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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D1
Full Name:
TBC1 domain family member 1
Alias:
KIAA1108; TBC; TBC1; TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; TBCD1
Type:
GTPase-activating protein for Rab
Mass (Da):
133084
Number AA:
1168
UniProt ID:
Q86TI0
International Prot ID:
IPI00164610
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
E
P
I
T
F
T
A
R
K
H
L
L
S
Site 2
S14
T
A
R
K
H
L
L
S
N
E
V
S
V
D
F
Site 3
S51
V
A
E
V
R
R
L
S
R
Q
S
T
R
K
E
Site 4
S54
V
R
R
L
S
R
Q
S
T
R
K
E
P
V
T
Site 5
T55
R
R
L
S
R
Q
S
T
R
K
E
P
V
T
K
Site 6
T61
S
T
R
K
E
P
V
T
K
Q
V
R
L
C
V
Site 7
S69
K
Q
V
R
L
C
V
S
P
S
G
L
R
C
E
Site 8
S71
V
R
L
C
V
S
P
S
G
L
R
C
E
P
E
Site 9
S82
C
E
P
E
P
G
R
S
Q
Q
W
D
P
L
I
Site 10
Y90
Q
Q
W
D
P
L
I
Y
S
S
I
F
E
C
K
Site 11
Y113
H
N
S
H
D
P
S
Y
F
A
C
L
I
K
E
Site 12
Y130
V
H
R
Q
S
I
C
Y
V
F
K
A
D
D
Q
Site 13
T138
V
F
K
A
D
D
Q
T
K
V
P
E
I
I
S
Site 14
S145
T
K
V
P
E
I
I
S
S
I
R
Q
A
G
K
Site 15
S146
K
V
P
E
I
I
S
S
I
R
Q
A
G
K
I
Site 16
T168
C
P
S
E
F
D
D
T
F
S
K
K
F
E
V
Site 17
S170
S
E
F
D
D
T
F
S
K
K
F
E
V
L
F
Site 18
S204
I
E
K
F
N
H
V
S
G
S
R
G
S
E
S
Site 19
S206
K
F
N
H
V
S
G
S
R
G
S
E
S
P
R
Site 20
S209
H
V
S
G
S
R
G
S
E
S
P
R
P
N
P
Site 21
S211
S
G
S
R
G
S
E
S
P
R
P
N
P
P
H
Site 22
S224
P
H
A
A
P
T
G
S
Q
E
P
V
R
R
P
Site 23
S235
V
R
R
P
M
R
K
S
F
S
Q
P
G
L
R
Site 24
S237
R
P
M
R
K
S
F
S
Q
P
G
L
R
S
L
Site 25
S243
F
S
Q
P
G
L
R
S
L
A
F
R
K
E
L
Site 26
S257
L
Q
D
G
G
L
R
S
S
G
F
F
S
S
F
Site 27
S258
Q
D
G
G
L
R
S
S
G
F
F
S
S
F
E
Site 28
S262
L
R
S
S
G
F
F
S
S
F
E
E
S
D
I
Site 29
S263
R
S
S
G
F
F
S
S
F
E
E
S
D
I
E
Site 30
S267
F
F
S
S
F
E
E
S
D
I
E
N
H
L
I
Site 31
S275
D
I
E
N
H
L
I
S
G
H
N
I
V
Q
P
Site 32
T290
T
D
I
E
E
N
R
T
M
L
F
T
I
G
Q
Site 33
T294
E
N
R
T
M
L
F
T
I
G
Q
S
E
V
Y
Site 34
S304
Q
S
E
V
Y
L
I
S
P
D
T
K
K
I
A
Site 35
T307
V
Y
L
I
S
P
D
T
K
K
I
A
L
E
K
Site 36
S320
E
K
N
F
K
E
I
S
F
C
S
Q
G
I
R
Site 37
S339
F
G
F
I
C
R
E
S
S
G
G
G
G
F
H
Site 38
S340
G
F
I
C
R
E
S
S
G
G
G
G
F
H
F
Site 39
S407
E
R
I
E
G
M
N
S
S
K
T
K
L
E
L
Site 40
S408
R
I
E
G
M
N
S
S
K
T
K
L
E
L
Q
Site 41
T410
E
G
M
N
S
S
K
T
K
L
E
L
Q
K
H
Site 42
S450
R
E
N
E
L
I
I
S
F
L
R
C
L
Y
E
Site 43
Y456
I
S
F
L
R
C
L
Y
E
E
K
Q
K
E
H
Site 44
S473
I
G
E
M
K
Q
T
S
Q
M
A
A
E
N
I
Site 45
S482
M
A
A
E
N
I
G
S
E
L
P
P
S
A
T
Site 46
S487
I
G
S
E
L
P
P
S
A
T
R
F
R
L
D
Site 47
T489
S
E
L
P
P
S
A
T
R
F
R
L
D
M
L
Site 48
S503
L
K
N
K
A
K
R
S
L
T
E
S
L
E
S
Site 49
T505
N
K
A
K
R
S
L
T
E
S
L
E
S
I
L
Site 50
S507
A
K
R
S
L
T
E
S
L
E
S
I
L
S
R
Site 51
S510
S
L
T
E
S
L
E
S
I
L
S
R
G
N
K
Site 52
S513
E
S
L
E
S
I
L
S
R
G
N
K
A
R
G
Site 53
S527
G
L
Q
E
H
S
I
S
V
D
L
D
S
S
L
Site 54
S533
I
S
V
D
L
D
S
S
L
S
S
T
L
S
N
Site 55
S535
V
D
L
D
S
S
L
S
S
T
L
S
N
T
S
Site 56
S536
D
L
D
S
S
L
S
S
T
L
S
N
T
S
K
Site 57
T537
L
D
S
S
L
S
S
T
L
S
N
T
S
K
E
Site 58
S539
S
S
L
S
S
T
L
S
N
T
S
K
E
P
S
Site 59
T541
L
S
S
T
L
S
N
T
S
K
E
P
S
V
C
Site 60
S542
S
S
T
L
S
N
T
S
K
E
P
S
V
C
E
Site 61
S546
S
N
T
S
K
E
P
S
V
C
E
K
E
A
L
Site 62
S556
E
K
E
A
L
P
I
S
E
S
S
F
K
L
L
Site 63
S559
A
L
P
I
S
E
S
S
F
K
L
L
G
S
S
Site 64
S565
S
S
F
K
L
L
G
S
S
E
D
L
S
S
D
Site 65
S566
S
F
K
L
L
G
S
S
E
D
L
S
S
D
S
Site 66
S570
L
G
S
S
E
D
L
S
S
D
S
E
S
H
L
Site 67
S571
G
S
S
E
D
L
S
S
D
S
E
S
H
L
P
Site 68
S573
S
E
D
L
S
S
D
S
E
S
H
L
P
E
E
Site 69
S575
D
L
S
S
D
S
E
S
H
L
P
E
E
P
A
Site 70
S585
P
E
E
P
A
P
L
S
P
Q
Q
A
F
R
R
Site 71
T596
A
F
R
R
R
A
N
T
L
S
H
F
P
I
E
Site 72
S598
R
R
R
A
N
T
L
S
H
F
P
I
E
C
Q
Site 73
S614
P
P
Q
P
A
R
G
S
P
G
V
S
Q
R
K
Site 74
S618
A
R
G
S
P
G
V
S
Q
R
K
L
M
R
Y
Site 75
Y625
S
Q
R
K
L
M
R
Y
H
S
V
S
T
E
T
Site 76
S627
R
K
L
M
R
Y
H
S
V
S
T
E
T
P
H
Site 77
S629
L
M
R
Y
H
S
V
S
T
E
T
P
H
E
R
Site 78
T632
Y
H
S
V
S
T
E
T
P
H
E
R
K
D
F
Site 79
S641
H
E
R
K
D
F
E
S
K
A
N
H
L
G
D
Site 80
T652
H
L
G
D
S
G
G
T
P
V
K
T
R
R
H
Site 81
T656
S
G
G
T
P
V
K
T
R
R
H
S
W
R
Q
Site 82
S660
P
V
K
T
R
R
H
S
W
R
Q
Q
I
F
L
Site 83
T671
Q
I
F
L
R
V
A
T
P
Q
K
A
C
D
S
Site 84
S678
T
P
Q
K
A
C
D
S
S
S
R
Y
E
D
Y
Site 85
S679
P
Q
K
A
C
D
S
S
S
R
Y
E
D
Y
S
Site 86
S680
Q
K
A
C
D
S
S
S
R
Y
E
D
Y
S
E
Site 87
Y682
A
C
D
S
S
S
R
Y
E
D
Y
S
E
L
G
Site 88
Y685
S
S
S
R
Y
E
D
Y
S
E
L
G
E
L
P
Site 89
S686
S
S
R
Y
E
D
Y
S
E
L
G
E
L
P
P
Site 90
S695
L
G
E
L
P
P
R
S
P
L
E
P
V
C
E
Site 91
T716
P
P
E
E
K
K
R
T
S
R
E
L
R
E
L
Site 92
S717
P
E
E
K
K
R
T
S
R
E
L
R
E
L
W
Site 93
Y760
N
K
R
L
K
L
D
Y
E
E
I
T
P
C
L
Site 94
T764
K
L
D
Y
E
E
I
T
P
C
L
K
E
V
T
Site 95
T772
P
C
L
K
E
V
T
T
V
W
E
K
M
L
S
Site 96
S779
T
V
W
E
K
M
L
S
T
P
G
R
S
K
I
Site 97
T780
V
W
E
K
M
L
S
T
P
G
R
S
K
I
K
Site 98
S795
F
D
M
E
K
M
H
S
A
V
G
Q
G
V
P
Site 99
Y834
Q
Q
P
K
D
V
P
Y
K
E
L
L
K
Q
L
Site 100
T858
D
L
G
R
T
F
P
T
H
P
Y
F
S
A
Q
Site 101
Y861
R
T
F
P
T
H
P
Y
F
S
A
Q
L
G
A
Site 102
Y880
L
Y
N
I
L
K
A
Y
S
L
L
D
Q
E
V
Site 103
S881
Y
N
I
L
K
A
Y
S
L
L
D
Q
E
V
G
Site 104
Y926
D
M
G
L
R
K
Q
Y
R
P
D
M
I
I
L
Site 105
Y947
L
S
R
L
L
H
D
Y
H
R
D
L
Y
N
H
Site 106
Y952
H
D
Y
H
R
D
L
Y
N
H
L
E
E
H
E
Site 107
S963
E
E
H
E
I
G
P
S
L
Y
A
A
P
W
F
Site 108
S1008
V
A
L
S
L
L
G
S
H
K
P
L
I
L
Q
Site 109
T1021
L
Q
H
E
N
L
E
T
I
V
D
F
I
K
S
Site 110
S1071
L
Q
E
E
L
I
D
S
S
P
L
S
D
N
Q
Site 111
S1072
Q
E
E
L
I
D
S
S
P
L
S
D
N
Q
R
Site 112
S1075
L
I
D
S
S
P
L
S
D
N
Q
R
M
D
K
Site 113
T1086
R
M
D
K
L
E
K
T
N
S
S
L
R
K
Q
Site 114
S1088
D
K
L
E
K
T
N
S
S
L
R
K
Q
N
L
Site 115
S1089
K
L
E
K
T
N
S
S
L
R
K
Q
N
L
D
Site 116
S1110
V
A
N
G
R
I
Q
S
L
E
A
T
I
E
K
Site 117
T1114
R
I
Q
S
L
E
A
T
I
E
K
L
L
S
S
Site 118
S1120
A
T
I
E
K
L
L
S
S
E
S
K
L
K
Q
Site 119
S1121
T
I
E
K
L
L
S
S
E
S
K
L
K
Q
A
Site 120
S1123
E
K
L
L
S
S
E
S
K
L
K
Q
A
M
L
Site 121
S1137
L
T
L
E
L
E
R
S
A
L
L
Q
T
V
E
Site 122
T1142
E
R
S
A
L
L
Q
T
V
E
E
L
R
R
R
Site 123
S1150
V
E
E
L
R
R
R
S
A
E
P
S
D
R
E
Site 124
S1154
R
R
R
S
A
E
P
S
D
R
E
P
E
C
T
Site 125
T1161
S
D
R
E
P
E
C
T
Q
P
E
P
T
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation