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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDZD3
Full Name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
Alias:
Intestinal and kidney-enriched PDZ protein;Natrium-phosphate cotransporter IIa C-terminal-associated protein 2;PDZ domain-containing protein 2;PDZ domain-containing protein 3;Sodium-hydrogen exchanger regulatory factor 4
Type:
Mass (Da):
61004
Number AA:
571
UniProt ID:
Q86UT5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
S
P
P
G
N
H
S
L
S
L
E
A
P
R
Site 2
S13
P
P
G
N
H
S
L
S
L
E
A
P
R
L
H
Site 3
T21
L
E
A
P
R
L
H
T
A
S
D
L
L
G
N
Site 4
S23
A
P
R
L
H
T
A
S
D
L
L
G
N
H
S
Site 5
S42
L
I
T
A
L
V
G
S
R
D
R
R
G
R
V
Site 6
S51
D
R
R
G
R
V
F
S
P
V
P
V
P
L
P
Site 7
T59
P
V
P
V
P
L
P
T
N
P
T
T
Q
H
P
Site 8
T63
P
L
P
T
N
P
T
T
Q
H
P
T
R
Q
K
Site 9
S73
P
T
R
Q
K
L
P
S
T
L
S
G
H
R
V
Site 10
T74
T
R
Q
K
L
P
S
T
L
S
G
H
R
V
C
Site 11
S76
Q
K
L
P
S
T
L
S
G
H
R
V
C
Q
A
Site 12
S109
P
H
P
P
D
P
W
S
L
E
R
P
R
F
C
Site 13
S119
R
P
R
F
C
L
L
S
K
E
E
G
K
S
F
Site 14
S125
L
S
K
E
E
G
K
S
F
G
F
H
L
Q
Q
Site 15
T148
V
C
R
V
D
P
G
T
S
A
Q
R
Q
G
L
Site 16
Y174
D
V
V
E
H
E
D
Y
A
V
V
V
R
R
I
Site 17
T214
E
D
A
H
L
C
P
T
L
G
P
G
V
R
P
Site 18
S236
D
E
G
G
F
G
F
S
V
T
H
G
N
Q
G
Site 19
T238
G
G
F
G
F
S
V
T
H
G
N
Q
G
P
F
Site 20
T251
P
F
W
L
V
L
S
T
G
G
A
A
E
R
A
Site 21
S273
L
L
E
V
N
G
V
S
V
E
K
F
T
H
N
Site 22
S289
L
T
R
K
L
W
Q
S
G
Q
Q
V
T
L
L
Site 23
T325
A
E
G
W
A
L
P
T
K
P
R
C
L
H
L
Site 24
T393
E
G
L
G
H
E
E
T
V
S
R
I
Q
G
Q
Site 25
S395
L
G
H
E
E
T
V
S
R
I
Q
G
Q
G
S
Site 26
S405
Q
G
Q
G
S
C
V
S
L
T
V
V
D
P
E
Site 27
S418
P
E
A
D
R
F
F
S
M
V
R
L
S
P
L
Site 28
S423
F
F
S
M
V
R
L
S
P
L
L
F
L
E
N
Site 29
T431
P
L
L
F
L
E
N
T
E
A
P
A
S
P
Q
Site 30
S436
E
N
T
E
A
P
A
S
P
Q
G
S
S
S
A
Site 31
S440
A
P
A
S
P
Q
G
S
S
S
A
S
L
V
E
Site 32
S442
A
S
P
Q
G
S
S
S
A
S
L
V
E
T
E
Site 33
S444
P
Q
G
S
S
S
A
S
L
V
E
T
E
D
P
Site 34
T448
S
S
A
S
L
V
E
T
E
D
P
S
L
E
D
Site 35
S452
L
V
E
T
E
D
P
S
L
E
D
T
S
V
P
Site 36
T456
E
D
P
S
L
E
D
T
S
V
P
S
V
P
L
Site 37
S457
D
P
S
L
E
D
T
S
V
P
S
V
P
L
G
Site 38
S460
L
E
D
T
S
V
P
S
V
P
L
G
S
R
Q
Site 39
Y471
G
S
R
Q
C
F
L
Y
P
G
P
G
G
S
Y
Site 40
S477
L
Y
P
G
P
G
G
S
Y
G
F
R
L
S
C
Site 41
Y478
Y
P
G
P
G
G
S
Y
G
F
R
L
S
C
V
Site 42
S483
G
S
Y
G
F
R
L
S
C
V
A
S
G
P
R
Site 43
S494
S
G
P
R
L
F
I
S
Q
V
T
P
G
G
S
Site 44
T497
R
L
F
I
S
Q
V
T
P
G
G
S
A
A
R
Site 45
S501
S
Q
V
T
P
G
G
S
A
A
R
A
G
L
Q
Site 46
Y519
V
I
L
E
V
N
G
Y
P
V
G
G
Q
N
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation