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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATG4D
Full Name:
Cysteine protease ATG4D
Alias:
APG4 autophagy 4 homolog D; APG4 autophagy 4 homologue D; APG4D; APG4-D; ATG4 autophagy related 4 D; AUTL4; AUT-like 4 cysteine endopeptidase; EC 3.4.22.-
Type:
EC 3.4.22.-; Protease; Autophagy; Ubiquitin conjugating system
Mass (Da):
52922
Number AA:
474
UniProt ID:
Q86TL0
International Prot ID:
IPI00328573
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0006914
GO:0019941
GO:0006623
Phosida
TranscriptoNet
STRING
Kinexus Products
Cysteine protease ATG4D pan-specific antibody AB-NN211-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN211-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
V
S
P
A
A
A
Q
Y
R
S
S
S
P
E
D
Site 2
S13
P
A
A
A
Q
Y
R
S
S
S
P
E
D
A
R
Site 3
S14
A
A
A
Q
Y
R
S
S
S
P
E
D
A
R
R
Site 4
S15
A
A
Q
Y
R
S
S
S
P
E
D
A
R
R
R
Site 5
S42
D
P
N
G
L
G
P
S
G
A
S
G
P
A
L
Site 6
S51
A
S
G
P
A
L
G
S
P
G
A
G
P
S
E
Site 7
S57
G
S
P
G
A
G
P
S
E
P
D
E
V
D
K
Site 8
Y78
T
A
W
N
N
V
K
Y
G
W
V
V
K
S
R
Site 9
S84
K
Y
G
W
V
V
K
S
R
T
S
F
S
K
I
Site 10
S87
W
V
V
K
S
R
T
S
F
S
K
I
S
S
I
Site 11
S89
V
K
S
R
T
S
F
S
K
I
S
S
I
H
L
Site 12
S93
T
S
F
S
K
I
S
S
I
H
L
C
G
R
R
Site 13
Y101
I
H
L
C
G
R
R
Y
R
F
E
G
E
G
D
Site 14
T123
F
V
S
R
L
W
L
T
Y
R
R
D
F
P
P
Site 15
Y124
V
S
R
L
W
L
T
Y
R
R
D
F
P
P
L
Site 16
T167
H
F
L
P
R
D
W
T
W
A
E
G
M
G
L
Site 17
S180
G
L
G
P
P
E
L
S
G
S
A
S
P
S
R
Site 18
S182
G
P
P
E
L
S
G
S
A
S
P
S
R
Y
H
Site 19
S184
P
E
L
S
G
S
A
S
P
S
R
Y
H
G
P
Site 20
S186
L
S
G
S
A
S
P
S
R
Y
H
G
P
A
R
Site 21
Y188
G
S
A
S
P
S
R
Y
H
G
P
A
R
W
M
Site 22
S238
R
L
V
E
L
G
Q
S
S
G
K
K
A
G
D
Site 23
Y247
G
K
K
A
G
D
W
Y
G
P
S
L
V
A
H
Site 24
S264
R
K
A
V
E
S
C
S
D
V
T
R
L
V
V
Site 25
Y317
G
E
T
L
N
P
V
Y
V
P
C
V
K
E
L
Site 26
Y343
G
K
P
R
H
S
L
Y
F
I
G
Y
Q
D
D
Site 27
Y354
Y
Q
D
D
F
L
L
Y
L
D
P
H
Y
C
Q
Site 28
T363
D
P
H
Y
C
Q
P
T
V
D
V
S
Q
A
D
Site 29
S367
C
Q
P
T
V
D
V
S
Q
A
D
F
P
L
E
Site 30
S375
Q
A
D
F
P
L
E
S
F
H
C
T
S
P
R
Site 31
T379
P
L
E
S
F
H
C
T
S
P
R
K
M
A
F
Site 32
S380
L
E
S
F
H
C
T
S
P
R
K
M
A
F
A
Site 33
T394
A
K
M
D
P
S
C
T
V
G
F
Y
A
G
D
Site 34
Y398
P
S
C
T
V
G
F
Y
A
G
D
R
K
E
F
Site 35
T407
G
D
R
K
E
F
E
T
L
C
S
E
L
T
R
Site 36
S410
K
E
F
E
T
L
C
S
E
L
T
R
V
L
S
Site 37
T413
E
T
L
C
S
E
L
T
R
V
L
S
S
S
S
Site 38
S417
S
E
L
T
R
V
L
S
S
S
S
A
T
E
R
Site 39
S418
E
L
T
R
V
L
S
S
S
S
A
T
E
R
Y
Site 40
S419
L
T
R
V
L
S
S
S
S
A
T
E
R
Y
P
Site 41
T422
V
L
S
S
S
S
A
T
E
R
Y
P
M
F
T
Site 42
Y425
S
S
S
A
T
E
R
Y
P
M
F
T
L
A
E
Site 43
T429
T
E
R
Y
P
M
F
T
L
A
E
G
H
A
Q
Site 44
S439
E
G
H
A
Q
D
H
S
L
D
D
L
C
S
Q
Site 45
S445
H
S
L
D
D
L
C
S
Q
L
A
Q
P
T
L
Site 46
T451
C
S
Q
L
A
Q
P
T
L
R
L
P
R
T
G
Site 47
T457
P
T
L
R
L
P
R
T
G
R
L
L
R
A
K
Site 48
S467
L
L
R
A
K
R
P
S
S
E
D
F
V
F
L
Site 49
S468
L
R
A
K
R
P
S
S
E
D
F
V
F
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation