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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARCH-III
Full Name:
E3 ubiquitin-protein ligase MARCH3
Alias:
E3 ubiquitin-protein ligase MARCH3; EC 6.3.2.-; MARCH-III; MARH3; Membrane-associated ring finger (C3HC4) 3; Membrane-associated RING-CH protein III; MGC48332; RING finger protein 173; RNF173
Type:
Ligase; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-
Mass (Da):
28504
Number AA:
253
UniProt ID:
Q86UD3
International Prot ID:
IPI00033653
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0005768
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
T
T
S
R
C
S
H
L
P
E
V
L
P
Site 2
S32
K
T
V
E
D
C
G
S
L
V
N
G
Q
P
Q
Site 3
Y40
L
V
N
G
Q
P
Q
Y
V
M
Q
V
S
A
K
Site 4
T61
T
V
V
R
T
L
A
T
Q
S
P
F
N
D
R
Site 5
S63
V
R
T
L
A
T
Q
S
P
F
N
D
R
P
M
Site 6
S79
R
I
C
H
E
G
S
S
Q
E
D
L
L
S
P
Site 7
S85
S
S
Q
E
D
L
L
S
P
C
E
C
T
G
T
Site 8
T92
S
P
C
E
C
T
G
T
L
G
T
I
H
R
S
Site 9
T95
E
C
T
G
T
L
G
T
I
H
R
S
C
L
E
Site 10
S106
S
C
L
E
H
W
L
S
S
S
N
T
S
Y
C
Site 11
S108
L
E
H
W
L
S
S
S
N
T
S
Y
C
E
L
Site 12
S111
W
L
S
S
S
N
T
S
Y
C
E
L
C
H
F
Site 13
Y112
L
S
S
S
N
T
S
Y
C
E
L
C
H
F
R
Site 14
Y206
W
T
L
V
S
F
R
Y
H
C
R
L
Y
N
E
Site 15
Y211
F
R
Y
H
C
R
L
Y
N
E
W
R
R
T
N
Site 16
T217
L
Y
N
E
W
R
R
T
N
Q
R
V
I
L
L
Site 17
S233
P
K
S
V
N
V
P
S
N
Q
P
S
L
L
G
Site 18
S237
N
V
P
S
N
Q
P
S
L
L
G
L
H
S
V
Site 19
S243
P
S
L
L
G
L
H
S
V
K
R
N
S
K
E
Site 20
S248
L
H
S
V
K
R
N
S
K
E
T
V
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation