
T
N
C
A
L
A
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation