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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SETD3
Full Name:
SET domain-containing protein 3
Alias:
C14orf154; DKFZp761E1415; FLJ23027; MGC87236; SET domain containing 3
Type:
Unknown function
Mass (Da):
67257
Number AA:
594
UniProt ID:
Q86TU7
International Prot ID:
IPI00165026
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
G
K
K
S
R
V
K
T
Q
K
S
G
T
G
A
Site 2
S12
S
R
V
K
T
Q
K
S
G
T
G
A
T
A
T
Site 3
T14
V
K
T
Q
K
S
G
T
G
A
T
A
T
V
S
Site 4
T17
Q
K
S
G
T
G
A
T
A
T
V
S
P
K
E
Site 5
S21
T
G
A
T
A
T
V
S
P
K
E
I
L
N
L
Site 6
S37
S
E
L
L
Q
K
C
S
S
P
A
P
G
P
G
Site 7
S38
E
L
L
Q
K
C
S
S
P
A
P
G
P
G
K
Site 8
Y50
P
G
K
E
W
E
E
Y
V
Q
I
R
T
L
V
Site 9
S68
R
K
K
Q
K
G
L
S
V
T
F
D
G
K
R
Site 10
T70
K
Q
K
G
L
S
V
T
F
D
G
K
R
E
D
Site 11
Y78
F
D
G
K
R
E
D
Y
F
P
D
L
M
K
W
Site 12
S87
P
D
L
M
K
W
A
S
E
N
G
A
S
V
E
Site 13
S92
W
A
S
E
N
G
A
S
V
E
G
F
E
M
V
Site 14
T111
E
G
F
G
L
R
A
T
R
D
I
K
A
E
E
Site 15
T130
V
P
R
K
L
L
M
T
V
E
S
A
K
N
S
Site 16
S137
T
V
E
S
A
K
N
S
V
L
G
P
L
Y
S
Site 17
Y143
N
S
V
L
G
P
L
Y
S
Q
D
R
I
L
Q
Site 18
S144
S
V
L
G
P
L
Y
S
Q
D
R
I
L
Q
A
Site 19
S167
H
L
L
C
E
R
A
S
P
N
S
F
W
Q
P
Site 20
Y175
P
N
S
F
W
Q
P
Y
I
Q
T
L
P
S
E
Site 21
S181
P
Y
I
Q
T
L
P
S
E
Y
D
T
P
L
Y
Site 22
Y183
I
Q
T
L
P
S
E
Y
D
T
P
L
Y
F
E
Site 23
T185
T
L
P
S
E
Y
D
T
P
L
Y
F
E
E
D
Site 24
Y188
S
E
Y
D
T
P
L
Y
F
E
E
D
E
V
R
Site 25
T200
E
V
R
Y
L
Q
S
T
Q
A
I
H
D
V
F
Site 26
S208
Q
A
I
H
D
V
F
S
Q
Y
K
N
T
A
R
Site 27
Y217
Y
K
N
T
A
R
Q
Y
A
Y
F
Y
K
V
I
Site 28
Y219
N
T
A
R
Q
Y
A
Y
F
Y
K
V
I
Q
T
Site 29
Y221
A
R
Q
Y
A
Y
F
Y
K
V
I
Q
T
H
P
Site 30
S238
N
K
L
P
L
K
D
S
F
T
Y
E
D
Y
R
Site 31
T240
L
P
L
K
D
S
F
T
Y
E
D
Y
R
W
A
Site 32
Y244
D
S
F
T
Y
E
D
Y
R
W
A
V
S
S
V
Site 33
Y288
N
G
L
I
T
T
G
Y
N
L
E
D
D
R
C
Site 34
Y310
F
R
A
G
E
Q
I
Y
I
F
Y
G
T
R
S
Site 35
Y313
G
E
Q
I
Y
I
F
Y
G
T
R
S
N
A
E
Site 36
S344
V
K
I
K
L
G
V
S
K
S
D
R
L
Y
A
Site 37
S346
I
K
L
G
V
S
K
S
D
R
L
Y
A
M
K
Site 38
Y350
V
S
K
S
D
R
L
Y
A
M
K
A
E
V
L
Site 39
T391
F
L
R
V
F
C
M
T
E
E
E
L
K
E
H
Site 40
T410
S
A
I
D
R
I
F
T
L
G
N
S
E
F
P
Site 41
S414
R
I
F
T
L
G
N
S
E
F
P
V
S
W
D
Site 42
S419
G
N
S
E
F
P
V
S
W
D
N
E
V
K
L
Site 43
S435
T
F
L
E
D
R
A
S
L
L
L
K
T
Y
K
Site 44
T443
L
L
L
K
T
Y
K
T
T
I
E
E
D
K
S
Site 45
S450
T
T
I
E
E
D
K
S
V
L
K
N
H
D
L
Site 46
S481
I
L
E
K
A
V
K
S
A
A
V
N
R
E
Y
Site 47
Y488
S
A
A
V
N
R
E
Y
Y
R
Q
Q
M
E
E
Site 48
Y489
A
A
V
N
R
E
Y
Y
R
Q
Q
M
E
E
K
Site 49
Y502
E
K
A
P
L
P
K
Y
E
E
S
N
L
G
L
Site 50
S512
S
N
L
G
L
L
E
S
S
V
G
D
S
R
L
Site 51
S513
N
L
G
L
L
E
S
S
V
G
D
S
R
L
P
Site 52
S558
G
L
V
N
G
E
N
S
I
P
N
G
T
R
S
Site 53
S565
S
I
P
N
G
T
R
S
E
N
E
S
L
N
Q
Site 54
S569
G
T
R
S
E
N
E
S
L
N
Q
E
S
K
R
Site 55
S584
A
V
E
D
A
K
G
S
S
S
D
S
T
A
G
Site 56
S585
V
E
D
A
K
G
S
S
S
D
S
T
A
G
V
Site 57
S586
E
D
A
K
G
S
S
S
D
S
T
A
G
V
K
Site 58
S588
A
K
G
S
S
S
D
S
T
A
G
V
K
E
_
Site 59
T589
K
G
S
S
S
D
S
T
A
G
V
K
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation