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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DPP9
Full Name:
Dipeptidyl peptidase 9
Alias:
Dipeptidyl peptidase IV-related 2; Dipeptidyl peptidase IX; Dipeptidyl peptidase-like 9; DKFZp762F117; DP9; DPLP9; DPRP2; DPRP-2; EC 3.4.14.5; FLJ16073
Type:
Membrane, Cytoplasm protein
Mass (Da):
98263
Number AA:
863
UniProt ID:
Q86TI2
International Prot ID:
IPI00465149
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0008236
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
T
G
T
P
T
A
D
Site 2
T6
_
_
M
A
T
T
G
T
P
T
A
D
R
G
D
Site 3
S30
R
F
Q
V
Q
K
H
S
W
D
G
L
R
S
I
Site 4
S41
L
R
S
I
I
H
G
S
R
K
Y
S
G
L
I
Site 5
Y44
I
I
H
G
S
R
K
Y
S
G
L
I
V
N
K
Site 6
S45
I
H
G
S
R
K
Y
S
G
L
I
V
N
K
A
Site 7
T62
D
F
Q
F
V
Q
K
T
D
E
S
G
P
H
S
Site 8
S65
F
V
Q
K
T
D
E
S
G
P
H
S
H
R
L
Site 9
S69
T
D
E
S
G
P
H
S
H
R
L
Y
Y
L
G
Site 10
Y73
G
P
H
S
H
R
L
Y
Y
L
G
M
P
Y
G
Site 11
Y74
P
H
S
H
R
L
Y
Y
L
G
M
P
Y
G
S
Site 12
Y79
L
Y
Y
L
G
M
P
Y
G
S
R
E
N
S
L
Site 13
S81
Y
L
G
M
P
Y
G
S
R
E
N
S
L
L
Y
Site 14
S85
P
Y
G
S
R
E
N
S
L
L
Y
S
E
I
P
Site 15
S89
R
E
N
S
L
L
Y
S
E
I
P
K
K
V
R
Site 16
S104
K
E
A
L
L
L
L
S
W
K
Q
M
L
D
H
Site 17
Y121
A
T
P
H
H
G
V
Y
S
R
E
E
E
L
L
Site 18
S122
T
P
H
H
G
V
Y
S
R
E
E
E
L
L
R
Site 19
S141
L
G
V
F
G
I
T
S
Y
D
F
H
S
E
S
Site 20
Y142
G
V
F
G
I
T
S
Y
D
F
H
S
E
S
G
Site 21
S158
F
L
F
Q
A
S
N
S
L
F
H
C
R
D
G
Site 22
S173
G
K
N
G
F
M
V
S
P
M
K
P
L
E
I
Site 23
T182
M
K
P
L
E
I
K
T
Q
C
S
G
P
R
M
Site 24
S185
L
E
I
K
T
Q
C
S
G
P
R
M
D
P
K
Site 25
S202
P
A
D
P
A
F
F
S
F
I
N
N
S
D
L
Site 26
T223
T
G
E
E
R
R
L
T
F
C
H
Q
G
L
S
Site 27
S230
T
F
C
H
Q
G
L
S
N
V
L
D
D
P
K
Site 28
S267
P
T
A
S
W
E
G
S
E
G
L
K
T
L
R
Site 29
T272
E
G
S
E
G
L
K
T
L
R
I
L
Y
E
E
Site 30
Y277
L
K
T
L
R
I
L
Y
E
E
V
D
E
S
E
Site 31
S283
L
Y
E
E
V
D
E
S
E
V
E
V
I
H
V
Site 32
S292
V
E
V
I
H
V
P
S
P
A
L
E
E
R
K
Site 33
T300
P
A
L
E
E
R
K
T
D
S
Y
R
Y
P
R
Site 34
S302
L
E
E
R
K
T
D
S
Y
R
Y
P
R
T
G
Site 35
Y303
E
E
R
K
T
D
S
Y
R
Y
P
R
T
G
S
Site 36
Y305
R
K
T
D
S
Y
R
Y
P
R
T
G
S
K
N
Site 37
T308
D
S
Y
R
Y
P
R
T
G
S
K
N
P
K
I
Site 38
S310
Y
R
Y
P
R
T
G
S
K
N
P
K
I
A
L
Site 39
S326
L
A
E
F
Q
T
D
S
Q
G
K
I
V
S
T
Site 40
T333
S
Q
G
K
I
V
S
T
Q
E
K
E
L
V
Q
Site 41
S343
K
E
L
V
Q
P
F
S
S
L
F
P
K
V
E
Site 42
S344
E
L
V
Q
P
F
S
S
L
F
P
K
V
E
Y
Site 43
Y351
S
L
F
P
K
V
E
Y
I
A
R
A
G
W
T
Site 44
S389
P
P
A
L
F
I
P
S
T
E
N
E
E
Q
R
Site 45
T390
P
A
L
F
I
P
S
T
E
N
E
E
Q
R
L
Site 46
S399
N
E
E
Q
R
L
A
S
A
R
A
V
P
R
N
Site 47
Y410
V
P
R
N
V
Q
P
Y
V
V
Y
E
E
V
T
Site 48
Y413
N
V
Q
P
Y
V
V
Y
E
E
V
T
N
V
W
Site 49
Y428
I
N
V
H
D
I
F
Y
P
F
P
Q
S
E
G
Site 50
S433
I
F
Y
P
F
P
Q
S
E
G
E
D
E
L
C
Site 51
S463
K
V
T
A
V
L
K
S
Q
G
Y
D
W
S
E
Site 52
Y466
A
V
L
K
S
Q
G
Y
D
W
S
E
P
F
S
Site 53
S469
K
S
Q
G
Y
D
W
S
E
P
F
S
P
G
E
Site 54
S473
Y
D
W
S
E
P
F
S
P
G
E
D
E
F
K
Site 55
S502
E
V
L
A
R
H
G
S
K
I
W
V
N
E
E
Site 56
Y514
N
E
E
T
K
L
V
Y
F
Q
G
T
K
D
T
Site 57
T521
Y
F
Q
G
T
K
D
T
P
L
E
H
H
L
Y
Site 58
Y528
T
P
L
E
H
H
L
Y
V
V
S
Y
E
A
A
Site 59
T542
A
G
E
I
V
R
L
T
T
P
G
F
S
H
S
Site 60
T543
G
E
I
V
R
L
T
T
P
G
F
S
H
S
C
Site 61
S547
R
L
T
T
P
G
F
S
H
S
C
S
M
S
Q
Site 62
S549
T
T
P
G
F
S
H
S
C
S
M
S
Q
N
F
Site 63
Y563
F
D
M
F
V
S
H
Y
S
S
V
S
T
P
P
Site 64
S564
D
M
F
V
S
H
Y
S
S
V
S
T
P
P
C
Site 65
T568
S
H
Y
S
S
V
S
T
P
P
C
V
H
V
Y
Site 66
Y575
T
P
P
C
V
H
V
Y
K
L
S
G
P
D
D
Site 67
S600
A
S
M
M
E
A
A
S
C
P
P
D
Y
V
P
Site 68
Y605
A
A
S
C
P
P
D
Y
V
P
P
E
I
F
H
Site 69
Y622
T
R
S
D
V
R
L
Y
G
M
I
Y
K
P
H
Site 70
Y626
V
R
L
Y
G
M
I
Y
K
P
H
A
L
Q
P
Site 71
T639
Q
P
G
K
K
H
P
T
V
L
F
V
Y
G
G
Site 72
S655
Q
V
Q
L
V
N
N
S
F
K
G
I
K
Y
L
Site 73
Y661
N
S
F
K
G
I
K
Y
L
R
L
N
T
L
A
Site 74
S682
V
V
I
D
G
R
G
S
C
Q
R
G
L
R
F
Site 75
Y731
V
A
I
H
G
W
S
Y
G
G
F
L
S
L
M
Site 76
Y762
P
V
T
V
W
M
A
Y
D
T
G
Y
T
E
R
Site 77
Y766
W
M
A
Y
D
T
G
Y
T
E
R
Y
M
D
V
Site 78
Y770
D
T
G
Y
T
E
R
Y
M
D
V
P
E
N
N
Site 79
Y781
P
E
N
N
Q
H
G
Y
E
A
G
S
V
A
L
Site 80
S785
Q
H
G
Y
E
A
G
S
V
A
L
H
V
E
K
Site 81
Y830
L
I
R
A
G
K
P
Y
Q
L
Q
I
Y
P
N
Site 82
Y835
K
P
Y
Q
L
Q
I
Y
P
N
E
R
H
S
I
Site 83
S841
I
Y
P
N
E
R
H
S
I
R
C
P
E
S
G
Site 84
S847
H
S
I
R
C
P
E
S
G
E
H
Y
E
V
T
Site 85
Y851
C
P
E
S
G
E
H
Y
E
V
T
L
L
H
F
Site 86
T854
S
G
E
H
Y
E
V
T
L
L
H
F
L
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation