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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
METTL3
Full Name:
N6-adenosine-methyltransferase 70 kDa subunit
Alias:
EC 2.1.1.62; MTA70; N6-adenosine-methyltransferase 70 kDa subunit
Type:
Methyltransferase, RNA processing
Mass (Da):
64474
Number AA:
580
UniProt ID:
Q86U44
International Prot ID:
IPI00009755
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
GO:0005654
GO:0016604
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0016422
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0001510
GO:0006139
GO:0006730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
A
H
K
K
Q
L
D
S
L
R
E
R
L
Q
R
Site 2
S30
Q
R
R
R
K
Q
D
S
G
H
L
D
L
R
N
Site 3
S43
R
N
P
E
A
A
L
S
P
T
F
R
S
D
S
Site 4
T45
P
E
A
A
L
S
P
T
F
R
S
D
S
P
V
Site 5
S48
A
L
S
P
T
F
R
S
D
S
P
V
P
T
A
Site 6
S50
S
P
T
F
R
S
D
S
P
V
P
T
A
P
T
Site 7
T54
R
S
D
S
P
V
P
T
A
P
T
S
G
G
P
Site 8
T57
S
P
V
P
T
A
P
T
S
G
G
P
K
P
S
Site 9
S58
P
V
P
T
A
P
T
S
G
G
P
K
P
S
T
Site 10
S64
T
S
G
G
P
K
P
S
T
A
S
A
V
P
E
Site 11
T65
S
G
G
P
K
P
S
T
A
S
A
V
P
E
L
Site 12
S67
G
P
K
P
S
T
A
S
A
V
P
E
L
A
T
Site 13
T112
S
T
P
D
A
P
A
T
Q
D
G
V
E
S
L
Site 14
Y147
A
H
P
T
L
V
T
Y
A
D
H
S
K
L
S
Site 15
T172
G
P
G
E
V
A
G
T
V
T
G
Q
K
R
R
Site 16
S184
K
R
R
A
E
Q
D
S
T
T
V
A
A
F
A
Site 17
T185
R
R
A
E
Q
D
S
T
T
V
A
A
F
A
S
Site 18
T186
R
A
E
Q
D
S
T
T
V
A
A
F
A
S
S
Site 19
S200
S
L
V
S
G
L
N
S
S
A
S
E
P
A
K
Site 20
S203
S
G
L
N
S
S
A
S
E
P
A
K
E
P
A
Site 21
S213
A
K
E
P
A
K
K
S
R
K
H
A
A
S
D
Site 22
S219
K
S
R
K
H
A
A
S
D
V
D
L
E
I
E
Site 23
S227
D
V
D
L
E
I
E
S
L
L
N
Q
Q
S
T
Site 24
S233
E
S
L
L
N
Q
Q
S
T
K
E
Q
Q
S
K
Site 25
T234
S
L
L
N
Q
Q
S
T
K
E
Q
Q
S
K
K
Site 26
S239
Q
S
T
K
E
Q
Q
S
K
K
V
S
Q
E
I
Site 27
S243
E
Q
Q
S
K
K
V
S
Q
E
I
L
E
L
L
Site 28
T252
E
I
L
E
L
L
N
T
T
T
A
K
E
Q
S
Site 29
S266
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Site 30
Y278
Q
V
Q
E
F
C
D
Y
G
T
K
E
E
C
M
Site 31
S288
K
E
E
C
M
K
A
S
D
A
D
R
P
C
R
Site 32
S310
I
N
K
H
T
D
E
S
L
G
D
C
S
F
L
Site 33
S339
E
I
D
A
C
M
D
S
E
A
P
G
S
K
D
Site 34
S344
M
D
S
E
A
P
G
S
K
D
H
T
P
S
Q
Site 35
T348
A
P
G
S
K
D
H
T
P
S
Q
E
L
A
L
Site 36
S350
G
S
K
D
H
T
P
S
Q
E
L
A
L
T
Q
Site 37
T356
P
S
Q
E
L
A
L
T
Q
S
V
G
G
D
S
Site 38
S358
Q
E
L
A
L
T
Q
S
V
G
G
D
S
S
A
Site 39
S363
T
Q
S
V
G
G
D
S
S
A
D
R
L
F
P
Site 40
S364
Q
S
V
G
G
D
S
S
A
D
R
L
F
P
P
Site 41
Y449
E
C
L
N
L
W
G
Y
E
R
V
D
E
I
I
Site 42
T510
I
V
A
E
V
R
S
T
S
H
K
P
D
E
I
Site 43
S511
V
A
E
V
R
S
T
S
H
K
P
D
E
I
Y
Site 44
Y518
S
H
K
P
D
E
I
Y
G
M
I
E
R
L
S
Site 45
S525
Y
G
M
I
E
R
L
S
P
G
T
R
K
I
E
Site 46
T528
I
E
R
L
S
P
G
T
R
K
I
E
L
F
G
Site 47
Y569
V
A
R
F
K
Q
R
Y
P
D
G
I
I
S
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation