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Updated November 2019
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Protein Info
Short Name:
TTC6
Full Name:
Tetratricopeptide repeat protein 6
Alias:
Type:
Mass (Da):
59379
Number AA:
520
UniProt ID:
Q86TZ1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
D
L
A
K
F
T
I
Y
Q
I
A
E
M
D
K
Site 2
S23
A
E
M
D
K
G
L
S
E
L
S
P
M
Q
Q
Site 3
S26
D
K
G
L
S
E
L
S
P
M
Q
Q
A
L
I
Site 4
Y34
P
M
Q
Q
A
L
I
Y
S
F
C
E
N
H
D
Site 5
S88
K
K
A
L
D
A
I
S
H
S
D
K
G
P
D
Site 6
S90
A
L
D
A
I
S
H
S
D
K
G
P
D
A
T
Site 7
Y111
L
Y
N
L
G
L
C
Y
M
E
E
G
N
L
Q
Site 8
Y121
E
G
N
L
Q
M
T
Y
K
L
A
I
T
D
L
Site 9
S133
T
D
L
T
T
A
I
S
M
D
K
N
S
Y
T
Site 10
Y143
K
N
S
Y
T
A
F
Y
N
R
A
L
C
Y
T
Site 11
Y247
N
P
C
F
L
D
A
Y
V
G
R
G
N
S
Y
Site 12
Y254
Y
V
G
R
G
N
S
Y
M
E
Y
G
H
D
E
Site 13
Y257
R
G
N
S
Y
M
E
Y
G
H
D
E
A
T
K
Site 14
Y289
K
A
R
I
S
F
G
Y
N
L
Q
A
Q
G
K
Site 15
Y315
I
D
T
D
P
K
N
Y
L
A
Y
E
G
R
A
Site 16
T352
S
T
T
A
E
F
L
T
N
R
G
V
I
H
E
Site 17
Y371
K
Q
N
A
M
K
D
Y
Q
D
A
I
T
L
N
Site 18
T376
K
D
Y
Q
D
A
I
T
L
N
P
K
Y
S
L
Site 19
Y385
N
P
K
Y
S
L
A
Y
F
N
A
G
N
I
Y
Site 20
Y392
Y
F
N
A
G
N
I
Y
F
H
H
R
Q
F
S
Site 21
S402
H
R
Q
F
S
Q
A
S
D
Y
F
S
K
A
L
Site 22
Y404
Q
F
S
Q
A
S
D
Y
F
S
K
A
L
K
F
Site 23
S406
S
Q
A
S
D
Y
F
S
K
A
L
K
F
D
P
Site 24
Y417
K
F
D
P
E
N
E
Y
V
L
M
N
R
A
I
Site 25
T427
M
N
R
A
I
T
N
T
I
L
K
K
Y
E
E
Site 26
Y432
T
N
T
I
L
K
K
Y
E
E
A
K
E
D
F
Site 27
Y460
Y
F
N
R
A
H
F
Y
Y
C
L
K
Q
Y
E
Site 28
Y461
F
N
R
A
H
F
Y
Y
C
L
K
Q
Y
E
L
Site 29
S478
E
D
L
N
K
A
L
S
L
K
P
N
D
A
L
Site 30
Y507
I
E
E
A
M
A
D
Y
N
Q
A
L
D
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation