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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF2IRD2
Full Name:
General transcription factor II-I repeat domain-containing protein 2A
Alias:
GTF2IRD2A
Type:
Nucleus protein
Mass (Da):
107231
Number AA:
949
UniProt ID:
Q86UP8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
P
V
E
E
E
S
S
S
E
T
R
M
V
V
Site 2
S17
P
V
E
E
E
S
S
S
E
T
R
M
V
V
T
Site 3
T19
E
E
E
S
S
S
E
T
R
M
V
V
T
F
L
Site 4
Y114
L
R
K
A
V
E
D
Y
F
C
F
C
Y
G
K
Site 5
Y119
E
D
Y
F
C
F
C
Y
G
K
A
L
G
T
T
Site 6
S141
E
K
M
L
R
D
Q
S
A
V
V
V
Q
G
L
Site 7
T164
P
E
N
Y
D
L
A
T
L
K
W
I
L
E
N
Site 8
S188
R
P
F
L
G
P
E
S
Q
L
G
G
P
G
M
Site 9
S202
M
V
T
D
A
E
R
S
I
V
S
P
S
E
S
Site 10
S205
D
A
E
R
S
I
V
S
P
S
E
S
C
G
P
Site 11
S207
E
R
S
I
V
S
P
S
E
S
C
G
P
I
N
Site 12
S209
S
I
V
S
P
S
E
S
C
G
P
I
N
V
K
Site 13
T217
C
G
P
I
N
V
K
T
E
P
M
E
D
S
G
Site 14
S223
K
T
E
P
M
E
D
S
G
I
S
L
K
A
E
Site 15
S233
S
L
K
A
E
A
V
S
V
K
K
E
S
E
D
Site 16
Y243
K
E
S
E
D
P
N
Y
Y
Q
Y
N
M
Q
G
Site 17
Y244
E
S
E
D
P
N
Y
Y
Q
Y
N
M
Q
G
S
Site 18
Y246
E
D
P
N
Y
Y
Q
Y
N
M
Q
G
S
H
P
Site 19
S251
Y
Q
Y
N
M
Q
G
S
H
P
S
S
T
S
N
Site 20
S255
M
Q
G
S
H
P
S
S
T
S
N
E
V
I
E
Site 21
S257
G
S
H
P
S
S
T
S
N
E
V
I
E
M
E
Site 22
S270
M
E
L
P
M
E
D
S
T
P
L
V
P
S
E
Site 23
T271
E
L
P
M
E
D
S
T
P
L
V
P
S
E
E
Site 24
S276
D
S
T
P
L
V
P
S
E
E
P
N
E
D
P
Site 25
S295
K
I
E
G
N
T
N
S
S
S
V
T
N
S
A
Site 26
S297
E
G
N
T
N
S
S
S
V
T
N
S
A
A
G
Site 27
T299
N
T
N
S
S
S
V
T
N
S
A
A
G
V
E
Site 28
S301
N
S
S
S
V
T
N
S
A
A
G
V
E
D
L
Site 29
S324
D
N
E
K
E
R
L
S
S
I
E
K
I
K
Q
Site 30
S325
N
E
K
E
R
L
S
S
I
E
K
I
K
Q
L
Site 31
S341
E
Q
V
N
D
L
F
S
R
K
F
G
E
A
I
Site 32
Y358
D
F
P
V
K
V
P
Y
R
K
I
T
F
N
P
Site 33
S388
A
P
G
Y
L
E
I
S
S
M
R
R
I
L
E
Site 34
S389
P
G
Y
L
E
I
S
S
M
R
R
I
L
E
A
Site 35
S414
P
L
P
G
L
E
L
S
N
V
G
K
R
K
I
Site 36
Y436
Q
E
K
W
E
R
A
Y
F
F
V
E
V
Q
N
Site 37
S455
L
I
C
K
Q
S
M
S
V
S
K
E
Y
N
L
Site 38
S457
C
K
Q
S
M
S
V
S
K
E
Y
N
L
R
R
Site 39
Y460
S
M
S
V
S
K
E
Y
N
L
R
R
H
Y
Q
Site 40
Y466
E
Y
N
L
R
R
H
Y
Q
T
N
H
S
K
H
Site 41
Y477
H
S
K
H
Y
D
Q
Y
M
E
R
M
R
D
E
Site 42
Y496
L
K
K
G
L
R
K
Y
L
L
G
L
S
D
T
Site 43
S501
R
K
Y
L
L
G
L
S
D
T
E
C
P
E
Q
Site 44
T503
Y
L
L
G
L
S
D
T
E
C
P
E
Q
K
Q
Site 45
S516
K
Q
V
F
A
H
P
S
P
T
Q
K
S
P
V
Site 46
S521
H
P
S
P
T
Q
K
S
P
V
Q
P
V
E
D
Site 47
S543
K
L
R
E
K
I
R
S
F
V
A
Y
S
I
A
Site 48
T555
S
I
A
I
D
E
I
T
D
I
N
N
T
T
Q
Site 49
S577
V
D
E
N
F
D
V
S
E
E
L
L
D
T
V
Site 50
T583
V
S
E
E
L
L
D
T
V
P
M
T
G
T
K
Site 51
T587
L
L
D
T
V
P
M
T
G
T
K
S
G
N
E
Site 52
S591
V
P
M
T
G
T
K
S
G
N
E
I
F
S
R
Site 53
S602
I
F
S
R
V
E
K
S
L
K
K
F
C
I
D
Site 54
S615
I
D
W
S
K
L
V
S
V
A
S
T
G
T
P
Site 55
T633
D
A
N
N
G
L
V
T
K
L
K
S
R
V
A
Site 56
T641
K
L
K
S
R
V
A
T
F
C
K
G
A
E
L
Site 57
S689
C
S
R
G
L
N
H
S
E
F
T
T
L
L
Y
Site 58
T693
L
N
H
S
E
F
T
T
L
L
Y
E
L
D
S
Site 59
Y696
S
E
F
T
T
L
L
Y
E
L
D
S
Q
Y
G
Site 60
S700
T
L
L
Y
E
L
D
S
Q
Y
G
S
L
L
Y
Site 61
Y702
L
Y
E
L
D
S
Q
Y
G
S
L
L
Y
Y
T
Site 62
S704
E
L
D
S
Q
Y
G
S
L
L
Y
Y
T
E
I
Site 63
Y707
S
Q
Y
G
S
L
L
Y
Y
T
E
I
K
W
L
Site 64
Y708
Q
Y
G
S
L
L
Y
Y
T
E
I
K
W
L
S
Site 65
T709
Y
G
S
L
L
Y
Y
T
E
I
K
W
L
S
R
Site 66
S726
V
L
K
R
F
F
E
S
L
E
E
I
D
S
F
Site 67
S732
E
S
L
E
E
I
D
S
F
M
S
S
R
G
K
Site 68
S735
E
E
I
D
S
F
M
S
S
R
G
K
P
L
P
Site 69
S736
E
I
D
S
F
M
S
S
R
G
K
P
L
P
Q
Site 70
S745
G
K
P
L
P
Q
L
S
S
I
D
W
I
R
D
Site 71
S746
K
P
L
P
Q
L
S
S
I
D
W
I
R
D
L
Site 72
S769
H
L
N
A
L
N
I
S
L
Q
G
H
S
Q
I
Site 73
T778
Q
G
H
S
Q
I
V
T
Q
M
Y
D
L
I
R
Site 74
T808
N
N
L
A
H
F
P
T
L
K
L
A
S
R
N
Site 75
S817
K
L
A
S
R
N
E
S
D
G
L
N
Y
I
P
Site 76
T831
P
K
I
A
E
L
K
T
E
F
Q
K
R
L
S
Site 77
S838
T
E
F
Q
K
R
L
S
D
F
K
L
Y
E
S
Site 78
Y843
R
L
S
D
F
K
L
Y
E
S
E
L
T
L
F
Site 79
T848
K
L
Y
E
S
E
L
T
L
F
S
S
P
F
S
Site 80
S851
E
S
E
L
T
L
F
S
S
P
F
S
T
K
I
Site 81
S852
S
E
L
T
L
F
S
S
P
F
S
T
K
I
D
Site 82
S855
T
L
F
S
S
P
F
S
T
K
I
D
S
V
H
Site 83
T856
L
F
S
S
P
F
S
T
K
I
D
S
V
H
E
Site 84
S860
P
F
S
T
K
I
D
S
V
H
E
E
L
Q
M
Site 85
T876
V
I
D
L
Q
C
N
T
V
L
K
T
K
Y
D
Site 86
Y882
N
T
V
L
K
T
K
Y
D
K
V
G
I
P
E
Site 87
Y891
K
V
G
I
P
E
F
Y
K
Y
L
W
G
S
Y
Site 88
Y893
G
I
P
E
F
Y
K
Y
L
W
G
S
Y
P
K
Site 89
S928
L
F
S
I
M
K
L
S
K
T
K
Y
C
S
Q
Site 90
T930
S
I
M
K
L
S
K
T
K
Y
C
S
Q
L
K
Site 91
Y932
M
K
L
S
K
T
K
Y
C
S
Q
L
K
D
S
Site 92
S934
L
S
K
T
K
Y
C
S
Q
L
K
D
S
Q
W
Site 93
S943
L
K
D
S
Q
W
D
S
V
L
H
I
A
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation